LOCUS       NM_001176                964 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens Rho GDP dissociation inhibitor gamma (ARHGDIG), mRNA.
ACCESSION   NM_001176
VERSION     NM_001176.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 964)
  AUTHORS   Sun,J., Zhu,Q., Yu,X., Liang,X., Guan,H., Zhao,H. and Yao,W.
  TITLE     RhoGDI3 at the trans-Golgi network participates in NLRP3
            inflammasome activation, VSMC phenotypic modulation, and neointima
            formation
  JOURNAL   Atherosclerosis 387, 117391 (2023)
   PUBMED   38029612
  REMARK    GeneRIF: RhoGDI3 at the trans-Golgi network participates in NLRP3
            inflammasome activation, VSMC phenotypic modulation, and neointima
            formation.
REFERENCE   2  (bases 1 to 964)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 964)
  AUTHORS   de Leon-Bautista,M.P., Cardenas-Aguayo,M.D., Casique-Aguirre,D.,
            Almaraz-Salinas,M., Parraguirre-Martinez,S., Olivo-Diaz,A.,
            Thompson-Bonilla,M.D. and Vargas,M.
  TITLE     Immunological and Functional Characterization of RhoGDI3 and Its
            Molecular Targets RhoG and RhoB in Human Pancreatic Cancerous and
            Normal Cells
  JOURNAL   PLoS One 11 (11), e0166370 (2016)
   PUBMED   27832197
  REMARK    GeneRIF: These results suggest that the levels of RhoG and RhoB
            GTPases and their negative regulator RhoGDI3 might be linked to the
            aggressiveness of the pancreatic cancerous cell lines. It is
            possible that RhoGDI3 could induce the downregulation of RhoG and
            RhoB.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 964)
  AUTHORS   Oshikawa,M., Tsutsui,C., Ikegami,T., Fuchida,Y., Matsubara,M.,
            Toyama,S., Usami,R., Ohtoko,K. and Kato,S.
  TITLE     Full-length transcriptome analysis of human retina-derived cell
            lines ARPE-19 and Y79 using the vector-capping method
  JOURNAL   Invest Ophthalmol Vis Sci 52 (9), 6662-6670 (2011)
   PUBMED   21697133
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 964)
  AUTHORS   Wooten,E.C., Iyer,L.K., Montefusco,M.C., Hedgepeth,A.K.,
            Payne,D.D., Kapur,N.K., Housman,D.E., Mendelsohn,M.E. and
            Huggins,G.S.
  TITLE     Application of gene network analysis techniques identifies
            AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic
            valve
  JOURNAL   PLoS One 5 (1), e8830 (2010)
   PUBMED   20098615
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 964)
  AUTHORS   Brunet,N., Morin,A. and Olofsson,B.
  TITLE     RhoGDI-3 regulates RhoG and targets this protein to the Golgi
            complex through its unique N-terminal domain
  JOURNAL   Traffic 3 (5), 342-357 (2002)
   PUBMED   11967128
REFERENCE   7  (bases 1 to 964)
  AUTHORS   Daniels,R.J., Peden,J.F., Lloyd,C., Horsley,S.W., Clark,K.,
            Tufarelli,C., Kearney,L., Buckle,V.J., Doggett,N.A., Flint,J. and
            Higgs,D.R.
  TITLE     Sequence, structure and pathology of the fully annotated terminal 2
            Mb of the short arm of human chromosome 16
  JOURNAL   Hum Mol Genet 10 (4), 339-352 (2001)
   PUBMED   11157797
REFERENCE   8  (bases 1 to 964)
  AUTHORS   Adra,C.N., Iyengar,A.R., Syed,F.A., Kanaan,I.N., Rilo,H.L., Yu,W.,
            Kheraj,R., Lin,S.R., Horiuchi,T., Khan,S., Weremowicz,S., Lim,B.,
            Morton,C.C. and Higgs,D.R.
  TITLE     Human ARHGDIG, a GDP-dissociation inhibitor for Rho proteins:
            genomic structure, sequence, expression analysis, and mapping to
            chromosome 16p13.3
  JOURNAL   Genomics 53 (1), 104-109 (1998)
   PUBMED   9787082
REFERENCE   9  (bases 1 to 964)
  AUTHORS   Adra,C.N., Manor,D., Ko,J.L., Zhu,S., Horiuchi,T., Van Aelst,L.,
            Cerione,R.A. and Lim,B.
  TITLE     RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with
            preferential expression in brain and pancreas
  JOURNAL   Proc Natl Acad Sci U S A 94 (9), 4279-4284 (1997)
   PUBMED   9113980
REFERENCE   10 (bases 1 to 964)
  AUTHORS   Zalcman,G., Closson,V., Camonis,J., Honore,N., Rousseau-Merck,M.F.,
            Tavitian,A. and Olofsson,B.
  TITLE     RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification
            of a non-cytosolic GDI protein interacting with the small
            GTP-binding proteins RhoB and RhoG
  JOURNAL   J Biol Chem 271 (48), 30366-30374 (1996)
   PUBMED   8939998
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Z69667.1, BC047699.1 and BM662457.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001176.3.
            
            Summary: The GDP-dissociation inhibitors (GDIs) play a primary role
            in modulating the activation of GTPases by inhibiting the exchange
            of GDP for GTP. See ARHGDIB (MIM 602843).[supplied by OMIM, Nov
            2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB593111.1, ERR279844.8487.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000219409.8/ ENSP00000219409.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                Z69667.1           18191-18205
            16-72               BC047699.1         1-57
            73-87               BC047699.1         59-73
            88-89               Z69667.1           18278-18279
            90-911              BC047699.1         76-897
            912-957             BM662457.1         21-66               c
            958-964             Z69667.1           20604-20610
FEATURES             Location/Qualifiers
     source          1..964
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..964
                     /gene="ARHGDIG"
                     /gene_synonym="RHOGDI-3"
                     /note="Rho GDP dissociation inhibitor gamma"
                     /db_xref="GeneID:398"
                     /db_xref="HGNC:HGNC:680"
                     /db_xref="MIM:602844"
     exon            1..163
                     /gene="ARHGDIG"
                     /gene_synonym="RHOGDI-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..768
                     /gene="ARHGDIG"
                     /gene_synonym="RHOGDI-3"
                     /note="RhoGDI gamma; rho GDI 3; rho-GDI gamma; Rho GDP
                     dissociation inhibitor (GDI) gamma"
                     /codon_start=1
                     /product="rho GDP-dissociation inhibitor 3"
                     /protein_id="NP_001167.2"
                     /db_xref="CCDS:CCDS10404.1"
                     /db_xref="GeneID:398"
                     /db_xref="HGNC:HGNC:680"
                     /db_xref="MIM:602844"
                     /translation="MLGLDACELGAQLLELLRLALCARVLLADKEGGPPAVDEVLDEA
                     VPEYRAPGRKSLLEIRQLDPDDRSLAKYKRVLLGPLPPAVDPSLPNVQVTRLTLLSEQ
                     APGPVVMDLTGDLAVLKDQVFVLKEGVDYRVKISFKVHREIVSGLKCLHHTYRRGLRV
                     DKTVYMVGSYGPSAQEYEFVTPVEEAPRGALVRGPYLVVSLFTDDDRTHHLSWEWGLC
                     ICQDWKD"
     exon            164..343
                     /gene="ARHGDIG"
                     /gene_synonym="RHOGDI-3"
                     /inference="alignment:Splign:2.1.0"
     exon            344..427
                     /gene="ARHGDIG"
                     /gene_synonym="RHOGDI-3"
                     /inference="alignment:Splign:2.1.0"
     exon            428..504
                     /gene="ARHGDIG"
                     /gene_synonym="RHOGDI-3"
                     /inference="alignment:Splign:2.1.0"
     exon            505..568
                     /gene="ARHGDIG"
                     /gene_synonym="RHOGDI-3"
                     /inference="alignment:Splign:2.1.0"
     exon            569..964
                     /gene="ARHGDIG"
                     /gene_synonym="RHOGDI-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      938..943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGDIG"
                     /gene_synonym="RHOGDI-3"
                     /note="hexamer: ATTAAA"
     polyA_site      964
                     /gene="ARHGDIG"
                     /gene_synonym="RHOGDI-3"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcgccg gggctgagcg ccgagcgggg cggcggcggg gcgggcggcg gctcctcggc
       61 ggctccgcgg cgcccgggcc gcgcgccgcc atgctgggcc tggacgcgtg cgagctgggg
      121 gcgcagctgc tggagctgct ccggctggcg ctgtgcgccc gagtcctcct ggctgacaag
      181 gagggtgggc cgccggcagt ggacgaggtg ttggatgagg ctgtgcccga gtaccgggcg
      241 ccggggagga agagcctctt ggagatccgg cagctggacc cggacgacag gagcctggcc
      301 aagtacaagc gggtgctgct ggggcccctg ccaccggccg tggacccaag cctgcccaat
      361 gtgcaggtga ccaggctgac actcctgtcg gaacaggctc cggggcccgt cgtcatggat
      421 ctcacagggg acctggctgt tctgaaggac caggtgtttg tcctgaagga aggtgttgat
      481 tacagagtga agatctcctt caaggtccac agggagattg tcagcggcct caagtgtctg
      541 caccacacct accgccgggg cctgcgcgtg gacaagaccg tctacatggt gggcagctat
      601 ggcccgagcg cccaggagta tgagtttgtg actccggtgg aggaagcgcc gaggggtgcg
      661 ctggtgcggg gcccctatct ggtggtgtcc ctcttcaccg acgatgacag gacgcaccac
      721 ctgtcctggg agtggggtct ctgcatctgc caggactgga aggactgaac ccccagtccg
      781 tgtctcccct acctccctca gttgttgcac agggaccccc aagcatcccc agcacccccc
      841 gtgagtgacc agaccctccc ctgctgcccc tgctgcccct gctgcccctg ctctgtcccg
      901 ggaccccctg gcctggcgct gtcccctgag ctgtcccatt aaacatggcc ctgtctctct
      961 cggt
//
