LOCUS       NM_032818               3678 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens Rho guanine nucleotide exchange factor 39 (ARHGEF39),
            mRNA.
ACCESSION   NM_032818 NM_001031728
VERSION     NM_032818.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3678)
  AUTHORS   Huang,Y., Zeng,J., Liu,T., Xu,Q., Song,X. and Zeng,J.
  TITLE     ARHGEF39 targeted by E2F1 fosters hepatocellular carcinoma
            metastasis by mediating fatty acid metabolism
  JOURNAL   Clin Res Hepatol Gastroenterol 48 (8), 102446 (2024)
   PUBMED   39128592
  REMARK    GeneRIF: ARHGEF39 targeted by E2F1 fosters hepatocellular carcinoma
            metastasis by mediating fatty acid metabolism.
REFERENCE   2  (bases 1 to 3678)
  AUTHORS   Gautam,Y., Caldwell,J., Kottyan,L., Chehade,M., Dellon,E.S.,
            Rothenberg,M.E. and Mersha,T.B.
  CONSRTM   Consortium of Eosinophilic Gastrointestinal Disease Researchers
            (CEGIR) investigators
  TITLE     Genome-wide admixture and association analysis identifies African
            ancestry-specific risk loci of eosinophilic esophagitis in African
            Americans
  JOURNAL   J Allergy Clin Immunol 151 (5), 1337-1350 (2023)
   PUBMED   36400179
  REMARK    GeneRIF: Genome-wide admixture and association analysis identifies
            African ancestry-specific risk loci of eosinophilic esophagitis in
            African Americans.
REFERENCE   3  (bases 1 to 3678)
  AUTHORS   Cooke,M., Kreider-Letterman,G., Baker,M.J., Zhang,S.,
            Sullivan,N.T., Eruslanov,E., Abba,M.C., Goicoechea,S.M.,
            Garcia-Mata,R. and Kazanietz,M.G.
  TITLE     FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase
            effectors for Rac1-dependent cell motility in human lung
            adenocarcinoma
  JOURNAL   Cell Rep 37 (5), 109905 (2021)
   PUBMED   34731623
  REMARK    GeneRIF: FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine
            kinase effectors for Rac1-dependent cell motility in human lung
            adenocarcinoma.
REFERENCE   4  (bases 1 to 3678)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3678)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3678)
  AUTHORS   Zhou,H., Cai,L., Zhang,X., Li,A., Miao,Y., Li,Q., Qiu,X. and
            Wang,E.
  TITLE     ARHGEF39 promotes tumor progression via activation of Rac1/P38
            MAPK/ATF2 signaling and predicts poor prognosis in non-small cell
            lung cancer patients
  JOURNAL   Lab Invest 98 (5), 670-681 (2018)
   PUBMED   29382922
  REMARK    GeneRIF: ARHGEF39 promotes tumor growth and invasion by activating
            the Rac1-P38-ATF2 signaling pathway, as well as increasing the
            expression of Cyclin A2, Cyclin D1, and MMP2 in NSCLC cells.
REFERENCE   7  (bases 1 to 3678)
  AUTHORS   Wang,H., Li,M., Tao,X., Qian,Y., Chen,L. and Tao,G.
  TITLE     ARHGEF39 promotes gastric cancer cell proliferation and migration
            via Akt signaling pathway
  JOURNAL   Mol Cell Biochem 440 (1-2), 33-42 (2018)
   PUBMED   28871449
  REMARK    GeneRIF: findings suggest that ARHGEF39 may contribute to cell
            proliferation and migration in gastric cancer via a possible
            mechanism involving Akt signaling.
REFERENCE   8  (bases 1 to 3678)
  AUTHORS   Wang,H., Li,Y., Wang,Y., Han,Z.G. and Cai,B.
  TITLE     C9orf100, a new member of the Dbl-family guanine nucleotide
            exchange factors, promotes cell proliferation and migration in
            hepatocellular carcinoma
  JOURNAL   Mol Med Rep 5 (5), 1169-1174 (2012)
   PUBMED   22327280
  REMARK    GeneRIF: C9orf100 plays a potential oncogenic role in the
            development and metastasis of HCC.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB109516.1, BC033666.1 and AL357874.13.
            
            On Nov 23, 2018 this sequence version replaced NM_032818.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.4269337.1,
                                           SRR18074967.1102390.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378387.4/ ENSP00000367638.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-380               DB109516.1         87-466
            381-1587            BC033666.1         404-1610
            1588-3677           AL357874.13        67453-69542         c
            3678-3678           AL357874.13        67452-67452         c
FEATURES             Location/Qualifiers
     source          1..3678
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..3678
                     /gene="ARHGEF39"
                     /gene_synonym="C9orf100"
                     /note="Rho guanine nucleotide exchange factor 39"
                     /db_xref="GeneID:84904"
                     /db_xref="HGNC:HGNC:25909"
     exon            1..164
                     /gene="ARHGEF39"
                     /gene_synonym="C9orf100"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1034
                     /gene="ARHGEF39"
                     /gene_synonym="C9orf100"
                     /note="vav-like protein C9orf100; Rho guanine nucleotide
                     exchange factor (GEF) 39"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 39"
                     /protein_id="NP_116207.2"
                     /db_xref="CCDS:CCDS6584.2"
                     /db_xref="GeneID:84904"
                     /db_xref="HGNC:HGNC:25909"
                     /translation="MELSCPGSRCPVQEQRARWERKRACTARELLETERRYQEQLGLV
                     ATYFLGILKAKGTLRPPERQALFGSWELIYGASQELLPYLEGGCWGQGLEGFCRHLEL
                     YNQFAANSERSQTTLQEQLKKNKGFRRFVRLQEGRPEFGGLQLQDLLPLPLQRLQQYE
                     NLVVALAENTGPNSPDHQQLTRAARLISETAQRVHTIGQKQKNDQHLRRVQALLSGRQ
                     AKGLTSGRWFLRQGWLLVVPPHGEPRPRMFFLFTDVLLMAKPRPPLHLLRSGTFACKA
                     LYPMAQCHLSRVFGHSGGPCGGLLSLSFPHEKLLLMSTDQEELSRWYHSLTWAISSQK
                     N"
     exon            165..259
                     /gene="ARHGEF39"
                     /gene_synonym="C9orf100"
                     /inference="alignment:Splign:2.1.0"
     exon            260..380
                     /gene="ARHGEF39"
                     /gene_synonym="C9orf100"
                     /inference="alignment:Splign:2.1.0"
     exon            381..499
                     /gene="ARHGEF39"
                     /gene_synonym="C9orf100"
                     /inference="alignment:Splign:2.1.0"
     exon            500..570
                     /gene="ARHGEF39"
                     /gene_synonym="C9orf100"
                     /inference="alignment:Splign:2.1.0"
     exon            571..699
                     /gene="ARHGEF39"
                     /gene_synonym="C9orf100"
                     /inference="alignment:Splign:2.1.0"
     exon            700..929
                     /gene="ARHGEF39"
                     /gene_synonym="C9orf100"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1018
                     /gene="ARHGEF39"
                     /gene_synonym="C9orf100"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..3678
                     /gene="ARHGEF39"
                     /gene_synonym="C9orf100"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1558..1563
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGEF39"
                     /gene_synonym="C9orf100"
                     /note="hexamer: AGTAAA"
     polyA_site      1587
                     /gene="ARHGEF39"
                     /gene_synonym="C9orf100"
                     /note="major polyA site"
     regulatory      3656..3661
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGEF39"
                     /gene_synonym="C9orf100"
                     /note="hexamer: ATTAAA"
     polyA_site      3678
                     /gene="ARHGEF39"
                     /gene_synonym="C9orf100"
ORIGIN      
        1 ggaagtgtcg atccctcagc cagggcatgg agctctcctg ccccggttcg cggtgcccgg
       61 tgcaagagca gcgtgcccgc tgggagcgga aacgcgcctg caccgcccgg gagctgctag
      121 agaccgagcg gcgctaccaa gaacagctgg ggctggtggc cacgtacttt ttggggatcc
      181 tgaaagccaa ggggaccctg cgaccacctg agcgccaggc cctgtttggc tcctgggagc
      241 tcatctacgg cgccagccag gagctgcttc cctacctgga aggaggatgc tggggccaag
      301 ggctggaggg cttctgccgc cacttggagc tctataacca atttgctgcc aactcagaga
      361 ggtcccagac caccctgcag gagcagctaa agaaaaataa aggtttccgg aggtttgtac
      421 ggcttcagga aggccgccct gagtttgggg gccttcagct ccaggacctg ctccctctgc
      481 ctctgcaacg gctccagcag tatgagaatc tcgtcgtagc tttggctgaa aacacaggtc
      541 ccaacagccc tgaccatcaa cagctcacac gggctgcccg actgataagt gagactgccc
      601 agagagtcca tactattggt cagaaacaga agaatgacca gcaccttcgg cgtgtccagg
      661 ctctgctcag tggacgccag gcaaaggggc tgacctcagg gcgctggttc ctacgccagg
      721 gctggctgtt agtggtgcct ccccatgggg agcctcggcc ccgcatgttc ttcctcttca
      781 ctgatgtgct cctcatggcc aagcctcggc ctccactgca cctgctgcgg agtggcacct
      841 ttgcctgcaa ggccctctac cccatggccc agtgtcatct cagcagggtc tttggccact
      901 caggaggccc ttgtggtggg ttgctcagtc tgtccttccc tcatgagaag ctactgctta
      961 tgtccacaga ccaggaggag ctgtcacgct ggtaccacag tctgacttgg gctatcagca
     1021 gccagaaaaa ctagaggaat cttatagatt ccagaactca ggatacctca gggataggtc
     1081 acagccaaga gtacaaagga atcttcagta ctgaacaaaa cagaaccctt catgatttga
     1141 caaaggtcac tttctgtttg cctggaccaa gctactccag atcatctgac caactcttaa
     1201 aaatcacggc caggcacagt ggctcatgcc tgtaatccca gcactttggg aagcagaggt
     1261 ggcaggatca ttccagccca ggagttcaag accagcctgg gcaacacagt gagtgagacc
     1321 ctgtctctat ttaagaaaaa ataattaaga aattttatta aaaaagaaga atcaggaaac
     1381 caagtccaac ccaactaaac ctcaaatgaa ccagccccta acacagatga ggggatttgg
     1441 gactgataag ctctgtgctg tgtccatggc ccgtcattta tcaaggctgc agctttgtaa
     1501 atgtggctat ttttatgttg tgtatagttt ctatcattta tttttccact ggatttgagt
     1561 aaagtttttt ttcttttttt tgggaaagac ccttctgtct cagttttgct atgagaaaag
     1621 ggatttttgg gccctgaacg cgggcatgct ggtggcctca ggaatacgag gaaaagagct
     1681 ggagctccct ctatcttctc tgctgtcaca ctggaaggca gcctcttttt gtcctaataa
     1741 ggacagctct tcaagaaggc ccagttgtcc ttaggcacct agtatgggtg tgtacaacca
     1801 actaggatcg aaaaaacaca caggagcact ccatcatgaa aacagacttt gttttagtcg
     1861 accttcagct gtcgtccctc cttcccagcc aaggctgtga ctggggccct ttgccacagc
     1921 ctggctgcac cttctccgta gtccccgccc cacctcccag gaagtagcta ggttccatgt
     1981 ctctgtgctc cagtttgtgg gctcctccca ggcctgactg tcaccaatct cctcctcgtc
     2041 ctcctttaaa cagaagtcct caggaagagg tctgctggcc tctgtgtggg gagagatcag
     2101 gaatgttcca gtttcagaga ctttgtctcc acctccagca gactcgcctc ccgagccttc
     2161 acctggttct gaagcctcca tatccttgtc cggcttgcta tcttgcagca gctcgtggat
     2221 ggtccatagc ttcatgttca gaagctcctg ctgggctcca gccagagtag tcacactgaa
     2281 gaaatgtcca ctcagtggct cccaacctat gtccccattc ctccctcctg ccacaaattc
     2341 cccaaaaatt cacagaatca ttgctctcct caccgctcaa aaagggggtc cagctgggcc
     2401 atcaggttgt tcaggtgctg ctctgtctgg gccagctgtt gtgtcaactg ggccagctgt
     2461 tgctctgggg ataagggaaa aaagggggca gaagtggtta tgtatcttct gctgtcccct
     2521 aaactccccc gacccagcac agacttctgc taaacccacc tgactgcagt ggctgctgct
     2581 tgcttgcctc ctcgtggaga accgcagttt catctttccc ctgttgtgga agaaggaaag
     2641 ggcagtactg aagcaacaag gttctgctcc atcacctcag tctccagagc cagccaagag
     2701 agagtgcaat ttgagatgga gacagtgatt gggtttttac ctcagagaat cacaatccta
     2761 gtctatctag ctcctcaccc agcatatgaa gcgacgtcct atgtcccaca catggtcagt
     2821 ttgctgaaac acctccagga atgagcaact ccctccggtt tgaaaaaagc tctggtggct
     2881 gagtgctgtg gctcacacct gtaatcccag cacttcggga agccaaggtg ggtggatcac
     2941 ctgaggtcag gagtttgaga ccagcctggc caacacggtg aaaccctgtc tctattaaaa
     3001 atacaaaaat tagccgggcg tggtggcagg tgcctgtaat cccagttact tgagaggctg
     3061 aggcaggaga atcgcttgaa cctgggagcc agaggttgca gtgagccgag attgcgccgc
     3121 tgcactccag cctgggtgac agagcgagac tccatctcga aaaaaacaaa aactttggtt
     3181 gttagacagt tcatgcacaa agccaaaatt tgtcctttat gtatcttctt tccatagtgc
     3241 ttactggagc cttccaaaat aatgtctcct caaggtgaca gcccctcagg aatttgaagg
     3301 caatggtcac accctcaccc actttcctga gttttttctg gtttattaac gtcagtcttt
     3361 acagtcagtg ctcattgacg gtggttttct ctggttgttt cctgaacacg tagtgctctt
     3421 aaagcaatgc cctgaggaga atacaattct ccaggggcat tctgattggc aggtgaagca
     3481 cagtgccatg ttcccagcac tgatttggga agtggcttgt cacatcccac agtgaactca
     3541 gtcaactgga atgcctaact ctctttcata agacctcctg ctacattatg tttctcccag
     3601 actgtactca ggtccaagaa cagaatttac tagtctatcc ttctcaaagt tcatcattaa
     3661 attcagtcat tcatccta
//
