LOCUS       NM_014448               2822 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens Rho guanine nucleotide exchange factor 16 (ARHGEF16),
            mRNA.
ACCESSION   NM_014448
VERSION     NM_014448.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2822)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 2822)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2822)
  AUTHORS   Yu,B., Xu,L., Chen,L., Wang,Y., Jiang,H., Wang,Y., Yan,Y., Luo,S.
            and Zhai,Z.
  TITLE     FYN is required for ARHGEF16 to promote proliferation and migration
            in colon cancer cells
  JOURNAL   Cell Death Dis 11 (8), 652 (2020)
   PUBMED   32811808
  REMARK    GeneRIF: FYN is required for ARHGEF16 to promote proliferation and
            migration in colon cancer cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2822)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2822)
  AUTHORS   Muller,P.M., Rademacher,J., Bagshaw,R.D., Wortmann,C., Barth,C.,
            van Unen,J., Alp,K.M., Giudice,G., Eccles,R.L., Heinrich,L.E.,
            Pascual-Vargas,P., Sanchez-Castro,M., Brandenburg,L., Mbamalu,G.,
            Tucholska,M., Spatt,L., Czajkowski,M.T., Welke,R.W., Zhang,S.,
            Nguyen,V., Rrustemi,T., Trnka,P., Freitag,K., Larsen,B., Popp,O.,
            Mertins,P., Gingras,A.C., Roth,F.P., Colwill,K., Bakal,C.,
            Pertz,O., Pawson,T., Petsalaki,E. and Rocks,O.
  TITLE     Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals
            spatially organized RAC1 signalling from integrin adhesions
  JOURNAL   Nat Cell Biol 22 (4), 498-511 (2020)
   PUBMED   32203420
REFERENCE   6  (bases 1 to 2822)
  AUTHORS   Benzinger,A., Muster,N., Koch,H.B., Yates,J.R. 3rd and Hermeking,H.
  TITLE     Targeted proteomic analysis of 14-3-3 sigma, a p53 effector
            commonly silenced in cancer
  JOURNAL   Mol Cell Proteomics 4 (6), 785-795 (2005)
   PUBMED   15778465
REFERENCE   7  (bases 1 to 2822)
  AUTHORS   Meek,S.E., Lane,W.S. and Piwnica-Worms,H.
  TITLE     Comprehensive proteomic analysis of interphase and mitotic
            14-3-3-binding proteins
  JOURNAL   J Biol Chem 279 (31), 32046-32054 (2004)
   PUBMED   15161933
REFERENCE   8  (bases 1 to 2822)
  AUTHORS   Rabizadeh,S. and Bredesen,D.E.
  TITLE     Ten years on: mediation of cell death by the common neurotrophin
            receptor p75(NTR)
  JOURNAL   Cytokine Growth Factor Rev 14 (3-4), 225-239 (2003)
   PUBMED   12787561
  REMARK    Review article
REFERENCE   9  (bases 1 to 2822)
  AUTHORS   Salehi,A.H., Xanthoudakis,S. and Barker,P.A.
  TITLE     NRAGE, a p75 neurotrophin receptor-interacting protein, induces
            caspase activation and cell death through a JNK-dependent
            mitochondrial pathway
  JOURNAL   J Biol Chem 277 (50), 48043-48050 (2002)
   PUBMED   12376548
REFERENCE   10 (bases 1 to 2822)
  AUTHORS   Harrington,A.W., Kim,J.Y. and Yoon,S.O.
  TITLE     Activation of Rac GTPase by p75 is necessary for c-jun N-terminal
            kinase-mediated apoptosis
  JOURNAL   J Neurosci 22 (1), 156-166 (2002)
   PUBMED   11756498
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL512413.23.
            
            On Nov 23, 2018 this sequence version replaced NM_014448.3.
            
            Summary: Although the specific function of this protein is not
            known yet, it is thought to be involved in protein-protein and
            protein-lipid interactions. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK095984.1, SRR9304717.512506.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378378.9/ ENSP00000367629.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AL512413.23        7997-8143
            148-754             AL512413.23        16398-17004
            755-800             AL512413.23        19480-19525
            801-970             AL512413.23        20500-20669
            971-1027            AL512413.23        22212-22268
            1028-1188           AL512413.23        22765-22925
            1189-1341           AL512413.23        26410-26562
            1342-1471           AL512413.23        26725-26854
            1472-1546           AL512413.23        28040-28114
            1547-1639           AL512413.23        29302-29394
            1640-1791           AL512413.23        31207-31358
            1792-1980           AL512413.23        31756-31944
            1981-2054           AL512413.23        32849-32922
            2055-2156           AL512413.23        33144-33245
            2157-2822           AL512413.23        33780-34445
FEATURES             Location/Qualifiers
     source          1..2822
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.32"
     gene            1..2822
                     /gene="ARHGEF16"
                     /gene_synonym="GEF16; NBR"
                     /note="Rho guanine nucleotide exchange factor 16"
                     /db_xref="GeneID:27237"
                     /db_xref="HGNC:HGNC:15515"
                     /db_xref="MIM:618871"
     exon            1..147
                     /gene="ARHGEF16"
                     /gene_synonym="GEF16; NBR"
                     /inference="alignment:Splign:2.1.0"
     exon            148..754
                     /gene="ARHGEF16"
                     /gene_synonym="GEF16; NBR"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..2296
                     /gene="ARHGEF16"
                     /gene_synonym="GEF16; NBR"
                     /note="Rho guanine exchange factor (GEF) 16; ephexin-4;
                     Rho guanine nucleotide exchange factor (GEF) 16; ephexin4"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 16"
                     /protein_id="NP_055263.2"
                     /db_xref="CCDS:CCDS46.2"
                     /db_xref="GeneID:27237"
                     /db_xref="HGNC:HGNC:15515"
                     /db_xref="MIM:618871"
                     /translation="MAQRHSDSSLEEKLLGHRFHSELRLDAGGNPASGLPMVRGSPRV
                     RDDAAFQPQVPAPPQPRPPGHEEPWPIVLSTESPAALKLGTQQLIPKSLAVASKAKTP
                     ARHQSFGAAVLSREAARRDPKLLPAPSFSLDDMDVDKDPGGMLRRNLRNQSYRAAMKG
                     LGKPGGQGDAIQLSPKLQALAEEPSQPHTRSPAKNKKTLGRKRGHKGSFKDDPQLYQE
                     IQERGLNTSQESDDDILDESSSPEGTQKVDATIVVKSYRPAQVTWSQLPEVVELGILD
                     QLSTEERKRQEAMFEILTSEFSYQHSLSILVEEFLQSKELRATVTQMEHHHLFSNILD
                     VLGASQRFFEDLEQRHKAQVLVEDISDILEEHAEKHFHPYIAYCSNEVYQQRTLQKLI
                     SSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHSERYKA
                     ASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKVKSLPLISASRWLLKRGEL
                     FLVEETGLFRKIASRPTCYLFLFNDVLVVTKKKSEESYMVQDYAQMNHIQVEKIEPSE
                     LPLPGGGNRSSSVPHPFQVTLLRNSEGRQEQLLLSSDSASDRARWIVALTHSERQWQG
                     LSSKGDLPQVEITKAFFAKQADEVTLQQADVVLVLQQEDGWLYGERLRDGETGWFPED
                     FARFITSRVAVEGNVRRMERLRVETDV"
     exon            755..800
                     /gene="ARHGEF16"
                     /gene_synonym="GEF16; NBR"
                     /inference="alignment:Splign:2.1.0"
     exon            801..970
                     /gene="ARHGEF16"
                     /gene_synonym="GEF16; NBR"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1027
                     /gene="ARHGEF16"
                     /gene_synonym="GEF16; NBR"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1188
                     /gene="ARHGEF16"
                     /gene_synonym="GEF16; NBR"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1341
                     /gene="ARHGEF16"
                     /gene_synonym="GEF16; NBR"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..1471
                     /gene="ARHGEF16"
                     /gene_synonym="GEF16; NBR"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1546
                     /gene="ARHGEF16"
                     /gene_synonym="GEF16; NBR"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1639
                     /gene="ARHGEF16"
                     /gene_synonym="GEF16; NBR"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1791
                     /gene="ARHGEF16"
                     /gene_synonym="GEF16; NBR"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1980
                     /gene="ARHGEF16"
                     /gene_synonym="GEF16; NBR"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2054
                     /gene="ARHGEF16"
                     /gene_synonym="GEF16; NBR"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2156
                     /gene="ARHGEF16"
                     /gene_synonym="GEF16; NBR"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2822
                     /gene="ARHGEF16"
                     /gene_synonym="GEF16; NBR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2802..2807
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGEF16"
                     /gene_synonym="GEF16; NBR"
                     /note="hexamer: ATTAAA"
     polyA_site      2822
                     /gene="ARHGEF16"
                     /gene_synonym="GEF16; NBR"
                     /note="major polyA site"
ORIGIN      
        1 agccagaccg cgcaggaagc ggaggaggcg ccccgggccg gaccgcgctg ccgcaggagc
       61 gaagcggctg caggacagga caggacccgg cgctggaagc tgcaccgcca gcgcgccgcc
      121 cctccgtccc tccgccccgc ggcgcaggac cccacagccg cccagcatgg cccagcggca
      181 ctcagacagc tccttggagg agaagctcct gggacaccgc ttccactcgg agctccggct
      241 cgatgccggg gggaacccag cctccgggct cccaatggtc cgtggctccc cgcgtgttag
      301 agacgatgcc gccttccagc cccaggtccc ggcaccccca cagcctcggc ccccggggca
      361 cgaggagcca tggcccatcg tcctgagcac agagagcccg gcggccctca agctgggcac
      421 ccaacagctg atccctaaga gcctggctgt ggccagcaag gcaaagaccc cagcccgcca
      481 ccagagcttc ggggcggctg tacttagcag ggaggccgcc cggcgggacc ctaagctcct
      541 cccagccccc agcttctccc tggatgacat ggacgtggac aaggaccccg ggggcatgct
      601 gaggcggaac ctgcggaacc aatcctaccg ggcggccatg aagggcctgg ggaagccagg
      661 tggccaggga gatgccatcc agctaagccc taagctccag gctctggctg aggaacccag
      721 ccagcctcat actcggagcc cggccaaaaa caagaagacg ctggggagga aacgtgggca
      781 caagggttcc ttcaaggacg acccccagct ctaccaggag atccaggagc ggggcctgaa
      841 caccagccag gagtctgatg acgacatcct cgatgagtcc tccagccccg agggaaccca
      901 gaaggtggac gccaccattg tggtcaagag ctaccggccc gcccaggtca cctggagcca
      961 gctcccagag gtggtggaat tgggcatcct ggaccagctc tccactgagg agcggaaaag
     1021 gcaggaggcc atgttcgaga tcctcacgtc ggagttctcc taccagcaca gcctgagcat
     1081 cctggtggag gagttcctgc agtccaagga gctgcgggcg accgtgaccc agatggagca
     1141 ccaccacctc ttctccaaca tcctggatgt cctgggtgcc agtcagaggt tcttcgagga
     1201 cctggagcag cggcacaagg cccaggtgct ggtcgaggac atcagtgaca tcctggagga
     1261 gcacgctgag aagcacttcc acccctacat cgcctactgc tccaacgagg tctaccaaca
     1321 gcgcacgctg cagaagctga taagcagcaa cgccgccttc cgagaggccc tgagagagat
     1381 tgagaggcgg ccggcgtgcg ggggcctgcc catgctctcc ttcctgatcc tccccatgca
     1441 gcgggtgacc cggctgcccc tcctgatgga tacgctctgc ctcaagaccc agggccactc
     1501 cgaaaggtac aaggctgcca gccgtgcact gaaggccatc agcaagctgg tgaggcagtg
     1561 caacgagggg gcccacagga tggagcgcat ggagcagatg tacacgctgc acacacagct
     1621 ggacttcagc aaggtcaagt ccctcccact gatctctgcc tcccggtggc tgctgaagcg
     1681 cggagagctg ttcttagtgg aagaaaccgg actttttcga aaaattgcca gccggccaac
     1741 gtgctacctt ttcctgttca acgatgtcct ggttgtgacc aagaagaaga gcgaggagag
     1801 ctacatggtc caggactacg cccagatgaa ccacatccag gtggagaaga tagagccgtc
     1861 tgagctccct ctgcccgggg gcggcaaccg tagctcctcc gtgccccacc ccttccaggt
     1921 gaccctgctt cgcaacagcg agggccgcca ggagcagctc ctgctctcct cggactccgc
     1981 gagtgaccgg gcacggtgga tcgtggcgct cacacacagt gagagacagt ggcagggcct
     2041 ctccagcaaa ggagacctgc cccaggtgga gatcaccaag gccttcttcg cgaagcaagc
     2101 agacgaggtc acactgcagc aggcggacgt ggtcctggtt ctgcagcagg aggatgggtg
     2161 gctctatggc gagaggctcc gggacggaga gacgggatgg ttccccgagg actttgcccg
     2221 cttcatcacc agccgtgtgg ccgtggaggg caatgtccgc aggatggagc gtctgcgggt
     2281 ggagacggac gtgtagccct ggcgaggcca gccggcggca gcacagcctg tctccaatca
     2341 gcaagtggtc gtgcctggct ctagagagcg tggggagctg gtctcaagga cccagcatgg
     2401 ttccctgggg cttcccaaga gcctgtggct gtggtgccgg gctccagaca cttcacggaa
     2461 ggaagatcac atgtccccag agaggcaccc ccaggcaagc tcgagggggc cacaccgtgt
     2521 cccagggagc ccagcctatt cccgttggct ggctgggccc ctcagctgct gggccccacc
     2581 tccccactgc acccaggggg caactccacc tggactgatg ggcacaggag gcaccaatag
     2641 cgattattgg gggcaatgcg aggtctcctc ctatgccctt cctacccctg agtgggacaa
     2701 gaagggccct gagtgcccag gagtgcccca cgttctgaga aggggccggc cggagggagg
     2761 ggacccggca gggagatttc ggttttgagg tttctaaata cattaaagtt atttcttaag
     2821 aa
//
