LOCUS       NM_005435               5482 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens Rho guanine nucleotide exchange factor 5 (ARHGEF5),
            mRNA.
ACCESSION   NM_005435
VERSION     NM_005435.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5482)
  AUTHORS   Liang,Z., Pan,J., Xie,S., Yang,X. and Cao,R.
  TITLE     Interaction between hTIM-1 and Envelope Protein Is Important for
            JEV Infection
  JOURNAL   Viruses 15 (7), 1589 (2023)
   PUBMED   37515282
  REMARK    GeneRIF: Interaction between hTIM-1 and Envelope Protein Is
            Important for JEV Infection.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5482)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   3  (bases 1 to 5482)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   4  (bases 1 to 5482)
  AUTHORS   Swaney,D.L., Ramms,D.J., Wang,Z., Park,J., Goto,Y., Soucheray,M.,
            Bhola,N., Kim,K., Zheng,F., Zeng,Y., McGregor,M., Herrington,K.A.,
            O'Keefe,R., Jin,N., VanLandingham,N.K., Foussard,H., Von Dollen,J.,
            Bouhaddou,M., Jimenez-Morales,D., Obernier,K., Kreisberg,J.F.,
            Kim,M., Johnson,D.E., Jura,N., Grandis,J.R., Gutkind,J.S.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein network map of head and neck cancer reveals PIK3CA mutant
            drug sensitivity
  JOURNAL   Science 374 (6563), eabf2911 (2021)
   PUBMED   34591642
REFERENCE   5  (bases 1 to 5482)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 5482)
  AUTHORS   Xie,X., Chang,S.W., Tatsumoto,T., Chan,A.M. and Miki,T.
  TITLE     TIM, a Dbl-related protein, regulates cell shape and cytoskeletal
            organization in a Rho-dependent manner
  JOURNAL   Cell Signal 17 (4), 461-471 (2005)
   PUBMED   15601624
REFERENCE   7  (bases 1 to 5482)
  AUTHORS   Debily,M.A., Camarca,A., Ciullo,M., Mayer,C., El Marhomy,S., Ba,I.,
            Jalil,A., Anzisi,A., Guardiola,J. and Piatier-Tonneau,D.
  TITLE     Expression and molecular characterization of alternative
            transcripts of the ARHGEF5/TIM oncogene specific for human breast
            cancer
  JOURNAL   Hum Mol Genet 13 (3), 323-334 (2004)
   PUBMED   14662653
REFERENCE   8  (bases 1 to 5482)
  AUTHORS   Snyder,J.T., Worthylake,D.K., Rossman,K.L., Betts,L., Pruitt,W.M.,
            Siderovski,D.P., Der,C.J. and Sondek,J.
  TITLE     Structural basis for the selective activation of Rho GTPases by Dbl
            exchange factors
  JOURNAL   Nat Struct Biol 9 (6), 468-475 (2002)
   PUBMED   12006984
REFERENCE   9  (bases 1 to 5482)
  AUTHORS   Takai,S., Chan,A.M., Yamada,K. and Miki,T.
  TITLE     Assignment of the human TIM proto-oncogene to 7q33-->q35
  JOURNAL   Cancer Genet Cytogenet 83 (1), 87-89 (1995)
   PUBMED   7656213
REFERENCE   10 (bases 1 to 5482)
  AUTHORS   Chan,A.M., McGovern,E.S., Catalano,G., Fleming,T.P. and Miki,T.
  TITLE     Expression cDNA cloning of a novel oncogene with sequence
            similarity to regulators of small GTP-binding proteins
  JOURNAL   Oncogene 9 (4), 1057-1063 (1994)
   PUBMED   8134109
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK160365.1, CD674013.1,
            BF209445.1, BI256663.1, AK123596.1 and BC010046.2.
            
            On Nov 22, 2018 this sequence version replaced NM_005435.3.
            
            Summary: Rho GTPases play a fundamental role in numerous cellular
            processes initiated by extracellular stimuli that work through G
            protein coupled receptors. The encoded protein may form a complex
            with G proteins and stimulate Rho-dependent signals. This protein
            may be involved in the control of cytoskeletal organization.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK160365.1, BC136661.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000056217.10/ ENSP00000056217.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-231               AK160365.1         63-293
            232-513             CD674013.1         159-440
            514-1468            AK160365.1         576-1530
            1469-1482           BF209445.1         454-467
            1483-1571           AK160365.1         1545-1633
            1572-1835           BI256663.1         285-548
            1836-5478           AK123596.1         41-3683
            5479-5482           BC010046.2         2430-2433
FEATURES             Location/Qualifiers
     source          1..5482
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q35"
     gene            1..5482
                     /gene="ARHGEF5"
                     /gene_synonym="GEF5; P60; TIM; TIM1"
                     /note="Rho guanine nucleotide exchange factor 5"
                     /db_xref="GeneID:7984"
                     /db_xref="HGNC:HGNC:13209"
                     /db_xref="MIM:600888"
     exon            1..100
                     /gene="ARHGEF5"
                     /gene_synonym="GEF5; P60; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            101..3266
                     /gene="ARHGEF5"
                     /gene_synonym="GEF5; P60; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..4906
                     /gene="ARHGEF5"
                     /gene_synonym="GEF5; P60; TIM; TIM1"
                     /note="transforming immortalized mammary oncogene; guanine
                     nucleotide regulatory protein TIM; p60 TIM; oncogene TIM;
                     ephexin-3; Rho guanine nucleotide exchange factor (GEF) 5;
                     ephexin3"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 5"
                     /protein_id="NP_005426.2"
                     /db_xref="CCDS:CCDS34771.1"
                     /db_xref="GeneID:7984"
                     /db_xref="HGNC:HGNC:13209"
                     /db_xref="MIM:600888"
                     /translation="MEAEEAQRGASPPISAIEEFSIIPEAPMRSSQVSALGLEAQEDE
                     DPSYKWREEHRLSATQQSELRDVCDYAIETMPSFPKEGSADVEPNQESLVAEACDTPE
                     HWEAVPQSLAGRQARTLAPPELWACPIQSEHLDMAPFSSDLGSEEEEVEFWPGLTSLT
                     LGSGQAEEEEETSSDNSGQTRYYSPCEEHPAETNQNEGSESGTIRQGEELPPEELQES
                     QGLLHPQEVQVLEEQGQQEAGFRGEGTLREDVCADGLLGEEQMIEQVNDEKGEQKQKQ
                     EQVQDVMLGRQGERMGLTGEPEGLNDGEWEQEDMERKAQGQGGPEQGEERKRELQVPE
                     ENRADSQDEKSQTFLGKSEEVTGKQEDHGIKEKGVPVSGQEAKEPESWDGGRLGAVGR
                     ARSREEENEHHGPSMPALIAPEDSPHCDLFPGASYLMTQIPGTQTESRAEELSPAALS
                     PSLEPIRCSHQPISLLGSFLTEESPDKEIDQNSQQEESRLRKGTVSSQGTEVVFASAS
                     VTPPRTPDSAPPSPAEAYPITPASVSARPPVAFPRRETSCAARAPETASAPLSMDDPS
                     PCGTSEMCPAALYGFPSTGTSPPRPPANSTGTVQHLRSDSFPGSHRTEQTPDLVGMLL
                     SYSHSELPQRPPKPAIYSSVTPRRDRRSGRDYSTVSASPTALSTLKQDSQESISNLER
                     PSSPPSIQPWVSPHNPAFATESPAYGSSPSFVSMEDVRIHEPLPPPPPQRRDTHPSVV
                     ETDGHARVVVPTLKQHSHPPPLALGSGLHAPHKGPLPQASDPAVARQHRPLPSTPDSS
                     HHAQATPRWRYNKPLPPTPDLPQPHLPPISAPGSSRIYRPLPPLPIIDPPTEPPPLPP
                     KSRGRSRSTRGGHMNSGGHAKTRPACQDWTVPLPASAGRTSWPPATARSTESFTSTSR
                     SKSEVSPGMAFSNMTNFLCPSSPTTPWTPELQGPTSKDEAGVSEHPEAPAREPLRRTT
                     PQQGASGPGRSPVGQARQPEKPSHLHLEKASSWPHRRDSGRPPGDSSGQAVAPSEGAN
                     KHKGWSRQGLRRPSILPEGSSDSRGPAVEKHPGPSDTVVFREKKPKEVMGGFSRRCSK
                     LINSSQLLYQEYSDVVLNKEIQSQQRLESLSETPGPSSPRQPRKALVSSESYLQRLSM
                     ASSGSLWQEIPVVRNSTVLLSMTHEDQKLQEVKFELIVSEASYLRSLNIAVDHFQLST
                     SLRATLSNQEHQWLFSRLQDVRDVSATFLSDLEENFENNIFSFQVCDVVLNHAPDFRR
                     VYLPYVTNQTYQERTFQSLMNSNSNFREVLEKLESDPVCQRLSLKSFLILPFQRITRL
                     KLLLQNILKRTQPGSSEEAEATKAHHALEQLIRDCNNNVQSMRRTEELIYLSQKIEFE
                     CKIFPLISQSRWLVKSGELTALEFSASPGLRRKLNTRPVHLHLFNDCLLLSRPREGSR
                     FLVFDHAPFSSIRGEKCEMKLHGPHKNLFRLFLRQNTQGAQAEFLFRTETQSEKLRWI
                     SALAMPREELDLLECYNSPQVQCLRAYKPRENDELALEKADVVMVTQQSSDGWLEGVR
                     LSDGERGWFPVQQVEFISNPEVRAQNLKEAHRVKTAKLQLVEQQA"
     exon            3267..3324
                     /gene="ARHGEF5"
                     /gene_synonym="GEF5; P60; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            3325..3389
                     /gene="ARHGEF5"
                     /gene_synonym="GEF5; P60; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            3390..3643
                     /gene="ARHGEF5"
                     /gene_synonym="GEF5; P60; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            3644..3804
                     /gene="ARHGEF5"
                     /gene_synonym="GEF5; P60; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            3805..3957
                     /gene="ARHGEF5"
                     /gene_synonym="GEF5; P60; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            3958..4087
                     /gene="ARHGEF5"
                     /gene_synonym="GEF5; P60; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            4088..4162
                     /gene="ARHGEF5"
                     /gene_synonym="GEF5; P60; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            4163..4252
                     /gene="ARHGEF5"
                     /gene_synonym="GEF5; P60; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            4253..4410
                     /gene="ARHGEF5"
                     /gene_synonym="GEF5; P60; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            4411..4572
                     /gene="ARHGEF5"
                     /gene_synonym="GEF5; P60; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            4573..4643
                     /gene="ARHGEF5"
                     /gene_synonym="GEF5; P60; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            4644..4748
                     /gene="ARHGEF5"
                     /gene_synonym="GEF5; P60; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            4749..5482
                     /gene="ARHGEF5"
                     /gene_synonym="GEF5; P60; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5458..5463
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGEF5"
                     /gene_synonym="GEF5; P60; TIM; TIM1"
                     /note="hexamer: AATAAA"
     polyA_site      5482
                     /gene="ARHGEF5"
                     /gene_synonym="GEF5; P60; TIM; TIM1"
                     /note="major polyA site"
ORIGIN      
        1 ggggcggccg ggcctgcgct ggggacggct ctggggactg cggccggcgc cgggacctgg
       61 aggggacgct ggggccgaag cagcatgtga caccgaccag gattcagccc tgatggaggc
      121 tgaggaggcc cagcgtggag cctctcctcc catctctgcc atagaggaat tcagcattat
      181 ccctgaggct cccatgagga gcagccaggt ctctgccttg gggcttgaag ctcaagaaga
      241 tgaggaccca tcctataagt ggagagagga acacagactc tcagcaactc agcagagtga
      301 gttaagggat gtgtgtgact atgcgattga gacgatgccc tcttttccca aggaaggttc
      361 tgcagatgtg gagcccaatc aggaaagcct tgtggctgag gcctgtgaca ctccggaaca
      421 ctgggaggca gtaccccaga gcctagcagg ccgacaagca aggactctag ctcccccaga
      481 gctctgggcc tgccccattc agagtgagca tctagacatg gccccatttt ccagtgacct
      541 gggaagcgaa gaagaggagg tggaattttg gccaggactt acttctttga cattgggatc
      601 tggacaggca gaagaagaag aggaaacctc ttcagataac tctggtcaga ccagatatta
      661 ttctccctgc gaagagcatc ctgcagagac caaccagaat gaaggctctg aaagtgggac
      721 tatcaggcag ggggaagagc tgccacctga ggagctgcag gaaagtcaag ggctcttgca
      781 tccccaggag gtccaagttc tggaggagca gggacagcag gaagcaggat ttcgggggga
      841 aggaactctg agggaggatg tttgtgccga tgggctatta ggggaggaac agatgataga
      901 gcaggttaat gatgaaaagg gagaacagaa gcaaaaacag gaacaggtac aagatgtgat
      961 gcttgggaga caaggagaaa gaatggggct cactggggag ccagagggtc tgaatgacgg
     1021 tgagtgggag caggaggata tggagaggaa ggctcagggt cagggaggtc cagaacaggg
     1081 agaagagagg aagagggagc tgcaggtgcc agaagagaat agggcggact ctcaggacga
     1141 aaagagtcaa acctttttgg gaaaatcaga ggaagtaact ggaaagcaag aagatcatgg
     1201 tataaaggag aaaggggtgc cagtcagcgg gcaggaggcg aaagagccag agagttggga
     1261 tgggggcagg ctgggggcag tgggaagagc gaggagcagg gaagaggaga atgagcatca
     1321 tgggccttca atgcccgctc tgatagcccc tgaggactct cctcactgtg acctgtttcc
     1381 aggtgcctca tatctcatga ctcagattcc cgggactcag acagagtcca gggctgagga
     1441 actgtccccc gcagctctgt ctccctcgct agagcccatc aggtgctctc accagcccat
     1501 ttctctactg ggctcctttt tgactgagga gtcacctgac aaggaaatag atcaaaacag
     1561 ccagcaagag gaatccaggc tgaggaaggg aacagtgtcc agccaaggga ctgaggtggt
     1621 ctttgccagt gcatctgtga ctcctccaag gacaccagat tcagctcctc ccagtcctgc
     1681 tgaagcctac cccatcacac ctgcctcggt atctgccagg cccccagttg cctttcccag
     1741 gagggaaacc tcttgtgctg cacgtgctcc agaaactgcc agtgcccctc tctcaatgga
     1801 tgacccatct ccctgtggga cttctgagat gtgcccggct gccctctatg gcttcccctc
     1861 caccgggacc agccctccga ggcccccagc caactccaca ggcaccgtcc agcacttacg
     1921 gagtgactcc ttccctggtt ctcacaggac agagcagact ccagacctgg tgggaatgtt
     1981 gctttcctac tcccactcag agctgcccca gaggcccccc aaacctgcca tctacagctc
     2041 tgtgacccca agaagggaca gaaggagtgg tagggactac agcaccgttt cagcatcccc
     2101 tactgcctta tccacgctga agcaggactc tcaagaatcc atctcaaatc tagagagacc
     2161 cagcagtcct cccagcatcc agccctgggt ctccccacat aatccagcct ttgccacaga
     2221 gtctcccgcc tacggttctt ccccatcctt tgtctccatg gaggatgtga ggatccacga
     2281 acctctgccc cctcctcccc cacagaggag ggacacccat ccctccgtgg tggagacaga
     2341 tggccatgct cgtgtagtgg ttcccacgct gaagcagcat agccaccctc ctccattggc
     2401 cctaggttca gggctgcatg ccccccataa aggcccactt ccccaagcct ctgaccccgc
     2461 tgtggccagg cagcaccgac ctctgccatc taccccagac agctcccacc atgctcaggc
     2521 cacccccagg tggagataca acaagccgct accccctacc cctgatttgc cgcagcccca
     2581 ccttcctccc atttctgctc ctggtagctc aaggatctac aggcctctac ccccactacc
     2641 catcatagac cctcccaccg aaccaccccc attgccccca aagtccaggg ggaggagcag
     2701 gagcactcgg ggaggacata tgaactcagg gggtcatgcc aaaacaagac ctgcttgtca
     2761 agactggaca gtccccctcc ctgcctctgc tggacgcacc tcctggcccc cggccacagc
     2821 tagatcaaca gagtctttca cttccaccag caggagtaag agcgaagtgt cccctggcat
     2881 ggctttcagc aacatgacaa acttcctatg cccctcttcc cctaccactc cctggactcc
     2941 ggagctccag ggacccacct ctaaggatga agcaggggtc tcagaacacc ctgaggcccc
     3001 tgcgagagaa cctttgagaa ggacaacccc tcagcaagga gccagtggcc cagggaggtc
     3061 acctgtgggc caagcaaggc agccagaaaa acccagccat ctgcacctgg agaaggcgtc
     3121 cagctggccc cacaggcggg actcagggag gccaccaggg gacagcagtg gacaggctgt
     3181 ggctcctagt gagggggcca acaagcacaa gggctggagc cggcagggcc tgcgcagacc
     3241 ttccatcttg cctgagggct cttcagattc aagaggtcca gccgtggaga aacatccggg
     3301 accctcagac actgttgttt ttcgggagaa aaaaccaaag gaggtgatgg gaggcttttc
     3361 aagacgctgc tccaaactca tcaactcctc ccagctgctt taccaggagt atagtgatgt
     3421 tgtcctgaat aaggagatcc agagccagca gcggctggag agcctgtccg agacacccgg
     3481 gcctagctct ccgcggcagc ctcggaaggc cctggtctcc tccgagtcgt acctgcagcg
     3541 gctctccatg gcctccagcg gctccctctg gcaggaaatc cccgtggtgc gcaacagcac
     3601 cgtgctgctc tccatgaccc atgaagacca aaagctgcaa gaggtcaaat ttgagctgat
     3661 tgtgtcagag gcctcctacc tgcgcagtct aaacatagct gtggatcatt tccaactttc
     3721 aacttcactc cgggccacac tttccaacca ggagcaccaa tggctcttct ctcgtttaca
     3781 ggatgtgcga gacgtcagcg ccacgttcct ttcagacctg gaagagaact ttgagaacaa
     3841 tatcttctcc ttccaagtat gtgacgtagt cctgaaccac gccccagact tccgccgggt
     3901 ctacctgcct tatgtcacca accagaccta tcaggaacgc accttccaga gcctgatgaa
     3961 tagcaacagc aatttccggg aggtcttgga gaagctggag agcgaccccg tctgccagcg
     4021 cctttccctc aagtcctttc tgattctgcc cttccaacgc atcacccgcc tcaaactgct
     4081 gctccagaac attctgaaga gaacacagcc tggctcctcg gaggaggcag aggccacgaa
     4141 ggcacaccac gccctggagc agctgatccg ggactgcaat aacaatgtcc agagtatgcg
     4201 acggacagag gaactaatct acctgagcca gaagattgag tttgagtgca aaatattccc
     4261 gctcatttct cagtcacgct ggctggtgaa aagtggggag ctgacagcct tggagttcag
     4321 tgcttcccca gggctacgaa ggaagctgaa cacgcgtcca gtccacctgc acctcttcaa
     4381 tgactgtctg ctgctgtctc ggccccgaga gggtagccga ttcctggtat ttgaccatgc
     4441 tcccttctcc tccattcggg gggaaaagtg tgaaatgaag ctacatggac ctcacaaaaa
     4501 cctgttccga ctctttctgc ggcagaacac tcagggcgcc caggccgagt tcctcttccg
     4561 cacggagact caaagtgaaa agcttcggtg gatctcagcc ttggccatgc caagagagga
     4621 gttggacctt ctggagtgtt acaactcccc ccaggtacag tgccttcgag cctacaagcc
     4681 ccgagagaat gatgaattgg cactggagaa agccgacgtg gtgatggtga ctcagcagag
     4741 cagtgacggc tggctggagg gcgtgaggct ctcagacggg gagcgaggct ggtttcctgt
     4801 gcagcaggtg gagttcattt ccaacccaga ggtccgtgca cagaacctga aggaagctca
     4861 tcgagtcaag actgccaaac tacagctggt ggaacagcaa gcctaagtct tctctgagag
     4921 gagtttcgtg agctgaagaa caagctgctc atggcaaggg ctggccccag aaccctgcaa
     4981 gagaggcctt ctgtggatgg agaactaggc cttctcaaag ctcaaggaca aaatccagct
     5041 aacccagtcc ctcggcccag gcctcctttc gtgctttgtg cttggtgggg gggatttcga
     5101 gggactttgc actggactct gggaaccttt catcattaaa aaaaggggga ccattggggc
     5161 ctgagccaag gaactttcct tctactgcct tatagtgctt aaacattctc cgcctccagg
     5221 gtgcagattc agagctggcc agagtttcag tgatagccgt atgttaaaca gaatctcacc
     5281 tcagtctcct ggagggagat gtttaagagg ggttaacaca tcagatggga gggtcagccc
     5341 ggtgacctct aaggtatctt ctaacctaga aattcaccat aattatggtg caaggtcagt
     5401 gtgtctctga gatctatgtc tgttggtggc aatgtgaggg tgatactctc tcactctaat
     5461 aaacttggca cttctccgag ta
//
