LOCUS       NM_001003702            2609 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens Rho guanine nucleotide exchange factor 35 (ARHGEF35),
            transcript variant 1, mRNA.
ACCESSION   NM_001003702
VERSION     NM_001003702.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2609)
  AUTHORS   Dougherty,M.L., Underwood,J.G., Nelson,B.J., Tseng,E., Munson,K.M.,
            Penn,O., Nowakowski,T.J., Pollen,A.A. and Eichler,E.E.
  TITLE     Transcriptional fates of human-specific segmental duplications in
            brain
  JOURNAL   Genome Res 28 (10), 1566-1576 (2018)
   PUBMED   30228200
REFERENCE   2  (bases 1 to 2609)
  AUTHORS   Fortna,A., Kim,Y., MacLaren,E., Marshall,K., Hahn,G., Meltesen,L.,
            Brenton,M., Hink,R., Burgers,S., Hernandez-Boussard,T.,
            Karimpour-Fard,A., Glueck,D., McGavran,L., Berry,R., Pollack,J. and
            Sikela,J.M.
  TITLE     Lineage-specific gene duplication and loss in human and great ape
            evolution
  JOURNAL   PLoS Biol 2 (7), E207 (2004)
   PUBMED   15252450
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004889.1.
            
            On Nov 22, 2019 this sequence version replaced NM_001003702.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK125680.1, BC136878.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378115.3/ ENSP00000367355.3
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-296               AC004889.1         47153-47448         c
            297-2609            AC004889.1         37698-40010         c
FEATURES             Location/Qualifiers
     source          1..2609
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q35"
     gene            1..2609
                     /gene="ARHGEF35"
                     /gene_synonym="ARHGEF5L"
                     /note="Rho guanine nucleotide exchange factor 35"
                     /db_xref="GeneID:445328"
                     /db_xref="HGNC:HGNC:33846"
     exon            1..296
                     /gene="ARHGEF35"
                     /gene_synonym="ARHGEF5L"
                     /inference="alignment:Splign:2.1.0"
     exon            297..2609
                     /gene="ARHGEF35"
                     /gene_synonym="ARHGEF5L"
                     /inference="alignment:Splign:2.1.0"
     CDS             309..1763
                     /gene="ARHGEF35"
                     /gene_synonym="ARHGEF5L"
                     /note="rho guanine nucleotide exchange factor 5-like
                     protein; Rho guanine nucleotide exchange factor (GEF) 35"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 35"
                     /protein_id="NP_001003702.2"
                     /db_xref="CCDS:CCDS34770.1"
                     /db_xref="GeneID:445328"
                     /db_xref="HGNC:HGNC:33846"
                     /translation="MEAEEAQHGASPPISAIEEFSIIPEAPMRSSQVSALGLEAQEDE
                     DPSYKWREEHRLSATQQSELRDVCDYAIETMPSFPKEGSADVEPNQESLVAEACDTPE
                     HWEAVPQSLAGRQARTLAPPELWACPIQSEHLDMAPFSSDLGSEEEEVEFWPGLTSLT
                     LGSGQAEEEEETSSDNSGQTRYYSPCEEHPAETNQNEGAESGTIRQGEELPSEELQES
                     QGLLHPQEVQVLEEQGQQEAGFRGEGTLREDVCADGLLGEEQMIEQVNDEKGEQKQKQ
                     EQVQDVMLGRQGERMGLTGEPEGLNDGEWEQEDMERKAQGQGGPEQGEERKRELQVPE
                     ENRADSQDEKSQTFLGKSEEVTGKQEDHGIKEKGVPVSGQEAKEPESWDGGRLGAVGR
                     ARSREEENEHHGPSMPALIAPEDSPHCDLFPGASYLVTQIPGTQTESRAEELSPAALS
                     PLLEPIRCSHQPISLLGSFLTEESPDKEKLLSVL"
     regulatory      2583..2588
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGEF35"
                     /gene_synonym="ARHGEF5L"
                     /note="hexamer: AATAAA"
     polyA_site      2609
                     /gene="ARHGEF35"
                     /gene_synonym="ARHGEF5L"
                     /note="major polyA site"
ORIGIN      
        1 tgcgcccggg ctcccctctc cgccggcccg gcacttccca gctctgacgc gggagcttct
       61 ttcacaccaa tggggctcgc gcgcggaggg gccctgcccc tcctccggga aggtgtgtcc
      121 ctgtttcctc acctgaaact tcctaggaga acccgatccc tccctcccgt cgggcggcca
      181 ggggcgggcc gcgggtgggg cggccgggcc tgcgctgggg acggctctgg ggactgcggc
      241 cggcgccggg acctggaggg gacgctgggg ccgaagcagc atgtgacacc gaccaggatt
      301 cagccctgat ggaggctgag gaggcccagc atggagcctc tcctcccatc tctgccatag
      361 aggaattcag cattatccct gaggctccca tgaggagcag ccaggtctct gccttggggc
      421 ttgaagctca agaagatgag gacccatcct ataagtggag agaggaacac agactctcag
      481 caactcagca gagtgagtta agggatgtgt gtgactatgc gattgagacg atgccctctt
      541 ttcccaagga aggttctgca gatgtggagc ccaatcagga aagccttgtg gctgaggcct
      601 gtgacactcc ggaacactgg gaggcagtac cccagagcct agcaggccga caagcaagga
      661 ctctagctcc cccagagctc tgggcctgcc ccattcagag tgagcatcta gacatggccc
      721 cattttccag tgacctggga agcgaagaag aggaggtgga attttggcca ggacttactt
      781 ctttgacatt gggatctgga caggcagaag aagaagagga aacctcttca gataactctg
      841 gtcagaccag atattattct ccctgcgaag agcatcctgc agagaccaac cagaatgaag
      901 gcgctgaaag tgggactatc aggcaggggg aagagctgcc atctgaggag ctgcaggaaa
      961 gtcaagggct cttgcatccc caggaggtcc aagttctgga ggagcaggga cagcaggaag
     1021 caggatttcg gggggaagga actctgaggg aggatgtttg tgccgatggg ctattagggg
     1081 aggaacagat gatagagcag gttaatgatg aaaagggaga acagaagcaa aaacaggaac
     1141 aggtacaaga tgtgatgctt gggagacaag gagaaagaat ggggctcact ggggagccag
     1201 agggtctgaa tgacggtgag tgggagcagg aggatatgga gaggaaggct cagggtcagg
     1261 gaggtccaga acagggagaa gagaggaaga gggagctgca ggtgccagaa gagaacaggg
     1321 cggactctca ggacgaaaag agtcaaacct ttttgggaaa atcagaggaa gtaactggaa
     1381 agcaagaaga tcatggtata aaggagaaag gggtcccagt cagcgggcag gaggcgaaag
     1441 agccagagag ttgggatggg ggcaggctgg gggcagtggg aagagcgagg agcagggaag
     1501 aggagaatga gcatcatggg ccttcaatgc ccgctctgat agcccctgag gactctcctc
     1561 actgtgacct gtttccaggt gcctcatatc tcgtgactca gattcccggg actcagacag
     1621 agtccagggc tgaggaactg tcccccgcag ctctgtctcc cttgctagag cccatcagat
     1681 gctctcacca gcccatttct ctactgggct cctttttgac tgaggagtca cctgacaagg
     1741 aaaaacttct atcagtactt tgatatgtca cagtttcatg tttatccagt tcaatgtatt
     1801 tttaaatttt tccttgagac ttctttgact gatagattat tgtgaagtgt gtttttaaat
     1861 ttccaaatgt ttagggattt tcatatcttt cttatgctga tttccaattg gattccctac
     1921 aatgatttct ggttttcatc tgctctggat gattactatc tcttttaaat ttgttgtggc
     1981 gagttttagg gcctaggaca gctctatctt gccatgtgtt tcgtcagcac tcaaaaaaaa
     2041 tatgtgtatt ctgctgttac tgtgtggaat attctgtaaa tgccaaatag attcttttgg
     2101 ttaatggcat tttgagttgt tttatattct tgttgatttt cttttttttc ctctttttaa
     2161 aaacatgaaa tgcttcacaa aattttgtgt aatctatatt caagaaccat tttaatcttg
     2221 ttggcatcat tctgatttta gaaagtgctg ccaaagccaa cactccttgc tgattttctg
     2281 tctagttcta tcaattattg aaaaaggcat gaggaaattt ctaactataa ttgtggattc
     2341 atctatatct cctttcagtt ttcttttttt aaaaaaaatc aatgaaaatt tattaaatta
     2401 agcataaagt tactttcaca tttatctaca accacagtga atacagttct tggcatgaag
     2461 acaccacaac ctttagaatt taaagcctcc tcacctgcaa gattacatat ataaaactcc
     2521 cactattgtt tctctaagag tggattagtt caccaagtta aaagttatat gatctagaat
     2581 ataataaaat ggaaatgatt tactcataa
//
