LOCUS       XM_011510189            5390 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens Rho guanine nucleotide exchange factor 11
            (ARHGEF11), transcript variant X22, mRNA.
ACCESSION   XM_011510189
VERSION     XM_011510189.4
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000001.11) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011510189.3.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5390
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
     gene            1..5390
                     /gene="ARHGEF11"
                     /gene_synonym="GTRAP48; PDZ-RHOGEF"
                     /note="Rho guanine nucleotide exchange factor 11; Derived
                     by automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 44 ESTs, 290 long SRA reads, and 100% coverage of the
                     annotated genomic feature by RNAseq alignments, including
                     4 samples with support for all annotated introns"
                     /db_xref="GeneID:9826"
                     /db_xref="HGNC:HGNC:14580"
                     /db_xref="MIM:605708"
     CDS             1393..4230
                     /gene="ARHGEF11"
                     /gene_synonym="GTRAP48; PDZ-RHOGEF"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 11
                     isoform X22"
                     /protein_id="XP_011508491.1"
                     /db_xref="GeneID:9826"
                     /db_xref="HGNC:HGNC:14580"
                     /db_xref="MIM:605708"
                     /translation="MFRRRTCGTEASLRWSHSLLSLPPSSRSEIRLGRSESLKGREEM
                     KRSRKAENVPRSRSDVDMDAAAEATRLHQSASSSTSSLSTRSLENPTPPFTPKMGRRS
                     IESPSLGFCTDTLLPHLLEDDLGQLSDLEPEPDAQNWQHTVGKDVVAGLTQREIDRQE
                     VINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNSWCEA
                     MKKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQRKESRF
                     QLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCRARD
                     QCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIHE
                     GPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQTFSPVLK
                     LNAVLIRSVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRNATRHP
                     GAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQGKH
                     QVLLEDPEQEGSAEEEELGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEGLADSA
                     LEDVENLRHLILWSLLPGHTMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQAPPG
                     GEGDNTQLAGLEGERPEQEDMGLCSLEHLPPRTRNSGIWESPELDRNLAEDASSTEAA
                     GGYKVVRKAEVAGSKVVPALPESGQSEPGPPEVEGGTKATGNCFYVSMPSGPPDSSTD
                     HSEAPMSPPQPDSLPAGQTEPQPQLQGGNDDPRRPSRSPPSLALRDVGMIFHTIEQLT
                     LKLNRLKDMELAHRELLKSLGGESSGGTTPVGSFHTEAARWTDGSLSPPAKEPLASDS
                     RNSHELGPCPEDGSDAPLEDSTADAAASPGP"
ORIGIN      
        1 tgctaggtaa atttgcccta agacacttgc taggatccta aagctactct aagcagaagc
       61 ctttgggttt gatgattatc aactcattgg caatctcaga agaaatagta ttagcaatat
      121 ggtgggtcag agattgttgt agatactcaa caggtataag atgccccagt tctagaaggc
      181 aataccctag gaatttgggg gcaaagacag atgatatgcc tcacttcttg gtgaggagca
      241 ttacttactt ctgggtgctt gaaggaaggt gcttagctct gcagccccag taactccact
      301 gggtgtttgt tgtggtggta cagtgaccca ttaggacact gaaaagtgtt ccgagttagt
      361 ctgggttggg attgttctaa cacaattctg gagggtgaat tcaataaggg atcagtgggc
      421 agtatgtttt ctaaccctgc agacaaaacc ctcaggaccc taggagatga gctccatttt
      481 ggatcatctg gcagtttggg cacaatgaat ggagaccgag acatttagct cctcattgca
      541 gcaacctgct gtgctattaa gagctctgca gacatttcca ggcctcctgt ggtcctagaa
      601 gcagagcagg atgtagatta ctaataatat cagaaaacca gcccaacagg gccacagcat
      661 ggaggtgggg tgaccatcct ggggcagcta ggggtcagag gtgccagctg tcttgggctg
      721 atgcactgca ggactcgaca ccgcaacacc cagtcatcag catctcatca aaccccagag
      781 acactcagta gccaagcacg gcaggccaag gagcgggtcc tgcctatcag taaaaaggcc
      841 cctttaagca caagcctgtc tgctcttgag aggaaatgga atcttaggaa cagtattgtt
      901 aagataagaa tggaactcat ccacatcaca actggaaggc taagaatcca gcagcagata
      961 gaactttctg acaggcagtg tggaaaatcc taaaatgagc tgtgaatata gtgactccac
     1021 tttcctctta agacctctta aaagaggttc gcctcaggca gagttaaagg tgggagctga
     1081 cccgttccaa agcagaggca acgtgaactg gccactaggg gcagggagct gggaccttgt
     1141 gttccctgtt gagggacgat gatgtctacc accttcttga cagaagcatg gtgtctcagg
     1201 cctctggaca cactacaact cagagtctgt tagccccaga tttcatcttc ctgttaggat
     1261 cccttcctaa tagctccaga ggaagatgac tgtccatcca tcaggctagg ctggggagag
     1321 aggaggagtt tgtagagcag caaaaatagt ctgtcattga gaagcttcca ctgccatcca
     1381 gctgctttgg ccatgttcag gaggagaacc tgtggcacgg aggcatcttt gagatggagc
     1441 cacagtcttt tgtcccttcc ccccagttca cgctcagaga ttcgcctggg ccgctctgaa
     1501 agcctcaagg gccgggaaga gatgaaacgg tctcgaaagg cagagaacgt gccccgctct
     1561 cgcagtgatg ttgacatgga tgctgctgcg gaggctactc gcctgcacca gtcagcctcg
     1621 tcctctacct ccagcctctc caccaggtct cttgagaacc caacccctcc attcactccc
     1681 aaaatgggcc gcaggagcat tgagtccccc agtttggggt tctgcacaga taccctcctt
     1741 ccccacctcc tagaggatga tctgggccag ctgtctgacc tggagccaga gccagatgcc
     1801 caaaattggc agcatacagt gggcaaggat gtggtggctg ggctaaccca gcgggagatt
     1861 gaccggcaag aggtcatcaa tgagctgttt gtgactgaag cttcccacct gcgcacactc
     1921 cgggtcctgg acctgatctt ctaccagcga atgaagaagg agaacctgat gccccgggag
     1981 gagctggccc ggctcttccc gaacctgcct gaactcatag agattcacaa ttcctggtgt
     2041 gaagccatga agaagctccg ggaggaaggc cccatcatca aagagatcag tgacctcatg
     2101 ctggcccggt ttgatggccc tgcccgagag gaactccagc aagtggctgc acagttctgt
     2161 tcctatcagt caatagccct agagctaatc aagaccaagc aacgcaagga gagtcgattc
     2221 cagctcttca tgcaggaggc tgagagccac cctcagtgtc ggcggctgca gctgagagac
     2281 ctcatcatct ctgagatgca gcggctcacc aagtacccgc tgctgctgga gagcatcatc
     2341 aagcacacag agggtggcac ctctgagcat gagaagctgt gccgggcccg ggaccagtgc
     2401 cgggagattc tcaagtatgt gaatgaagcg gtaaaacaaa cagagaaccg ccaccgttta
     2461 gagggctacc agaaacgcct ggatgccacc gccctggaga gggccagcaa ccccctggca
     2521 gcagagttca agagcctgga tcttacaacc agaaaaatga tccatgaggg acccctgacc
     2581 tggaggatca gcaaggataa gaccttggac ctccacgtgc tgctgctgga ggacctccta
     2641 gtgctgctac agaaacagga tgagaagcta ttgctgaagt gccacagcaa gactgctgtg
     2701 ggctcctcag acagcaagca gaccttcagc cccgtgctca agctcaatgc tgtgctcatc
     2761 cgctctgtgg ccacagataa acgggccttc ttcatcatct gcacctccaa gctgggccca
     2821 ccccagatct atgagctggt tgcattgacg tcatcagaca agaacacatg gatggagctc
     2881 ttagaagagg ccgtgcggaa tgccaccagg caccccggag ctgccccaat gcccgtccat
     2941 cctccacccc caggtccccg ggagccagcc cagcagggcc ccacacccag cagggtagaa
     3001 ctggatgact cagacgtgtt ccatggtgaa cctgaacctg aggagctgcc tggaggcact
     3061 gggtcccagc agagggtcca agggaagcac caggtcctgc tagaggaccc tgagcaggag
     3121 ggcagtgcag aggaagagga actgggtgtc ctgccttgcc cttccacatc cctggatgga
     3181 gagaacaggg gcatcaggac aaggaacccc atccacttgg ccttcccagg ccctctgttc
     3241 atggaagggc tcgctgactc cgctctggaa gatgtggaga acctgcgaca tctgatcctg
     3301 tggagcctgc tgccaggtca caccatggaa actcaggctg cccaggagcc cgaggacgac
     3361 ctgacaccca caccttctgt catcagcgtc acctctcacc cctgggaccc aggctcccca
     3421 gggcaagcac cccctggggg tgaaggggac aacacccagc ttgcagggct ggagggggaa
     3481 cggccagagc aggaagacat gggtctctgt tctctggaac acctaccccc aaggaccaga
     3541 aattctggga tatgggagtc tccagaactg gacaggaatc tggctgaaga tgcttcaagc
     3601 acagaggcag caggaggtta caaagttgtg agaaaagctg aggtggcagg cagcaaggtt
     3661 gtccctgcac taccagagag tggccagtca gagcctgggc cacctgaagt ggaaggcgga
     3721 acaaaggcta cggggaactg cttttatgtc agcatgccat caggaccccc ggactcaagc
     3781 accgaccact cagaggcacc catgagcccc cctcagcctg acagcctccc tgcagggcag
     3841 acagagcctc agcctcagct gcagggaggc aacgatgatc caagacgccc cagccgctct
     3901 cctccaagcc tggccctcag ggacgtgggc atgatcttcc ataccattga gcagctcact
     3961 ctcaagctca acaggctcaa ggatatggag ctggcccaca gagagctgct caagtccctt
     4021 gggggagagt catctggtgg caccacgcct gtgggcagtt tccacacaga agcagctaga
     4081 tggacagatg gctccctctc acctcccgct aaggagcccc tagcttctga ctccaggaac
     4141 agccatgaac tggggccctg ccctgaggat ggctctgacg cccccctgga agacagcaca
     4201 gcagacgcag ccgcgtcacc aggaccataa ccgtacaaac caccaaatcc tctgcgtccc
     4261 cactcctcct tcagggactg gcctgagacc ggggcacagg gtagggggga tcccaacact
     4321 cctccctgtg gaggaggcag ttagggaaac taggatccag ccaaggcccg gggggagacc
     4381 cgcatgttgc ttggtctgct caagtcggag tcaggtttca gtgtcttttc cctcccttag
     4441 cccaaccctc caaggcctca tgtctcctaa gcatgctgac tgcatccgaa aggcccccac
     4501 tcaccatggt ctgccctcac cccacatatg tgtgtacacg cgcacgcctg tatgtgcgct
     4561 gccctcagac atgcaagtga aaggaggagg cttctgtgta aatgcacttt cttcctcccc
     4621 tctttctcca taagacccca ggcagaggtg ggtgcctccc ctcccctctt tgtcactttg
     4681 gtttcctata aatatgtatg tatcgtatgt gcatctttgc tattgtaaat aactttgacc
     4741 ttttttgttc ctgttcctga agtgctggag gcagttatgg aaggagctgc ttagggaaga
     4801 ggggtttcac ttgtatctcc ttagttaaca acccagttcc aggatcgagc ctaaagcggg
     4861 agccaggcct gagtgttcct gtccctgtga gtgggaaggt cttctggctc cccatcccac
     4921 ctggctccag agcctgccct ccacagcttg ctgccaagct actccctccc tccctggact
     4981 tctcatcttc acaagatggg gatcatgggg gtttcttacc ccacctatgt ccccctcttc
     5041 cccaccctgt ccctgtagaa aaccagtgaa gcaggtacgg agctgaggac tgggccccag
     5101 gaggtgggga caggggtctg aatgccgagt ccctgaattc acccaggacc atccaagggg
     5161 ccaccgcagc attggcccca tcaccacgtc ctcacccaac tctccctgat gaatagaata
     5221 tacacactgt gctaggtgta tatatacata tatatatata taaatatata tataatatat
     5281 aaaatataga tatggaaatg actgttctgc tgttaagata atgtatactc ttttattttc
     5341 ttcctttcat ggttaagatt ttttttttaa gaaaagttaa atatccttca
//
