LOCUS       NM_001162383            4169 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens Rho/Rac guanine nucleotide exchange factor 2
            (ARHGEF2), transcript variant 1, mRNA.
ACCESSION   NM_001162383
VERSION     NM_001162383.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4169)
  AUTHORS   Luan,Y., Deng,Z., Zhu,Y., Dai,L., Yang,Y. and Xia,Z.
  TITLE     Decoupling actin assembly from microtubule disassembly by
            TBC1D3C-mediated direct GEF-H1 activation
  JOURNAL   Life Sci Alliance 8 (1), e202402585 (2024)
   PUBMED   39467635
  REMARK    GeneRIF: Decoupling actin assembly from microtubule disassembly by
            TBC1D3C-mediated direct GEF-H1 activation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4169)
  AUTHORS   Smart,K., Kramer,A.H., Smart,S., Hodgson,L. and Sharp,D.J.
  TITLE     Fidgetin-like 2 depletion enhances cell migration by regulating
            GEF-H1, RhoA, and FAK
  JOURNAL   Biophys J 122 (18), 3600-3610 (2023)
   PUBMED   36523161
  REMARK    GeneRIF: Fidgetin-like 2 depletion enhances cell migration by
            regulating GEF-H1, RhoA, and FAK.
REFERENCE   3  (bases 1 to 4169)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   4  (bases 1 to 4169)
  AUTHORS   Hu,Q., Lai,J., Chen,H., Cai,Y., Yue,Z., Lin,H. and Sun,L.
  TITLE     Reducing GEF-H1 Expression Inhibits Renal Cyst Formation,
            Inflammation, and Fibrosis via RhoA Signaling in Nephronophthisis
  JOURNAL   Int J Mol Sci 24 (4), 3504 (2023)
   PUBMED   36834937
  REMARK    GeneRIF: Reducing GEF-H1 Expression Inhibits Renal Cyst Formation,
            Inflammation, and Fibrosis via RhoA Signaling in Nephronophthisis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4169)
  AUTHORS   Chen,X., Shao,Y., Wei,W., Zhu,S., Li,Y., Chen,Y., Li,H., Tian,H.,
            Sun,G., Niu,Y. and Shang,Z.
  TITLE     Androgen deprivation restores ARHGEF2 to promote neuroendocrine
            differentiation of prostate cancer
  JOURNAL   Cell Death Dis 13 (11), 927 (2022)
   PUBMED   36335093
  REMARK    GeneRIF: Androgen deprivation restores ARHGEF2 to promote
            neuroendocrine differentiation of prostate cancer.
            Erratum:[Cell Death Dis. 2023 Oct 2;14(10):647. doi:
            10.1038/s41419-023-06051-0.. PMID: 37783705]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4169)
  AUTHORS   Krendel,M., Zenke,F.T. and Bokoch,G.M.
  TITLE     Nucleotide exchange factor GEF-H1 mediates cross-talk between
            microtubules and the actin cytoskeleton
  JOURNAL   Nat Cell Biol 4 (4), 294-301 (2002)
   PUBMED   11912491
  REMARK    GeneRIF: GEF-H1 is regulated by an interaction with microtubules.
REFERENCE   7  (bases 1 to 4169)
  AUTHORS   Harrington,A.W., Kim,J.Y. and Yoon,S.O.
  TITLE     Activation of Rac GTPase by p75 is necessary for c-jun N-terminal
            kinase-mediated apoptosis
  JOURNAL   J Neurosci 22 (1), 156-166 (2002)
   PUBMED   11756498
REFERENCE   8  (bases 1 to 4169)
  AUTHORS   Gao,Y., Xing,J., Streuli,M., Leto,T.L. and Zheng,Y.
  TITLE     Trp(56) of rac1 specifies interaction with a subset of guanine
            nucleotide exchange factors
  JOURNAL   J Biol Chem 276 (50), 47530-47541 (2001)
   PUBMED   11595749
  REMARK    Erratum:[J Biol Chem. 2005 Jan 14;280(2):1704]
REFERENCE   9  (bases 1 to 4169)
  AUTHORS   Ren,Y., Li,R., Zheng,Y. and Busch,H.
  TITLE     Cloning and characterization of GEF-H1, a microtubule-associated
            guanine nucleotide exchange factor for Rac and Rho GTPases
  JOURNAL   J Biol Chem 273 (52), 34954-34960 (1998)
   PUBMED   9857026
REFERENCE   10 (bases 1 to 4169)
  AUTHORS   Reddy,A.B., Chatterjee,A., Rothblum,L.I., Black,A. and Busch,H.
  TITLE     Isolation and characterization of complementary DNA to
            proliferating cell nucleolar antigen P40
  JOURNAL   Cancer Res 49 (7), 1763-1767 (1989)
   PUBMED   2466560
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL355388.30, CN388788.1, BC020567.1 and BC027722.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001162383.1.
            
            Summary: Rho GTPases play a fundamental role in numerous cellular
            processes that are initiated by extracellular stimuli that work
            through G protein coupled receptors. The encoded protein may form
            complex with G proteins and stimulate rho-dependent signals.
            Alternatively spliced transcript variants encoding different
            isoforms have been identified.[provided by RefSeq, Jun 2009].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC020567.1, U72206.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361247.9/ ENSP00000354837.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AL355388.30        72226-72227         c
            3-20                CN388788.1         3-20
            21-3803             BC020567.1         1-3783
            3804-4169           BC027722.1         187-552
FEATURES             Location/Qualifiers
     source          1..4169
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q22"
     gene            1..4169
                     /gene="ARHGEF2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lfc; LFP40; NEDMHM;
                     P40"
                     /note="Rho/Rac guanine nucleotide exchange factor 2"
                     /db_xref="GeneID:9181"
                     /db_xref="HGNC:HGNC:682"
                     /db_xref="MIM:607560"
     exon            1..183
                     /gene="ARHGEF2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lfc; LFP40; NEDMHM;
                     P40"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..3081
                     /gene="ARHGEF2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lfc; LFP40; NEDMHM;
                     P40"
                     /note="isoform 1 is encoded by transcript variant 1;
                     proliferating cell nucleolar antigen p40; rho guanine
                     nucleotide exchange factor 2; microtubule-regulated
                     Rho-GEF; guanine nucleotide exchange factor H1; Rho/Rac
                     guanine nucleotide exchange factor (GEF) 2"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 2 isoform
                     1"
                     /protein_id="NP_001155855.1"
                     /db_xref="CCDS:CCDS53376.1"
                     /db_xref="GeneID:9181"
                     /db_xref="HGNC:HGNC:682"
                     /db_xref="MIM:607560"
                     /translation="MSRIESLTRARIDRSRELASKTREKEKMKEAKDARYTNGHLFTT
                     ISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCTKVKQKQQKAALLKNN
                     TALQSVSLRSKTTIRERPSSAIYPSDSFRQSLLGSRRGRSSLSLAKSVSTTNIAGHFN
                     DESPLGLRRILSQSTDSLNMRNRTLSVESLIDEAEVIYSELMSDFEMDEKDFAADSWS
                     LAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVV
                     QGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQM
                     CKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRIT
                     KYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMD
                     PRAQTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQ
                     KYIFPTLDKPSVVSLQNLIVRDIANQEKGMFLISAAPPEMYEVHTASRDDRSTWIRVI
                     QQSVRTCPSREDFPLIETEDEAYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAE
                     EDGGSGMALPTLPRGLFRSESLESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPRE
                     PALPLEPDSGGNTSPGVTANGEARTFNGSIELCRADSDSSQRDRNGNQLRSPQEEALQ
                     RLVNLYGLLHGLQAAVAQQDTLMEARFPEGPERREKLCRANSRDGEAGRAGAAPVAPE
                     KQATELALLQRQHALLQEELRRCRRLGEERATEAGSLEARLRESEQARALLEREAEEA
                     RRQLAALGQTEPLPAEAPWARRPVDPRRRSLPAGDALYLSFNPPQPSRGTDRLDLPVT
                     TRSVHRNFEDRERQELGSPEERLQDSSDPDTGSEEEGSSRLSPPHSPRDFTRMQDIPE
                     ETESRDGEAVASES"
     exon            184..328
                     /gene="ARHGEF2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lfc; LFP40; NEDMHM;
                     P40"
                     /inference="alignment:Splign:2.1.0"
     exon            329..396
                     /gene="ARHGEF2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lfc; LFP40; NEDMHM;
                     P40"
                     /inference="alignment:Splign:2.1.0"
     exon            397..460
                     /gene="ARHGEF2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lfc; LFP40; NEDMHM;
                     P40"
                     /inference="alignment:Splign:2.1.0"
     exon            461..590
                     /gene="ARHGEF2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lfc; LFP40; NEDMHM;
                     P40"
                     /inference="alignment:Splign:2.1.0"
     exon            591..700
                     /gene="ARHGEF2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lfc; LFP40; NEDMHM;
                     P40"
                     /inference="alignment:Splign:2.1.0"
     exon            701..844
                     /gene="ARHGEF2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lfc; LFP40; NEDMHM;
                     P40"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1095
                     /gene="ARHGEF2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lfc; LFP40; NEDMHM;
                     P40"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1221
                     /gene="ARHGEF2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lfc; LFP40; NEDMHM;
                     P40"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1339
                     /gene="ARHGEF2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lfc; LFP40; NEDMHM;
                     P40"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1588
                     /gene="ARHGEF2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lfc; LFP40; NEDMHM;
                     P40"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1665
                     /gene="ARHGEF2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lfc; LFP40; NEDMHM;
                     P40"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1835
                     /gene="ARHGEF2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lfc; LFP40; NEDMHM;
                     P40"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1903
                     /gene="ARHGEF2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lfc; LFP40; NEDMHM;
                     P40"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2104
                     /gene="ARHGEF2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lfc; LFP40; NEDMHM;
                     P40"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2224
                     /gene="ARHGEF2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lfc; LFP40; NEDMHM;
                     P40"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2292
                     /gene="ARHGEF2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lfc; LFP40; NEDMHM;
                     P40"
                     /inference="alignment:Splign:2.1.0"
     exon            2293..2328
                     /gene="ARHGEF2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lfc; LFP40; NEDMHM;
                     P40"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2379
                     /gene="ARHGEF2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lfc; LFP40; NEDMHM;
                     P40"
                     /inference="alignment:Splign:2.1.0"
     exon            2380..2823
                     /gene="ARHGEF2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lfc; LFP40; NEDMHM;
                     P40"
                     /inference="alignment:Splign:2.1.0"
     exon            2824..3007
                     /gene="ARHGEF2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lfc; LFP40; NEDMHM;
                     P40"
                     /inference="alignment:Splign:2.1.0"
     exon            3008..4169
                     /gene="ARHGEF2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lfc; LFP40; NEDMHM;
                     P40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4150..4155
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGEF2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lfc; LFP40; NEDMHM;
                     P40"
                     /note="hexamer: ATTAAA"
     polyA_site      4169
                     /gene="ARHGEF2"
                     /gene_synonym="GEF; GEF-H1; GEFH1; Lfc; LFP40; NEDMHM;
                     P40"
                     /note="major polyA site"
ORIGIN      
        1 gagtcagact tcctgtcccc gagaccaacg cgtgcgggcc gaacccctcc ccccgccttc
       61 ccccaacaat acaggacgcc ggggtccgcg ccgcgtcctc cctggtcccc ccgtccgatt
      121 atgtctcgga tcgaatccct cacgcgggcg cggatcgacc ggagcagaga gctggcgagc
      181 aagacccggg aaaaggagaa gatgaaggaa gccaaggatg cccgctatac caatgggcac
      241 ctcttcacca ccatttcagt ttcaggcatg accatgtgct atgcctgtaa caagagcatc
      301 acagccaagg aagccctcat ctgcccaacc tgcaatgtga ctatccacaa ccgctgtaaa
      361 gacaccctcg ccaactgtac caaggtcaag cagaagcaac agaaagcggc cctgctgaag
      421 aacaacaccg ccttgcagtc cgtttctctt cgaagtaaga caaccatccg ggagcggcca
      481 agctcggcca tctacccctc cgacagcttc cggcagtccc tcctgggctc ccgccgtggc
      541 cgctcctcct tgtctttagc caagagtgtt tctaccacca acattgctgg acatttcaat
      601 gatgagtctc ccctggggct gcgccggatc ctctcacagt ccacagactc cctcaacatg
      661 cggaaccgaa ccctatccgt ggaatccctc attgacgaag cagaggtaat ctacagtgag
      721 ctgatgagtg actttgagat ggatgagaag gactttgcag ctgactcttg gagtcttgct
      781 gtggacagca gcttcctgca gcagcataaa aaggaggtga tgaagcagca agatgtcatc
      841 tatgagctaa tccagacaga gctgcaccat gtgaggacac tgaagatcat gacccgcctc
      901 ttccgcacgg ggatgctgga agagctacac ttggagccag gagtggtcca gggcctgttc
      961 ccctgcgtgg acgagctcag tgacatccat acacgcttcc tcagccagct attagaacgc
     1021 cgacgccagg ccctgtgccc tggcagcacc cggaactttg tcatccatcg cttgggtgat
     1081 ctgctcatca gccagttctc aggtcctagt gcggagcaga tgtgtaagac ctactcggag
     1141 ttctgcagcc gccacagcaa ggccttaaag ctctataagg agctgtacgc ccgagacaaa
     1201 cgcttccagc aattcatccg gaaagtgacc cgccccgccg tgctcaagcg gcacggggta
     1261 caggagtgca tcctgctggt gactcagcgc atcaccaagt acccgttact catcagccgc
     1321 atcctgcagc attcccacgg gatcgaggag gagcgccagg acctgaccac agcactgggg
     1381 ctagtgaagg agctgctgtc caatgtggac gagggtattt atcagctgga gaaaggggcc
     1441 cgtctgcagg agatctacaa ccgcatggac cctcgggccc aaaccccagt gcctggcaag
     1501 ggcccctttg gccgagagga acttctgagg cgcaaactca tccacgatgg ctgcctgctc
     1561 tggaagacag cgacggggcg cttcaaagat gtgctagtgc tgctgatgac agatgtactg
     1621 gtgtttctcc aggaaaagga ccagaagtac atctttccta ccctggacaa gccttcagtg
     1681 gtatcgctgc agaatctaat cgtacgagac attgccaacc aggagaaagg gatgtttctg
     1741 atcagcgcag ccccacctga gatgtacgag gtgcacacag catcccggga tgaccggagc
     1801 acctggatcc gggtcattca gcagagcgtg cgcacatgcc catccaggga ggacttcccc
     1861 ctgattgaga cagaggatga ggcttacctg cggcgaatta agatggagtt gcagcagaag
     1921 gaccgggcac tggtggagct gctgcgagag aaggtcgggc tgtttgctga gatgacccat
     1981 ttccaggccg aagaggatgg tggcagtggg atggccctgc ccaccctgcc caggggcctt
     2041 ttccgctctg agtcccttga gtcccctcgt ggcgagcggc tgctgcagga tgccatccgt
     2101 gaggtggagg gtctgaaaga cctgctggtg gggccaggag tggaactgct cttgacaccc
     2161 cgagagccag ccctgccctt ggaaccagac agcggtggta acacgagtcc tggggtcact
     2221 gccaatggtg aggccagaac cttcaatggc tccattgaac tctgcagagc tgactcagac
     2281 tctagccaga gggatcgaaa tggaaatcag ctgagatcac cgcaagagga ggcgttacag
     2341 cgattggtca atctctatgg acttctacat ggcctacagg cagctgtggc ccagcaggac
     2401 actctgatgg aagcccggtt ccctgagggc cctgagcggc gggagaagct gtgccgagcc
     2461 aactctcggg atggggaggc tggcagggct ggggctgccc ctgtggcccc tgaaaagcag
     2521 gccacggaac tggcattact gcagcggcaa catgcgctgc tgcaggagga gctacggcgc
     2581 tgccggcggc taggtgaaga acgggcaacc gaagctggca gcctggaggc ccggctccgg
     2641 gagagtgagc aggcccgggc actgctggag cgtgaggccg aagaggctcg aaggcagctg
     2701 gccgccctgg gccagaccga gccactccca gctgaggccc cctgggcccg cagacctgtg
     2761 gatcctcggc ggcgcagcct ccccgcaggc gatgccctgt acttgagttt caacccccca
     2821 cagcccagcc gaggcactga ccgcctggat ctacctgtca ctactcgctc tgtccatcga
     2881 aactttgagg accgagagag gcaggaactg gggagccccg aagagcggct gcaagacagc
     2941 agtgaccctg acactggcag cgaggaggaa ggtagcagcc gtctgtctcc gccccacagt
     3001 ccacgagact ttaccagaat gcaggacatc ccggaggaga cggagagccg cgacggggag
     3061 gctgtagcct ccgagagcta agggggcccc tcccccctgc cccgtgcccc actgaagaac
     3121 attactgagg gggctaacct tggggactcc aatttgccaa tgatgaggga acatttgaaa
     3181 gaactgcaaa ttgtccttgc cagctcttgg gatccttgga tacctggggc catttaagaa
     3241 gctaggggaa ttaggccaca acaccccctg ggacatccga aagctacacc acagatgcca
     3301 gtggttcatg ccttcttccc gcaactttag gaaaatttat ttatttattg tttattagtt
     3361 atggggggag aggggagatt taaaggacca gggacatggg aaccaagcca tagggatcag
     3421 agggccttgt ccttgaacac tactggggta tattcaggct catccacgca gctgctgggt
     3481 tcttgcccta acggccctcc cctgcaacat ccgtcttgga ggagaggctg cagccacagc
     3541 accctactgc cctttaaata aaggagggct gtgggcaggg ccatgtccct ttctcctctc
     3601 ccctcaacct cttactgctg ttctcccttt ctccgtcctt catggaagcc ctgggagata
     3661 acctggcttc ctggagttga tggaataaag gttggggtgg ccataatggt ttgttggggg
     3721 tgagggaaaa aacccacagg gaccagaatg ttttgttgtt cttttgtttt cttttttgta
     3781 ccaaagtcaa ctgcacgtgt tttatatttt taagagatcg taggcaatta gagatcgaag
     3841 cctcctatct ccacatctct gaagaagttg aggggtgggg gagagaatga cttctgcctt
     3901 catctgcagt aacgggggga cctatactga cctcttcccc agccatttag aaacaagttc
     3961 tagggtgggt tggaaaatct ccaagagccc tgacctcatc ttccacctca gcaaccatga
     4021 cctgaaacct cagcgtgaat ttgggggatt tttcagtgga acccttgccc ccaaatgtcg
     4081 accagccccc aaatgtcgaa gaattttctt cttgccaatt ttgttgttta aaaaaaaaat
     4141 tcagggaaaa ttaaaaacct ggaactcca
//
