LOCUS       NM_004309               1837 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens Rho GDP dissociation inhibitor alpha (ARHGDIA),
            transcript variant 2, mRNA.
ACCESSION   NM_004309
VERSION     NM_004309.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1837)
  AUTHORS   Song,G. and Jin,F.
  TITLE     RhoGDI1 interacts with PHLDA2, suppresses the proliferation,
            migration, and invasion of trophoblast cells, and participates in
            the pathogenesis of preeclampsia
  JOURNAL   Hum Cell 35 (5), 1440-1452 (2022)
   PUBMED   35841528
  REMARK    GeneRIF: RhoGDI1 interacts with PHLDA2, suppresses the
            proliferation, migration, and invasion of trophoblast cells, and
            participates in the pathogenesis of preeclampsia.
REFERENCE   2  (bases 1 to 1837)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 1837)
  AUTHORS   Zhou,K.Y., Zhou,Y.H., Ji,H.L. and Luo,Y.K.
  TITLE     miR-497 promotes the migration and invasion of human medulloblast
            Daoy cell line through targeted regulation of ARHGDIA in vitro
  JOURNAL   Neurosci Lett 772, 136469 (2022)
   PUBMED   35066091
  REMARK    GeneRIF: miR-497 promotes the migration and invasion of human
            medulloblast Daoy cell line through targeted regulation of ARHGDIA
            in vitro.
REFERENCE   4  (bases 1 to 1837)
  AUTHORS   Huang,G., Zhang,J., Qing,G., Liu,D., Wang,X., Chen,Y., Wu,Y., Li,Y.
            and Guo,S.
  TITLE     Downregulation of miR-483-5p inhibits TGF-beta1-induced EMT by
            targeting RhoGDI1 in pulmonary fibrosis
  JOURNAL   Mol Med Rep 24 (1) (2021)
   PUBMED   34080651
  REMARK    GeneRIF: Downregulation of miR4835p inhibits TGFbeta1induced EMT by
            targeting RhoGDI1 in pulmonary fibrosis.
REFERENCE   5  (bases 1 to 1837)
  AUTHORS   Garcia-Mata,R., Boulter,E. and Burridge,K.
  TITLE     The 'invisible hand': regulation of RHO GTPases by RHOGDIs
  JOURNAL   Nat Rev Mol Cell Biol 12 (8), 493-504 (2011)
   PUBMED   21779026
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1837)
  AUTHORS   Gosser,Y.Q., Nomanbhoy,T.K., Aghazadeh,B., Manor,D., Combs,C.,
            Cerione,R.A. and Rosen,M.K.
  TITLE     C-terminal binding domain of Rho GDP-dissociation inhibitor directs
            N-terminal inhibitory peptide to GTPases
  JOURNAL   Nature 387 (6635), 814-819 (1997)
   PUBMED   9194563
REFERENCE   7  (bases 1 to 1837)
  AUTHORS   Wagner,T., Tommerup,N., Wirth,J., Leffers,H., Zimmer,J., Back,E.,
            Weissenbach,J. and Scherer,G.
  TITLE     A somatic cell hybrid panel for distal 17q: GDIA1 maps to 17q25.3
  JOURNAL   Cytogenet Cell Genet 76 (3-4), 172-175 (1997)
   PUBMED   9186513
REFERENCE   8  (bases 1 to 1837)
  AUTHORS   Leffers,H., Nielsen,M.S., Andersen,A.H., Honore,B., Madsen,P.,
            Vandekerckhove,J. and Celis,J.E.
  TITLE     Identification of two human Rho GDP dissociation inhibitor proteins
            whose overexpression leads to disruption of the actin cytoskeleton
  JOURNAL   Exp Cell Res 209 (2), 165-174 (1993)
   PUBMED   8262133
REFERENCE   9  (bases 1 to 1837)
  AUTHORS   Kwong,C.H., Malech,H.L., Rotrosen,D. and Leto,T.L.
  TITLE     Regulation of the human neutrophil NADPH oxidase by rho-related
            G-proteins
  JOURNAL   Biochemistry 32 (21), 5711-5717 (1993)
   PUBMED   8504089
REFERENCE   10 (bases 1 to 1837)
  AUTHORS   Hancock,J.F. and Hall,A.
  TITLE     A novel role for RhoGDI as an inhibitor of GAP proteins
  JOURNAL   EMBO J 12 (5), 1915-1921 (1993)
   PUBMED   8491184
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC005851.2 and AI751683.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004309.5.
            
            Summary: This gene encodes a protein that plays a key role in the
            regulation of signaling through Rho GTPases. The encoded protein
            inhibits the disassociation of Rho family members from GDP (guanine
            diphosphate), thereby maintaining these factors in an inactive
            state. Activity of this protein is important in a variety of
            cellular processes, and expression of this gene may be altered in
            tumors. Mutations in this gene have been found in individuals with
            nephrotic syndrome, type 8. Alternate splicing results in multiple
            transcript variants. [provided by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005851.2, SRR3476690.670940.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145245
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000269321.12/ ENSP00000269321.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1536              BC005851.2         26-1561
            1537-1537           AI751683.1         303-303             c
            1538-1837           BC005851.2         1563-1862
FEATURES             Location/Qualifiers
     source          1..1837
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..1837
                     /gene="ARHGDIA"
                     /gene_synonym="GDIA1; HEL-S-47e; NPHS8; RHOGDI; RHOGDI-1"
                     /note="Rho GDP dissociation inhibitor alpha"
                     /db_xref="GeneID:396"
                     /db_xref="HGNC:HGNC:678"
                     /db_xref="MIM:601925"
     exon            1..40
                     /gene="ARHGDIA"
                     /gene_synonym="GDIA1; HEL-S-47e; NPHS8; RHOGDI; RHOGDI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            41..257
                     /gene="ARHGDIA"
                     /gene_synonym="GDIA1; HEL-S-47e; NPHS8; RHOGDI; RHOGDI-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..682
                     /gene="ARHGDIA"
                     /gene_synonym="GDIA1; HEL-S-47e; NPHS8; RHOGDI; RHOGDI-1"
                     /note="isoform a is encoded by transcript variant 2; rho
                     GDP-dissociation inhibitor 1; epididymis secretory sperm
                     binding protein Li 47e; Rho GDP dissociation inhibitor
                     (GDI) alpha; GDP-dissociation inhibitor, aplysia
                     RAS-related 1"
                     /codon_start=1
                     /product="rho GDP-dissociation inhibitor 1 isoform a"
                     /protein_id="NP_004300.1"
                     /db_xref="CCDS:CCDS11788.1"
                     /db_xref="GeneID:396"
                     /db_xref="HGNC:HGNC:678"
                     /db_xref="MIM:601925"
                     /translation="MAEQEPTAEQLAQIAAENEEDEHSVNYKPPAQKSIQEIQELDKD
                     DESLRKYKEALLGRVAVSADPNVPNVVVTGLTLVCSSAPGPLELDLTGDLESFKKQSF
                     VLKEGVEYRIKISFRVNREIVSGMKYIQHTYRKGVKIDKTDYMVGSYGPRAEEYEFLT
                     PVEEAPKGMLARGSYSIKSRFTDDDKTDHLSWEWNLTIKKDWKD"
     exon            258..341
                     /gene="ARHGDIA"
                     /gene_synonym="GDIA1; HEL-S-47e; NPHS8; RHOGDI; RHOGDI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            342..418
                     /gene="ARHGDIA"
                     /gene_synonym="GDIA1; HEL-S-47e; NPHS8; RHOGDI; RHOGDI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            419..482
                     /gene="ARHGDIA"
                     /gene_synonym="GDIA1; HEL-S-47e; NPHS8; RHOGDI; RHOGDI-1"
                     /inference="alignment:Splign:2.1.0"
     exon            483..1837
                     /gene="ARHGDIA"
                     /gene_synonym="GDIA1; HEL-S-47e; NPHS8; RHOGDI; RHOGDI-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1819..1824
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGDIA"
                     /gene_synonym="GDIA1; HEL-S-47e; NPHS8; RHOGDI; RHOGDI-1"
                     /note="hexamer: AATAAA"
     polyA_site      1837
                     /gene="ARHGDIA"
                     /gene_synonym="GDIA1; HEL-S-47e; NPHS8; RHOGDI; RHOGDI-1"
                     /note="major polyA site"
ORIGIN      
        1 agtgcgggag ggatcctgaa ccgcgcggcc gaaccctccg gtgtcccgac ccaggctaag
       61 cttgagcatg gctgagcagg agcccacagc cgagcagctg gcccagattg cagcggagaa
      121 cgaggaggat gagcactcgg tcaactacaa gcccccggcc cagaagagca tccaggagat
      181 ccaggagctg gacaaggacg acgagagcct gcgaaagtac aaggaggccc tgctgggccg
      241 cgtggccgtt tccgcagacc ccaacgtccc caacgtcgtg gtgactggcc tgaccctggt
      301 gtgcagctcg gccccgggcc ccctggagct ggacctgacg ggcgacctgg agagcttcaa
      361 gaagcagtcg tttgtgctga aggagggtgt ggagtaccgg ataaaaatct ctttccgggt
      421 taaccgagag atagtgtccg gcatgaagta catccagcat acgtacagga aaggcgtcaa
      481 gattgacaag actgactaca tggtaggcag ctatgggccc cgggccgagg agtacgagtt
      541 cctgaccccc gtggaggagg cacccaaggg tatgctggcc cggggcagct acagcatcaa
      601 gtcccgcttc acagacgacg acaagaccga ccacctgtcc tgggagtgga atctcaccat
      661 caagaaggac tggaaggact gagcccagcc agaggcgggc agggcagact gacggacgga
      721 cgacggacag gcggatgtgt cccccccagc ccctcccctc cccataccaa agtgctgaca
      781 ggccctccgt gcccctccca ccctggtccg cctccctggc ctggctcaac cgagtgcctc
      841 cgacccccct cctcagccct cccccaccca caggcccagc ctcctcggtc tcctgtctcg
      901 ttgctgcttc tgcctgtgct gtgggggaga gaggccgcag ccaggcctct gctgcccttt
      961 ctgtgccccc caggttctat ctccccgtca cacccgaggc ctggcttcag gagggagcgg
     1021 agcagccatt ctccaggccc cgtggttgcc cctggacgtg tgcgtctgct gctccggggt
     1081 ggagctgggg tgtgggatgc acggcctcgt gggggccggg ccgtcctcca gccccgctgc
     1141 tccctggcca gcccccttgt cgctgtcggt cccgtctaac catgatgcct taacatgtgg
     1201 agtgtaccgt ggggcctcac tagcctctaa ctccctgtgt ctgcatgagc atgtggcctc
     1261 cccgtccctt ccccggtggc gaacccagtg acccagggac acgtggggtg tgctgctgct
     1321 gctccccagc ccaccagtgc ctggccagcc tgcccccttc cctggacagg gctgtggaga
     1381 tggctccggc ggcttgggga aagccaaatt gccaaaactc aagtcacctc agtaccatcc
     1441 aggaggctgg gtattgtcct gcctctgcct tttctgtctc agcgggcagt gcccagagcc
     1501 cacacccccc caagagccct cgatggacag cctcactcac cccacctggg cccagccagg
     1561 agccccgcct ggccatcagt atttattgcc tccgtccgtg ccgtccctgg gccactggcc
     1621 tggcgcctgt tcccccaggc tctcagtgcc accacccccg gcaggccttc cctgacccag
     1681 ccaggaacaa acaagggacc aagtgcacac attgctgaga gccgtctcct gtgcctcccc
     1741 cgccccatcc ccggtcttcg tgttgtgtct gccaggctca ggcagaggcg cctgtccctg
     1801 cttcttttct gaccgggaaa taaatgcccc tgaagga
//
