LOCUS       NM_001001669            4943 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens Rho guanine nucleotide exchange factor 37 (ARHGEF37),
            mRNA.
ACCESSION   NM_001001669 XM_371776
VERSION     NM_001001669.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4943)
  AUTHORS   Viplav,A., Saha,T., Huertas,J., Selenschik,P., Ebrahimkutty,M.P.,
            Grill,D., Lehrich,J., Hentschel,A., Biasizzo,M., Mengoni,S.,
            Ahrends,R., Gerke,V., Cojocaru,V., Klingauf,J. and Galic,M.
  TITLE     ArhGEF37 assists dynamin 2 during clathrin-mediated endocytosis
  JOURNAL   J Cell Sci 132 (9) (2019)
   PUBMED   30926623
  REMARK    GeneRIF: ArhGEF37 was identified as a constituent of
            clathrin-mediated endocytosis: ArhGEF37 accumulated at dynamin
            2-rich late endocytic sites.  Endocytosis rates increased in the
            presence of ArhGEF37.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4943)
  CONSRTM   GENDEP Investigators; MARS Investigators; STAR*D Investigators
  TITLE     Common genetic variation and antidepressant efficacy in major
            depressive disorder: a meta-analysis of three genome-wide
            pharmacogenetic studies
  JOURNAL   Am J Psychiatry 170 (2), 207-217 (2013)
   PUBMED   23377640
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC021078.5, BC041325.1, BF508325.1, AK123597.1, BF510234.1,
            AK023814.1 and AC022100.7.
            
            On Nov 22, 2018 this sequence version replaced NM_001001669.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.145398.1,
                                           SRR1803614.2098.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333677.7/ ENSP00000328083.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AC021078.5         35295-35368         c
            75-1603             BC041325.1         1-1529
            1604-1778           BF508325.1         1-175               c
            1779-1829           AK123597.1         345-395
            1830-2242           BF510234.1         58-470
            2243-2464           AK123597.1         809-1030
            2465-4541           AK023814.1         1430-3506
            4542-4829           AK123597.1         3108-3395
            4830-4939           AK023814.1         3795-3904
            4940-4943           AC022100.7         136958-136961       c
FEATURES             Location/Qualifiers
     source          1..4943
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q32"
     gene            1..4943
                     /gene="ARHGEF37"
                     /note="Rho guanine nucleotide exchange factor 37"
                     /db_xref="GeneID:389337"
                     /db_xref="HGNC:HGNC:34430"
                     /db_xref="MIM:620664"
     exon            1..127
                     /gene="ARHGEF37"
                     /inference="alignment:Splign:2.1.0"
     exon            128..324
                     /gene="ARHGEF37"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..2166
                     /gene="ARHGEF37"
                     /note="Rho guanine nucleotide exchange factor (GEF) 37"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 37"
                     /protein_id="NP_001001669.2"
                     /db_xref="CCDS:CCDS43385.1"
                     /db_xref="GeneID:389337"
                     /db_xref="HGNC:HGNC:34430"
                     /db_xref="MIM:620664"
                     /translation="MAKHGADEPSSRSGSPDREGRASEDRSLLHQRLAVRELIDTEVS
                     YLHMLQLCASDIRSRLQQLPQGDLDVLFSNIDDIIKVNSRFLHDLQETASKEEEQVQL
                     VGNIFLEFQEELEQVYKVYCASYDQALLLVDTYRKEPELQRHIQGIVEAVVPQAGSSG
                     LSFLLVIPLQRITRYPLLLQKILENTVPDASAYPVLQRAVSALQDVNTNINEYKMRKE
                     VASKYTKVEQLTLRERLARINTHTLSKKTTRLSQLLKQEAGLIPRTEDKEFDDLEERF
                     QWVSLCVTELKNNVAAYLDNLQAFLYFRPHEYNLDIPEGPAVQYCNLARDLHLEAFLK
                     FKQRLEGLVWQPLCSLAKALLGPQNLIKKRLDKLLDFERVEEKLLEVGSVTYQEEAAR
                     HTYQALNSLLVAELPQFNQLVMQWLGQIMCTFVTLQRDLAKQVLQRAEGSMAQLPHHH
                     VPEPAFRKLVEDALGRTSNQLRSFQETFEKVQPPPTTQPLLPGSERQVQALLSRYGPG
                     KLYQVTSNISGTGTLDLTLPRGQIVAILQNKDTKGNSGRWLVDTGGHRGYVPAGKLQL
                     YHVVPSAEELRRQAGLNKDPRCLTPEPSPALVPSIPTMNQVIAAYPFVARSSHEVSLQ
                     AGQPVTILEAQDKKGNPEWSLVEVNGQRGYVPSGFLARARSPVLWGWSLPS"
     exon            325..448
                     /gene="ARHGEF37"
                     /inference="alignment:Splign:2.1.0"
     exon            449..596
                     /gene="ARHGEF37"
                     /inference="alignment:Splign:2.1.0"
     exon            597..796
                     /gene="ARHGEF37"
                     /inference="alignment:Splign:2.1.0"
     exon            797..927
                     /gene="ARHGEF37"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1032
                     /gene="ARHGEF37"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1143
                     /gene="ARHGEF37"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1473
                     /gene="ARHGEF37"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1602
                     /gene="ARHGEF37"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1798
                     /gene="ARHGEF37"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1956
                     /gene="ARHGEF37"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..4943
                     /gene="ARHGEF37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4920..4925
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGEF37"
                     /note="hexamer: AATAAA"
     polyA_site      4943
                     /gene="ARHGEF37"
                     /note="major polyA site"
ORIGIN      
        1 gggcacagcc acccggagcg gcgcgggtgc cgggagctgg gcgacgcgcc cctcctgccc
       61 cggctgcgct gttgcccggg cggccgacct ccgtgcgtga gcgccggcag gcaccttgcg
      121 cgcgcggaac ctgctgacat ggccaagcat ggagccgacg agccatcctc caggtcaggg
      181 agtccggaca gggaaggtag ggcctctgag gacagatcgc tgcttcatca gaggctggct
      241 gtccgggagc tcatcgacac tgaggtctcc tacttgcaca tgctccagct ctgtgcctct
      301 gacatcagga gccgcctcca gcagttgccg cagggagatc tggatgtcct gttctcaaac
      361 attgatgata tcatcaaagt gaacagcaga ttcctccatg atctgcagga gacagcctcc
      421 aaggaagagg aacaagtgca gctagttggt aacatatttc tggaattcca agaggagttg
      481 gagcaagtct ataaggtcta ctgtgccagc tacgaccagg ccttgctact ggtggacacg
      541 taccggaagg agccggagct gcagcggcac atccagggca tcgttgaggc ggtggtgccg
      601 caagctggat cttcaggcct cagtttcttg ctggtaattc ctctgcagag gatcaccagg
      661 tacccactgc tgctgcagaa aatcctggag aacacagtcc ctgatgccag tgcctatcct
      721 gtccttcaga gggctgtctc tgccctccag gacgtgaaca ccaatatcaa tgagtacaag
      781 atgcgcaagg aagtggcctc caagtacacc aaggtagagc agctgaccct ccgggagcgg
      841 ctggcccgca tcaacacaca caccctctcc aagaagacca cccggctgag ccagctgctg
      901 aagcaggagg cggggctgat ccccaggaca gaagacaagg aatttgatga tttagaagag
      961 aggttccagt gggtgtctct gtgtgtgact gagctgaaga acaacgtggc tgcttacctg
     1021 gacaatctgc aggctttcct ctacttcagg ccgcacgaat acaatctgga catccccgag
     1081 gggcctgcag tgcagtattg caatttggca agagaccttc accttgaggc cttcctgaaa
     1141 tttaagcaac ggctagaagg cctggtgtgg cagccactgt gcagcctggc caaagccctg
     1201 cttggccctc agaacctgat caagaagcgt ctggacaagc tactggactt tgagcgggtg
     1261 gaagagaagc tgctggaggt gggcagtgtg acctaccagg aggaggccgc ccggcacaca
     1321 taccaggcac tcaactcgct gctagtggct gagctcccac agtttaacca gctggtcatg
     1381 cagtggctgg gccagatcat gtgcacattc gtgaccctcc agagggacct tgcaaagcaa
     1441 gtgctgcaga gggcagaggg aagcatggcc cagctgcccc accaccacgt cccagagcct
     1501 gccttcagga agctggtgga ggacgcactg ggccggacga gtaaccagct tcgctccttt
     1561 caagagacct ttgagaaagt gcagccacct cccaccacac aaccgctcct tccagggtct
     1621 gaacgccagg tgcaggctct cctgagcagg tatggccctg ggaagctgta ccaggtgaca
     1681 agcaacatca gtgggactgg gactctggac ctgactctgc ctcggggcca aatcgtggcc
     1741 atccttcaaa acaaggacac caaaggcaac agcggccgct ggctggtgga caccggggga
     1801 catcgtgggt atgtgccggc tgggaaacta cagctgtacc atgtggtccc cagtgcagag
     1861 gagctcagaa ggcaggcggg gctgaacaaa gacccccgat gtctaacacc ggagcccagc
     1921 ccagctctag tgccctctat tcccaccatg aaccaggtca tagccgcgta cccttttgtg
     1981 gccagaagca gccatgaagt gagcctgcag gcaggccagc ctgtgaccat cctggaggcc
     2041 caggacaaga aggggaaccc tgagtggagc ctggtggaag tgaatggaca gaggggttat
     2101 gtgccttctg gcttcttggc cagggctcgg agcccagttc tgtggggctg gagtctgccc
     2161 tcttagggta ccctctttgg agcctacatt gccaaatgat gggggaggct tagaggctct
     2221 gaccctgggg ggaaaagaag caaaggaaag gtggaggtgg aagggaagac caggccaggg
     2281 tgggtgaagc acactcagga ggcagccaga agacatgggc gggcctcgca gagtgcttgg
     2341 tgtggtgggg gcacaggagg ctccagccag gactgctcat tatgtctgca taaagaactc
     2401 attccgacct ggggtcacaa tgcacttgga cagcaggtca cagctgattg gccaggactc
     2461 tccataggtt atggccagtc ttagctgtgc ctgcatccgg gcctgcctgt gggcgtgggt
     2521 cacacgggat aatgttacct gcgtgctgtg tggttgcagg aagcgggttc tggaggagtc
     2581 cagaactgcc tggtcagaca gttcacttcc tacacatggt atcaggagac atcataacca
     2641 atgagtcagc ttttatttct ctatgctgga agctgagttt atcttgggca gtgacccact
     2701 gggagccctc tcaagtgggg aagccatgga tttatcggtg tagcagagag gttcccaaga
     2761 ctcttgactg gtcctgggag tgggtgtgac caagtcatag ttctggaatg tgtgtaggca
     2821 aattcagagg ctgttccagg gaagagggga ttttgatact gtgttaggtg gggtgtgtga
     2881 ggctgttggc agcaggtgaa cagctactgc tgtgttctca ggactaggga acaaaggggt
     2941 atgcaaatca tagaggaaac tctgggaagg cggtgataag gcctggtggg tggggaggtt
     3001 agggaatggc ttgctttcct gtttctggtt agaaggggag ccagggggaa cccccagtgg
     3061 tttcaggtgg cccctgaggt cctggaggca gccgtggatg tgatgcaatt ggctgtggga
     3121 ccttagatgt aggacacaac ttcagtgttc ccatccagaa agacctcact cacagggttg
     3181 tgctgagaat gacgtggggc taagcatgca gagctccctg taaactgtga agtgtgatac
     3241 aaatgtaaat gacagcagtg atctcggggt ggcccccggc atgctgccct cccccacgcc
     3301 catgcctgtg gcagcaaacc ttgttcatca gtatagcttt ctttcctgta acccaggatc
     3361 taccttgggg ggcttctcaa tactgcattc tatgtagcca gcctctttaa cttggtaagt
     3421 gagccacccc attctagaac ctggaaattg gagcccctca aaaacagttc ctgttcaagg
     3481 aggactgacc tgctggggca atgttgggtg cagtgcagtc cctgcttggg gtggtcatgt
     3541 ctaggctgtt gctctgggca aagataagtt gcaagattca cagaaatggg aaaatgtgac
     3601 caagtgtgat cttaacaact gacaaagttt gtaaccaacc caagttagaa tgtgtgtcaa
     3661 acaggaggta gtttagatat gcttccaaga acatgtctgt gttataacca tagtgcctaa
     3721 gcagtgagct ctggtttttg aagggctttt aagaaatata tacatgtctg tgtcagtcta
     3781 taacttgcct cctctgggcc tgttaaagca tgaagactgc atgacacaag agaaatgcaa
     3841 gccctacggt tcctttctca gcagcgaatt cacttgagag gatgctcttg actcattctc
     3901 tctgctcttt cctgctcaga tttctgataa aaatagagag cataggggaa cagataatga
     3961 aataggaaac ccactcgtgg gttccacaga tacctaccga aggcctactg tgtgctagaa
     4021 ttgtagctca ggagttctca gtgtagctgc tcactgaagt taccatggca ggtttcaact
     4081 ggcagaatcc aggctccgtc ccacccagag attctgatga aattggttta gggtgtggct
     4141 cgggcctcag gaattcagaa agcttcccag gtgcttccaa tgtgcagcca gggttaggga
     4201 cctctaccct agacacaaag tattggacag atagacctgg tgccagagat ggccatgagc
     4261 tgtaagctag gacgtgcccc acctgagctc tgcactagct agttcaaaca ggcgctttaa
     4321 aggcagtgtg aaaggggaca gcctgttctg ccaggtctca gaatgtatat ttattaagtg
     4381 ccattaaaag ggacctgaac aaaattggat gtcttgtagg cataagggag gaaaataaaa
     4441 tatacttgga accaagtcta tgtcatgaag ggaaaataaa aatgtattca gtagcacgtg
     4501 ggttatggtt tctcatagac caggggataa gattaaaagt cactgaagag tgggaaaatg
     4561 catgttgaga agatgagaat ggcctgtatt ttctccaggg gaatctgtgt aatgtgcctt
     4621 ttccctctcc aaatgcctag aaccatggca ctgtgtctta tttatttaac cgttgggctg
     4681 tctcatacta aacttgcaaa gatatttgcc tatgaactga acaagacttc caggagttga
     4741 agtctggttc acaagggtac cccttgcctc ctgtgatgga gtgagaactc ttaaacccct
     4801 caggccccaa ctcagttgtg gagatgagga caagattaca atatcaaaag aaagatgaat
     4861 gaattcttgg ttaatatgac gaaccccagc tcaatgagta actgatgtga actgctggga
     4921 ataaaggact tcaaagatgg aaa
//
