LOCUS       XM_017002923            7144 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens Rho guanine nucleotide exchange factor 11
            (ARHGEF11), transcript variant X16, mRNA.
ACCESSION   XM_017002923
VERSION     XM_017002923.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000001.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017002923.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7144
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
     gene            1..7144
                     /gene="ARHGEF11"
                     /gene_synonym="GTRAP48; PDZ-RHOGEF"
                     /note="Rho guanine nucleotide exchange factor 11; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 55 ESTs, 533 long SRA reads, and 100% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     140 samples with support for all annotated introns"
                     /db_xref="GeneID:9826"
                     /db_xref="HGNC:HGNC:14580"
                     /db_xref="MIM:605708"
     CDS             1413..5984
                     /gene="ARHGEF11"
                     /gene_synonym="GTRAP48; PDZ-RHOGEF"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 11
                     isoform X16"
                     /protein_id="XP_016858412.1"
                     /db_xref="GeneID:9826"
                     /db_xref="HGNC:HGNC:14580"
                     /db_xref="MIM:605708"
                     /translation="MSVRLPQSIDRLSSLSSLGDSAPERKSPSHHRQPSDASETTGLV
                     QRCVIIQKDQHGFGFTVSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSH
                     LEVVKLIKSGAYVALTLLGSSPSSMGISGLQQDPSPAGAPRITSVIPSPPPPPPLPPP
                     QRITGPKPLQDPEVQKHATQILRNMLRQEEKELQDILPLYGDTSQRPSEGRLSLDSQE
                     GDSGLDSGTERFPSLSESLMNRNSVLSDPGLDSPRTSPVIMARVAQHHRRQGSDAAVP
                     STGDQGVDQSPKPLIIGPEEDYDPGYFNNESDIIFQDLEKLKSRPAHLGVFLRYIFSQ
                     ADPSPLLFYLCAEVYQQASPKDSRSLGKDIWNIFLEKNAPLRVKIPEMLQAEIDSRLR
                     NSEDARGVLCEAQEAAMPEIQEQIHDYRTKRTLGLGSLYGENDLLDLDGDPLRERQVA
                     EKQLAALGDILSKYEEDRSAPMDFALNTYMSHAGIRLREARPSNTAEKAQSAPDKDKW
                     LPFFPKTKKQSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSPVEVKPGNV
                     RNIIQHFENNQQYDAPEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSESLKGREEMKR
                     SRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMGRRSIE
                     SPSLGFCTDTLLPHLLEDDLGQLSDLEPEPDAQNWQHTVGKDVVAGLTQREIDRQEVI
                     NELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEAMK
                     KLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRFQL
                     FMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARDQC
                     REILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHEGP
                     LTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLKLN
                     AVLIRSVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRNATRHPGA
                     APMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQGKHQV
                     LLEDPEQEGSAEEEELGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEGLADSALE
                     DVENLRHLILWSLLPGHTMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQAPPGGE
                     GDNTQLAGLEGERPEQEDMGLCSLEHLPPRTRNSGIWESPELDRNLAEDASSTEAAGG
                     YKVVRKAEVAGSKVVPALPESGQSEPGPPEVEGGTKATGNCFYVSMPSGPPDSSTDHS
                     EAPMSPPQPDSLPAGQTEPQPQLQGGNDDPRRPSRSPPSLALRDVGMIFHTIEQLTLK
                     LNRLKDMELAHRELLKSLGGESSGGTTPVGSFHTEAARWTDGSLSPPAKEPLASDSRN
                     SHELGPCPEDGSDAPLEDSTADAAASPGP"
ORIGIN      
        1 agtcggacgc ccgctcgtgc cggcctgccg cagccgccgc agccttccct gtgcgccgag
       61 cctggcgtcc cgagcggccg cgaaggccgg aacacggcgg tcgggcgcgg ggcgagcggc
      121 gccgggagcc cgaggcccgg ccgggcgtcc tgcgcgaggc actgcgggct cctgcctgcg
      181 agattaggcg aggggcggaa agggaggcaa ggagaggccg agaggagaca ggcgatcgga
      241 ttttccagga gtctggtgtg gaagaaaaac ccacctcgaa ctcaaatcca caataataat
      301 ccgaacgaat aataagggag ccgtctttct ggccgggcga gagagaggga gagagaaggg
      361 ggaacgggag gaagcgaaat ctccgtttca tggaggctga ggcaagagaa aatttcggag
      421 cctggatgtg gaggagccca acagcagaac taactcagga aattgtcttt cagaaaaagg
      481 ccgaacgtag gctgggtctg agaatcaggc tggggtaggt ggaggaacct gcaagtttaa
      541 aggaaaaaga aaaggagaga atattttcag agattatctc tggtttgtta tcattactac
      601 catcttaaag gtaaaaagca ttgcatttca ggtgttcttt gatttttatt ttattttttt
      661 ttttggtgca attggctcat ttaagaattt caaaacattt aatgtaaaag cttttttttt
      721 tttaaggaag tccataaatt ttggttccca gggttgcact ggacttggaa ggagtgctgt
      781 tgtgtacata ctattgtatg gttttattta ttattttact gtacaaatca gccgaaagaa
      841 tttttccaag tgccatttcg gatttattaa tccttttttt tttcctttcc tcaaagatat
      901 ttgctgttgt catattaagc attggagact agaaaattac tttccccctt tgagctagag
      961 ggtctcttgc caacagaagg acagctgaga aagctggatt taaaggatgg ttttatctgt
     1021 actttgcagt taacagtgat attttgaagg cacatttttc tgtgattcat ttttttttgg
     1081 ccatagtgct aaccttgaag agattcgtgg ctgggttttt ggtttctgag aaggtcgtag
     1141 tttttcctct tttccttttt ttttcttttt tcttttcttt tctttttttt taaagcgggg
     1201 gaggggaaga ggggctgaga aaggaaatca tgttcactgg tagaagtaga gtggagcatc
     1261 agttaccagg gtcctgagag ctggaggaga aaggattcta tcttcaagtt gggaggccct
     1321 cctctcacct tgctcaaaaa ttgcaagcga ttcaatcctg atcaagacac caaagctaca
     1381 ggattctgga accgtggaga caccgagaaa ccatgagtgt aaggttaccc cagagtatag
     1441 acaggttaag tagcctgtct tctctgggag attctgcacc agagcgcaag tccccttccc
     1501 accatcgcca gccttcggat gcctctgaga caacaggtct cgttcaacgc tgtgtcatta
     1561 tccaaaagga ccagcatggc ttcggcttca cagtcagtgg ggatcgcatt gttctggtgc
     1621 agtctgtgcg gcctggaggt gcagccatga aggccggtgt gaaagagggc gaccggatca
     1681 tcaaagtcaa cggcaccatg gtgaccaata gctcacacct ggaagtggta aagctgatca
     1741 aatctggcgc ctatgtcgca ctcaccctcc tgggctcttc accttcatcc atgggcatct
     1801 ctgggctcca gcaggaccca tccccagcag gagctccccg aatcacgtca gtgatcccct
     1861 caccaccacc tcctccacct ctaccacctc cacaacgcat cacaggaccc aaacctctgc
     1921 aggatcccga agttcaaaaa catgccaccc agatcctcag gaatatgctg aggcaggaag
     1981 aaaaagaatt acaggacata cttccactat atggtgacac cagccagaga ccatcagaag
     2041 gccggctctc tctggattcc caggaggggg acagtggctt ggactctggg acagaacgct
     2101 ttccttccct cagtgagtca ttgatgaatc ggaactcggt actgtcagac cctgggctag
     2161 acagtcctcg aacctcccct gtgatcatgg ccagggtggc ccagcaccac aggcggcagg
     2221 gctcggatgc agcagtcccc tcaaccggtg accagggtgt agatcaaagc ccaaagcctt
     2281 taattattgg cccagaggaa gactatgacc cgggttattt caacaacgag agcgacatca
     2341 tattccagga tctggagaaa ctgaagtctc ggccagctca cctgggggtt tttctacgtt
     2401 acatcttctc tcaggcggac cccagtccac tgctttttta cctgtgtgca gaagtttatc
     2461 agcaggcaag ccccaaggat tcccgaagct tggggaaaga catctggaat attttcctgg
     2521 agaaaaatgc gcctctgaga gtgaagatcc ctgagatgct acaggctgaa attgactcgc
     2581 gcctgcggaa cagcgaagat gcccgtggtg ttctctgtga agctcaagag gcagccatgc
     2641 ctgagatcca agagcagatc cacgactaca gaacgaagcg cacactgggg ctgggcagcc
     2701 tgtatggtga aaatgacctg ctggacctgg atggggaccc tctccgagag cgccaagtgg
     2761 ctgagaagca gctggctgcc cttggagata ttttgtccaa gtatgaggaa gacaggagcg
     2821 cccccatgga cttcgccctc aatacctaca tgagccatgc tgggatccgt cttcgagagg
     2881 cacgaccttc caacacagct gaaaaggccc agtctgctcc tgacaaggac aagtggctac
     2941 cgttcttccc taagaccaag aagcagagca gcaattccaa gaaagaaaag gatgccttgg
     3001 aggacaagaa gcgaaaccct atcctcaaat acattgggaa gcccaaaagc tcttctcaaa
     3061 gcacatttca tattcccttg tcccctgtgg aagtcaaacc aggcaatgtg aggaacatca
     3121 ttcagcactt tgagaacaac cagcagtatg atgccccaga acctgggaca caacgactct
     3181 cgaccggaag ctttcctgag gacctgctgg agagtgacag ttcacgctca gagattcgcc
     3241 tgggccgctc tgaaagcctc aagggccggg aagagatgaa acggtctcga aaggcagaga
     3301 acgtgccccg ctctcgcagt gatgttgaca tggatgctgc tgcggaggct actcgcctgc
     3361 accagtcagc ctcgtcctct acctccagcc tctccaccag gtctcttgag aacccaaccc
     3421 ctccattcac tcccaaaatg ggccgcagga gcattgagtc ccccagtttg gggttctgca
     3481 cagataccct ccttccccac ctcctagagg atgatctggg ccagctgtct gacctggagc
     3541 cagagccaga tgcccaaaat tggcagcata cagtgggcaa ggatgtggtg gctgggctaa
     3601 cccagcggga gattgaccgg caagaggtca tcaatgagct gtttgtgact gaagcttccc
     3661 acctgcgcac actccgggtc ctggacctga tcttctacca gcgaatgaag aaggagaacc
     3721 tgatgccccg ggaggagctg gcccggctct tcccgaacct gcctgaactc atagagattc
     3781 acaattcctg gtgtgaagcc atgaagaagc tccgggagga aggccccatc atcaaagaga
     3841 tcagtgacct catgctggcc cggtttgatg gccctgcccg agaggaactc cagcaagtgg
     3901 ctgcacagtt ctgttcctat cagtcaatag ccctagagct aatcaagacc aagcaacgca
     3961 aggagagtcg attccagctc ttcatgcagg aggctgagag ccaccctcag tgtcggcggc
     4021 tgcagctgag agacctcatc atctctgaga tgcagcggct caccaagtac ccgctgctgc
     4081 tggagagcat catcaagcac acagagggtg gcacctctga gcatgagaag ctgtgccggg
     4141 cccgggacca gtgccgggag attctcaagt atgtgaatga agcggtaaaa caaacagaga
     4201 accgccaccg tttagagggc taccagaaac gcctggatgc caccgccctg gagagggcca
     4261 gcaaccccct ggcagcagag ttcaagagcc tggatcttac aaccagaaaa atgatccatg
     4321 agggacccct gacctggagg atcagcaagg ataagacctt ggacctccac gtgctgctgc
     4381 tggaggacct cctagtgctg ctacagaaac aggatgagaa gctattgctg aagtgccaca
     4441 gcaagactgc tgtgggctcc tcagacagca agcagacctt cagccccgtg ctcaagctca
     4501 atgctgtgct catccgctct gtggccacag ataaacgggc cttcttcatc atctgcacct
     4561 ccaagctggg cccaccccag atctatgagc tggttgcatt gacgtcatca gacaagaaca
     4621 catggatgga gctcttagaa gaggccgtgc ggaatgccac caggcacccc ggagctgccc
     4681 caatgcccgt ccatcctcca cccccaggtc cccgggagcc agcccagcag ggccccacac
     4741 ccagcagggt agaactggat gactcagacg tgttccatgg tgaacctgaa cctgaggagc
     4801 tgcctggagg cactgggtcc cagcagaggg tccaagggaa gcaccaggtc ctgctagagg
     4861 accctgagca ggagggcagt gcagaggaag aggaactggg tgtcctgcct tgcccttcca
     4921 catccctgga tggagagaac aggggcatca ggacaaggaa ccccatccac ttggccttcc
     4981 caggccctct gttcatggaa gggctcgctg actccgctct ggaagatgtg gagaacctgc
     5041 gacatctgat cctgtggagc ctgctgccag gtcacaccat ggaaactcag gctgcccagg
     5101 agcccgagga cgacctgaca cccacacctt ctgtcatcag cgtcacctct cacccctggg
     5161 acccaggctc cccagggcaa gcaccccctg ggggtgaagg ggacaacacc cagcttgcag
     5221 ggctggaggg ggaacggcca gagcaggaag acatgggtct ctgttctctg gaacacctac
     5281 ccccaaggac cagaaattct gggatatggg agtctccaga actggacagg aatctggctg
     5341 aagatgcttc aagcacagag gcagcaggag gttacaaagt tgtgagaaaa gctgaggtgg
     5401 caggcagcaa ggttgtccct gcactaccag agagtggcca gtcagagcct gggccacctg
     5461 aagtggaagg cggaacaaag gctacgggga actgctttta tgtcagcatg ccatcaggac
     5521 ccccggactc aagcaccgac cactcagagg cacccatgag cccccctcag cctgacagcc
     5581 tccctgcagg gcagacagag cctcagcctc agctgcaggg aggcaacgat gatccaagac
     5641 gccccagccg ctctcctcca agcctggccc tcagggacgt gggcatgatc ttccatacca
     5701 ttgagcagct cactctcaag ctcaacaggc tcaaggatat ggagctggcc cacagagagc
     5761 tgctcaagtc ccttggggga gagtcatctg gtggcaccac gcctgtgggc agtttccaca
     5821 cagaagcagc tagatggaca gatggctccc tctcacctcc cgctaaggag cccctagctt
     5881 ctgactccag gaacagccat gaactggggc cctgccctga ggatggctct gacgcccccc
     5941 tggaagacag cacagcagac gcagccgcgt caccaggacc ataaccgtac aaaccaccaa
     6001 atcctctgcg tccccactcc tccttcaggg actggcctga gaccggggca cagggtaggg
     6061 gggatcccaa cactcctccc tgtggaggag gcagttaggg aaactaggat ccagccaagg
     6121 cccgggggga gacccgcatg ttgcttggtc tgctcaagtc ggagtcaggt ttcagtgtct
     6181 tttccctccc ttagcccaac cctccaaggc ctcatgtctc ctaagcatgc tgactgcatc
     6241 cgaaaggccc ccactcacca tggtctgccc tcaccccaca tatgtgtgta cacgcgcacg
     6301 cctgtatgtg cgctgccctc agacatgcaa gtgaaaggag gaggcttctg tgtaaatgca
     6361 ctttcttcct cccctctttc tccataagac cccaggcaga ggtgggtgcc tcccctcccc
     6421 tctttgtcac tttggtttcc tataaatatg tatgtatcgt atgtgcatct ttgctattgt
     6481 aaataacttt gacctttttt gttcctgttc ctgaagtgct ggaggcagtt atggaaggag
     6541 ctgcttaggg aagaggggtt tcacttgtat ctccttagtt aacaacccag ttccaggatc
     6601 gagcctaaag cgggagccag gcctgagtgt tcctgtccct gtgagtggga aggtcttctg
     6661 gctccccatc ccacctggct ccagagcctg ccctccacag cttgctgcca agctactccc
     6721 tccctccctg gacttctcat cttcacaaga tggggatcat gggggtttct taccccacct
     6781 atgtccccct cttccccacc ctgtccctgt agaaaaccag tgaagcaggt acggagctga
     6841 ggactgggcc ccaggaggtg gggacagggg tctgaatgcc gagtccctga attcacccag
     6901 gaccatccaa ggggccaccg cagcattggc cccatcacca cgtcctcacc caactctccc
     6961 tgatgaatag aatatacaca ctgtgctagg tgtatatata catatatata tatataaata
     7021 tatatataat atataaaata tagatatgga aatgactgtt ctgctgttaa gataatgtat
     7081 actcttttat tttcttcctt tcatggttaa gatttttttt ttaagaaaag ttaaatatcc
     7141 ttca
//
