LOCUS       NM_001175               1174 bp    mRNA    linear   PRI 01-MAY-2024
DEFINITION  Homo sapiens Rho GDP dissociation inhibitor beta (ARHGDIB),
            transcript variant 1, mRNA.
ACCESSION   NM_001175
VERSION     NM_001175.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1174)
  AUTHORS   Yang,Y., Tian,Z., He,L., Meng,H., Xie,X., Yang,Z., Wang,X., Zhao,Y.
            and Huang,C.
  TITLE     RhoGDIbeta inhibition via miR-200c/AUF1/SOX2/miR-137 axis
            contributed to lncRNA MEG3 downregulation-mediated malignant
            transformation of human bronchial epithelial cells
  JOURNAL   Mol Carcinog 63 (5), 977-990 (2024)
   PUBMED   38376344
  REMARK    GeneRIF: RhoGDIbeta inhibition via miR-200c/AUF1/SOX2/miR-137 axis
            contributed to lncRNA MEG3 downregulation-mediated malignant
            transformation of human bronchial epithelial cells.
REFERENCE   2  (bases 1 to 1174)
  AUTHORS   Gleason,N. and Kowluru,A.
  TITLE     Hyperglycemic Stress Induces Expression, Degradation, and Nuclear
            Association of Rho GDP Dissociation Inhibitor 2 (RhoGDIbeta) in
            Pancreatic beta-Cells
  JOURNAL   Cells 13 (3), 272 (2024)
   PUBMED   38334664
  REMARK    GeneRIF: Hyperglycemic Stress Induces Expression, Degradation, and
            Nuclear Association of Rho GDP Dissociation Inhibitor 2
            (RhoGDIbeta) in Pancreatic beta-Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1174)
  AUTHORS   Nagar,H., Kim,S., Lee,I., Choi,S.J., Piao,S., Jeon,B.H., Shong,M.
            and Kim,C.S.
  TITLE     CRIF1 deficiency suppresses endothelial cell migration via
            upregulation of RhoGDI2
  JOURNAL   PLoS One 16 (8), e0256646 (2021)
   PUBMED   34437633
  REMARK    GeneRIF: CRIF1 deficiency suppresses endothelial cell migration via
            upregulation of RhoGDI2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1174)
  AUTHORS   Zeng,Y., Ren,M., Li,Y., Liu,Y., Chen,C., Su,J., Su,B., Xia,H.,
            Liu,F., Jiang,H., Ling,H., Zeng,X. and Su,Q.
  TITLE     Knockdown of RhoGDI2 represses human gastric cancer cell
            proliferation, invasion and drug resistance via the Rac1/Pak1/LIMK1
            pathway
  JOURNAL   Cancer Lett 492, 136-146 (2020)
   PUBMED   32860848
  REMARK    GeneRIF: Knockdown of RhoGDI2 represses human gastric cancer cell
            proliferation, invasion and drug resistance via the Rac1/Pak1/LIMK1
            pathway.
REFERENCE   5  (bases 1 to 1174)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 1174)
  AUTHORS   Adra,C.N., Kobayashi,H., Rowley,J.D. and Lim,B.
  TITLE     Assignment of the human GDID4 gene, a GDP/GTP-exchange regulator,
            to chromosome 12p12.3
  JOURNAL   Genomics 24 (1), 188-190 (1994)
   PUBMED   7896279
REFERENCE   7  (bases 1 to 1174)
  AUTHORS   Shisheva,A., Sudhof,T.C. and Czech,M.P.
  TITLE     Cloning, characterization, and expression of a novel GDP
            dissociation inhibitor isoform from skeletal muscle
  JOURNAL   Mol Cell Biol 14 (5), 3459-3468 (1994)
   PUBMED   7513052
REFERENCE   8  (bases 1 to 1174)
  AUTHORS   Leffers,H., Nielsen,M.S., Andersen,A.H., Honore,B., Madsen,P.,
            Vandekerckhove,J. and Celis,J.E.
  TITLE     Identification of two human Rho GDP dissociation inhibitor proteins
            whose overexpression leads to disruption of the actin cytoskeleton
  JOURNAL   Exp Cell Res 209 (2), 165-174 (1993)
   PUBMED   8262133
REFERENCE   9  (bases 1 to 1174)
  AUTHORS   Adra,C.N., Ko,J., Leonard,D., Wirth,L.J., Cerione,R.A. and Lim,B.
  TITLE     Identification of a novel protein with GDP dissociation inhibitor
            activity for the ras-like proteins CDC42Hs and rac I
  JOURNAL   Genes Chromosomes Cancer 8 (4), 253-261 (1993)
   PUBMED   7512369
REFERENCE   10 (bases 1 to 1174)
  AUTHORS   Aebersold,R. and Leavitt,J.
  TITLE     Sequence analysis of proteins separated by polyacrylamide gel
            electrophoresis: towards an integrated protein database
  JOURNAL   Electrophoresis 11 (7), 517-527 (1990)
   PUBMED   2226408
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY996333.1, BM849963.1 and BC009200.2.
            
            On Nov 23, 2018 this sequence version replaced NM_001175.6.
            
            Summary: Members of the Rho (or ARH) protein family (see MIM
            165390) and other Ras-related small GTP-binding proteins (see MIM
            179520) are involved in diverse cellular events, including cell
            signaling, proliferation, cytoskeletal organization, and secretion.
            The GTP-binding proteins are active only in the GTP-bound state. At
            least 3 classes of proteins tightly regulate cycling between the
            GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs),
            guanine nucleotide-releasing factors (GRFs), and GDP-dissociation
            inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate
            of GDP dissociation from Ras-like GTPases (summary by Scherle et
            al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.294441.1,
                                           SRR1163657.305462.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142670, SAMEA2149004
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000228945.9/ ENSP00000228945.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-623               BY996333.1         34-656
            624-974             BM849963.1         241-591
            975-1174            BC009200.2         949-1148
FEATURES             Location/Qualifiers
     source          1..1174
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p12.3"
     gene            1..1174
                     /gene="ARHGDIB"
                     /gene_synonym="D4; GDIA2; GDID4; Ly-GDI; LYGDI; RAP1GN1;
                     RhoGDI2"
                     /note="Rho GDP dissociation inhibitor beta"
                     /db_xref="GeneID:397"
                     /db_xref="HGNC:HGNC:679"
                     /db_xref="MIM:602843"
     exon            1..65
                     /gene="ARHGDIB"
                     /gene_synonym="D4; GDIA2; GDID4; Ly-GDI; LYGDI; RAP1GN1;
                     RhoGDI2"
                     /inference="alignment:Splign:2.1.0"
     exon            66..258
                     /gene="ARHGDIB"
                     /gene_synonym="D4; GDIA2; GDID4; Ly-GDI; LYGDI; RAP1GN1;
                     RhoGDI2"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..683
                     /gene="ARHGDIB"
                     /gene_synonym="D4; GDIA2; GDID4; Ly-GDI; LYGDI; RAP1GN1;
                     RhoGDI2"
                     /note="Rho GDI 2; rho-GDI beta; Rho GDP dissociation
                     inhibitor (GDI) beta"
                     /codon_start=1
                     /product="rho GDP-dissociation inhibitor 2"
                     /protein_id="NP_001166.3"
                     /db_xref="CCDS:CCDS8671.1"
                     /db_xref="GeneID:397"
                     /db_xref="HGNC:HGNC:679"
                     /db_xref="MIM:602843"
                     /translation="MTEKAPEPHVEEDDDDELDSKLNYKPPPQKSLKELQEMDKDDES
                     LIKYKKTLLGDGPVVTDPKAPNVVVTRLTLVCESAPGPITMDLTGDLEALKKETIVLK
                     EGSEYRVKIHFKVNRDIVSGLKYVQHTYRTGVKVDKATFMVGSYGPRPEEYEFLTPVE
                     EAPKGMLARGTYHNKSFFTDDDKQDHLSWEWNLSIKKEWTE"
     exon            259..342
                     /gene="ARHGDIB"
                     /gene_synonym="D4; GDIA2; GDID4; Ly-GDI; LYGDI; RAP1GN1;
                     RhoGDI2"
                     /inference="alignment:Splign:2.1.0"
     exon            343..419
                     /gene="ARHGDIB"
                     /gene_synonym="D4; GDIA2; GDID4; Ly-GDI; LYGDI; RAP1GN1;
                     RhoGDI2"
                     /inference="alignment:Splign:2.1.0"
     exon            420..483
                     /gene="ARHGDIB"
                     /gene_synonym="D4; GDIA2; GDID4; Ly-GDI; LYGDI; RAP1GN1;
                     RhoGDI2"
                     /inference="alignment:Splign:2.1.0"
     exon            484..1174
                     /gene="ARHGDIB"
                     /gene_synonym="D4; GDIA2; GDID4; Ly-GDI; LYGDI; RAP1GN1;
                     RhoGDI2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1157..1162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGDIB"
                     /gene_synonym="D4; GDIA2; GDID4; Ly-GDI; LYGDI; RAP1GN1;
                     RhoGDI2"
                     /note="hexamer: AATAAA"
     polyA_site      1174
                     /gene="ARHGDIB"
                     /gene_synonym="D4; GDIA2; GDID4; Ly-GDI; LYGDI; RAP1GN1;
                     RhoGDI2"
                     /note="major polyA site"
ORIGIN      
        1 gccagtactc agaagtcaga gttgagagac agaggcaccc cggacagaga cgtgaagcac
       61 tgaataaata gatcagaatg actgaaaaag ccccagagcc acatgtggag gaggatgacg
      121 atgatgagct ggacagcaag ctcaattata agcctccacc acagaagtcc ctgaaagagc
      181 tgcaggaaat ggacaaagat gatgagagtc taattaagta caagaaaacg ctgctgggag
      241 atggtcctgt ggtgacagat ccgaaagccc ccaatgtcgt tgtcacccgg ctcaccctgg
      301 tttgtgagag tgccccggga ccaatcacca tggaccttac tggagatctg gaagccctca
      361 aaaaggaaac cattgtgtta aaggaaggtt ctgaatatag agtcaaaatt cacttcaaag
      421 tgaacaggga tattgtgtca ggcctgaaat acgttcagca cacctacagg actggggtga
      481 aagtggataa agcaacattt atggttggca gctatggacc tcggcctgag gagtatgagt
      541 tcctcactcc agttgaggag gctcccaagg gcatgctggc gcgaggcacg taccacaaca
      601 agtccttctt caccgacgat gacaagcaag accacctcag ctgggagtgg aacctgtcga
      661 ttaagaagga gtggacagaa tgaatgcatc cacccctttc cccacccttg ccacctggaa
      721 gaattctctc aggcgtgttc agcaccctgt ccctcctccc tgtccacagc tgggtccctc
      781 ttcaacactg ccacatttcc ttattgatgc atcttttccc accctgtcac tcaacgtggt
      841 ccctagaaca agaggcttaa aaccgggctt tcacccaacc tgctccctct gatcctccat
      901 cagggccaga tcttccacgt ctccatctca gtacacaatc atttaatatt tccctgtctt
      961 acccctattc aagcaactag aggccagaaa atgggcaaat tatcactaac aggtctttga
     1021 ctcaggttcc agtagttcat tctaatgcct agattctttt gtggttgttg ctggcccaat
     1081 gagtccctag tcacatcccc tgccagaggg agttcttctt ttgtgagaga cactgtaaac
     1141 gacacaagag aacaagaata aaacaataac tgtg
//
