LOCUS       NM_153213               3322 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens Rho guanine nucleotide exchange factor 19 (ARHGEF19),
            mRNA.
ACCESSION   NM_153213
VERSION     NM_153213.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3322)
  AUTHORS   Omble,A., Mahajan,S., Bhoite,A. and Kulkarni,K.
  TITLE     Dishevelled2 activates WGEF via its interaction with a unique
            internal peptide motif of the GEF
  JOURNAL   Commun Biol 7 (1), 543 (2024)
   PUBMED   38714795
  REMARK    GeneRIF: Dishevelled2 activates WGEF via its interaction with a
            unique internal peptide motif of the GEF.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3322)
  AUTHORS   Wang,Z., Kan,G., Sheng,C., Yao,C., Mao,Y. and Chen,S.
  TITLE     ARHGEF19 regulates MAPK/ERK signaling and promotes the progression
            of small cell lung cancer
  JOURNAL   Biochem Biophys Res Commun 533 (4), 792-799 (2020)
   PUBMED   32993957
  REMARK    GeneRIF: ARHGEF19 regulates MAPK/ERK signaling and promotes the
            progression of small cell lung cancer.
REFERENCE   3  (bases 1 to 3322)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3322)
  AUTHORS   Li,Y., Ye,Z., Chen,S., Pan,Z., Zhou,Q., Li,Y.Z., Shuai,W.D.,
            Kuang,C.M., Peng,Q.H., Shi,W., Mao,X., Liu,R.Y. and Huang,W.
  TITLE     ARHGEF19 interacts with BRAF to activate MAPK signaling during the
            tumorigenesis of non-small cell lung cancer
  JOURNAL   Int J Cancer 142 (7), 1379-1391 (2018)
   PUBMED   29164615
  REMARK    GeneRIF: These findings suggest that ARHGEF19 upregulation, due to
            the low expression of miR-29 in non-small cell lung cancer tissues,
            may play a crucial role in non-small cell lung cancer tumorigenesis
            by activating MAPK signaling
REFERENCE   5  (bases 1 to 3322)
  AUTHORS   Zhou,J., Tao,Y., Peng,C., Gu,P. and Wang,W.
  TITLE     miR-503 regulates metastatic function through Rho guanine
            nucleotide exchanger factor 19 in hepatocellular carcinoma
  JOURNAL   J Surg Res 188 (1), 129-136 (2014)
   PUBMED   24405610
  REMARK    GeneRIF: overcomes the suppressive influence of miR-503 in
            hepatocellular carcinoma cells
REFERENCE   6  (bases 1 to 3322)
  AUTHORS   Caddy,J., Wilanowski,T., Darido,C., Dworkin,S., Ting,S.B., Zhao,Q.,
            Rank,G., Auden,A., Srivastava,S., Papenfuss,T.A., Murdoch,J.N.,
            Humbert,P.O., Parekh,V., Boulos,N., Weber,T., Zuo,J.,
            Cunningham,J.M. and Jane,S.M.
  TITLE     Epidermal wound repair is regulated by the planar cell polarity
            signaling pathway
  JOURNAL   Dev Cell 19 (1), 138-147 (2010)
   PUBMED   20643356
  REMARK    Erratum:[Dev Cell. 2010 Aug 17;19(2):353. Parekh, Vishwas [added]]
REFERENCE   7  (bases 1 to 3322)
  AUTHORS   Horii,T., Morita,S., Kimura,M. and Hatada,I.
  TITLE     Epigenetic regulation of adipocyte differentiation by a Rho guanine
            nucleotide exchange factor, WGEF
  JOURNAL   PLoS One 4 (6), e5809 (2009)
   PUBMED   19503838
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3322)
  AUTHORS   Tanegashima,K., Zhao,H. and Dawid,I.B.
  TITLE     WGEF activates Rho in the Wnt-PCP pathway and controls convergent
            extension in Xenopus gastrulation
  JOURNAL   EMBO J 27 (4), 606-617 (2008)
   PUBMED   18256687
REFERENCE   9  (bases 1 to 3322)
  AUTHORS   Wang,Y., Suzuki,H., Yokoo,T., Tada-Iida,K., Kihara,R., Miura,M.,
            Watanabe,K., Sone,H., Shimano,H., Toyoshima,H. and Yamada,N.
  TITLE     WGEF is a novel RhoGEF expressed in intestine, liver, heart, and
            kidney
  JOURNAL   Biochem Biophys Res Commun 324 (3), 1053-1058 (2004)
   PUBMED   15485661
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK297707.1, BC040640.1 and AL137736.1.
            
            On Nov 23, 2018 this sequence version replaced NM_153213.4.
            
            Summary: Guanine nucleotide exchange factors (GEFs) such as
            ARHGEF19 accelerate the GTPase activity of Rho GTPases (see RHOA,
            MIM 165390).[supplied by OMIM, Dec 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040640.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000270747.8/ ENSP00000270747.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AK297707.1         20-62
            44-3072             BC040640.1         1-3029
            3073-3322           AL137736.1         1786-2035
FEATURES             Location/Qualifiers
     source          1..3322
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.13"
     gene            1..3322
                     /gene="ARHGEF19"
                     /gene_synonym="WGEF"
                     /note="Rho guanine nucleotide exchange factor 19"
                     /db_xref="GeneID:128272"
                     /db_xref="HGNC:HGNC:26604"
                     /db_xref="MIM:612496"
     exon            1..151
                     /gene="ARHGEF19"
                     /gene_synonym="WGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            152..592
                     /gene="ARHGEF19"
                     /gene_synonym="WGEF"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..2589
                     /gene="ARHGEF19"
                     /gene_synonym="WGEF"
                     /note="weakly similar to Rho GEF; ephexin-2; Rho guanine
                     nucleotide exchange factor (GEF) 19; ephexin2"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 19"
                     /protein_id="NP_694945.2"
                     /db_xref="CCDS:CCDS170.1"
                     /db_xref="GeneID:128272"
                     /db_xref="HGNC:HGNC:26604"
                     /db_xref="MIM:612496"
                     /translation="MDCGPPATLQPHLTGPPGTAHHPVAVCQQESLSFAELPALKPPS
                     PVCLDLFPVAPEELRAPGSRWSLGTPAPLQGLLWPLSPGGSDTEITSGGMRPSRAGSW
                     PHCPGAQPPALEGPWSPRHTQPQRRASHGSEKKSAWRKMRVYQREEVPGCPEAHAVFL
                     EPGQVVQEQALSTEEPRVELSGSTRVSLEGPERRRFSASELMTRLHSSLRLGRNSAAR
                     ALISGSGTGAAREGKASGMEARSVEMSGDRVSRPAPGDSREGDWSEPRLDTQEEPPLG
                     SRSTNERRQSRFLLNSVLYQEYSDVASARELRRQQREEEGPGDEAEGAEEGPGPPRAN
                     LSPSSSFRAQRSARGSTFSLWQDIPDVRGSGVLATLSLRDCKLQEAKFELITSEASYI
                     HSLSVAVGHFLGSAELSECLGAQDKQWLFSKLPEVKSTSERFLQDLEQRLEADVLRFS
                     VCDVVLDHCPAFRRVYLPYVTNQAYQERTYQRLLLENPRFPGILARLEESPVCQRLPL
                     TSFLILPFQRITRLKMLVENILKRTAQGSEDEDMATKAFNALKELVQECNASVQSMKR
                     TEELIHLSKKIHFEGKIFPLISQARWLVRHGELVELAPLPAAPPAKLKLSSKAVYLHL
                     FNDCLLLSRRKELGKFAVFVHAKMAELQVRDLSLKLQGIPGHVFLLQLLHGQHMKHQF
                     LLRARTESEKQRWISALCPSSPQEDKEVISEGEDCPQVQCVRTYKALHPDELTLEKTD
                     ILSVRTWTSDGWLEGVRLADGEKGWVPQAYVEEISSLSARLRNLRENKRVTSATSKLG
                     EAPV"
     exon            593..874
                     /gene="ARHGEF19"
                     /gene_synonym="WGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            875..977
                     /gene="ARHGEF19"
                     /gene_synonym="WGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1054
                     /gene="ARHGEF19"
                     /gene_synonym="WGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1317
                     /gene="ARHGEF19"
                     /gene_synonym="WGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1478
                     /gene="ARHGEF19"
                     /gene_synonym="WGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1631
                     /gene="ARHGEF19"
                     /gene_synonym="WGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1761
                     /gene="ARHGEF19"
                     /gene_synonym="WGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1836
                     /gene="ARHGEF19"
                     /gene_synonym="WGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..1926
                     /gene="ARHGEF19"
                     /gene_synonym="WGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2087
                     /gene="ARHGEF19"
                     /gene_synonym="WGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2246
                     /gene="ARHGEF19"
                     /gene_synonym="WGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2326
                     /gene="ARHGEF19"
                     /gene_synonym="WGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2431
                     /gene="ARHGEF19"
                     /gene_synonym="WGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..3322
                     /gene="ARHGEF19"
                     /gene_synonym="WGEF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3051..3056
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGEF19"
                     /gene_synonym="WGEF"
                     /note="hexamer: AATAAA"
     polyA_site      3072
                     /gene="ARHGEF19"
                     /gene_synonym="WGEF"
                     /note="major polyA site"
     regulatory      3297..3302
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGEF19"
                     /gene_synonym="WGEF"
                     /note="hexamer: ATTAAA"
     polyA_site      3322
                     /gene="ARHGEF19"
                     /gene_synonym="WGEF"
ORIGIN      
        1 acacaatacc caggagcttg ccttgctcgg ctctggggcc atgctgacat gctgacatcg
       61 ccccctgagg acttggctgc aaccccagag cccccagggt gtcccggagc cctggaccgt
      121 gctggcagct ggacggagct ccctggctga gggccaggtg ggtggcagag caaaagagga
      181 atggactgtg ggccacctgc taccctccag ccccacctga ctgggccacc tggcactgcc
      241 caccaccctg tagcagtgtg ccagcaggag agtctgtcct ttgcagagct gcccgccctg
      301 aagcccccga gcccagtgtg tctggacctt ttccctgttg ccccagagga gcttcgggct
      361 cctggcagcc gctggtccct ggggacccct gcccctctcc aagggttgct atggccatta
      421 tccccaggag gctcagatac agagatcacc agcgggggga tgcggcccag cagggctggc
      481 agctggccac actgtcctgg tgcccagccc ccagctctgg agggaccctg gagtccccga
      541 cacacacagc cacagcgccg ggccagccac ggctcggaga agaagtctgc ctggcgcaag
      601 atgcgggtgt accagcgtga agaggtcccc ggctgccccg aggcccacgc tgtcttccta
      661 gagcctggcc aggtagtgca agagcaggcc ctgagcacag aggagcccag ggtggagttg
      721 tctgggtcca cccgagtgag cctcgaaggt cctgagcgga ggcgcttctc ggcatcggag
      781 ctgatgaccc ggctgcactc ttctctgcgc ctggggcgga attcagcagc ccgggcactc
      841 atctctgggt caggcaccgg agcagcccgg gaagggaaag catctggaat ggaggctcga
      901 agtgtagaga tgagcgggga ccgggtgtcg cggccagccc ctggtgactc acgagagggc
      961 gattggtccg agcccaggct agacacacag gaagagccgc ctttggggtc caggagcacc
     1021 aacgagcggc gccagtctcg attcctcctt aactccgtcc tctatcagga atacagcgac
     1081 gtggccagcg cccgcgaact gcggcggcag cagcgcgagg aggagggccc gggggacgag
     1141 gccgagggcg cagaggaggg gccggggccg ccgcgggcca acctctcccc cagcagctcc
     1201 ttccgggcgc agcgctcggc gcgaggctcc accttctcgc tgtggcagga tatccccgac
     1261 gtacgcggca gcggcgtcct ggccacgctg agcctgcggg actgcaagct gcaggaggcc
     1321 aagtttgagc tgatcacctc cgaggcctcc tacatccaca gcctgtcggt ggctgtgggc
     1381 cacttcttag gctctgccga gctgagcgag tgtctggggg cgcaggacaa gcagtggctg
     1441 ttttccaaac tgcccgaggt caagagcacc agcgagaggt tcctgcagga cctggagcag
     1501 cggctggagg cagatgtgct gcgcttcagc gtgtgcgacg tggtgctgga ccactgcccg
     1561 gccttccgca gagtctacct gccctatgtc accaaccagg cctaccagga gcgcacctac
     1621 cagcgcctgc tcctggagaa ccccaggttc cctggcatcc tggctcgcct ggaggagtct
     1681 cctgtgtgcc agcgtctgcc ccttacctcc ttccttatcc tgcccttcca gaggatcacc
     1741 cgcctcaaga tgttggtgga gaacatcctg aagcggacag cacagggctc tgaagacgaa
     1801 gacatggcca ccaaggcctt caatgcgctc aaggagctgg tgcaggagtg caatgctagt
     1861 gtacagtcca tgaagaggac agaggaactc atccacctga gcaagaagat ccactttgag
     1921 ggcaagattt tcccgctgat ctctcaggcc cgctggctgg ttcggcatgg agagttggta
     1981 gagctggcac cactgcctgc agcaccccct gccaagctga agctgtccag caaggcagtc
     2041 tacctccacc tcttcaatga ctgcttgctg ctctctcggc ggaaggagct agggaagttt
     2101 gccgttttcg tccatgccaa gatggctgag ctgcaggtgc gggacctgag cctgaagctg
     2161 cagggcatcc ccggccacgt gttcctcctc cagctcctcc acgggcagca catgaagcac
     2221 cagttcctgc tgcgggcccg gacggaaagt gagaagcagc gatggatctc agccttgtgc
     2281 ccctccagcc cccaggagga caaggaggtc atcagtgagg gggaagattg cccccaggtt
     2341 cagtgtgtta ggacatacaa ggcactgcac ccagatgagc tgaccttgga gaagactgac
     2401 atcctgtcag tgaggacctg gaccagtgac ggctggctgg aaggggtccg cctggcagat
     2461 ggtgagaagg ggtgggtgcc ccaggcctat gtggaagaga tcagcagcct cagcgcccgc
     2521 ctccgaaacc tccgggagaa taagcgagtc acaagtgcca ccagcaaact gggggaggct
     2581 cctgtgtgat gggcagccat ggcctaggac cccacctcca tgcctggctc ctggatggtc
     2641 ctggaggggc ctgcagtgtc tccattcccc aagctgctcc tgctggcact tcgcttctgt
     2701 ggccttggca ttgagggcac aggctggaca caggaatggg ggcgcctcca gagggtctct
     2761 ccgtcctcat gctcctcagt gtccacactt caaggccaag gatagtttct tcctctgaca
     2821 tggggaccat aacaggtgat cactgatacc tggcaaagac tggggccctc tcctttctat
     2881 gtcctcaatc ctgcctgact cttggtcctt ctggcaggga cctggctggg gaacgttctg
     2941 gtgctgatgg tgctgggacc tatatgtata tttatatata tctggggtct tgtctaccac
     3001 ctcccctggt cagagcctga gtgggtgctg gttgctgtgt cttgtctgta aataaactcc
     3061 tatcatgcct ttgcttggag tctgtgatcc atctgatgct gcccccaccc ccacagtcct
     3121 attttcccag ctaaagacca ggagagtctc cggctggctc ccaactgggg ctttgcattt
     3181 ctctagagtt catctctgag ctgtaagggt gaccaggggg cagggggacg attgtgtatc
     3241 agctaggctg cttttggctg caagtaacaa aatatcagat acaaataggc ttaaacatta
     3301 aagagatttg attagttctt ta
//
