LOCUS       NP_004300                204 aa            linear   PRI 28-APR-2025
DEFINITION  rho GDP-dissociation inhibitor 1 isoform a [Homo sapiens].
ACCESSION   NP_004300
VERSION     NP_004300.1
DBSOURCE    REFSEQ: accession NM_004309.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 204)
  AUTHORS   Song,G. and Jin,F.
  TITLE     RhoGDI1 interacts with PHLDA2, suppresses the proliferation,
            migration, and invasion of trophoblast cells, and participates in
            the pathogenesis of preeclampsia
  JOURNAL   Hum Cell 35 (5), 1440-1452 (2022)
   PUBMED   35841528
  REMARK    GeneRIF: RhoGDI1 interacts with PHLDA2, suppresses the
            proliferation, migration, and invasion of trophoblast cells, and
            participates in the pathogenesis of preeclampsia.
REFERENCE   2  (residues 1 to 204)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (residues 1 to 204)
  AUTHORS   Zhou,K.Y., Zhou,Y.H., Ji,H.L. and Luo,Y.K.
  TITLE     miR-497 promotes the migration and invasion of human medulloblast
            Daoy cell line through targeted regulation of ARHGDIA in vitro
  JOURNAL   Neurosci Lett 772, 136469 (2022)
   PUBMED   35066091
  REMARK    GeneRIF: miR-497 promotes the migration and invasion of human
            medulloblast Daoy cell line through targeted regulation of ARHGDIA
            in vitro.
REFERENCE   4  (residues 1 to 204)
  AUTHORS   Huang,G., Zhang,J., Qing,G., Liu,D., Wang,X., Chen,Y., Wu,Y., Li,Y.
            and Guo,S.
  TITLE     Downregulation of miR-483-5p inhibits TGF-beta1-induced EMT by
            targeting RhoGDI1 in pulmonary fibrosis
  JOURNAL   Mol Med Rep 24 (1) (2021)
   PUBMED   34080651
  REMARK    GeneRIF: Downregulation of miR4835p inhibits TGFbeta1induced EMT by
            targeting RhoGDI1 in pulmonary fibrosis.
REFERENCE   5  (residues 1 to 204)
  AUTHORS   Garcia-Mata,R., Boulter,E. and Burridge,K.
  TITLE     The 'invisible hand': regulation of RHO GTPases by RHOGDIs
  JOURNAL   Nat Rev Mol Cell Biol 12 (8), 493-504 (2011)
   PUBMED   21779026
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 204)
  AUTHORS   Gosser,Y.Q., Nomanbhoy,T.K., Aghazadeh,B., Manor,D., Combs,C.,
            Cerione,R.A. and Rosen,M.K.
  TITLE     C-terminal binding domain of Rho GDP-dissociation inhibitor directs
            N-terminal inhibitory peptide to GTPases
  JOURNAL   Nature 387 (6635), 814-819 (1997)
   PUBMED   9194563
REFERENCE   7  (residues 1 to 204)
  AUTHORS   Wagner,T., Tommerup,N., Wirth,J., Leffers,H., Zimmer,J., Back,E.,
            Weissenbach,J. and Scherer,G.
  TITLE     A somatic cell hybrid panel for distal 17q: GDIA1 maps to 17q25.3
  JOURNAL   Cytogenet Cell Genet 76 (3-4), 172-175 (1997)
   PUBMED   9186513
REFERENCE   8  (residues 1 to 204)
  AUTHORS   Leffers,H., Nielsen,M.S., Andersen,A.H., Honore,B., Madsen,P.,
            Vandekerckhove,J. and Celis,J.E.
  TITLE     Identification of two human Rho GDP dissociation inhibitor proteins
            whose overexpression leads to disruption of the actin cytoskeleton
  JOURNAL   Exp Cell Res 209 (2), 165-174 (1993)
   PUBMED   8262133
REFERENCE   9  (residues 1 to 204)
  AUTHORS   Kwong,C.H., Malech,H.L., Rotrosen,D. and Leto,T.L.
  TITLE     Regulation of the human neutrophil NADPH oxidase by rho-related
            G-proteins
  JOURNAL   Biochemistry 32 (21), 5711-5717 (1993)
   PUBMED   8504089
REFERENCE   10 (residues 1 to 204)
  AUTHORS   Hancock,J.F. and Hall,A.
  TITLE     A novel role for RhoGDI as an inhibitor of GAP proteins
  JOURNAL   EMBO J 12 (5), 1915-1921 (1993)
   PUBMED   8491184
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC005851.2 and AI751683.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a protein that plays a key role in the
            regulation of signaling through Rho GTPases. The encoded protein
            inhibits the disassociation of Rho family members from GDP (guanine
            diphosphate), thereby maintaining these factors in an inactive
            state. Activity of this protein is important in a variety of
            cellular processes, and expression of this gene may be altered in
            tumors. Mutations in this gene have been found in individuals with
            nephrotic syndrome, type 8. Alternate splicing results in multiple
            transcript variants. [provided by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005851.2, SRR3476690.670940.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145245
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000269321.12/ ENSP00000269321.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..204
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     Protein         1..204
                     /product="rho GDP-dissociation inhibitor 1 isoform a"
                     /note="rho GDP-dissociation inhibitor 1; epididymis
                     secretory sperm binding protein Li 47e; Rho GDP
                     dissociation inhibitor (GDI) alpha; GDP-dissociation
                     inhibitor, aplysia RAS-related 1"
                     /calculated_mol_wt=23076
     Region          1..36
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P52565.3)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine. /evidence=ECO:0000269|Ref.12,
                     ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:20068231;
                     propagated from UniProtKB/Swiss-Prot (P52565.3)"
     Region          12..201
                     /region_name="Rho_GDI"
                     /note="RHO protein GDP dissociation inhibitor; pfam02115"
                     /db_xref="CDD:460449"
     Site            34
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q99PT1; propagated from
                     UniProtKB/Swiss-Prot (P52565.3)"
     Site            43
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q99PT1; propagated from
                     UniProtKB/Swiss-Prot (P52565.3)"
     Site            47
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (P52565.3)"
     Site            105
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (P52565.3)"
     Site            127
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (P52565.3)"
     Site            141
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:16916647,
                     ECO:0007744|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (P52565.3)"
     Site            178
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0007744|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (P52565.3)"
     CDS             1..204
                     /gene="ARHGDIA"
                     /gene_synonym="GDIA1; HEL-S-47e; NPHS8; RHOGDI; RHOGDI-1"
                     /coded_by="NM_004309.6:68..682"
                     /note="isoform a is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS11788.1"
                     /db_xref="GeneID:396"
                     /db_xref="HGNC:HGNC:678"
                     /db_xref="MIM:601925"
ORIGIN      
        1 maeqeptaeq laqiaaenee dehsvnykpp aqksiqeiqe ldkddeslrk ykeallgrva
       61 vsadpnvpnv vvtgltlvcs sapgpleldl tgdlesfkkq sfvlkegvey rikisfrvnr
      121 eivsgmkyiq htyrkgvkid ktdymvgsyg praeeyeflt pveeapkgml argsysiksr
      181 ftdddktdhl swewnltikk dwkd
//
