LOCUS       NM_014786               8163 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens Rho guanine nucleotide exchange factor 17 (ARHGEF17),
            mRNA.
ACCESSION   NM_014786
VERSION     NM_014786.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8163)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 8163)
  AUTHORS   Weber,P., Baltus,D., Jatho,A., Drews,O., Zelarayan,L.C., Wieland,T.
            and Lutz,S.
  TITLE     RhoGEF17-An Essential Regulator of Endothelial Cell Death and
            Growth
  JOURNAL   Cells 10 (4), 741 (2021)
   PUBMED   33801779
  REMARK    GeneRIF: RhoGEF17-An Essential Regulator of Endothelial Cell Death
            and Growth.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8163)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 8163)
  AUTHORS   Yang,X., Li,J., Fang,Y., Zhang,Z., Jin,D., Chen,X., Zhao,Y., Li,M.,
            Huan,L., Kent,T.A., Dong,J.F., Jiang,R., Yang,S., Jin,L., Zhang,J.,
            Zhong,T.P. and Yu,F.
  TITLE     Rho Guanine Nucleotide Exchange Factor ARHGEF17 Is a Risk Gene for
            Intracranial Aneurysms
  JOURNAL   Circ Genom Precis Med 11 (7), e002099 (2018)
   PUBMED   29997225
  REMARK    GeneRIF: results provide compelling evidence that ARHGEF17 is a
            risk gene for Intracranial aneurysm.
REFERENCE   5  (bases 1 to 8163)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 8163)
  AUTHORS   Rabizadeh,S. and Bredesen,D.E.
  TITLE     Ten years on: mediation of cell death by the common neurotrophin
            receptor p75(NTR)
  JOURNAL   Cytokine Growth Factor Rev 14 (3-4), 225-239 (2003)
   PUBMED   12787561
  REMARK    Review article
REFERENCE   7  (bases 1 to 8163)
  AUTHORS   Salehi,A.H., Xanthoudakis,S. and Barker,P.A.
  TITLE     NRAGE, a p75 neurotrophin receptor-interacting protein, induces
            caspase activation and cell death through a JNK-dependent
            mitochondrial pathway
  JOURNAL   J Biol Chem 277 (50), 48043-48050 (2002)
   PUBMED   12376548
REFERENCE   8  (bases 1 to 8163)
  AUTHORS   Rumenapp,U., Freichel-Blomquist,A., Wittinghofer,B., Jakobs,K.H.
            and Wieland,T.
  TITLE     A mammalian Rho-specific guanine-nucleotide exchange factor
            (p164-RhoGEF) without a pleckstrin homology domain
  JOURNAL   Biochem J 366 (Pt 3), 721-728 (2002)
   PUBMED   12071859
  REMARK    GeneRIF: a Rho-specific GEF with novel structural and regulatory
            properties and predominant expression in the heart
REFERENCE   9  (bases 1 to 8163)
  AUTHORS   Harrington,A.W., Kim,J.Y. and Yoon,S.O.
  TITLE     Activation of Rac GTPase by p75 is necessary for c-jun N-terminal
            kinase-mediated apoptosis
  JOURNAL   J Neurosci 22 (1), 156-166 (2002)
   PUBMED   11756498
REFERENCE   10 (bases 1 to 8163)
  AUTHORS   Carson-Walter,E.B., Watkins,D.N., Nanda,A., Vogelstein,B.,
            Kinzler,K.W. and St Croix,B.
  TITLE     Cell surface tumor endothelial markers are conserved in mice and
            humans
  JOURNAL   Cancer Res 61 (18), 6649-6655 (2001)
   PUBMED   11559528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP002761.3, BC137228.1, AI312037.1, BM684780.1 and AP000562.5.
            
            On May 17, 2019 this sequence version replaced NM_014786.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC137228.1, AF378754.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263674.4/ ENSP00000263674.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-342               AP002761.3         143978-144319
            343-7683            BC137228.1         1-7341
            7684-7896           AI312037.1         2-214               c
            7897-8155           BM684780.1         18-276              c
            8156-8163           AP000562.5         76874-76881
FEATURES             Location/Qualifiers
     source          1..8163
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     gene            1..8163
                     /gene="ARHGEF17"
                     /gene_synonym="p164-RhoGEF; P164RHOGEF; RHOGEF17; TEM4"
                     /note="Rho guanine nucleotide exchange factor 17"
                     /db_xref="GeneID:9828"
                     /db_xref="HGNC:HGNC:21726"
                     /db_xref="MIM:617043"
     exon            1..3555
                     /gene="ARHGEF17"
                     /gene_synonym="p164-RhoGEF; P164RHOGEF; RHOGEF17; TEM4"
                     /inference="alignment:Splign:2.1.0"
     CDS             364..6555
                     /gene="ARHGEF17"
                     /gene_synonym="p164-RhoGEF; P164RHOGEF; RHOGEF17; TEM4"
                     /note="Rho-specific guanine-nucleotide exchange factor 164
                     kDa; tumor endothelial marker 4; 164 kDa Rho-specific
                     guanine-nucleotide exchange factor; Rho guanine nucleotide
                     exchange factor (GEF) 17"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 17"
                     /protein_id="NP_055601.2"
                     /db_xref="CCDS:CCDS8221.1"
                     /db_xref="GeneID:9828"
                     /db_xref="HGNC:HGNC:21726"
                     /db_xref="MIM:617043"
                     /translation="MADGAPRPQLYRSVSFKLLERWSGGPGLREEDTDTPGLRRRASC
                     RPTTAARGQPSRRVSKLASGPLAAPAQPRPLRSLSPSVRQLSRRFDAPRLDDGSAGTR
                     DGGVLPAAAEEAAEGPARGAWPSVTEMRKLFGGPGSRRPSADSESPGTPSPDGAAWEP
                     PARESRQPPTPPPRTCFPLAGLRSARPLTGPETEGRLRRPQQQQERAQRPADGLHSWH
                     IFSQPQAGARASCSSSSIAASYPVSRSRAASSSEEEEEGPPQLPGAQSPAYHGGHSSG
                     SDDDRDGEGGHRWGGRPGLRPGSSLLDQDCRPDSDGLNLSSMNSAGVSGSPEPPTSPR
                     APREEGLREWGSGSPPCVPGPQEGLRPMSDSVGGAFRVAKVSFPSYLASPAGSRGSSR
                     YSSTETLKDDDLWSSRGSGGWGVYRSPSFGAGEGLLRSQARTRAKGPGGTSRALRDGG
                     FEPEKSRQRKSLSNPDIASETLTLLSFLRSDLSELRVRKPGGSSGDRGSNPLDGRDSP
                     SAGGPVGQLEPIPIPAPASPGTRPTLKDLTATLRRAKSFTCSEKPMARRLPRTSALKS
                     SSSELLLTGPGAEEDPLPLIVQDQYVQEARQVFEKIQRMGAQQDDGSDAPPGSPDWAG
                     DVTRGQRSQEELSGPESSLTDEGIGADPEPPVAAFCGLGTTGMWRPLSSSSAQTNHHG
                     PGTEDSLGGWALVSPETPPTPGALRRRRKVPPSGSGGSELSNGEAGEAYRSLSDPIPQ
                     RHRAATSEEPTGFSVDSNLLGSLSPKTGLPATSAMDEGLTSGHSDWSVGSEESKGYQE
                     VIQSIVQGPGTLGRVVDDRIAGKAPKKKSLSDPSRRGELAGPGFEGPGGEPIREVEPM
                     LPPSSSEPILVEQRAEPEEPGATRSRAQSERALPEALPPPATAHRNFHLDPKLADILS
                     PRLIRRGSKKRPARSSHQELRRDEGSQDQTGSLSRARPSSRHVRHASVPATFMPIVVP
                     EPPTSVGPPVAVPEPIGFPTRAHPTLQAPSLEDVTKQYMLNLHSGEVPAPVPVDMPCL
                     PLAAPPSAEAKPPEAARPADEPTPASKCCSKPQVDMRKHVAMTLLDTEQSYVESLRTL
                     MQGYMQPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGA
                     LLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSD
                     LMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAE
                     RHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTL
                     KRKSGSLRRSSMSLYTAASVIDTASKYKMLWKLPLEDADIIKGASQATNRENIQKAIS
                     RLDEDLTTLGQMSKLSESLGFPHQSLDDALRDLSAAMHRDLSEKQALCYALSFPPTKL
                     ELCATRPEGTDSYIFEFPHPDARLGFEQAFDEAKRKLASSKSCLDPEFLKAIPIMKTR
                     SGMQFSCAAPTLNSCPEPSPEVWVCNSDGYVGQVCLLSLRAEPDVEACIAVCSARILC
                     IGAVPGLQPRCHREPPPSLRSPPETAPEPAGPELDVEAAADEEAATLAEPGPQPCLHI
                     SIAGSGLEMTPGLGEGDPRPELVPFDSDSDDESSPSPSGTLQSQASRSTISSSFGNEE
                     TPSSKEATAETTSSEEEQEPGFLPLSGSFGPGGPCGTSPMDGRALRRSSHGSFTRGSL
                     EDLLSVDPEAYQSSVWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQV
                     FVSLANGELVVYQREAGHFWDPQNFKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVL
                     SPDTLQLEHMFYVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVT
                     PPVHRMLAGSDAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMPTSPGTVSCPRA
                     PLSPTGLGQGHTGHVRFLAAVQLPDGFNLLCPTPPPPPDTGPEKLPSLEHRDSPWHRG
                     PAPARPKMLVISGGDGYEDFRLSSGGGSSSETVGRDDSTNHLLLWRV"
     exon            3556..3633
                     /gene="ARHGEF17"
                     /gene_synonym="p164-RhoGEF; P164RHOGEF; RHOGEF17; TEM4"
                     /inference="alignment:Splign:2.1.0"
     exon            3634..3816
                     /gene="ARHGEF17"
                     /gene_synonym="p164-RhoGEF; P164RHOGEF; RHOGEF17; TEM4"
                     /inference="alignment:Splign:2.1.0"
     exon            3817..3933
                     /gene="ARHGEF17"
                     /gene_synonym="p164-RhoGEF; P164RHOGEF; RHOGEF17; TEM4"
                     /inference="alignment:Splign:2.1.0"
     exon            3934..4026
                     /gene="ARHGEF17"
                     /gene_synonym="p164-RhoGEF; P164RHOGEF; RHOGEF17; TEM4"
                     /inference="alignment:Splign:2.1.0"
     exon            4027..4203
                     /gene="ARHGEF17"
                     /gene_synonym="p164-RhoGEF; P164RHOGEF; RHOGEF17; TEM4"
                     /inference="alignment:Splign:2.1.0"
     exon            4204..4254
                     /gene="ARHGEF17"
                     /gene_synonym="p164-RhoGEF; P164RHOGEF; RHOGEF17; TEM4"
                     /inference="alignment:Splign:2.1.0"
     exon            4255..4364
                     /gene="ARHGEF17"
                     /gene_synonym="p164-RhoGEF; P164RHOGEF; RHOGEF17; TEM4"
                     /inference="alignment:Splign:2.1.0"
     exon            4365..4450
                     /gene="ARHGEF17"
                     /gene_synonym="p164-RhoGEF; P164RHOGEF; RHOGEF17; TEM4"
                     /inference="alignment:Splign:2.1.0"
     exon            4451..4569
                     /gene="ARHGEF17"
                     /gene_synonym="p164-RhoGEF; P164RHOGEF; RHOGEF17; TEM4"
                     /inference="alignment:Splign:2.1.0"
     exon            4570..4783
                     /gene="ARHGEF17"
                     /gene_synonym="p164-RhoGEF; P164RHOGEF; RHOGEF17; TEM4"
                     /inference="alignment:Splign:2.1.0"
     exon            4784..4857
                     /gene="ARHGEF17"
                     /gene_synonym="p164-RhoGEF; P164RHOGEF; RHOGEF17; TEM4"
                     /inference="alignment:Splign:2.1.0"
     exon            4858..5057
                     /gene="ARHGEF17"
                     /gene_synonym="p164-RhoGEF; P164RHOGEF; RHOGEF17; TEM4"
                     /inference="alignment:Splign:2.1.0"
     exon            5058..5359
                     /gene="ARHGEF17"
                     /gene_synonym="p164-RhoGEF; P164RHOGEF; RHOGEF17; TEM4"
                     /inference="alignment:Splign:2.1.0"
     exon            5360..5609
                     /gene="ARHGEF17"
                     /gene_synonym="p164-RhoGEF; P164RHOGEF; RHOGEF17; TEM4"
                     /inference="alignment:Splign:2.1.0"
     exon            5610..5696
                     /gene="ARHGEF17"
                     /gene_synonym="p164-RhoGEF; P164RHOGEF; RHOGEF17; TEM4"
                     /inference="alignment:Splign:2.1.0"
     exon            5697..5764
                     /gene="ARHGEF17"
                     /gene_synonym="p164-RhoGEF; P164RHOGEF; RHOGEF17; TEM4"
                     /inference="alignment:Splign:2.1.0"
     exon            5765..5913
                     /gene="ARHGEF17"
                     /gene_synonym="p164-RhoGEF; P164RHOGEF; RHOGEF17; TEM4"
                     /inference="alignment:Splign:2.1.0"
     exon            5914..6088
                     /gene="ARHGEF17"
                     /gene_synonym="p164-RhoGEF; P164RHOGEF; RHOGEF17; TEM4"
                     /inference="alignment:Splign:2.1.0"
     exon            6089..6358
                     /gene="ARHGEF17"
                     /gene_synonym="p164-RhoGEF; P164RHOGEF; RHOGEF17; TEM4"
                     /inference="alignment:Splign:2.1.0"
     exon            6359..8163
                     /gene="ARHGEF17"
                     /gene_synonym="p164-RhoGEF; P164RHOGEF; RHOGEF17; TEM4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7840..7845
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGEF17"
                     /gene_synonym="p164-RhoGEF; P164RHOGEF; RHOGEF17; TEM4"
                     /note="hexamer: AATAAA"
     polyA_site      7866
                     /gene="ARHGEF17"
                     /gene_synonym="p164-RhoGEF; P164RHOGEF; RHOGEF17; TEM4"
                     /note="major polyA site"
     polyA_site      7896
                     /gene="ARHGEF17"
                     /gene_synonym="p164-RhoGEF; P164RHOGEF; RHOGEF17; TEM4"
     regulatory      8057..8062
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGEF17"
                     /gene_synonym="p164-RhoGEF; P164RHOGEF; RHOGEF17; TEM4"
                     /note="hexamer: AATAAA"
     polyA_site      8079
                     /gene="ARHGEF17"
                     /gene_synonym="p164-RhoGEF; P164RHOGEF; RHOGEF17; TEM4"
     polyA_site      8163
                     /gene="ARHGEF17"
                     /gene_synonym="p164-RhoGEF; P164RHOGEF; RHOGEF17; TEM4"
ORIGIN      
        1 aaaagggtgc caggagcgag cagccaaggg cgttgggcag gcggacgcag agtcgaggaa
       61 ccaagcgctg ggatcccgcc caggcggtgc cgcggtgccc ctggtcgctc cagccgcggc
      121 gggggctggg cctgggggtc ggcgctgagg cgggaggggc cgcccgggat ggagacgttg
      181 cggccggtgg ccacagaaac ttgagccgcg gcagagaaac ctctgctccg gtctctgcgt
      241 cctcttccca cactcccgtg cgctgctttc ggcgtgggcc gctgcgctcc tagggagtgg
      301 gggcgcaggg ggggttggcc gcggctgccc gaggccagcc cccccggagt gagttacgcc
      361 actatggcgg acggggcacc ccggccccag ctttaccgca gcgtctcgtt caagctgctg
      421 gagcgctgga gcggcggccc cgggctgagg gaggaggaca cggacacccc cggcttgagg
      481 cgacgcgcct cgtgccggcc gaccacggct gcccggggcc agccctctcg gcgcgtgtcc
      541 aagctggcgt ctgggcccct ggccgccccc gcgcagccgc gcccgctccg cagcctctcg
      601 ccgtcggttc gccagctctc ccggcgcttc gacgcgccgc gtctggacga cggctccgct
      661 gggacccgag acggaggcgt cttacccgcg gccgcggaag aagcggccga gggcccagcg
      721 cgaggagcct ggcccagcgt caccgagatg cgcaagctct tcggcggtcc tggctccagg
      781 aggcccagcg ccgactctga atccccagga acgcccagcc ccgacggtgc cgcgtgggag
      841 cctccggctc gggagtcgcg gcagccaccg acgccacccc ctcggacatg cttccccctg
      901 gcgggtctgc gttcggcgcg gcccctgacc gggccggaga ccgaagggag gctgcgccgg
      961 ccgcagcagc aacaggagcg ggcgcagcgt ccagcggatg gtttacattc ttggcatatc
     1021 ttctcccaac cgcaggccgg ggcccgggcc tcctgctcct cctcctccat cgccgcctcc
     1081 tatcctgtca gccgcagtcg tgctgccagc tccagcgagg aggaagagga gggcccgccg
     1141 cagctgcctg gagcccagag tccggcctac cacggcggcc actcctcggg cagtgacgac
     1201 gaccgagacg gtgagggcgg ccaccgctgg ggagggaggc ccgggctcag gcctggaagc
     1261 tccctattgg atcaggactg caggcctgac agtgatgggt taaatctaag cagcatgaac
     1321 tcagcagggg tttctgggag ccctgagccc ccaacatctc caagagcccc tagagaagaa
     1381 ggactccggg agtggggtag tggctctccg ccctgcgtcc caggtcccca ggagggactt
     1441 cggcctatgt ctgactctgt gggaggagct ttccgtgtgg ccaaggtgag ctttccctcg
     1501 tacctggcca gccccgcagg ctcccgcggt agcagccgtt attccagcac ggagaccctc
     1561 aaggacgacg acctatggtc tagtaggggt tctgggggct ggggcgtgta ccgctcccct
     1621 agctttggag ctggggaagg gctcctgcgg tcccaggctc gaacccgtgc caaaggacct
     1681 ggaggcacct ctagggcatt gagggatgga ggatttgagc ctgaaaagag tcgacagcgg
     1741 aagtccctgt caaatccaga tatcgcctca gagaccctga cgcttctcag tttcctgcgc
     1801 tcagaccttt cagagctgag ggtccgaaaa cctggtggga gctccgggga ccgtggaagc
     1861 aaccccctag atggcagaga ctcaccatcc gcaggtggcc ctgtggggca acttgaaccc
     1921 atacccatcc cagccccagc atcacctggc acgcgcccca cactcaagga cttgacagcc
     1981 actctgcgga gagcaaagtc attcacctgc tctgagaagc ccatggcccg ccgcctgccc
     2041 cgcaccagtg ctctgaagtc cagctcctcc gagctcctgc tcacaggccc tggtgccgag
     2101 gaggatccgc tgcccctcat cgtccaggac caatatgtgc aggaggcccg ccaggttttt
     2161 gagaagatcc agcgcatggg tgcccaacaa gatgatggaa gcgatgcccc ccctggaagc
     2221 cctgactggg caggggatgt gacccgaggg cagcggtccc aggaggagct ctcaggccct
     2281 gagtccagtc tgacagatga aggcattggg gcagaccctg agcctcctgt tgcagcattt
     2341 tgcggcctgg gtaccacagg gatgtggcga cctctttcct catcctcggc ccagacgaac
     2401 caccatggcc ctgggactga ggacagtctg ggcgggtggg ccctggtgtc gcctgagacc
     2461 cctcccacac caggtgccct ccgccgacga cgcaaagtcc caccttcagg ttctggtggg
     2521 agcgaattga gcaatgggga ggcaggggag gcctacaggt ccctgagtga cccaattcct
     2581 cagcgccacc gggctgccac ctctgaagag cctactgggt tctctgtgga cagcaacctc
     2641 ctgggctcac tgagccccaa gacagggctc cctgccacct cagccatgga tgagggcttg
     2701 accagtggtc acagtgactg gtctgtgggc agtgaagaga gcaagggata tcaggaggtt
     2761 attcagagca tagttcaggg gcctggcacc ctggggcgtg tggtggacga caggattgct
     2821 ggcaaagccc ccaagaagaa atccctgagt gaccccagcc gccgtgggga gctggctggg
     2881 cctggattcg agggccctgg aggggagccc atccgagaag ttgagcccat gctgcctcca
     2941 tccagcagcg agcccatcct tgtagagcag cgggcagagc cagaagaacc tggtgccacc
     3001 aggagccggg cacagtctga aagggcccta cctgaggctc tgcctccccc tgccactgcc
     3061 caccgaaact ttcaccttga ccccaagctg gctgacattc tgtccccgag gctaatccgc
     3121 cgaggctcca agaagcgccc agctcggagt agtcaccagg agcttcggag agacgagggc
     3181 agtcaggacc agactggcag cctgtctcgg gcccggccct cctccagaca cgttcgccat
     3241 gccagtgtgc ccgccacatt tatgcctatt gtggtgcctg agccaccaac ttctgttggt
     3301 ccccctgtgg ctgtgccaga acccataggc ttccctaccc gagcccatcc cacgttgcag
     3361 gcaccatcgc tcgaggacgt caccaagcag tacatgctga acctgcactc cggtgaggtc
     3421 cctgccccag tgccagtgga catgccctgc ttgcctctgg ctgcaccgcc ctctgctgag
     3481 gccaagcccc ctgaggcagc tcggcctgca gatgagccta cccctgccag caagtgctgc
     3541 agcaagccac aggtggacat gcggaagcac gtggccatga ccctgctgga cacagagcag
     3601 tcgtatgtgg agtcgctgcg caccctgatg cagggctaca tgcagccgct gaagcagcca
     3661 gagaactccg tgctctgtga cccttcactg gtggacgaga tcttcgacca gatccccgag
     3721 ctcctggagc accacgagca attcctggag caggttcggc actgcatgca gacctggcat
     3781 gcccagcaga aggtgggagc cctgctcgtc cagtcgttct ccaaggatgt cctagtaaac
     3841 atctattctg cctatatcga taacttcctc aatgcaaagg atgctgtgcg tgtggccaag
     3901 gaggcgaggc ctgcctttct caagttccta gagcaaagca tgcgtgagaa caaggagaag
     3961 caggcgctgt ctgacctcat gatcaagcct gtgcagcgga tcccacgcta cgagcttctg
     4021 gtgaaggacc tcctgaagca tacacctgag gaccacccgg accatccact cctgctggag
     4081 gcgcagcgga acatcaagca ggtggctgag cgcatcaaca agggtgtgcg gagtgccgag
     4141 gaggcggagc gccatgcccg tgtgctgcag gagatagagg ctcacatcga gggcatggag
     4201 gatctccagg cccctctgcg gcggttcctg agacaggaga tggtcattga agtgaaggcg
     4261 atcggtggca agaaggaccg gtctctcttc ctgttcacgg acctcatcgt ctgcaccact
     4321 ctgaagcgaa agtcaggctc cctgcggcgc agctccatga gcctgtacac ggcagccagt
     4381 gtcattgaca cagccagcaa gtacaagatg ctgtggaagc tgccgctgga agacgcagac
     4441 atcatcaaag gggcatccca agccaccaat cgggagaaca tccagaaggc catcagccgc
     4501 cttgatgagg acctcaccac cctgggccaa atgagcaagc tctctgagag ccttggtttc
     4561 ccccaccaga gcctggacga tgcactgcgg gacctctcag ctgccatgca ccgggacctg
     4621 tcggagaagc aggcgctgtg ctacgcgctt tccttcccgc caaccaagct ggagctgtgc
     4681 gccactcggc ccgagggcac cgactcctac atttttgagt tccctcaccc tgacgcccgc
     4741 cttggttttg aacaggcctt cgatgaggcc aagaggaagc tggcatccag caaaagctgt
     4801 ctagaccctg agttcctgaa ggccatcccc atcatgaaaa cccgcagtgg catgcagttc
     4861 tcctgtgcgg ctcccaccct gaacagctgc ccggagccct cgcctgaggt atgggtctgc
     4921 aacagcgacg gctacgtggg ccaggtgtgc ctgctgagcc tgcgcgccga gccggacgtg
     4981 gaggcctgca tcgccgtctg ttccgcccgc atcctctgca tcggggcggt gcccgggctg
     5041 cagcctcgct gccaccggga gcctcctccg tcgctgagga gtcctccaga gacggcaccg
     5101 gagcccgccg ggccggagct ggacgtcgag gccgctgcag acgaggaagc cgcgacgctc
     5161 gcggagccgg ggccgcagcc ctgccttcac atctccattg caggctcggg cttggagatg
     5221 acgccgggcc tcggcgaggg tgacccccgc ccagagctgg tgccctttga cagtgactct
     5281 gacgatgagt cttcgcccag cccctcgggg acgctgcaga gccaggccag ccggtccacc
     5341 atctcctcca gctttggcaa tgaggagacc ccgagttcca aggaggccac ggcagagacc
     5401 accagctcag aggaggagca ggagccaggc ttcctgccac tgtctggctc ctttgggcct
     5461 ggtggtccct gcggcaccag cccaatggat gggagagccc ttcgccgctc cagccacggc
     5521 tccttcaccc ggggcagcct tgaggacctg ctgagtgtcg accctgaggc ctaccagagc
     5581 tccgtgtggc tgggcactga ggatggctgt gtccacgtgt accagtcctc cgacagcatc
     5641 cgtgaccgca ggaacagcat gaagctccag catgcggcct ctgtgacctg catcttgtat
     5701 ctgaataacc aggtgtttgt gtctctggcc aatggagagc ttgtggtcta ccaaagggaa
     5761 gcaggccatt tctgggaccc ccagaacttc aaatcagtga ccttgggcac ccaggggagc
     5821 cccatcacca agatggtatc tgtgggtggg cggctgtggt gtggctgcca gaaccgagtc
     5881 cttgtcctga gccctgacac gctgcagctg gagcacatgt tttacgtggg tcaggattca
     5941 agccgctgcg tggcttgcat ggtggactcc agcctgggtg tgtgggtgac attgaaaggt
     6001 agtgcccacg tgtgtctcta ccatccagac acctttgagc agctggcaga agtagacgtc
     6061 actcctcccg tgcacaggat gctggcaggc tcggatgcca tcatccggca gcacaaggct
     6121 gcctgtctgc gaatcacagc gctgctggtg tgtgaggagc tgctgtgggt gggcaccagt
     6181 gctggtgtcg tcctcaccat gcccacttcg cccggtactg tcagctgccc acgggcacca
     6241 ctcagtccca caggcctcgg ccagggacac accggccacg tccgcttctt ggctgcagtc
     6301 cagctgccag atggcttcaa cctgctctgc ccaaccccac cacctccccc agacacaggc
     6361 cccgagaagc tgccatcact ggagcaccgg gactcccctt ggcaccgagg ccccgcccct
     6421 gccaggccta aaatgctggt tatcagtgga ggtgatggct atgaggactt ccgactcagc
     6481 agtgggggcg gcagcagcag tgagactgtg ggtcgagacg acagcacaaa ccacctcctc
     6541 ctgtggaggg tgtgaccctg tctgccgtgg cccaggactc gcccgcccac ctgccttcag
     6601 cctgcttgcc tctccctagc ccacacgcag actttgacca ggagtatcca gccaggggca
     6661 cacatgtgcc tgcgtgggct ctgccttgtc ttcgcggaag cattcctgat ggaacaccca
     6721 ctggccagcc aggccatggc ttctcccgac cctctggctg ccccggtgct tccagtcatg
     6781 atcgggtggg ggacatgtgg gctgaccagg acctctgacc ctggagcttc taccaaagac
     6841 acagctgggt ctggacccca cggggctggg gagggccatg tgcaatattt ggagggtttt
     6901 ctggagggca gcaggaaggc tggggaattc cccatgtaca gtatttatgt ttctttttag
     6961 atgtgtacct tcccaagcac ttatttatgc agtgacctgg tcacctgggg tgggggtgat
     7021 ttgaggaaat gacatgagga aaagaaacct attcctgccc tggggaccac cctgggactc
     7081 taaccaagcc ttcctggagg gacccatgcg cccctgagcc ccattccatt catacagaca
     7141 cacacgtacg cacactgcat gtccaaggcc ctaaacattg cccgttgaca taaactttcc
     7201 agggccccag cctgatgggg ctgccctcag tcctctagat caagatgctg actattaggg
     7261 ggcagtgatt gccatctggg gacctgtcag gctttgtcat ttcccagttt gttggtggtg
     7321 cctttagtgg ttccctaatt tgggaacact gatggggcct tggacagggc tttctctcag
     7381 gtaggagaaa tgggcccatg atctcctcac agtcgccccc agtccttggc cctgcttccc
     7441 tgtgtctcat gcactggcac atatggtcac cttggagggc agacctagga gcccctctga
     7501 ccactgaatc cgtctccaca ccccttctgc caagggaagc cccttcagga aggacccccc
     7561 aaagctgagg ggctgaatgt agccttttca acagagaagg ctcccacttg agagcagcct
     7621 ctacctgacc ccctggacca cagagagcca ctctgaccct cagccccctc gcttcttcag
     7681 ctaaaactcc aaaggtttgg tttcagatgg ggtttgtttt gttctgtttg gttttggttt
     7741 tgtttggggt gggtgggtca ttgcggtctt agattatgtt tctcttgcta ccaaacagtc
     7801 atgtattaac tctctttgga tgatgaagtt taaagagtca ataaatagaa acaccagatg
     7861 actgcattgg tggccacagt ggcctcctgt cagcaacctc agggctcagt ctccctggcc
     7921 acatgggcct tccgacgtcc acacacttgg gaagaaggga ggccttggag acccagaaga
     7981 gtgctggacg gcgaggttgc cacgatttgc tgtgttacct gggcaggtgg ctgggctgca
     8041 gtttcctcat caggaaaata aaggggttgt accagttcag tgctttgtaa ccagggttac
     8101 atggtagaat cccttgcaga tgacatgtaa atgcagaaac atgattcgta acttatttac
     8161 gta
//
