LOCUS       NM_015595               5149 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens Rho guanine nucleotide exchange factor 26 (ARHGEF26),
            transcript variant 2, mRNA.
ACCESSION   NM_015595
VERSION     NM_015595.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5149)
  AUTHORS   Zhu,Q.M., MacDonald,B.T., Mizoguchi,T., Chaffin,M., Leed,A.,
            Arduini,A., Malolepsza,E., Lage,K., Kaushik,V.K., Kathiresan,S. and
            Ellinor,P.T.
  TITLE     Endothelial ARHGEF26 is an angiogenic factor promoting VEGF
            signalling
  JOURNAL   Cardiovasc Res 118 (13), 2833-2846 (2022)
   PUBMED   34849650
  REMARK    GeneRIF: Endothelial ARHGEF26 is an angiogenic factor promoting
            VEGF signalling.
REFERENCE   2  (bases 1 to 5149)
  AUTHORS   Bourgeois,J.S., Wang,L., Rabino,A.F., Everitt,J., Alvarez,M.I.,
            Awadia,S., Wittchen,E.S., Garcia-Mata,R. and Ko,D.C.
  TITLE     ARHGEF26 enhances Salmonella invasion and inflammation in cells and
            mice
  JOURNAL   PLoS Pathog 17 (7), e1009713 (2021)
   PUBMED   34242364
  REMARK    GeneRIF: ARHGEF26 enhances Salmonella invasion and inflammation in
            cells and mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5149)
  AUTHORS   Chen,Q., Lu,X., Liu,Q.X., Zhou,D., Qiu,Y., Dai,J.G. and Zheng,H.
  TITLE     SGEF is a potential prognostic and therapeutic target for lung
            adenocarcinoma
  JOURNAL   World J Surg Oncol 16 (1), 32 (2018)
   PUBMED   29454349
  REMARK    GeneRIF: High SGEF expression is associated with lung
            adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5149)
  AUTHORS   Klarin,D., Zhu,Q.M., Emdin,C.A., Chaffin,M., Horner,S.,
            McMillan,B.J., Leed,A., Weale,M.E., Spencer,C.C.A., Aguet,F.,
            Segre,A.V., Ardlie,K.G., Khera,A.V., Kaushik,V.K., Natarajan,P. and
            Kathiresan,S.
  CONSRTM   CARDIoGRAMplusC4D Consortium
  TITLE     Genetic analysis in UK Biobank links insulin resistance and
            transendothelial migration pathways to coronary artery disease
  JOURNAL   Nat Genet 49 (9), 1392-1397 (2017)
   PUBMED   28714974
  REMARK    GeneRIF: Phenome-wide association scanning showed that CCDC92
            likely affects coronary artery disease through insulin resistance
            pathways, whereas experimental analysis suggests that ARHGEF26
            influences the transendothelial migration of leukocytes.
REFERENCE   5  (bases 1 to 5149)
  AUTHORS   Wang,H., Wu,R., Yu,L., Wu,F., Li,S., Zhao,Y., Li,H., Luo,G.,
            Wang,J. and Zhou,J.
  TITLE     SGEF is overexpressed in prostate cancer and contributes to
            prostate cancer progression
  JOURNAL   Oncol Rep 28 (4), 1468-1474 (2012)
   PUBMED   22824926
  REMARK    GeneRIF: SGEF is a novel promoter of human prostate cancer
            progression and development.
REFERENCE   6  (bases 1 to 5149)
  AUTHORS   Krishna Subbaiah,V., Massimi,P., Boon,S.S., Myers,M.P., Sharek,L.,
            Garcia-Mata,R. and Banks,L.
  TITLE     The invasive capacity of HPV transformed cells requires the
            hDlg-dependent enhancement of SGEF/RhoG activity
  JOURNAL   PLoS Pathog 8 (2), e1002543 (2012)
   PUBMED   22383878
  REMARK    GeneRIF: The invasive capacity of HPV transformed cells requires
            the hDlg-dependent enhancement of SGEF/RhoG activity.
REFERENCE   7  (bases 1 to 5149)
  AUTHORS   Kim,S.W., Kim,S., Nam,E.J., Jeong,Y.W., Lee,S.H., Paek,J.H.,
            Kim,J.H., Kim,J.W. and Kim,Y.T.
  TITLE     Comparative proteomic analysis of advanced serous epithelial
            ovarian carcinoma: possible predictors of chemoresistant disease
  JOURNAL   OMICS 15 (5), 281-292 (2011)
   PUBMED   21332407
REFERENCE   8  (bases 1 to 5149)
  AUTHORS   Yamada,S., Ohira,M., Horie,H., Ando,K., Takayasu,H., Suzuki,Y.,
            Sugano,S., Hirata,T., Goto,T., Matsunaga,T., Hiyama,E., Hayashi,Y.,
            Ando,H., Suita,S., Kaneko,M., Sasaki,F., Hashizume,K., Ohnuma,N.
            and Nakagawara,A.
  TITLE     Expression profiling and differential screening between
            hepatoblastomas and the corresponding normal livers: identification
            of high expression of the PLK1 oncogene as a poor-prognostic
            indicator of hepatoblastomas
  JOURNAL   Oncogene 23 (35), 5901-5911 (2004)
   PUBMED   15221005
REFERENCE   9  (bases 1 to 5149)
  AUTHORS   Ellerbroek,S.M., Wennerberg,K., Arthur,W.T., Dunty,J.M.,
            Bowman,D.R., DeMali,K.A., Der,C. and Burridge,K.
  TITLE     SGEF, a RhoG guanine nucleotide exchange factor that stimulates
            macropinocytosis
  JOURNAL   Mol Biol Cell 15 (7), 3309-3319 (2004)
   PUBMED   15133129
REFERENCE   10 (bases 1 to 5149)
  AUTHORS   Qi,H., Fournier,A., Grenier,J., Fillion,C., Labrie,Y. and Labrie,C.
  TITLE     Isolation of the novel human guanine nucleotide exchange factor Src
            homology 3 domain-containing guanine nucleotide exchange factor
            (SGEF) and of C-terminal SGEF, an N-terminally truncated form of
            SGEF, the expression of which is regulated by androgen in prostate
            cancer cells
  JOURNAL   Endocrinology 144 (5), 1742-1752 (2003)
   PUBMED   12697679
  REMARK    GeneRIF: SGEF gene on chromosome 3q25.2. CSGEF expression
            controlled by androgen-responsive promoter of SGEF gene. SGEF may
            be regulator of Rho guanosine triphosphatases. CSGEF may function
            as regulator of Rho guanosine triphosphatase in prostate
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA248533.1, DB069290.1,
            AY552599.1 and AC018452.11.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_015595.3.
            
            Summary: This gene encodes a member of the Rho-guanine nucleotide
            exchange factor (Rho-GEF) family. These proteins regulate Rho
            GTPases by catalyzing the exchange of GDP for GTP. The encoded
            protein specifically activates RhoG and plays a role in the
            promotion of macropinocytosis. Underexpression of the encoded
            protein may be a predictive marker of chemoresistant disease.
            Alternatively spliced transcript variants encoding multiple
            isoforms have been observed for this gene. [provided by RefSeq, Oct
            2011].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078655.1, AF415175.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000465093.6/ ENSP00000423418.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-265               DA248533.1         31-295
            266-551             DB069290.1         266-551
            552-2797            AY552599.1         371-2616
            2798-5149           AC018452.11        24218-26569         c
FEATURES             Location/Qualifiers
     source          1..5149
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.2"
     gene            1..5149
                     /gene="ARHGEF26"
                     /gene_synonym="CSGEF; HMFN1864; SGEF"
                     /note="Rho guanine nucleotide exchange factor 26"
                     /db_xref="GeneID:26084"
                     /db_xref="HGNC:HGNC:24490"
                     /db_xref="MIM:617552"
     exon            1..130
                     /gene="ARHGEF26"
                     /gene_synonym="CSGEF; HMFN1864; SGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            131..1264
                     /gene="ARHGEF26"
                     /gene_synonym="CSGEF; HMFN1864; SGEF"
                     /inference="alignment:Splign:2.1.0"
     CDS             182..2797
                     /gene="ARHGEF26"
                     /gene_synonym="CSGEF; HMFN1864; SGEF"
                     /note="isoform 1 is encoded by transcript variant 2; Src
                     homology 3 domain-containing guanine nucleotide exchange
                     factor; SH3 domain-containing guanine exchange factor; Rho
                     guanine nucleotide exchange factor (GEF) 26; testicular
                     tissue protein Li 171"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 26
                     isoform 1"
                     /protein_id="NP_056410.3"
                     /db_xref="CCDS:CCDS46938.1"
                     /db_xref="GeneID:26084"
                     /db_xref="HGNC:HGNC:24490"
                     /db_xref="MIM:617552"
                     /translation="MDGESEVDFSSNSITPLWRRRSIPQPHQVLGRSKPRPQSYQSPN
                     GLLITDFPVEDGGTLLAAQIPAQVPTASDSRTVHRSPLLLGAQRRAVANGGTASPEYR
                     AASPRLRRPKSPKLPKAVPGGSPKSPANGAVTLPAPPPPPVLRPPRTPNAPAPCTPEE
                     DLTGLTASPVPSPTANGLAANNDSPGSGSQSGRKAKDPERGLFPGPQKSSSEQKLPLQ
                     RLPSQENELLENPSVVLSTNSPAALKVGKQQIIPKSLASEIKISKSNNQNVEPHKRLL
                     KVRSMVEGLGGPLGHAGEESEVDNDVDSPGSLRRGLRSTSYRRAVVSGFDFDSPTSSK
                     KKNRMSQPVLKVVMEDKEKFSSLGRIKKKMLKGQGTFDGEENAVLYQNYKEKALDIDS
                     DEESEPKEQKSDEKIVIHHKPLRSTWSQLSAVKRKGLSQTVSQEERKRQEAIFEVISS
                     EHSYLLSLEILIRMFKNSKELSDTMTKTERHHLFSNITDVCEASKKFFIELEARHQNN
                     IFIDDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQKLLATNPSFKEVLSRIESHEDC
                     RNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEVCKRALKEVSKLVRLCNEGA
                     RKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRGELTAYVEDTVLFSRRTSKQQVY
                     FFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCDNEELNSSPGKNSSTMLYSRQSS
                     ASHLFTLTVLSNHANEKVEMLLGAETQSERARWITALGHSSGKPPADRTSLTQVEIVR
                     SFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWFPMECAKEITCQATIDK
                     NVERMGRLLGLETNV"
     exon            1265..1304
                     /gene="ARHGEF26"
                     /gene_synonym="CSGEF; HMFN1864; SGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1450
                     /gene="ARHGEF26"
                     /gene_synonym="CSGEF; HMFN1864; SGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1507
                     /gene="ARHGEF26"
                     /gene_synonym="CSGEF; HMFN1864; SGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1668
                     /gene="ARHGEF26"
                     /gene_synonym="CSGEF; HMFN1864; SGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1821
                     /gene="ARHGEF26"
                     /gene_synonym="CSGEF; HMFN1864; SGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..1951
                     /gene="ARHGEF26"
                     /gene_synonym="CSGEF; HMFN1864; SGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2026
                     /gene="ARHGEF26"
                     /gene_synonym="CSGEF; HMFN1864; SGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2116
                     /gene="ARHGEF26"
                     /gene_synonym="CSGEF; HMFN1864; SGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2271
                     /gene="ARHGEF26"
                     /gene_synonym="CSGEF; HMFN1864; SGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..2481
                     /gene="ARHGEF26"
                     /gene_synonym="CSGEF; HMFN1864; SGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..2549
                     /gene="ARHGEF26"
                     /gene_synonym="CSGEF; HMFN1864; SGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..2654
                     /gene="ARHGEF26"
                     /gene_synonym="CSGEF; HMFN1864; SGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..5149
                     /gene="ARHGEF26"
                     /gene_synonym="CSGEF; HMFN1864; SGEF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5128..5133
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGEF26"
                     /gene_synonym="CSGEF; HMFN1864; SGEF"
                     /note="hexamer: TATAAA"
     polyA_site      5149
                     /gene="ARHGEF26"
                     /gene_synonym="CSGEF; HMFN1864; SGEF"
                     /note="major polyA site"
ORIGIN      
        1 gggccggcgc cggcgccgcg gtcggcggca gcgctctcct aagctctcgc ggctgcgctt
       61 cggtcccgga cccgggccac ccacggggta gtgggtgctc ctcggccccg gacattgcaa
      121 gccccagaag gcaagactaa ctcggtgttg ctcctcccgg cgctgacttc gaggcccggc
      181 tatggacggc gagagcgagg tggatttttc tagcaacagc ataacccctt tgtggcggag
      241 gcggtcgatt cctcagcccc accaggttct gggccggagc aagccgaggc cccagtccta
      301 ccagagcccc aacgggttac taattacgga tttcccggtg gaggacggag ggacgctcct
      361 cgcagcgcag attcccgccc aggtgcccac cgcctcggac agcaggacgg tacataggag
      421 ccccctgctt ctgggcgccc agcggagagc ggtggccaat ggtgggacgg catccccgga
      481 gtacagggct gcctctcctc gacttcgacg gcccaagtca cccaagctcc ccaaagcggt
      541 gcctggcggc tccccgaaat ccccagcaaa tggcgcggtg accttgcctg cgccgccgcc
      601 gccgccggtt ctgcgccccc cgcggactcc taacgcgccc gccccctgca cccccgagga
      661 ggaccttact gggttgactg ccagcccggt gccttcgccc actgcaaatg gccttgccgc
      721 taataacgac tctcctgggt caggttcgca gtccggccgg aaggcaaagg accccgaacg
      781 ggggctcttt cctgggcccc agaaaagttc ttcggaacaa aaactccccc tccaaaggct
      841 gccctcccag gagaacgagc tcctcgagaa tccttccgtg gttttgagta caaacagccc
      901 cgccgccctc aaagtgggga agcagcagat cattccgaag agtctggcct cggaaattaa
      961 aataagtaaa tccaacaatc aaaatgtgga gccccacaag agactcctca aggtgcgcag
     1021 catggtggag ggcctaggag gacccctggg tcacgcaggg gaggagagtg aggtcgataa
     1081 cgacgtggat agcccagggt ctctgcggag aggcttgcgg tccacgtctt atcgcagggc
     1141 agtggtcagt ggctttgatt ttgacagtcc taccagctcg aagaagaaga acagaatgtc
     1201 ccagcctgtt ctgaaagtgg tgatggaaga caaggagaag ttttccagtc tgggaaggat
     1261 aaagaaaaaa atgctgaaag gacaaggaac atttgatggg gaagaaaatg ctgtcctgta
     1321 tcaaaactac aaggaaaagg cccttgacat tgattctgat gaagagtcag agcccaaaga
     1381 acagaagtca gatgaaaaaa ttgtgattca ccataagcca ttgagatcca catggagcca
     1441 actctctgcg gtgaaaagaa agggattatc tcagacagta agccaggagg aaagaaagag
     1501 acaagaggct atctttgaag tcatatcctc tgaacattca tatttactca gcttggagat
     1561 cttgatacga atgtttaaaa attctaaaga actgagtgat acaatgacta aaaccgagag
     1621 gcaccatctt ttctccaata ttacagatgt ctgtgaggca agcaaaaagt tctttataga
     1681 gttggaagca agacatcaga ataatatctt catagatgac ataagtgaca ttgtggaaaa
     1741 acacacagca tccacatttg acccatatgt gaaatactgc acaaatgaag tctaccaaca
     1801 acgaacacta caaaaattgt tagctaccaa tccatccttt aaggaagtat tgtcaaggat
     1861 tgagtcccat gaagactgta ggaacttacc catgatctct tttctcattc tccccatgca
     1921 gagggtgacc cgccttcccc tgctgatgga tactatctgt caaaaaacac ctaaggactc
     1981 tccgaagtat gaagtctgca aaagagcctt gaaggaagtt agcaagttgg ttcgactatg
     2041 caatgagggc gcccggaaga tggaaaggac tgagatgatg tacacaatta actcccagct
     2101 ggaatttaaa attaagcctt ttcctttagt ctcctcttcc cggtggttgg taaaaagagg
     2161 tgaattgaca gcctatgttg aagacactgt gcttttctca agaaggacat ccaaacagca
     2221 agtctacttc tttctcttta acgatgtgct cattatcacc aagaagaaga gtgaagaaag
     2281 ttacaacgtc aatgattatt ccttaagaga tcagctattg gtggaatctt gtgacaatga
     2341 agagcttaat tcttctccag ggaagaacag ctccacaatg ctctattcaa gacagagctc
     2401 tgccagtcac ctctttactc tgacagtcct tagtaaccac gcgaatgaga aagtggagat
     2461 gctactagga gctgagacgc agagcgagcg agcccgctgg ataactgccc tgggacacag
     2521 cagcgggaag ccgcctgcag accgaacctc actgacccag gtggaaatcg ttaggtcatt
     2581 tactgctaag cagccagatg aactctccct gcaggtggct gacgtcgtcc tcatctatca
     2641 acgtgtcagc gatggctggt atgaggggga acgactacga gatggagaaa gaggctggtt
     2701 tcctatggaa tgtgccaagg agataacatg tcaagctaca attgataaga atgtggagag
     2761 aatgggacgc ttgctaggac tggagaccaa cgtgtagtct ctcagatggt cttttgttac
     2821 tgcaagattt gcacgacact taccgggctg gttggttctg ggctagtttt attgttaatt
     2881 ttgtcacagc ctatttaatt aaaagaacga aaacacttgc ctttaagctt gccaggttgt
     2941 tctgctctct catgagaaga gcttggatac agtgagtttg cacagctcag tttttaccta
     3001 accacacact tgcagacctc ctgaggtaca cagaatagct gagcagttca cttcagggat
     3061 caggtcatct ctgctcctcc tagtttcacc atgttctggc aataaaaaac acatattata
     3121 tcctggtttt ctctatcctt gcattactaa ggtgactgtc tctctttata catccttgta
     3181 tggttctccc agtattagca agattgtata tctgtaaaga atgtccagtt ttgtaaatat
     3241 ttccctgcct ttttttttct ttttttacat ctgattttaa tgcttcgtta acttcaaaag
     3301 gaactggtag agttcagaag gtgagctgtt gtttttctaa acctcttccc aggaagggga
     3361 cattgacact tgaatttttg tcaccttttt cctcattaga aggaaagtag aaagccttac
     3421 tttaggattt ttaaaaaaaa atccatctca ccccatattg ttcttaaata agtatagact
     3481 aattaaccta agctaccttt aacaacgtag aatttagatg ggttcatata tgtgagaaaa
     3541 acctgaatat aggacagggg tcctactttt ttccccacct ctgtcgccca ggctagagta
     3601 tagtggtgtg atcttggccc actgcaacct ctgcttccta ggttcaagtg attctcctgc
     3661 ctcagcctcc caagtagctg ggattgtaag agtatgccac cacgcccagc tactttttgt
     3721 atttttagta gagacagggt ttcatcatgt tggccaggat ggtctcttaa ctcctgccct
     3781 caagtgatcc accagagagg agatcctcgg cctccccaag tgctgggatt ataggcatga
     3841 gccaccgtgc ccagcctact ttctaattaa ttaaaaaaaa aaaaaaaaaa aaaaaaaaac
     3901 cttcccaaat gagctgataa aaaactgacg tgaggctgct ttgccttcaa taatacctag
     3961 ttttcagctg ttccaactcg tttccaaata gaaattagct ggaacacact acagtaatct
     4021 caaggaaggg aaaattaggc cttaaaagat accaagaagt cagcatggta cccaattgaa
     4081 accttttgac cttagtggga attcattcta tttgcactaa aagccttaac ttgctgtatt
     4141 cagagtccct cttaactgtg agtttctata gaactttact ttttccacta gtgcacagag
     4201 agagaaaggt tatcttaata gtcggtttca tggagatgaa ggatgggaga ttaagagggg
     4261 ggaaatgatt tttactggca gctatattcc ctctctgttc tatttgcttt aacaaaggga
     4321 taaaacctgg caaagtgtac attattggag gactcaaatc tgtatgtgac atgtcccaac
     4381 tactgtccgc taactagtta tccaaattgt aaagctacag aagcccagtt gaggggtaag
     4441 tgtgcctggc tcacacagcc tgcaccctgt cacctcggca atgagccagt gtggggcact
     4501 ggggacttct aacccttgga ttgctctttt tgacctgtgc ataccttcta attgtaaaat
     4561 atatttcaga ccgtgagtac cttgagatct gagcaactgt gttaatgaag taatagcaat
     4621 ggtccacagt gaaagatgtg ttggggtttg caaaacaagc attccgtcac ctctttaata
     4681 atgtcacaga ctttttaaaa gagaggctat caagttgtaa tataatctgt catgttttat
     4741 ttaggaagga aggtaaattt gtgcttgcac ggggatcatt ttgtattatt tttgctaata
     4801 cccagttgaa gctaaaaagc aactatttga atcctgtgaa ttaatttata agaatgttaa
     4861 acagctttgg aaatacatgc atcttatgaa tcatagcctt atttagcaag atcaatgtta
     4921 aagtgttgtt atatggcaag tatttaacac attcacagtg tttgtttgat ttcaactgtg
     4981 aattgtctta agttttttca aacctagttg tttctatgga cacctgctct gaattgtaca
     5041 ttgacttcat tactaaagaa caaaaatgtt catttttgtc ccagtaaatt gagactgctt
     5101 gtacactttc agaaaaatat gtgaatttat aaagattttg tagatactt
//
