LOCUS       NM_032496               2599 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens Rho GTPase activating protein 9 (ARHGAP9), transcript
            variant 1, mRNA.
ACCESSION   NM_032496
VERSION     NM_032496.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2599)
  AUTHORS   Sun,J., Zhao,X., Jiang,H., Yang,T., Li,D., Yang,X., Jia,A., Ma,Y.
            and Qian,Z.
  TITLE     ARHGAP9 inhibits colorectal cancer cell proliferation, invasion and
            EMT via targeting PI3K/AKT/mTOR signaling pathway
  JOURNAL   Tissue Cell 77, 101817 (2022)
   PUBMED   35679685
  REMARK    GeneRIF: ARHGAP9 inhibits colorectal cancer cell proliferation,
            invasion and EMT via targeting PI3K/AKT/mTOR signaling pathway.
REFERENCE   2  (bases 1 to 2599)
  AUTHORS   Ji,W., Zhang,L. and Zhu,H.
  TITLE     GATA binding protein 5 (GATA5) induces Rho GTPase activating
            protein 9 (ARHGAP9) to inhibit the malignant process of lung
            adenocarcinoma cells
  JOURNAL   Bioengineered 13 (2), 2878-2888 (2022)
   PUBMED   35040754
  REMARK    GeneRIF: GATA binding protein 5 (GATA5) induces Rho GTPase
            activating protein 9 (ARHGAP9) to inhibit the malignant process of
            lung adenocarcinoma cells.
REFERENCE   3  (bases 1 to 2599)
  AUTHORS   He,X., Zou,H. and Wang,F.
  TITLE     SOX4-induced upregulation of ARHGAP9 promotes the progression of
            acute myeloid leukemia
  JOURNAL   Drug Dev Res 82 (8), 1227-1234 (2021)
   PUBMED   34159626
  REMARK    GeneRIF: SOX4-induced upregulation of ARHGAP9 promotes the
            progression of acute myeloid leukemia.
REFERENCE   4  (bases 1 to 2599)
  AUTHORS   Han,C., He,S., Wang,R., Gao,X., Wang,H., Qiao,J., Meng,X., Li,Y.
            and Yu,L.
  TITLE     The role of ARHGAP9: clinical implication and potential function in
            acute myeloid leukemia
  JOURNAL   J Transl Med 19 (1), 65 (2021)
   PUBMED   33579308
  REMARK    GeneRIF: The role of ARHGAP9: clinical implication and potential
            function in acute myeloid leukemia.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2599)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2599)
  AUTHORS   Voss,M., Lettau,M. and Janssen,O.
  TITLE     Identification of SH3 domain interaction partners of human FasL
            (CD178) by phage display screening
  JOURNAL   BMC Immunol 10, 53 (2009)
   PUBMED   19807924
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2599)
  AUTHORS   Ceccarelli,D.F., Blasutig,I.M., Goudreault,M., Li,Z., Ruston,J.,
            Pawson,T. and Sicheri,F.
  TITLE     Non-canonical interaction of phosphoinositides with pleckstrin
            homology domains of Tiam1 and ArhGAP9
  JOURNAL   J Biol Chem 282 (18), 13864-13874 (2007)
   PUBMED   17339315
REFERENCE   8  (bases 1 to 2599)
  AUTHORS   Ang,B.K., Lim,C.Y., Koh,S.S., Sivakumar,N., Taib,S., Lim,K.B.,
            Ahmed,S., Rajagopal,G. and Ong,S.H.
  TITLE     ArhGAP9, a novel MAP kinase docking protein, inhibits Erk and p38
            activation through WW domain binding
  JOURNAL   J Mol Signal 2, 1 (2007)
   PUBMED   17284314
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2599)
  AUTHORS   Peck,J., Douglas,G. 4th, Wu,C.H. and Burbelo,P.D.
  TITLE     Human RhoGAP domain-containing proteins: structure, function and
            evolutionary relationships
  JOURNAL   FEBS Lett 528 (1-3), 27-34 (2002)
   PUBMED   12297274
  REMARK    Review article
REFERENCE   10 (bases 1 to 2599)
  AUTHORS   Furukawa,Y., Kawasoe,T., Daigo,Y., Nishiwaki,T., Ishiguro,H.,
            Takahashi,M., Kitayama,J. and Nakamura,Y.
  TITLE     Isolation of a novel human gene, ARHGAP9, encoding a rho-GTPase
            activating protein
  JOURNAL   Biochem Biophys Res Commun 284 (3), 643-649 (2001)
   PUBMED   11396949
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC408597.1 and AB051853.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_032496.3.
            
            Summary: This gene encodes a member of the Rho-GAP family of GTPase
            activating proteins. The protein has substantial GAP activity
            towards several Rho-family GTPases in vitro, converting them to an
            inactive GDP-bound state. It is implicated in regulating adhesion
            of hematopoietic cells to the extracellular matrix. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB051853.1, SRR18074968.2024504.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393791.8/ ENSP00000377380.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DC408597.1         7-22
            17-2599             AB051853.1         1-2583
FEATURES             Location/Qualifiers
     source          1..2599
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.3"
     gene            1..2599
                     /gene="ARHGAP9"
                     /gene_synonym="10C; RGL1"
                     /note="Rho GTPase activating protein 9"
                     /db_xref="GeneID:64333"
                     /db_xref="HGNC:HGNC:14130"
                     /db_xref="MIM:610576"
     exon            1..137
                     /gene="ARHGAP9"
                     /gene_synonym="10C; RGL1"
                     /inference="alignment:Splign:2.1.0"
     exon            138..471
                     /gene="ARHGAP9"
                     /gene_synonym="10C; RGL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..2351
                     /gene="ARHGAP9"
                     /gene_synonym="10C; RGL1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     rho-type GTPase-activating protein 9"
                     /codon_start=1
                     /product="rho GTPase-activating protein 9 isoform 1"
                     /protein_id="NP_115885.2"
                     /db_xref="CCDS:CCDS8941.2"
                     /db_xref="GeneID:64333"
                     /db_xref="HGNC:HGNC:14130"
                     /db_xref="MIM:610576"
                     /translation="MLSSRWWPSSWGILGLGPRSPPRGSQLCALYAFTYTGADGQQVS
                     LAEGDRFLLLRKTNSDWWLARRLEAPSTSRPIFVPAAYMIEESIPSQSPTTVIPGQLL
                     WTPGPKLFHGSLEELSQALPSRAQASSEQPPPLPRKMCRSVSTDNLSPSLLKPFQEGP
                     SGRSLSQEDLPSEASASTAGPQPLMSEPPVYCNLVDLRRCPRSPPPGPACPLLQRLDA
                     WEQHLDPNSGRCFYINSLTGCKSWKPPRRSRSETNPGSMEGTQTLKRNNDVLQPQAKG
                     FRSDTGTPEPLDPQGSLSLSQRTSQLDPPALQAPRPLPQLLDDPHEVEKSGLLNMTKI
                     AQGGRKLRKNWGPSWVVLTGNSLVFYREPPPTAPSSGWGPAGSRPESSVDLRGAALAH
                     GRHLSSRRNVLHIRTIPGHEFLLQSDHETELRAWHRALRTVIERLDRENPLELRLSGS
                     GPAELSAGEDEEEESELVSKPLLRLSSRRSSIRGPEGTEQNRVRNKLKRLIAKRPPLQ
                     SLQERGLLRDQVFGCQLESLCQREGDTVPSFLRLCIAAVDKRGLDVDGIYRVSGNLAV
                     VQKLRFLVDRERAVTSDGRYVFPEQPGQEGRLDLDSTEWDDIHVVTGALKLFLRELPQ
                     PLVPPLLLPHFRAALALSESEQCLSQIQELIGSMPKPNHDTLRYLLEHLCRVIAHSDK
                     NRMTPHNLGIVFGPTLFRPEQETSDPAAHALYPGQLVQLMLTNFTSLFP"
     exon            472..689
                     /gene="ARHGAP9"
                     /gene_synonym="10C; RGL1"
                     /inference="alignment:Splign:2.1.0"
     exon            690..911
                     /gene="ARHGAP9"
                     /gene_synonym="10C; RGL1"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1025
                     /gene="ARHGAP9"
                     /gene_synonym="10C; RGL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1118
                     /gene="ARHGAP9"
                     /gene_synonym="10C; RGL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1180
                     /gene="ARHGAP9"
                     /gene_synonym="10C; RGL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1271
                     /gene="ARHGAP9"
                     /gene_synonym="10C; RGL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1367
                     /gene="ARHGAP9"
                     /gene_synonym="10C; RGL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1466
                     /gene="ARHGAP9"
                     /gene_synonym="10C; RGL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1599
                     /gene="ARHGAP9"
                     /gene_synonym="10C; RGL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1707
                     /gene="ARHGAP9"
                     /gene_synonym="10C; RGL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1806
                     /gene="ARHGAP9"
                     /gene_synonym="10C; RGL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1884
                     /gene="ARHGAP9"
                     /gene_synonym="10C; RGL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..1938
                     /gene="ARHGAP9"
                     /gene_synonym="10C; RGL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2073
                     /gene="ARHGAP9"
                     /gene_synonym="10C; RGL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2179
                     /gene="ARHGAP9"
                     /gene_synonym="10C; RGL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2599
                     /gene="ARHGAP9"
                     /gene_synonym="10C; RGL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2583..2588
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP9"
                     /gene_synonym="10C; RGL1"
                     /note="hexamer: CATAAA"
     polyA_site      2599
                     /gene="ARHGAP9"
                     /gene_synonym="10C; RGL1"
                     /note="major polyA site"
ORIGIN      
        1 gtcattaacc ttgtgtctcc ctgtttctgt cttgaacctg attctttctt cttatctcct
       61 tcctgtgtcc acctcaagac tcccaccact acccaggacc aactcctgct cctgaatctt
      121 ctgatgggcc ccacaaggtg acagtgctgg ctacaatgct atccagccgg tggtggccaa
      181 gttcctgggg gatcctaggg ctgggccccc gaagccctcc tcggggatcc cagctctgtg
      241 ccctctatgc ctttacttat actggggcag atggccagca ggtgtctctg gctgaagggg
      301 ataggttcct actgcttcga aagaccaact ccgactggtg gttggcaaga cgcctagaag
      361 ctccctccac ctctcgaccc atcttcgtcc cagcagccta tatgatagag gaatccatcc
      421 cttcccagag tccaactacc gtcatccccg gccaattgct ctggactcct gggccgaagt
      481 tgtttcatgg ttccctggag gagttgtctc aggccctccc aagcagggct caggctagct
      541 cggagcagcc tcctccactt ccccgcaaaa tgtgtaggag cgtcagcact gacaatctga
      601 gccccagcct tctgaagcct ttccaggaag gaccaagcgg aagatccctc tcccaggaag
      661 acttgccgtc agaagccagt gccagcacag caggccccca gcccctcatg tcagagcccc
      721 ctgtgtactg taacctggtg gaccttcgcc gctgtcctcg gtccccaccc ccaggccctg
      781 catgccccct gctgcagagg ctggatgcct gggagcagca cctggacccc aactctggac
      841 gctgcttcta cataaattca ctgactggct gcaagtcctg gaagcccccg cgccgcagtc
      901 gcagcgagac gaaccctggc tccatggagg ggacacagac cctgaagagg aacaatgatg
      961 tcctgcaacc tcaggcaaag ggcttcagat ctgacacagg gaccccagaa ccgcttgacc
     1021 cacagggttc actcagcctc agccaacgca cctcgcagct tgaccctcca gccttgcagg
     1081 cccctcgacc tctgccgcag ctcctggacg acccccatga ggtggaaaag tcgggtctgc
     1141 tcaacatgac caagattgcc caaggggggc gcaagctcag gaagaactgg ggcccgtctt
     1201 gggtggtgtt aacgggtaac agcctggtgt tctaccgaga gccaccgccg acagcgccct
     1261 cctcaggctg gggaccagcg ggtagccggc ccgaaagtag cgtggacctg cgcggggcgg
     1321 ccctggcgca cggccgccac ctgtccagcc gccgcaacgt cctgcacatc cgcacgatcc
     1381 ctggccacga gttcctgctg cagtcggacc acgagacaga gctgcgagcc tggcaccgcg
     1441 cgctgcggac tgtcatcgag cggctggatc gggagaaccc cctggagctg cgtctgtcgg
     1501 gctctggacc cgcggagctg agcgccgggg aggacgaaga agaggagtcg gagctggtgt
     1561 ccaagccgct gctgcgcctc agcagccgcc ggagctccat tcgggggccc gaaggcaccg
     1621 agcagaaccg cgtgcgcaac aaactaaagc ggctcatcgc gaagagaccg cccttacaaa
     1681 gcctgcagga gcggggtctg ctccgagacc aggtgttcgg ctgccagttg gaatcactct
     1741 gccagcggga aggagacacg gtgcccagct ttttgcggct ctgcattgct gctgtggata
     1801 aaagaggtct agatgtggat ggcatttatc gggtgagcgg gaacttggca gtggtccaga
     1861 agcttcgctt tctggtggac agagagcgtg cggtcacctc cgatgggagg tatgtgttcc
     1921 cagaacagcc aggacaagaa ggtcggttag atttggacag tactgagtgg gatgacattc
     1981 atgtggtcac cggagccctg aagctttttc tccgggagct gccccagcct ctggtgccac
     2041 cactgctgct gccccatttc cgtgctgccc ttgcactctc cgaatcagag cagtgcctct
     2101 ctcagataca agaattaata ggctcaatgc caaagcccaa ccatgacact ctacggtacc
     2161 tcctggagca tttatgcagg gtgatagcac actcagataa gaatcgcatg acaccccaca
     2221 acctgggaat tgtgtttgga ccaaccctgt ttcggccaga gcaggagaca tctgacccag
     2281 cagcccatgc tctctaccca gggcagctgg tccagctgat gctcaccaac ttcaccagcc
     2341 tcttcccctg atgcagggaa ggaagaagag aaaacatatt tccggtcatc tctggtggtg
     2401 agaggctggt gttctgtttt gaggatatcc ctttaaatct cccaaatgac tgtctctatc
     2461 ttcatgagtg tgacttgagg tgttgggatg ggtgagggag cttctctaaa gaggaaagtg
     2521 agtggattaa cccctgcttc tcttcttgtt ccctgttatc attcctcccc aacataataa
     2581 tacataaagt ggcatggta
//
