LOCUS       NM_018125               4625 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens Rho guanine nucleotide exchange factor 10 like
            (ARHGEF10L), transcript variant 1, mRNA.
ACCESSION   NM_018125
VERSION     NM_018125.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4625)
  AUTHORS   Wang,D.W., Tang,J.Y., Zhang,G.Q. and Chang,X.T.
  TITLE     ARHGEF10L expression regulates cell proliferation and migration in
            gastric tumorigenesis
  JOURNAL   Biosci Biotechnol Biochem 84 (7), 1362-1372 (2020)
   PUBMED   32154766
  REMARK    GeneRIF: ARHGEF10L expression regulates cell proliferation and
            migration in gastric tumorigenesis.
REFERENCE   2  (bases 1 to 4625)
  AUTHORS   Tang,J., Liu,C., Xu,B., Wang,D., Ma,Z. and Chang,X.
  TITLE     ARHGEF10L contributes to liver tumorigenesis through RhoA-ROCK1
            signaling and the epithelial-mesenchymal transition
  JOURNAL   Exp Cell Res 374 (1), 46-68 (2019)
   PUBMED   30444969
  REMARK    GeneRIF: increased expression of ARHGEF10L stimulates
            hepatocellular tumorigenesis by activating the RhoA-ROCK1- phospho
            Ezrin/Radixin/Moesin pathway and epithelial-mesenchymal transition.
REFERENCE   3  (bases 1 to 4625)
  AUTHORS   Earp,M., Tyrer,J.P., Winham,S.J., Lin,H.Y., Chornokur,G.,
            Dennis,J., Aben,K.K.H., Anton-Culver,H., Antonenkova,N.,
            Bandera,E.V., Bean,Y.T., Beckmann,M.W., Bjorge,L., Bogdanova,N.,
            Brinton,L.A., Brooks-Wilson,A., Bruinsma,F., Bunker,C.H.,
            Butzow,R., Campbell,I.G., Carty,K., Chang-Claude,J., Cook,L.S.,
            Cramer,D.W., Cunningham,J.M., Cybulski,C., Dansonka-Mieszkowska,A.,
            Despierre,E., Doherty,J.A., Dork,T., du Bois,A., Durst,M.,
            Easton,D.F., Eccles,D.M., Edwards,R.P., Ekici,A.B., Fasching,P.A.,
            Fridley,B.L., Gentry-Maharaj,A., Giles,G.G., Glasspool,R.,
            Goodman,M.T., Gronwald,J., Harter,P., Hein,A., Heitz,F.,
            Hildebrandt,M.A.T., Hillemanns,P., Hogdall,C.K., Hogdall,E.,
            Hosono,S., Iversen,E.S., Jakubowska,A., Jensen,A., Ji,B.T.,
            Jung,A.Y., Karlan,B.Y., Kellar,M., Kiemeney,L.A., Kiong Lim,B.,
            Kjaer,S.K., Krakstad,C., Kupryjanczyk,J., Lambrechts,D.,
            Lambrechts,S., Le,N.D., Lele,S., Lester,J., Levine,D.A., Li,Z.,
            Liang,D., Lissowska,J., Lu,K., Lubinski,J., Lundvall,L.,
            Massuger,L.F.A.G., Matsuo,K., McGuire,V., McLaughlin,J.R.,
            McNeish,I., Menon,U., Milne,R.L., Modugno,F., Moysich,K.B.,
            Ness,R.B., Nevanlinna,H., Odunsi,K., Olson,S.H., Orlow,I.,
            Orsulic,S., Paul,J., Pejovic,T., Pelttari,L.M., Permuth,J.B.,
            Pike,M.C., Poole,E.M., Rosen,B., Rossing,M.A., Rothstein,J.H.,
            Runnebaum,I.B., Rzepecka,I.K., Schernhammer,E., Schwaab,I.,
            Shu,X.O., Shvetsov,Y.B., Siddiqui,N., Sieh,W., Song,H.,
            Southey,M.C., Spiewankiewicz,B., Sucheston-Campbell,L.,
            Tangen,I.L., Teo,S.H., Terry,K.L., Thompson,P.J., Thomsen,L.,
            Tworoger,S.S., van Altena,A.M., Vergote,I., Vestrheim Thomsen,L.C.,
            Vierkant,R.A., Walsh,C.S., Wang-Gohrke,S., Wentzensen,N.,
            Whittemore,A.S., Wicklund,K.G., Wilkens,L.R., Woo,Y.L., Wu,A.H.,
            Wu,X., Xiang,Y.B., Yang,H., Zheng,W., Ziogas,A., Lee,A.W.,
            Pearce,C.L., Berchuck,A., Schildkraut,J.M., Ramus,S.J.,
            Monteiro,A.N.A., Narod,S.A., Sellers,T.A., Gayther,S.A.,
            Kelemen,L.E., Chenevix-Trench,G., Risch,H.A., Pharoah,P.D.P.,
            Goode,E.L. and Phelan,C.M.
  TITLE     Variants in genes encoding small GTPases and association with
            epithelial ovarian cancer susceptibility
  JOURNAL   PLoS One 13 (7), e0197561 (2018)
   PUBMED   29979793
  REMARK    GeneRIF: Inherited variants in ARHGEF10L and AKAP6, with potential
            transcriptional regulatory function and association with Epithelial
            ovarian cancer risk, warrant investigation in independent
            Epithelial ovarian cancer study populations.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4625)
  AUTHORS   Lange,C.M., Kutalik,Z., Morikawa,K., Bibert,S., Cerny,A.,
            Dollenmaier,G., Dufour,J.F., Gerlach,T.J., Heim,M.H.,
            Malinverni,R., Mullhaupt,B., Negro,F., Moradpour,D. and Bochud,P.Y.
  CONSRTM   Swiss Hepatitis C Cohort Study Group
  TITLE     Serum ferritin levels are associated with a distinct phenotype of
            chronic hepatitis C poorly responding to pegylated interferon-alpha
            and ribavirin therapy
  JOURNAL   Hepatology 55 (4), 1038-1047 (2012)
   PUBMED   22095909
REFERENCE   5  (bases 1 to 4625)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   6  (bases 1 to 4625)
  AUTHORS   Takefuji,M., Asano,H., Mori,K., Amano,M., Kato,K., Watanabe,T.,
            Morita,Y., Katsumi,A., Itoh,T., Takenawa,T., Hirashiki,A.,
            Izawa,H., Nagata,K., Hirayama,H., Takatsu,F., Naoe,T., Yokota,M.
            and Kaibuchi,K.
  TITLE     Mutation of ARHGAP9 in patients with coronary spastic angina
  JOURNAL   J Hum Genet 55 (1), 42-49 (2010)
   PUBMED   19911011
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4625)
  AUTHORS   Stacey,S.N., Gudbjartsson,D.F., Sulem,P., Bergthorsson,J.T.,
            Kumar,R., Thorleifsson,G., Sigurdsson,A., Jakobsdottir,M.,
            Sigurgeirsson,B., Benediktsdottir,K.R., Thorisdottir,K.,
            Ragnarsson,R., Scherer,D., Rudnai,P., Gurzau,E., Koppova,K.,
            Hoiom,V., Botella-Estrada,R., Soriano,V., Juberias,P., Grasa,M.,
            Carapeto,F.J., Tabuenca,P., Gilaberte,Y., Gudmundsson,J.,
            Thorlacius,S., Helgason,A., Thorlacius,T., Jonasdottir,A.,
            Blondal,T., Gudjonsson,S.A., Jonsson,G.F., Saemundsdottir,J.,
            Kristjansson,K., Bjornsdottir,G., Sveinsdottir,S.G., Mouy,M.,
            Geller,F., Nagore,E., Mayordomo,J.I., Hansson,J., Rafnar,T.,
            Kong,A., Olafsson,J.H., Thorsteinsdottir,U. and Stefansson,K.
  TITLE     Common variants on 1p36 and 1q42 are associated with cutaneous
            basal cell carcinoma but not with melanoma or pigmentation traits
  JOURNAL   Nat Genet 40 (11), 1313-1318 (2008)
   PUBMED   18849993
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   8  (bases 1 to 4625)
  AUTHORS   Winkler,S., Mohl,M., Wieland,T. and Lutz,S.
  TITLE     GrinchGEF--a novel Rho-specific guanine nucleotide exchange factor
  JOURNAL   Biochem Biophys Res Commun 335 (4), 1280-1286 (2005)
   PUBMED   16112081
  REMARK    GeneRIF: In intact cells, GrinchGEF induced specifically Rho
            activation and enhanced RhoA-C-specific downstream effects.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL390994.30, AB046846.1,
            BC065561.1, AK092020.1 and AW455769.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_018125.3.
            
            Summary: This gene belongs to the RhoGEF subfamily of RhoGTPases.
            Members of this subfamily are activated by specific guanine
            nucleotide exchange factors (GEFs) and are involved in signal
            transduction. The encoded protein shows cytosolic distribution.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jun 2016].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB046846.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361221.8/ ENSP00000355060.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               AL390994.30        79378-79514
            138-2056            AB046846.1         1-1919
            2057-3625           BC065561.1         422-1990
            3626-4383           AK092020.1         2477-3234
            4384-4625           AW455769.1         244-485
FEATURES             Location/Qualifiers
     source          1..4625
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.13"
     gene            1..4625
                     /gene="ARHGEF10L"
                     /gene_synonym="GrinchGEF"
                     /note="Rho guanine nucleotide exchange factor 10 like"
                     /db_xref="GeneID:55160"
                     /db_xref="HGNC:HGNC:25540"
                     /db_xref="MIM:612494"
     exon            1..253
                     /gene="ARHGEF10L"
                     /gene_synonym="GrinchGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            254..333
                     /gene="ARHGEF10L"
                     /gene_synonym="GrinchGEF"
                     /inference="alignment:Splign:2.1.0"
     CDS             297..4136
                     /gene="ARHGEF10L"
                     /gene_synonym="GrinchGEF"
                     /note="isoform 1 is encoded by transcript variant 1; rho
                     guanine nucleotide exchange factor 10-like protein; Rho
                     guanine nucleotide exchange factor (GEF) 10-like"
                     /codon_start=1
                     /product="rho guanine nucleotide exchange factor 10-like
                     protein isoform 1"
                     /protein_id="NP_060595.3"
                     /db_xref="CCDS:CCDS182.1"
                     /db_xref="GeneID:55160"
                     /db_xref="HGNC:HGNC:25540"
                     /db_xref="MIM:612494"
                     /translation="MASSNPPPQPAIGDQLVPGVPGPSSEAEDDPGEAFEFDDSDDEE
                     DTSAALGVPSLAPERDTDPPLIHLDSIPVTDPDPAAAPPGTGVPAWVSNGDAADAAFS
                     GARHSSWKRKSSRRIDRFTFPALEEDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGA
                     PRQAEDLGWSSSEFESYSEDSGEEAKPEVEVEPAKHRVSFQPKLSPDLTRLKERYART
                     KRDILALRVGGRDMQELKHKYDCKMTQLMKAAKSGTKDGLEKTRMAVMRKVSFLHRKD
                     VLGDSEEEDMGLLEVSVSDIKPPAPELGPMPEGLSPQQVVRRHILGSIVQSEGSYVES
                     LKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEK
                     IGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPAFLEFLKRRQVCSPDRVT
                     LYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLAD
                     QVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLN
                     DMLVCANINFKPANHRGQLEISSLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDN
                     VLIQHSGAKKASASGQAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQN
                     LNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKPDKSGRPISFMVVFITPNP
                     LSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWCPILACCIPAFSSRALSLQ
                     LGALVHSPVNCPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRPSPRTVKSFP
                     LAAPVLCMEYIPELEEEAESRDESPTVADPSATVHPTICLGLQDGSILLYSSVDTGTQ
                     CLVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAAYPRTSGGVLWDLESPPVCLTVGPG
                     PVRTLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQDEAVSVTHMVKAGSGVWMAF
                     SSGTSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQGLLWVGTDQGVIV
                     LLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVATSILAPDILRSDQEEAEGPRAEED
                     KPDGQAHEPMPDSHVGRELTRKKGILLQYRLRSTAHLPGPLLSMREPAPADGAALEHS
                     EEDGSIYEMADDPDIWVRSRPCARDAHRKEICSVAIISGGQGYRNFGSALGSSGRQAP
                     CGETDSTLLIWQVPLML"
     exon            334..519
                     /gene="ARHGEF10L"
                     /gene_synonym="GrinchGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            520..553
                     /gene="ARHGEF10L"
                     /gene_synonym="GrinchGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            554..645
                     /gene="ARHGEF10L"
                     /gene_synonym="GrinchGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            646..729
                     /gene="ARHGEF10L"
                     /gene_synonym="GrinchGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            730..905
                     /gene="ARHGEF10L"
                     /gene_synonym="GrinchGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1022
                     /gene="ARHGEF10L"
                     /gene_synonym="GrinchGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1131
                     /gene="ARHGEF10L"
                     /gene_synonym="GrinchGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..1238
                     /gene="ARHGEF10L"
                     /gene_synonym="GrinchGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1316
                     /gene="ARHGEF10L"
                     /gene_synonym="GrinchGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1496
                     /gene="ARHGEF10L"
                     /gene_synonym="GrinchGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1613
                     /gene="ARHGEF10L"
                     /gene_synonym="GrinchGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1706
                     /gene="ARHGEF10L"
                     /gene_synonym="GrinchGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1880
                     /gene="ARHGEF10L"
                     /gene_synonym="GrinchGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2026
                     /gene="ARHGEF10L"
                     /gene_synonym="GrinchGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2041
                     /gene="ARHGEF10L"
                     /gene_synonym="GrinchGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2223
                     /gene="ARHGEF10L"
                     /gene_synonym="GrinchGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2339
                     /gene="ARHGEF10L"
                     /gene_synonym="GrinchGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2467
                     /gene="ARHGEF10L"
                     /gene_synonym="GrinchGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..2568
                     /gene="ARHGEF10L"
                     /gene_synonym="GrinchGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2569..2690
                     /gene="ARHGEF10L"
                     /gene_synonym="GrinchGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..2777
                     /gene="ARHGEF10L"
                     /gene_synonym="GrinchGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            2778..3001
                     /gene="ARHGEF10L"
                     /gene_synonym="GrinchGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3002..3156
                     /gene="ARHGEF10L"
                     /gene_synonym="GrinchGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3157..3305
                     /gene="ARHGEF10L"
                     /gene_synonym="GrinchGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3306..3480
                     /gene="ARHGEF10L"
                     /gene_synonym="GrinchGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3481..3603
                     /gene="ARHGEF10L"
                     /gene_synonym="GrinchGEF"
                     /inference="alignment:Splign:2.1.0"
     exon            3604..4625
                     /gene="ARHGEF10L"
                     /gene_synonym="GrinchGEF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4600..4605
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGEF10L"
                     /gene_synonym="GrinchGEF"
                     /note="hexamer: AATAAA"
     polyA_site      4625
                     /gene="ARHGEF10L"
                     /gene_synonym="GrinchGEF"
                     /note="major polyA site"
ORIGIN      
        1 gcgtcgcgca cggcggcggc ggcgggacca ggcctcggag cgcggcgggc gcgggcgcag
       61 tcccggcggg cccggacctc gcgggcgggc gggcggcgcg gccattggct cgggtggcgg
      121 cggctgcggc ggtgggggcg ccgtcccggc catgggcgcc cgcggcggcc tgcggagctg
      181 gaggcgcggc gccggccgcc aggcgccttt gtgagcggcg cggacgacaa aggcgcgggc
      241 ccgggcagcc gaggtgtgta gctgggacgg tgctggtctg agctggacct tgtctgatgg
      301 cttcctccaa ccctcctcca cagcctgcca taggagatca gctggttcca ggagtcccag
      361 gcccctcctc tgaggcagag gacgacccag gagaggcgtt tgagtttgat gacagtgatg
      421 atgaagagga caccagcgca gccctgggcg tccccagcct tgctcctgag agggacacag
      481 accccccact gatccacttg gactccatcc ctgtcactga cccagaccca gcagctgctc
      541 cacccggcac aggggtgcca gcctgggtga gcaatgggga tgcagcggac gcagccttct
      601 ccggggcccg gcactccagc tggaagcgga agagttcccg tcgcattgac cggttcactt
      661 tccccgccct ggaagaggat gtgatttatg acgacgtccc ctgcgagagc ccagatgcgc
      721 atcagcccgg ggcagagagg aacctgctct acgaggatgc gcaccgggct ggggcccctc
      781 ggcaggcgga ggacctaggc tggagctcca gtgagttcga gagctacagc gaggactcgg
      841 gggaggaggc caagccggag gtcgaggtcg agcccgccaa gcaccgagtg tccttccagc
      901 ccaagctttc tccagacctg actaggctaa aggagagata cgccaggact aagagagaca
      961 tcttggcttt gagagttggg gggagagaca tgcaggagct gaagcacaag tacgattgta
     1021 agatgaccca gctcatgaag gccgccaaga gcgggaccaa ggatgggctg gagaagacac
     1081 ggatggccgt gatgcgcaaa gtctccttcc tgcacaggaa ggacgtcctc ggtgactcgg
     1141 aggaggagga catggggctc ctggaggtca gcgtttcgga catcaagccc ccagccccag
     1201 agctgggccc catgccagag ggcctgagcc ctcagcaggt ggtccggagg catatcctgg
     1261 gctccatcgt gcagagcgaa ggcagctacg tggagtctct gaagcggata ctccaggact
     1321 accgcaaccc cctgatggag atggagccca aggcgctgag cgcccgcaag tgccaggtgg
     1381 tgttcttccg cgtgaaggag atcctgcact gccactccat gttccagatc gccctgtcct
     1441 cccgcgtggc tgagtgggat tccaccgaga agatcgggga cctcttcgtg gcctcgtttt
     1501 ccaagtccat ggtgctagat gtgtacagtg actacgtgaa caacttcacc agtgccatgt
     1561 ccatcatcaa gaaggcctgc ctcaccaagc ctgccttcct cgagttcctc aagcgacggc
     1621 aggtgtgcag cccagaccgt gtcaccctct acgggctgat ggtcaagccc atccagaggt
     1681 tcccacagtt catactcctg cttcaggaca tgctgaagaa cacccccagg ggccatccgg
     1741 acaggctgtc gctgcagctg gccctcacag agctggagac gctggctgag aagctgaacg
     1801 agcagaagcg gctggctgac caggtggctg agatccagca gctgaccaag agcgtcagtg
     1861 accgcagcag cctcaacaag ctgttgacct caggccagcg gcagctgctc ctgtgtgaga
     1921 cgttgacgga gaccgtgtac ggtgaccgcg ggcagctaat taagtccaag gagcgtcggg
     1981 tcttcctgct caacgacatg cttgtctgtg ccaacatcaa cttcaagcct gccaaccaca
     2041 ggggccagct ggagatcagc agcctggtgc ccctggggcc caagtatgtg gtgaagtgga
     2101 acacggcgct gccccaggtg caggtggtgg aggtgggcca ggacggtggc acctatgaca
     2161 aggacaatgt gctcatccag cactcaggcg ccaagaaggc ctctgcctca gggcaggctc
     2221 agaataaggt gtacctcggc cccccacgcc tcttccagga gctgcaggac ctgcagaagg
     2281 acctggccgt ggtggagcag atcacgcttc tcatcagcac gctgcacggc acctaccaga
     2341 acctgaacat gactgtggct caagactggt gcctggccct gcagaggctg atgcgggtga
     2401 aggaggaaga gatccactcg gccaacaagt gccgtctcag gctcctgctt cctgggaaac
     2461 ccgacaagtc cggccgcccc attagcttca tggtggtttt catcaccccc aaccccctga
     2521 gcaagatttc ctgggtcaac aggttacatt tggccaaaat cggactccgg gaggagaacc
     2581 agccaggctg gctatgcccg gatgaggaca agaagagcaa agccccattc tggtgcccga
     2641 tcctggcctg ctgcatccct gccttctcct cccgggcact cagcctgcag cttggggccc
     2701 tggtccacag tcctgtcaac tgtcccctgc tgggtttctc agcagtcagc acctcccttc
     2761 cacagggcta cctctgggtc gggggcggac aggaaggcgc agggggccag gtggaaatct
     2821 tttccttgaa ccggccctcg ccccgcaccg tcaagtcctt cccactggca gcccctgtgc
     2881 tctgcatgga gtatatcccg gagctggagg aggaggcgga gagcagagac gagagcccga
     2941 cagttgctga cccctcggcc acggtgcatc caaccatctg cctcgggctc caggatggca
     3001 gcatcctcct ctacagcagt gtggacactg gcacccagtg cctggtgagc tgcaggagcc
     3061 caggtctgca gcctgtgctc tgcctgcgac acagcccctt ccacctgctc gctggcctgc
     3121 aggatgggac ccttgctgct taccctcgga ccagcggagg tgtcctgtgg gacctggaga
     3181 gccctcccgt gtgcctgact gtggggcccg ggcctgtccg caccctgttg agcctggagg
     3241 atgccgtgtg ggccagctgt gggccccggg tcactgtcct ggaagccacc accctgcagc
     3301 ctcagcaaag cttcgaggcg caccaggacg aggcagtgag cgtgacacac atggtgaagg
     3361 cgggcagcgg cgtctggatg gccttctcct ccggcacctc catccgcctc ttccacactg
     3421 agaccctgga gcatctgcaa gagatcaaca tcgccaccag gaccaccttc ctcctgccag
     3481 gccagaagca cttgtgtgtc accagcctcc tgatctgcca gggtctgctc tgggtgggca
     3541 ctgaccaggg tgtcatcgtc ctgctgcccg tgcctcggct ggaaggcatc cccaagatca
     3601 cagggaaagg catggtctca ctcaacgggc actgtgggcc tgtggccttc ctggctgtgg
     3661 ctaccagcat cctggcccct gacatcctgc ggagtgacca ggaggaggct gaggggcccc
     3721 gggctgagga ggacaagcca gacgggcagg cacacgagcc catgcccgat agccacgtgg
     3781 gccgagagct gacccgcaag aagggcatcc tcttgcagta ccgcctgcgc tccaccgcac
     3841 acctcccggg cccgctgctc tccatgcggg agccggcgcc tgctgatggc gcagctttgg
     3901 agcacagcga ggaggacggc tccatttacg agatggccga cgaccccgac atctgggtgc
     3961 gcagccggcc ctgcgcccgc gacgcccacc gcaaggagat ttgctctgtg gccatcatct
     4021 ccggcgggca gggctaccgc aactttggca gcgctctggg cagcagtggg aggcaggccc
     4081 cgtgtgggga gacggacagc accctcctca tctggcaggt gcccttgatg ctatagcgcc
     4141 tcccctctcc cctcagaggg cacagctgca ggcctgacca aggccacgcc cggctctcgt
     4201 gctctaggac ctgcacggga cttgtggatg ggcctggact ctccagaaac tacttgggca
     4261 gagcaaagga aaacctcttg ttttaaaaaa atttttttca gagtgttttg gggaggagtt
     4321 ttagggcttg gggagaggga ggacacatct ggaggaaatg gccttctttt taaaagcaaa
     4381 aaacacaaaa cctcacaact gcctggcaag cccagtatca cttgtttggg ccctagcggg
     4441 actccaaggc agccacacgc ccctcctgga agggtgtgtg cgtgtgagtg tgtgcgagtg
     4501 tgtgggctgg tgtgtgaata tctataaata agtatatatg gtgtatatta tatgtgtata
     4561 aataaagtct gtacatattg gagctctggg agatgctgga ataaaagaca agagttacat
     4621 ctgga
//
