LOCUS       NM_001242729            5457 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens Rho guanine nucleotide exchange factor 38 (ARHGEF38),
            transcript variant 1, mRNA.
ACCESSION   NM_001242729
VERSION     NM_001242729.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5457)
  AUTHORS   Lansdon,L.A., Dickinson,A., Arlis,S., Liu,H., Hlas,A., Hahn,A.,
            Bonde,G., Long,A., Standley,J., Tyryshkina,A., Wehby,G., Lee,N.R.,
            Daack-Hirsch,S., Mohlke,K., Girirajan,S., Darbro,B.W.,
            Cornell,R.A., Houston,D.W., Murray,J.C. and Manak,J.R.
  TITLE     Genome-wide analysis of copy-number variation in humans with cleft
            lip and/or cleft palate identifies COBLL1, RIC1, and ARHGEF38 as
            clefting genes
  JOURNAL   Am J Hum Genet 110 (1), 71-91 (2023)
   PUBMED   36493769
  REMARK    GeneRIF: Genome-wide analysis of copy-number variation in humans
            with cleft lip and/or cleft palate identifies COBLL1, RIC1, and
            ARHGEF38 as clefting genes.
REFERENCE   2  (bases 1 to 5457)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 5457)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5457)
  AUTHORS   Ong,B.A., Li,J., McDonough,J.M., Wei,Z., Kim,C., Chiavacci,R.,
            Mentch,F., Caboot,J.B., Spergel,J., Allen,J.L., Sleiman,P.M. and
            Hakonarson,H.
  TITLE     Gene network analysis in a pediatric cohort identifies novel lung
            function genes
  JOURNAL   PLoS One 8 (9), e72899 (2013)
   PUBMED   24023788
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5457)
  AUTHORS   Kalsi,G., Kuo,P.H., Aliev,F., Alexander,J., McMichael,O.,
            Patterson,D.G., Walsh,D., Zhao,Z., Schuckit,M., Nurnberger,J. Jr.,
            Edenberg,H., Kramer,J., Hesselbrock,V., Tischfield,J.A.,
            Vladimirov,V., Prescott,C.A., Dick,D.M., Kendler,K.S. and
            Riley,B.P.
  TITLE     A systematic gene-based screen of chr4q22-q32 identifies
            association of a novel susceptibility gene, DKK2, with the
            quantitative trait of alcohol dependence symptom counts
  JOURNAL   Hum Mol Genet 19 (12), 2497-2506 (2010)
   PUBMED   20332099
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Erratum:[Hum Mol Genet. 2010 Oct 15;19(20):4121. Hesselbrock,
            Victor [added]; Tischfield, Jay A [added]]
REFERENCE   6  (bases 1 to 5457)
  AUTHORS   Hancock,D.B., Eijgelsheim,M., Wilk,J.B., Gharib,S.A., Loehr,L.R.,
            Marciante,K.D., Franceschini,N., van Durme,Y.M., Chen,T.H.,
            Barr,R.G., Schabath,M.B., Couper,D.J., Brusselle,G.G., Psaty,B.M.,
            van Duijn,C.M., Rotter,J.I., Uitterlinden,A.G., Hofman,A.,
            Punjabi,N.M., Rivadeneira,F., Morrison,A.C., Enright,P.L.,
            North,K.E., Heckbert,S.R., Lumley,T., Stricker,B.H., O'Connor,G.T.
            and London,S.J.
  TITLE     Meta-analyses of genome-wide association studies identify multiple
            loci associated with pulmonary function
  JOURNAL   Nat Genet 42 (1), 45-52 (2010)
   PUBMED   20010835
REFERENCE   7  (bases 1 to 5457)
  AUTHORS   Takefuji,M., Asano,H., Mori,K., Amano,M., Kato,K., Watanabe,T.,
            Morita,Y., Katsumi,A., Itoh,T., Takenawa,T., Hirashiki,A.,
            Izawa,H., Nagata,K., Hirayama,H., Takatsu,F., Naoe,T., Yokota,M.
            and Kaibuchi,K.
  TITLE     Mutation of ARHGAP9 in patients with coronary spastic angina
  JOURNAL   J Hum Genet 55 (1), 42-49 (2010)
   PUBMED   19911011
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 5457)
  AUTHORS   Uhl,G.R., Liu,Q.R., Drgon,T., Johnson,C., Walther,D., Rose,J.E.,
            David,S.P., Niaura,R. and Lerman,C.
  TITLE     Molecular genetics of successful smoking cessation: convergent
            genome-wide association study results
  JOURNAL   Arch Gen Psychiatry 65 (6), 683-693 (2008)
   PUBMED   18519826
  REMARK    GeneRIF: Clinical trial and genome-wide association study of
            gene-disease association, gene-environment interaction, and
            pharmacogenomic / toxicogenomic. (HuGE Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK000191.1, DT932593.1, AC105391.1 and AK125951.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001242729.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968540,
                              SAMEA1968832 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000420470.3/ ENSP00000416125.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-689               AK000191.1         1-689
            690-1409            DT932593.1         1-720
            1410-1522           AC105391.1         72719-72831
            1523-3077           AK125951.1         1-1555
            3078-3837           AC105391.1         92170-92929
            3838-5456           AK125951.1         2315-3933
            5457-5457           AC105391.1         94549-94549
FEATURES             Location/Qualifiers
     source          1..5457
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q24"
     gene            1..5457
                     /gene="ARHGEF38"
                     /note="Rho guanine nucleotide exchange factor 38"
                     /db_xref="GeneID:54848"
                     /db_xref="HGNC:HGNC:25968"
                     /db_xref="MIM:619919"
     exon            1..342
                     /gene="ARHGEF38"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..2480
                     /gene="ARHGEF38"
                     /note="isoform 1 is encoded by transcript variant 1; Rho
                     guanine nucleotide exchange factor (GEF) 38"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 38
                     isoform 1"
                     /protein_id="NP_001229658.1"
                     /db_xref="CCDS:CCDS56338.1"
                     /db_xref="GeneID:54848"
                     /db_xref="HGNC:HGNC:25968"
                     /db_xref="MIM:619919"
                     /translation="MEPKEATGKENMVTKKKNLAFLRSRLYMLERRKTDTVVESSVSG
                     DHSGTLRRSQSDRTEYNQKLQEKMTPQGECSVAETLTPEEEHHMKRMMAKREKIIKEL
                     IQTEKDYLNDLELCVREVVQPLRNKKTDRLDVDSLFSNIESVHQISAKLLSLLEEATT
                     DVEPAMQVIGEVFLQIKGPLEDIYKIYCYHHDEAHSILESYEKEEELKEHLSHCIQSL
                     KKIYMQEGKPNLLDMGSLMIKPIQRVMKYPLLLCELRNSTPPSHPDYRALDDAFAAVK
                     DINVNINELKRRKDLVLKYKKNDEDESLKDKLSKLNIHSISKKSKRVTNHLKILTRGE
                     SQVKDNTFNREEKLFRALEKTVRLCVKNISLCLQHIQDAMPLALQSVMDLQEISYNKD
                     DEMDYSETLSNALNSCHDFASHLQRLILTPLSALLSLFPGPHKLIQKRYDKLLDCNSY
                     LQRSTGEESDLAKKEYEALNAQLVEELQAFNQAARKILLNCLCSFITLLRDLMLVAQQ
                     AYSTLVPMPLLVSSISEIQNQVLEEIQNLNCVKENSATFIERKLSFEKKKPVQILPEM
                     PHQTDIHRSKLLSTYSAEELYQAKRKCNATQEYDINLLEGDLVAVIEQKDPLGSTSRW
                     LVDTGNVKGYVYSSFLKPYNPAKMQKVDAENRFCDDDFENISLFVSSRPASDSVTGTS
                     ESSIGDSSSSLSGTCGKFETNGTDVDSFQEVDEQIFYAVHAFQARSDHELSLQEYQRV
                     HILRFCDLSGNKEWWLAEAQGQKGYVPANYLGKMTYA"
     exon            343..530
                     /gene="ARHGEF38"
                     /inference="alignment:Splign:2.1.0"
     exon            531..654
                     /gene="ARHGEF38"
                     /inference="alignment:Splign:2.1.0"
     exon            655..802
                     /gene="ARHGEF38"
                     /inference="alignment:Splign:2.1.0"
     exon            803..820
                     /gene="ARHGEF38"
                     /inference="alignment:Splign:2.1.0"
     exon            821..1020
                     /gene="ARHGEF38"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1154
                     /gene="ARHGEF38"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1259
                     /gene="ARHGEF38"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1379
                     /gene="ARHGEF38"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1691
                     /gene="ARHGEF38"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1835
                     /gene="ARHGEF38"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..2034
                     /gene="ARHGEF38"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2294
                     /gene="ARHGEF38"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..5457
                     /gene="ARHGEF38"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2994..2999
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGEF38"
                     /note="hexamer: AATATA"
     polyA_site      3021
                     /gene="ARHGEF38"
                     /note="major polyA site"
     regulatory      3383..3388
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGEF38"
                     /note="hexamer: AATAAA"
     polyA_site      3412
                     /gene="ARHGEF38"
                     /note="major polyA site"
     regulatory      5048..5053
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGEF38"
                     /note="hexamer: AATAAA"
     polyA_site      5069
                     /gene="ARHGEF38"
     regulatory      5438..5443
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGEF38"
                     /note="hexamer: AATAAA"
     polyA_site      5457
                     /gene="ARHGEF38"
                     /note="major polyA site"
ORIGIN      
        1 agtcacagcc aggtaaccct ggagtgaagc ggtttagtta gaagggagca gataaactcg
       61 tcactctagt agctttaacc ctcaccctga ggcaccttag caatcagcca ttgcctgcaa
      121 gcctccaaag cttgtctttg cctaatatgg agcccaaaga agccactggg aaagaaaaca
      181 tggtcaccaa gaaaaagaat ctggccttct tgaggtctag actctatatg ctggagagaa
      241 ggaagactga cactgtggtt gagagcagtg tttctgggga ccactctggc accttgagga
      301 ggagccaatc tgacaggacc gaatacaacc agaaattaca agaaaagatg actccacagg
      361 gtgagtgttc tgtagctgag accttaaccc cagaggaaga gcatcatatg aagaggatga
      421 tggcaaagcg ggaaaagatc attaaggagc tgatacagac agaaaaggat tatctcaatg
      481 atctagagct gtgtgttagg gaagtggttc agcccctgag aaataaaaag actgataggc
      541 tggatgtgga tagcttgttt agcaacattg agtccgtgca tcagatatca gccaagctgc
      601 tgtcattgtt ggaagaggcc acaacagacg tggaaccggc catgcaagta attggagaag
      661 tattcttgca gattaaaggg ccactggaag atatttataa aatctactgc tatcaccatg
      721 atgaagcaca tagtatactg gagtcctatg aaaaggaaga agagctgaag gaacatttga
      781 gccactgtat ccagtcctta aagaaaatat acatgcaaga aggcaaacca aacttattgg
      841 acatgggctc tttgatgatc aaaccaattc aacgtgtgat gaaatacccc ctattactgt
      901 gcgaacttcg gaattccacc cctccctctc acccagatta cagagcactg gacgatgcct
      961 ttgctgctgt gaaggacatt aatgttaaca tcaatgaact taaaagaagg aaagatttag
     1021 ttctaaaata caagaagaat gacgaggatg aatcacttaa agacaaattg tctaaactaa
     1081 atattcattc aattagcaag aaatcaaaaa gagtgacaaa tcatctgaag attctgacca
     1141 gaggagaatc acaggttaaa gacaatacct ttaacagaga agaaaagctg tttagagctt
     1201 tagaaaagac tgtgaggctt tgtgtgaaga acatttcact ctgtcttcaa cacatacagg
     1261 atgccatgcc cctggctctg cagagtgtga tggaccttca ggagatttca tacaacaaag
     1321 acgatgagat ggactattct gagaccctaa gtaatgcctt aaattcgtgt catgactttg
     1381 catctcactt acagagactc atcctgaccc ccttgtcagc cctgctgtcc ttattcccag
     1441 ggcctcacaa gctcatccag aaacgctatg acaaactgct ggattgcaac agctacctgc
     1501 agcgatcaac gggagaggag tcagacttgg ccaaaaagga gtatgaggcc ctcaacgccc
     1561 agcttgtgga ggagctccag gcattcaacc aggctgctcg gaagattctg ttgaactgtc
     1621 tatgcagctt cattaccctc cttagggacc tgatgctcgt ggcacagcag gcttactcca
     1681 cacttgtgcc gatgccactg ttggtttcaa gcatttctga gattcagaat caagtactag
     1741 aagagatcca aaatttgaat tgtgtgaaag aaaacagtgc cacctttatt gagaggaaac
     1801 tcagttttga aaagaagaaa cctgtgcaga ttctgccaga aatgccacat caaactgaca
     1861 ttcatcgctc caaacttcta tccacatata gtgcagagga actctatcaa gctaagcgca
     1921 agtgcaatgc tacacaagaa tatgacatca atcttctgga aggagacttg gtggctgtga
     1981 tagaacagaa agatccactg gggagtacaa gcaggtggct tgtggacaca ggaaatgtga
     2041 aaggatatgt ttattcctcc ttcctaaaac cctacaatcc agcaaaaatg cagaaagtgg
     2101 atgctgagaa caggttctgt gacgatgatt ttgagaacat cagcctcttc gtgtcttcac
     2161 ggccagctag tgacagtgtc acaggcacct cagaaagcag cattggtgat agcagctcat
     2221 ctcttagtgg cacatgtgga aagtttgaaa caaatggtac tgatgttgac agttttcaag
     2281 aagtagacga acagattttc tatgcagttc atgcttttca agcacggagt gaccatgaac
     2341 tcagccttca ggaataccag agagttcata tactcaggtt ttgtgaccta agtggcaata
     2401 aagagtggtg gttagctgaa gctcaagggc agaaaggata cgtgccagct aactaccttg
     2461 gaaagatgac ttatgcttaa gaaaataagc cttcaacttt tattttccag caagttgttg
     2521 attgactacc tcataaaact gacattacaa aactttggac cagaaagcaa gaaacctctg
     2581 aactacagaa actgatactg tactgggttt tcaggaatac tgtacttcct aacaggatta
     2641 ttgcatgaat gtattataaa ggatacatgt tgaaagaaat actaagccaa cagaaatagc
     2701 aaagcaaatg acccaagctt caactatcaa ctatttaaaa gtgaagatct tttgaaggag
     2761 taattatatt cttttatcat caagaaaggt tggatccaaa ggtttttcaa tttacttttt
     2821 tttttactgt atgatgtatt ttgccttaaa tgtttttgtt tttcatattg ctctcttgca
     2881 aatgcataca tgtttatata catacatata aaccatatat attatgtagc tttatacacg
     2941 tatgtggata atatgaatta tacacctata tgtataaatc agagtataca ccaaatatac
     3001 ataagaagaa tataccacca actagaagtc tttgataata tattttgtta atgtttcgtt
     3061 tatatgtttt gaactaaaac tgaataactt gatattaaca tgtaacatta ctgaatgcac
     3121 actatatgcc agacattgtt ctaagtgctt tatatgtagt aacttgttta atattcaaaa
     3181 cattatgaag aaaccatggc ccaaaaaggt gaagtaattt aatccaaatc acattgctat
     3241 taagtggtgg gcctggactt aaacctaggt agtgtaaacc aaaaataaaa ttctaaggct
     3301 tccaaccatc taaatagact tccccttcag ccagggcttt tttctttctt ttcttgttgt
     3361 tttttttttt ttttaaagag acaataaaag gaggtttttt tattcaaagg tataactgga
     3421 taagtagatt tgtttacaat cattcttgtg aaatactttt ttaaaaaaat acgatcaact
     3481 tctttgcaaa tagtagacac atacctcaac aatgatgacc taatttttga tccataatgt
     3541 aagattaggt agaaataggc aagctcacac tgctaaatta actatcaaat actcagtcaa
     3601 aactccattt gtggccccca cttcttgatc tatttctgtt ccacttcgtc ttctaccatc
     3661 ttgccgactt tcctgagcaa ctgctttgtc gactctctct acctgaccaa ttgccagatc
     3721 gacaacctga ctggcctgac cagccactcc tctgtctgga attaaaagat gtttccatca
     3781 taatattctt taatttcagg taatttagct ggcactgaga gtatccagcc ggaatcatgc
     3841 cactttgcct gtaacctttg actcaattgg aggaatatca aagcaaacac ccatatttcc
     3901 tttcaggagg cacactctgg taatctgaga cactgcatta ctattcagct ttctaagttc
     3961 tttccaagca cagctgacat cctgtatttc ctctaggctt tccagagtca tggtcacaaa
     4021 ccccttatca gagttgatta aagatcatgg ttcaaagctt gatacaccag aaatgtgggc
     4081 taaagctgca gccaatgcat ctatcgcccc tttctcttct atcagtatct gagctgatgg
     4141 ttggaaaaaa atcaacagca gcataagaaa tggaagccag agaccttatg gcatccatgc
     4201 ttttaaattt aactaaatcc attgtagaag gaacacctac acatttaaaa gtaatttgtg
     4261 ttttttgttc cacatgtctt agttgacctt tctcttggtt gataaaaaca tatacaaacc
     4321 cctgtctgtc cagctttacc cacgcatcca gagagatgga tataggactc aatatcctga
     4381 ggaggagaac tttgaatcac caggtcaact acaggaatgt ccaaaccacg aggagccaca
     4441 ttggttgcca ccaaaacttt ataattacct ctctgaagcc ttttagtgta atttctcttt
     4501 gtgactgtgc aatgtcccca tgtaaacaca gtgcattctg ttttgtgcgg attcatggcc
     4561 atgtcagtta cattcttctt cgtctcacag aaaataatag ccctcccttc agatccactg
     4621 tagacttgaa ggacatctca ttttcatctg tgttttataa aggaggaaat tgaggacctc
     4681 acatggaggg actggaattt aaaaccaggt cttctgactt taaggccttt cttttagtgt
     4741 tttccctttt cttttcctta agtcactaaa atctgtagtt atataatctt acataaagca
     4801 tatgcaaaat agaaaaatga tagtcaccac atatctacta atgggattaa aatgtacaat
     4861 cctaaaagct tacttgttag cacacttgct tatctgtcca ttcattcatt gaaccagtaa
     4921 gtatttattg agagttagtg ggaatacaat gctgtgcaag acaaacaaga tccctccatt
     4981 cataccactt aaattctagt ggggaaaaca tctgcacata acaaactaaa taaaatgatc
     5041 ataaaataat aaatgctatt tatataaaac tggctacttt cattactgct cagttaaagg
     5101 gtcttgtagc tcattttatg acatgaaaaa aatcaaggtc taaaagctcc ttgagacaat
     5161 ttaaactcta ataccaaata tacctctata aaataccaaa ctgagctaaa tacggtatat
     5221 gtgtacttat acatatgtac ataacctaaa tatacgtgtg cacacattat ctatacaaag
     5281 agccatactc agtgaaagat aaattacctc ctaaactaaa gtcccctctg aggtacaaca
     5341 gaaattaaaa taattgcttc tcttctcaac tctatgtagc acgtattttc catgatggga
     5401 taaatgtttt catttcaagt gccaatgtgt gaactgtaat aaacattact gctttca
//
