LOCUS       NM_001145451            4494 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens Rho guanine nucleotide exchange factor 33 (ARHGEF33),
            transcript variant 1, mRNA.
ACCESSION   NM_001145451
VERSION     NM_001145451.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4494)
  AUTHORS   Ishaque,N., Abba,M.L., Hauser,C., Patil,N., Paramasivam,N.,
            Huebschmann,D., Leupold,J.H., Balasubramanian,G.P., Kleinheinz,K.,
            Toprak,U.H., Hutter,B., Benner,A., Shavinskaya,A., Zhou,C., Gu,Z.,
            Kerssemakers,J., Marx,A., Moniuszko,M., Kozlowski,M., Reszec,J.,
            Niklinski,J., Eils,J., Schlesner,M., Eils,R., Brors,B. and
            Allgayer,H.
  TITLE     Whole genome sequencing puts forward hypotheses on metastasis
            evolution and therapy in colorectal cancer
  JOURNAL   Nat Commun 9 (1), 4782 (2018)
   PUBMED   30429477
  REMARK    Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC018693.8 and AC019171.4.
            
            On Apr 17, 2020 this sequence version replaced NM_001145451.4.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409978.7/ ENSP00000387020.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               AC018693.8         125378-125489
            113-185             AC018693.8         131280-131352
            186-295             AC018693.8         154866-154975
            296-345             AC018693.8         156877-156926
            346-510             AC019171.4         2285-2449
            511-632             AC019171.4         3087-3208
            633-775             AC019171.4         4487-4629
            776-835             AC019171.4         9153-9212
            836-1060            AC019171.4         10713-10937
            1061-1190           AC019171.4         17279-17408
            1191-1323           AC019171.4         24367-24499
            1324-1407           AC019171.4         26540-26623
            1408-1491           AC019171.4         27751-27834
            1492-1640           AC019171.4         30277-30425
            1641-1805           AC019171.4         31412-31576
            1806-2613           AC019171.4         33219-34026
            2614-2753           AC019171.4         39384-39523
            2754-4494           AC019171.4         47092-48832
FEATURES             Location/Qualifiers
     source          1..4494
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p22.1"
     gene            1..4494
                     /gene="ARHGEF33"
                     /note="Rho guanine nucleotide exchange factor 33"
                     /db_xref="GeneID:100271715"
                     /db_xref="HGNC:HGNC:37252"
     exon            1..112
                     /gene="ARHGEF33"
                     /inference="alignment:Splign:2.1.0"
     exon            113..185
                     /gene="ARHGEF33"
                     /inference="alignment:Splign:2.1.0"
     exon            186..295
                     /gene="ARHGEF33"
                     /inference="alignment:Splign:2.1.0"
     CDS             271..2883
                     /gene="ARHGEF33"
                     /note="isoform 1 is encoded by transcript variant 1; DH
                     and coiled-coil domain-containing protein ENSP00000381780;
                     Rho guanine nucleotide exchange factor (GEF) 33"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 33
                     isoform 1"
                     /protein_id="NP_001138923.2"
                     /db_xref="CCDS:CCDS46263.2"
                     /db_xref="GeneID:100271715"
                     /db_xref="HGNC:HGNC:37252"
                     /translation="MEKTKTKQGENEHMPVNNPSTQIYQLQALASELKTGFTEAMQEL
                     SRIQHGEYALEEKVKSCRCSMEEKVTEMKNSLNYFKEELSNAMSMIQAITSKQEEMQQ
                     KIEQLQQEKRRESRKVKAKKTQKEEHSSQAGPAQAQGSPFRSINIPEPVLPSEDFTNL
                     LPSQAYEKAQESRSVHVGDSNVKGMMGPGVNPTTPEAEENLKSCLSADIQSKGHLPSG
                     MWRQPKDGKEWGEEYVTKDHPDKLKEAGQGRHSSLENVLCETSLAAKRQTVALELLES
                     ERKYVINISLILKIKATFQGSDGKRNSKERSLFPGSLRYLVQQHLDLLHALQERVLKW
                     PRQGVLGDLFLKLTNDENNFLDYYVAYLRDLPECISLVHVVVLKEGDEEIKSDIYTLF
                     FHIVQRIPEYLIHLQNVLKFTEQEHPDYYLLLVCVQRLRVFISHYTLLFQCNEDLLIQ
                     KRKKLKKSSMAKLYKGLASQCANAGQDASPTAGPEAVRDTGIHSEELLQPYPSAPSSG
                     PAITHLMPPVKKSQQQQSLMESMQPGKPSDWELEGRKHERPESLLAPTQFCAAEQDVK
                     ALAGPLQAIPEMDFESSPAEPLGNVERSLRAPAELLPDARGFVPAAYEEFEYGGEIFA
                     LPAPYDEEPFQAPALFENCSPASSESSLDICFLRPVSFAMEAERPEHPLQPLPKSATS
                     PAGSSSAYKLEAAAQAHGKAKPLSRSLKEFPRAPPADGVAPRLYSTRSSSGGRAPIKA
                     ERAAQAHGPAAAAVAARGASRTFFPQQRSQSEKQTYLEVRREMHLEDTTRFCPKEERE
                     SEQTSFSDQNPRQDQKGGFRSSFRKLFKKKSSGSEYREKTNENPSMDPSPTKQDFFRN
                     RLALANDLDQGTAV"
     exon            296..345
                     /gene="ARHGEF33"
                     /inference="alignment:Splign:2.1.0"
     exon            346..510
                     /gene="ARHGEF33"
                     /inference="alignment:Splign:2.1.0"
     exon            511..632
                     /gene="ARHGEF33"
                     /inference="alignment:Splign:2.1.0"
     exon            633..775
                     /gene="ARHGEF33"
                     /inference="alignment:Splign:2.1.0"
     exon            776..835
                     /gene="ARHGEF33"
                     /inference="alignment:Splign:2.1.0"
     exon            836..1060
                     /gene="ARHGEF33"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1190
                     /gene="ARHGEF33"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1323
                     /gene="ARHGEF33"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1407
                     /gene="ARHGEF33"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1491
                     /gene="ARHGEF33"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1640
                     /gene="ARHGEF33"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1805
                     /gene="ARHGEF33"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..2613
                     /gene="ARHGEF33"
                     /inference="alignment:Splign:2.1.0"
     exon            2614..2753
                     /gene="ARHGEF33"
                     /inference="alignment:Splign:2.1.0"
     exon            2754..4494
                     /gene="ARHGEF33"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3173..3178
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGEF33"
                     /note="hexamer: AATAAA"
     polyA_site      3196
                     /gene="ARHGEF33"
                     /note="major polyA site"
     regulatory      4472..4477
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGEF33"
                     /note="hexamer: AATAAA"
     polyA_site      4494
                     /gene="ARHGEF33"
                     /note="major polyA site"
ORIGIN      
        1 gtttcagggg aagtcaagcc tctctactgc ttctttttat aacctttaag ttaattcaga
       61 acccagataa gccttgatct gaggatgata taaccaccgc aggcaacatg ggaacttcta
      121 gagaaaacaa gaagaagact tcaaaaaaca tgctgtgatg tctcccagtg gagacagggc
      181 acgaggtgca gggaagagga ggtggcctga gccaggacga tgaggatgca atgttgaaga
      241 ataagctgga gaagagaagt aaccggcact atggaaaaaa ccaaaacaaa gcaaggagag
      301 aatgaacata tgccggtgaa taatccttcc acgcagattt accagttgca ggccctagcc
      361 tccgaactca aaactggttt cacagaagca atgcaagaac tgtcaagaat tcaacatgga
      421 gaatatgctt tggaagaaaa ggttaagagc tgcagatgtt ccatggaaga aaaagttact
      481 gagatgaaga attcattaaa ctatttcaag gaagagctga gcaatgccat gtcgatgatc
      541 caagccatca cttccaaaca agaagaaatg caacagaaaa tcgagcagct tcaacaggag
      601 aagcgaagag aatctcgaaa agttaaagcc aagaaaactc aaaaagaaga gcacagctca
      661 caggccgggc ctgcccaagc acaaggaagt ccttttcgtt ctatcaatat ccctgagcct
      721 gttcttccaa gcgaagactt taccaacctt ttgccttctc aggcctacga gaaagcccaa
      781 gagtccagat ctgttcatgt aggagacagt aatgtaaaag gaatgatggg tcctggagtg
      841 aacccaacaa ctccagaagc agaagaaaac ctcaagtctt gcctctcggc tgatatccag
      901 tccaagggcc atctcccatc tggcatgtgg aggcagccta aggatggtaa agaatggggt
      961 gaagaatacg tcacaaaaga ccacccagat aaactcaagg aggctggcca gggtagacac
     1021 agctccttgg aaaacgtttt atgtgaaacc tccttagctg ctaaaagaca gactgtggcc
     1081 ctggaactgc ttgaatctga aagaaaatat gtcattaaca tctctctgat cttgaagata
     1141 aaagccacat tccaggggtc agatggaaag aggaattcca aagagagaag cctcttccct
     1201 ggctctttac ggtacctcgt ccagcagcac ctggatctgc ttcacgcact gcaggaaagg
     1261 gtcctgaagt ggccacgcca aggcgttctt ggagatttat tccttaagtt aacaaatgac
     1321 gagaataatt tcttggatta ttatgttgcc tacctaaggg acctgcctga gtgcatctca
     1381 ttggttcatg ttgtagtcct gaaagagggt gatgaagaga ttaaatctga catctacacg
     1441 ttgttttttc acatagtcca gcgcatccct gaatatctga tacatctgca gaacgtcctg
     1501 aagttcacag agcaggagca ccctgactat tatctactac tggtgtgtgt ccagcgcctc
     1561 cgagtattta tctcacacta caccctgctg tttcaatgca atgaagattt gcttattcag
     1621 aaacggaaaa agctcaagaa gtcatccatg gcgaagctgt acaaagggct ggcttcccag
     1681 tgtgccaatg ctgggcaaga tgcttccccc actgcaggtc ctgaggctgt ccgtgacact
     1741 gggatccact cagaagagtt gctgcaaccc tacccttctg ctcccagttc tggccctgcc
     1801 atcacacatc tgatgccccc agtgaagaaa agccaacagc agcaaagcct gatggagagc
     1861 atgcagcccg ggaagcccag tgactgggag ctggagggca ggaagcacga gcggcccgag
     1921 agccttctgg caccgacgca gttctgcgcg gccgagcagg acgtgaaggc gctggccggg
     1981 cccctgcagg ccatcccgga gatggacttc gagtcctctc cggcggagcc gctgggcaac
     2041 gtggagcgct ccctgcgcgc cccggccgag ctcctgcccg atgcccgcgg cttcgtgccc
     2101 gcggcctacg aagagttcga gtacggcggc gagatcttcg cgctgcccgc gccctacgac
     2161 gaggagccgt tccaggctcc ggccctcttc gagaactgct cgcctgcctc ctccgagtcc
     2221 agcctggaca tctgcttcct gcggcccgtc agcttcgcca tggaggccga gcggccggag
     2281 cacccgctgc agccgctgcc caagagcgct acgtcgccgg cgggcagcag cagcgcctac
     2341 aaactggagg cggcggcgca ggcgcacggc aaggccaagc cgctgagccg ctctctcaaa
     2401 gagttcccgc gtgcgccgcc agccgacggc gtggccccac gcctctacag cacgcgcagc
     2461 agcagcggcg gccgcgcgcc catcaaggcc gagcgcgccg cgcaggcgca cggcccggcc
     2521 gccgccgccg tcgccgcccg cggcgcatcc aggaccttct tcccccaaca gaggtcccaa
     2581 agcgaaaaac agacctattt ggaagtaagg agggagatgc atttagaaga tactaccaga
     2641 ttctgtccca aagaagaaag agaaagtgaa caaacatctt tcagcgatca aaatcccagg
     2701 caagaccaga aggggggctt tcgcagctcc ttccgcaagc tctttaaaaa gaagtccagt
     2761 ggatcagaat acagggaaaa aactaatgag aatccctcaa tggatccttc acccaccaaa
     2821 caagatttct tcagaaaccg acttgctctt gcaaatgacc ttgaccaagg aacagctgtg
     2881 taaaacatac ttaaagttgt attgtcaagt ggtaagatga ggataaaaag cttgtatata
     2941 tctgtgtagg aatatatata tatatctata tctatatata tatatatatc gatgtataaa
     3001 tccctgagga aaactaatat aaatacttac atatgaaact aaacatacaa gacattgaag
     3061 agatgaagat tagtttctgg ttaagatctg gctttttgaa cctcaacact ggggaaaagg
     3121 gaaatgaaga cttttcacat cattacagaa aaacacaata aatttggagg aaaataaatg
     3181 tttgtaagaa tgaaaacttc caacttgaag tcattccccg agtataatac tgagcatgtt
     3241 catatttaac atggatttga attttatgct tcctaggcat ttaacttatt aactcatcca
     3301 gtgttcttaa actaatatac actatgttag gggccagttc tgtcttgctt catgtcttcc
     3361 aaaaacccta aggcaatatc taacatccct taaggcaaag gattaattaa cagaactgta
     3421 ttttatatgt tgcatatctg agttatggag aatttgtgct taaaccatga ttcagaaggt
     3481 tcaaagctta aaaacacatt gatctccaaa cttgttctgt ggttatggaa atcagtaaag
     3541 ggaacaagga tttctgtaga aactggggag agaggaaggc aaagaaacat tttcccttgt
     3601 gtgggttgag ctgaggatgg aaacagtcca gtctgtgttt tattgagtac tcagtattca
     3661 agacccactc gtgatcttga gtgtcacaca cactcacaac cagatggact aggaaaaaag
     3721 cagtgattta gccacatctt gttaaaaaga ctttctgcag cctgaaaaga aggtggcaat
     3781 agcaccaaaa cttcaatggc tcacacacag cagttgctac aaacagcagg tcaaagtgaa
     3841 aattcaggat tgcagcactt gactgttttc ctattttgta aagaaaccaa gctcttaaag
     3901 cttagaggaa tcagattgca acgaggcctg cctggctctg gggtgataaa atgtgctctg
     3961 tttccacatg gatatgtgca agatggtcag catccttgat atgccccaaa catcagattt
     4021 ataatagaaa aaaaattggg tttaaacaat ttgtctttat tcccaggcag ttcggtatag
     4081 taaattaggg gtatttggtt tctgttcatt caaaatcttg gtactcaaac tggtgtcttc
     4141 agaagctgtt cctctattga agcgtttgtt gataaaatag gcaaaggttc acatgtaagt
     4201 gttgcaagtt ttcttctcct tgtctgatga caaattagga actcacctac tgcgttttga
     4261 atagtagttg tctggaacac ataaaggatc actgccaagt tttttgagtt tccaggatct
     4321 aagtttaagc caagattttt gtttcccaga agtttatgaa ttcatttgaa attagatttt
     4381 tctcttatta tgtggccggc agtgcttgca agcacaacgc caaatcgact ggacgtggaa
     4441 agtgaaatac tacagaagtc acaatctatt aaataaaatg ttaacataat aaaa
//
