LOCUS       NM_018071               5893 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens Rho guanine nucleotide exchange factor 40 (ARHGEF40),
            transcript variant 1, mRNA.
ACCESSION   NM_018071 XM_370737
VERSION     NM_018071.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5893)
  AUTHORS   Gu,J., Zhang,X., Jiang,G., Li,Q., Wang,E. and Yu,J.
  TITLE     ARHGEF40 promotes non-small cell lung cancer proliferation and
            invasion via the AKT-Wnt axis by binding to RhoA
  JOURNAL   Mol Carcinog 61 (11), 1016-1030 (2022)
   PUBMED   36000254
  REMARK    GeneRIF: ARHGEF40 promotes non-small cell lung cancer proliferation
            and invasion via the AKT-Wnt axis by binding to RhoA.
REFERENCE   2  (bases 1 to 5893)
  AUTHORS   Campos,C., Fragoso,S., Luis,R., Pinto,F., Brito,C., Esteves,S.,
            Pataco,M., Santos,S., Machado,P., Vicente,J.B., Rosa,J.C.,
            Cavaco,B.M., Moura,C. and Pojo,M.
  TITLE     High-Throughput Sequencing Identifies 3 Novel Susceptibility Genes
            for Hereditary Melanoma
  JOURNAL   Genes (Basel) 11 (4), 403 (2020)
   PUBMED   32276436
  REMARK    GeneRIF: High-Throughput Sequencing Identifies 3 Novel
            Susceptibility Genes for Hereditary Melanoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5893)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5893)
  AUTHORS   Fujiwara,S., Matsui,T.S., Ohashi,K., Mizuno,K. and Deguchi,S.
  TITLE     Keratin-binding ability of the N-terminal Solo domain of Solo is
            critical for its function in cellular mechanotransduction
  JOURNAL   Genes Cells 24 (5), 390-402 (2019)
   PUBMED   30929300
  REMARK    GeneRIF: Keratin binding domain is critical for Solo localization
            and its function in regulating mechanotransduction.
REFERENCE   5  (bases 1 to 5893)
  AUTHORS   Tse,S.W., Broderick,J.A., Wei,M.L., Luo,M.H., Smith,D.,
            McCaffery,P., Stamm,S. and Andreadis,A.
  TITLE     Identification, expression analysis, genomic organization and
            cellular location of a novel protein with a RhoGEF domain
  JOURNAL   Gene 359, 63-72 (2005)
   PUBMED   16143467
  REMARK    GeneRIF: Solo mRNA is ubiquitously expressed but enriched in brain,
            and it undergoes extensive alternative splicing.
REFERENCE   6  (bases 1 to 5893)
  AUTHORS   Jikuya,H., Takano,J., Kikuno,R., Hirosawa,M., Nagase,T., Nomura,N.
            and Ohara,O.
  TITLE     Characterization of long cDNA clones from human adult spleen. II.
            The complete sequences of 81 cDNA clones
  JOURNAL   DNA Res 10 (1), 49-57 (2003)
   PUBMED   12693554
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY010070.1, AK074057.1,
            BC142692.1, AL161668.6 and HY277017.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_018071.4.
            
            Summary: This gene encodes a protein similar to guanosine
            nucleotide exchange factors for Rho GTPases. The encoded protein
            contains in its C-terminus a GEF domain involved in exchange
            activity and a pleckstrin homology domain. Alternatively spliced
            transcripts that encode different proteins have been described.
            [provided by RefSeq, Mar 2014].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK074057.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298694.9/ ENSP00000298694.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                HY010070.1         46-68
            24-2958             AK074057.1         13-2947
            2959-5190           BC142692.1         2973-5204
            5191-5477           AL161668.6         142882-143168
            5478-5893           HY277017.1         28-443              c
FEATURES             Location/Qualifiers
     source          1..5893
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..5893
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
                     /note="Rho guanine nucleotide exchange factor 40"
                     /db_xref="GeneID:55701"
                     /db_xref="HGNC:HGNC:25516"
                     /db_xref="MIM:610018"
     exon            1..96
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..4653
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein SOLO; Rho guanine nucleotide exchange factor (GEF)
                     40"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 40
                     isoform 1"
                     /protein_id="NP_060541.3"
                     /db_xref="CCDS:CCDS32041.1"
                     /db_xref="GeneID:55701"
                     /db_xref="HGNC:HGNC:25516"
                     /db_xref="MIM:610018"
                     /translation="MEPEPVEDCVQSTLAALYPPFEATAPTLLGQVFQVVERTYREDA
                     LRYTLDFLVPAKHLLAKVQQEACAQYSGFLFFHEGWPLCLHEQVVVQLAALPWQLLRP
                     GDFYLQVVPSAAQAPRLALKCLAPGGGRVQEVPVPNEACAYLFTPEWLQGINKDRPTG
                     RLSTCLLSAPSGIQRLPWAELICPRFVHKEGLMVGHQPSTLPPELPSGPPGLPSPPLP
                     EEALGTRSPGDGHNAPVEGPEGEYVELLEVTLPVRGSPTDAEGSPGLSRVRTVPTRKG
                     AGGKGRHRRHRAWMHQKGLGPRGQDGARPPGEGSSTGASPESPPGAEAVPEAAVLEVS
                     EPPAEAVGEASGSCPLRPGELRGGGGGGQGAEGPPGTPRRTGKGNRRKKRAAGRGALS
                     RGGDSAPLSPGDKEDASHQEALGNLPSPSEHKLPECHLVKEEYEGSGKPESEPKELKT
                     AGEKEPQLSEACGPTEEGAGERELEGPGLLCMAGHTGPEGPLSDTPTPPLETVQEGKG
                     DNIPEEALAVSVSDHPDVAWDLMASGFLILTGGVDQSGRALLTITPPCPPEEPPPSRD
                     TLNTTLHYLHSLLRPDLQTLGLSVLLDLRQAPPLPPALIPALSQLQDSGDPPLVQRLL
                     ILIHDDLPTELCGFQGAEVLSENDLKRVAKPEELQWELGGHRDPSPSHWVEIHQEVVR
                     LCRLCQGVLGSVRQAIEELEGAAEPEEEEAVGMPKPLQKVLADPRLTALQRDGGAILM
                     RLRSTPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQEQRQCLRRLQQVLQWLSG
                     PGEEQLASFAMPGDTLSALQETELRFRAFSAEVQERLAQAREALALEENATSQKVLDI
                     FEQRLEQVESGLHRALRLQRFFQQAHEWVDEGFARLAGAGPGREAVLAALALRRAPEP
                     SAGTFQEMRALALDLGSPAALREWGRCQARCQELERRIQQHVGEEASPRGYRRRRADG
                     ASSGGAQWGPRSPSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEGPELAPEAEGR
                     PPRAVLIRGLEVTSTEVVDRTCSPREHVLLGRARGPDGPWGVGTPRMERKRSISAQQR
                     LVSELIACEQDYVATLSEPVPPPGPELTPELRGTWAAALSARERLRSFHRTHFLRELQ
                     GCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLAALSPLSKGSMEAGPYLPRAL
                     QQPLEQLTRYGRLLEELLREAGPELSSECRALGAAVQLLREQEARGRDLLAVEAVRGC
                     EIDLKEQGQLLHRDPFTVICGRKKCLRHVFLFEHLLLFSKLKGPEGGSEMFVYKQAFK
                     TADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPEIKLKWTSSIAQLLWRQAAHN
                     KELRVQQMVSMGIGNKPFLDIKALGERTLSALLTGRAARTRASVAVSSFEHAGPSLPG
                     LSPGACSLPARVEEEAWDLDVKQISLAPETLDSSGDVSPGPRNSPSLQPPHPGSSTPT
                     LASRGILGLSRQSHARALSDPTTPL"
     exon            97..294
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
                     /inference="alignment:Splign:2.1.0"
     exon            295..1543
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1711
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1832
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1929
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2010
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2127
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2223
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2339
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2466
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..2589
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..2733
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
                     /inference="alignment:Splign:2.1.0"
     exon            2734..3344
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
                     /inference="alignment:Splign:2.1.0"
     exon            3345..3579
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
                     /inference="alignment:Splign:2.1.0"
     exon            3580..3666
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
                     /inference="alignment:Splign:2.1.0"
     exon            3667..3882
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
                     /inference="alignment:Splign:2.1.0"
     exon            3883..4053
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
                     /inference="alignment:Splign:2.1.0"
     exon            4054..4231
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
                     /inference="alignment:Splign:2.1.0"
     exon            4232..4336
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
                     /inference="alignment:Splign:2.1.0"
     exon            4337..4480
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
                     /inference="alignment:Splign:2.1.0"
     exon            4481..4611
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
                     /inference="alignment:Splign:2.1.0"
     exon            4612..4658
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
                     /inference="alignment:Splign:2.1.0"
     exon            4659..5893
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5171..5176
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
                     /note="hexamer: ATTAAA"
     polyA_site      5190
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
                     /note="major polyA site"
     polyA_site      5792
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
     regulatory      5864..5869
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
                     /note="hexamer: AATAAA"
     polyA_site      5893
                     /gene="ARHGEF40"
                     /gene_synonym="SOLO"
ORIGIN      
        1 agacccggcg agacacgagc ggcgggaggg aggcggtggc gcgcccggcc ccgcccgccc
       61 gaccaagcgt cggacgcggc ccggcgccga gccatggagc ctgagccagt ggaggactgt
      121 gtgcagagca ctctcgccgc cctgtatcca ccctttgagg caacagcccc caccctgttg
      181 ggccaggtgt tccaggtggt ggagaggact tatcgggagg acgcactgag gtacacgctg
      241 gacttcctgg taccagccaa gcacctgctt gccaaggtcc agcaggaagc ctgtgcccaa
      301 tacagtggat tcctcttctt ccatgagggg tggccgctct gcctgcatga acaggtggtg
      361 gtgcagctag cagccctacc ctggcaactg ctgcgcccag gagacttcta tctgcaggtg
      421 gtgccctcag ctgcccaagc accccgacta gcactcaagt gtctggcccc tgggggtggg
      481 cgggtgcagg aggttcctgt gcccaatgag gcttgtgcct acctattcac acctgagtgg
      541 ctacaaggca tcaacaagga ccggccaaca ggtcgcctca gtacctgcct actgtctgcg
      601 ccctctggga ttcagcggct gccctgggct gagctcatct gtccacgatt tgtgcacaaa
      661 gagggcctca tggttggaca tcagccaagt acactgcccc cagaactgcc ctctggacct
      721 ccagggcttc ccagccctcc acttcctgag gaggcgctgg gtacccggag tcctggggat
      781 gggcacaatg cccctgtgga aggacctgag ggcgagtatg tggagctgtt agaggtgacg
      841 ctgcccgtga gggggagccc aacagatgct gaaggctccc caggcctctc cagagtccgg
      901 acggtaccca cccgcaaggg cgctggaggg aagggccgcc accggagaca ccgggcgtgg
      961 atgcaccaga agggcctggg gcctcggggc caggatggag cacgcccacc cggcgagggg
     1021 agcagcaccg gagcctcccc tgagtctccc ccaggagctg aggctgtccc agaggcagca
     1081 gtcttggagg tgtctgagcc cccagcagag gctgtgggag aagcctccgg atcttgcccc
     1141 ctgaggccag gggagcttag aggaggagga ggaggaggcc agggggctga aggaccacct
     1201 ggtacccctc ggagaacagg caaaggaaac agaagaaaga agcgagctgc aggtcgaggg
     1261 gctcttagcc gaggagggga cagtgcccca ctgagccctg gggacaagga agatgccagc
     1321 caccaagaag cccttggcaa tctgccctca ccaagtgagc acaagcttcc agaatgccac
     1381 ctggttaagg aggaatatga aggctcaggg aagccagaat ctgagccaaa agagctcaaa
     1441 acagcaggcg agaaagagcc tcagctctct gaagcctgtg ggcctacaga agagggggcc
     1501 ggagagagag agctggaggg gccaggcctg ctgtgtatgg caggacacac aggcccagaa
     1561 ggccccctgt ctgacactcc aacacctccg ctggagactg tgcaggaagg aaaaggggac
     1621 aacattccag aagaggccct tgcagtctcc gtctctgatc accctgatgt agcttgggac
     1681 ttgatggcat ctggattcct catcctgacg ggaggggtgg accagagtgg gcgagctctg
     1741 ctgaccatta ccccaccgtg ccctcctgag gagcccccac cctcccgaga cacgctgaac
     1801 acaactcttc attacctcca ctcactgctc aggcctgatc tacagacact ggggctgtcc
     1861 gtcctgctgg accttcgtca ggcacctcca ctgcctccag cactcattcc tgccttgagc
     1921 caacttcagg actcaggaga tcctcccctt gttcagcggc tgctgattct cattcatgat
     1981 gaccttccaa ctgaactctg tggatttcag ggtgctgagg tgctgtcaga gaatgatctg
     2041 aaaagagtgg ccaagccaga ggagctgcag tgggagttag gaggtcacag ggacccctct
     2101 cccagtcact gggtagagat acaccaggaa gtggtaaggc tatgtcgcct gtgccaaggt
     2161 gtgctgggct cggtacggca ggccattgag gagctggagg gagcagcaga gccagaggaa
     2221 gaggaggcag tgggaatgcc caagccactg cagaaggtgc tggcagatcc ccggctgacg
     2281 gcactgcaga gggatggggg ggccatcctg atgaggctgc gctccactcc cagcagcaag
     2341 ctggagggcc aaggcccagc tacactgtat caggaagtgg acgaggccat tcaccagctt
     2401 gtgcgcctct ccaacctgca cgtgcagcag caagagcagc ggcagtgcct gcggcgactc
     2461 cagcaggtgt tgcagtggct ctcgggccca ggggaggagc agctggcaag ctttgctatg
     2521 cctggggaca ccttgtctgc cctgcaggag acagagctgc gattccgtgc tttcagcgct
     2581 gaggtccagg agcgcctggc ccaggcacgg gaggccctgg ctctggagga gaatgccacc
     2641 tcccagaagg tgctggatat ctttgaacag cggctggagc aggttgagag tggcctccat
     2701 cgggccctgc ggctacagcg cttcttccag caggcacatg aatgggtgga tgagggcttt
     2761 gctcggctgg caggagctgg gccgggtcgg gaggctgtgc tggctgcact ggccctgcgg
     2821 cgggccccag agcccagtgc cggcaccttc caggagatgc gggccctggc cctggacctg
     2881 ggcagcccag cagccctgcg agaatggggc cgctgccagg cccgctgcca agagctagag
     2941 aggaggatcc agcaacacgt gggagaggag gcgagcccac ggggctaccg acgacggcgg
     3001 gcagacggtg ccagcagtgg aggggcccag tgggggcccc gcagcccctc gcccagcctc
     3061 agctccttgc tgctccccag cagccctggg ccacggccag ccccatccca ttgctccctg
     3121 gccccatgtg gagaggacta tgaggaagag ggccctgagc tggctccaga agcagagggc
     3181 aggcccccaa gagctgtgct gatccgaggc ctggaggtca ccagcactga ggtggtagac
     3241 aggacgtgct caccacggga acacgtgctg ctgggccggg ctagggggcc agacggaccc
     3301 tggggagtag gcaccccccg gatggagcgc aagcgaagca tcagtgccca gcagcggctg
     3361 gtgtctgagc tgattgcctg tgaacaagat tacgtggcca ccttgagtga gccagtgcca
     3421 ccccctgggc ctgagctgac gcctgaactt cggggcacct gggctgctgc cctgagtgcc
     3481 cgggaaaggc ttcgcagctt ccaccggaca cactttctgc gggagcttca gggctgcgcc
     3541 acccaccccc tacgcattgg ggcctgcttc cttcgccacg gggaccagtt cagcctttat
     3601 gcacagtacg tgaagcaccg acacaaactg gagaatggtc tggctgcgct cagtccctta
     3661 agcaagggct ccatggaggc tggcccttac ctgccccgag ccctgcagca gcctctggaa
     3721 cagctgactc ggtatgggcg gctcctggag gagctcctga gggaagctgg gcctgagctc
     3781 agttctgagt gccgggccct tggggctgct gtacagctgc tccgggaaca agaggcccgt
     3841 ggcagagacc tgctggccgt ggaggcggtg cgtggctgtg agatagatct gaaggagcag
     3901 ggacagctct tgcatcgaga ccccttcact gtcatctgtg gccgaaagaa gtgccttcgc
     3961 catgtctttc tcttcgagca tctcctcctg ttcagcaagc tcaagggccc tgaagggggg
     4021 tcagagatgt ttgtttacaa gcaggccttt aagactgctg atatggggct gacagaaaac
     4081 atcggggaca gcggactctg ctttgagttg tggtttcggc ggcggcgtgc acgagaggca
     4141 tacactctgc aggcaacctc accagagatc aaactcaagt ggacaagttc tattgcccag
     4201 ctgctgtgga gacaggcagc ccacaacaag gagctccgag tgcagcagat ggtgtccatg
     4261 ggcattggga ataaaccctt cctggacatc aaagcccttg gggagcggac gctgagtgcc
     4321 ctgctcactg gaagagccgc ccgcacccgg gcctccgtgg ccgtgtcatc ctttgagcat
     4381 gccggcccct cccttcccgg cctttcgccg ggagcctgct ccctgcctgc ccgcgtcgag
     4441 gaggaggcct gggatctgga cgtcaagcaa atttccctgg ccccagaaac acttgactct
     4501 tctggagatg tgtccccagg accaagaaac agccccagcc tgcaaccccc ccaccctggg
     4561 agcagcactc ccaccctggc cagtcgaggg atcttagggc tatcccgaca gagtcatgct
     4621 cgagccctga gtgaccccac cacgcctctg tgacctggag aagatccaga acttgcgtgc
     4681 agcttctcct ctcagcacac tttgggctgg gatggcagtg gggcataatg gagccctggg
     4741 cgatcgctga atttcttccc tctgcttcct ggacacagag gaggtctaac gaccagagta
     4801 ttgccctgcc accactatct ctagtctccc tagcttggtg ccttctcctg caggagtcag
     4861 agcagccaca ttgcttgcct tcataccctg gaggtgggga agttatccct cttccggtgc
     4921 tttcccatcc tgggccactg tatccaggac atcactccca tgccagccct ccctggcagc
     4981 ccatgttctc ctcttttctc accccctgac tttccctgag aagaatcatc tctgccaggt
     5041 caactggagt ccctggtgac tccattctga ggtgtcacaa gcaatgaagc tatgcaaaca
     5101 ataggagggt gtgacagggg aaccgtagac tttatatatg taattactgt tattataata
     5161 ctattgttat attaaatgta tttactcaca ctttgcctct aaggagctag agtagtcctc
     5221 tggattaagg tgataaataa cttgagcact ttccctcaac cagcccttaa ctagaacaca
     5281 gaaaataaaa ccaagactgg aaggtcccct ctacccctcc caggcccaga gctagctgac
     5341 tgtgtatgag cctgggagaa tgtgtctcct ccacagtggc tcccagaggt tccacacact
     5401 ctctgaagct ccttctccca cactgcacct actccttgag gctgaactgg tcacagacaa
     5461 actgggatcc agcacagtcc agcagttctc aaaatgaggt cctcaggcca cagtgcgtga
     5521 gaacttgctt ggctgtttgt taaatgctaa ttcttgggcc ccatcagagc tactgcatcg
     5581 aaacctgggg gtaaaaccca atattctgca tttcttatca aactctttgg gtgataacta
     5641 agtgtctgaa gaggtgacta tttcctgaca gaaggaccca aagagggaag caggacatag
     5701 gtaggcagac agacacaggg ccctgtgcct caagacacct gtttattggg gacacgactc
     5761 tgcaataggg atgacaggaa tcgtaccaaa aatagcgacg tctacagggc ccctgatggg
     5821 gctagaaggg tacagtgccc cccaccctca ccccttgtac aaaaataaac tctcacgcct
     5881 atggaccagc aaa
//
