LOCUS       NM_001030055            9589 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens Rho GTPase activating protein 5 (ARHGAP5), transcript
            variant 1, mRNA.
ACCESSION   NM_001030055
VERSION     NM_001030055.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9589)
  AUTHORS   Deng,S., Qian,L., Liu,L., Liu,H., Xu,Z., Liu,Y., Wang,Y., Chen,L.
            and Zhou,Y.
  TITLE     Circular RNA ARHGAP5 inhibits cisplatin resistance in cervical
            squamous cell carcinoma by interacting with AUF1
  JOURNAL   Cancer Sci 114 (4), 1582-1595 (2023)
   PUBMED   36632741
  REMARK    GeneRIF: Circular RNA ARHGAP5 inhibits cisplatin resistance in
            cervical squamous cell carcinoma by interacting with AUF1.
REFERENCE   2  (bases 1 to 9589)
  AUTHORS   Lippincott,M.F., Xu,W., Smith,A.A., Miao,X., Lafont,A., Shennib,O.,
            Farley,G.J., Sabbagh,R., Delaney,A., Stamou,M., Plummer,L.,
            Salnikov,K., Georgopoulos,N.A., Mericq,V., Quinton,R.,
            Mau-Them,F.T., Nambot,S., Hamad,A., Brittain,H., Tooze,R.S.,
            Calpena,E., Wilkie,A.O.M., Willems,M., Crowley,W.F.,
            Balasubramanian,R., Lamarche-Vane,N., Davis,E.E. and Seminara,S.B.
  TITLE     The p190 RhoGAPs, ARHGAP35, and ARHGAP5 are implicated in GnRH
            neuronal development: Evidence from patients with idiopathic
            hypogonadotropic hypogonadism, zebrafish, and in vitro GAP activity
            assay
  JOURNAL   Genet Med 24 (12), 2501-2515 (2022)
   PUBMED   36178483
  REMARK    GeneRIF: The p190 RhoGAPs, ARHGAP35, and ARHGAP5 are implicated in
            GnRH neuronal development: Evidence from patients with idiopathic
            hypogonadotropic hypogonadism, zebrafish, and in vitro GAP activity
            assay.
REFERENCE   3  (bases 1 to 9589)
  AUTHORS   Tian,T., Chen,Z.H., Zheng,Z., Liu,Y., Zhao,Q., Liu,Y., Qiu,H.,
            Long,Q., Chen,M., Li,L., Xie,F., Luo,G., Wu,X. and Deng,W.
  TITLE     Investigation of the role and mechanism of ARHGAP5-mediated
            colorectal cancer metastasis
  JOURNAL   Theranostics 10 (13), 5998-6010 (2020)
   PUBMED   32483433
  REMARK    GeneRIF: Investigation of the role and mechanism of
            ARHGAP5-mediated colorectal cancer metastasis.
            Erratum:[Theranostics. 2025 Jan 9;15(5):2085. doi:
            10.7150/thno.108943.. PMID: 39897546]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9589)
  AUTHORS   Muller,P.M., Rademacher,J., Bagshaw,R.D., Wortmann,C., Barth,C.,
            van Unen,J., Alp,K.M., Giudice,G., Eccles,R.L., Heinrich,L.E.,
            Pascual-Vargas,P., Sanchez-Castro,M., Brandenburg,L., Mbamalu,G.,
            Tucholska,M., Spatt,L., Czajkowski,M.T., Welke,R.W., Zhang,S.,
            Nguyen,V., Rrustemi,T., Trnka,P., Freitag,K., Larsen,B., Popp,O.,
            Mertins,P., Gingras,A.C., Roth,F.P., Colwill,K., Bakal,C.,
            Pertz,O., Pawson,T., Petsalaki,E. and Rocks,O.
  TITLE     Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals
            spatially organized RAC1 signalling from integrin adhesions
  JOURNAL   Nat Cell Biol 22 (4), 498-511 (2020)
   PUBMED   32203420
REFERENCE   5  (bases 1 to 9589)
  AUTHORS   Dong,G., Wang,B., An,Y., Li,J., Wang,X., Jia,J. and Yang,Q.
  TITLE     SIRT1 suppresses the migration and invasion of gastric cancer by
            regulating ARHGAP5 expression
  JOURNAL   Cell Death Dis 9 (10), 977 (2018)
   PUBMED   30250020
  REMARK    GeneRIF: These results indicate that SIRT1 suppresses migration and
            invasion of gastric cancer by downregulating ARHGAP5 through an
            interaction with c-JUN, and these phenomena represent a novel
            mechanism of the antitumor action of SIRT1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9589)
  AUTHORS   Chakravarty,G., Roy,D., Gonzales,M., Gay,J., Contreras,A. and
            Rosen,J.M.
  TITLE     P190-B, a Rho-GTPase-activating protein, is differentially
            expressed in terminal end buds and breast cancer
  JOURNAL   Cell Growth Differ 11 (7), 343-354 (2000)
   PUBMED   10939588
REFERENCE   7  (bases 1 to 9589)
  AUTHORS   Zrihan-Licht,S., Fu,Y., Settleman,J., Schinkmann,K., Shaw,L.,
            Keydar,I., Avraham,S. and Avraham,H.
  TITLE     RAFTK/Pyk2 tyrosine kinase mediates the association of p190 RhoGAP
            with RasGAP and is involved in breast cancer cell invasion
  JOURNAL   Oncogene 19 (10), 1318-1328 (2000)
   PUBMED   10713673
REFERENCE   8  (bases 1 to 9589)
  AUTHORS   Burbelo,P.D., Miyamoto,S., Utani,A., Brill,S., Yamada,K.M., Hall,A.
            and Yamada,Y.
  TITLE     p190-B, a new member of the Rho GAP family, and Rho are induced to
            cluster after integrin cross-linking
  JOURNAL   J Biol Chem 270 (52), 30919-30926 (1995)
   PUBMED   8537347
REFERENCE   9  (bases 1 to 9589)
  AUTHORS   Foster,R., Hu,K.Q., Shaywitz,D.A. and Settleman,J.
  TITLE     p190 RhoGAP, the major RasGAP-associated protein, binds GTP
            directly
  JOURNAL   Mol Cell Biol 14 (11), 7173-7181 (1994)
   PUBMED   7935432
REFERENCE   10 (bases 1 to 9589)
  AUTHORS   Ellis,C., Moran,M., McCormick,F. and Pawson,T.
  TITLE     Phosphorylation of GAP and GAP-associated proteins by transforming
            and mitogenic tyrosine kinases
  JOURNAL   Nature 343 (6256), 377-381 (1990)
   PUBMED   1689011
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL161665.5, BC050059.1 and
            AL045112.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001030055.1.
            
            Summary: Rho GTPase activating protein 5 negatively regulates RHO
            GTPases, a family which may mediate cytoskeleton changes by
            stimulating the hydrolysis of bound GTP. Two transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.20632.1,
                                           SRR1660807.242455.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000345122.8/ ENSP00000371897.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               AL161665.5         145055-145186       c
            133-4017            AL161665.5         128104-131988       c
            4018-4447           BC050059.1         3959-4388
            4448-4729           AL045112.1         234-515
            4730-9589           AL161665.5         62762-67621         c
FEATURES             Location/Qualifiers
     source          1..9589
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q12"
     gene            1..9589
                     /gene="ARHGAP5"
                     /gene_synonym="GFI2; p190-B; p190BRhoGAP; RhoGAP5"
                     /note="Rho GTPase activating protein 5"
                     /db_xref="GeneID:394"
                     /db_xref="HGNC:HGNC:675"
                     /db_xref="MIM:602680"
     exon            1..132
                     /gene="ARHGAP5"
                     /gene_synonym="GFI2; p190-B; p190BRhoGAP; RhoGAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            133..4017
                     /gene="ARHGAP5"
                     /gene_synonym="GFI2; p190-B; p190BRhoGAP; RhoGAP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..4809
                     /gene="ARHGAP5"
                     /gene_synonym="GFI2; p190-B; p190BRhoGAP; RhoGAP5"
                     /note="isoform a is encoded by transcript variant 1;
                     growth factor independent 2; rho GTPase-activating protein
                     5; p105 RhoGAP; p100 RasGAP-associated p105 protein;
                     rho-type GTPase-activating protein 5"
                     /codon_start=1
                     /product="rho GTPase-activating protein 5 isoform a"
                     /protein_id="NP_001025226.1"
                     /db_xref="CCDS:CCDS32062.1"
                     /db_xref="GeneID:394"
                     /db_xref="HGNC:HGNC:675"
                     /db_xref="MIM:602680"
                     /translation="MMAKNKEPRPPSYTISIVGLSGTEKDKGNCGVGKSCLCNRFVRS
                     KADEYYPEHTSVLSTIDFGGRVVNNDHFLYWGDIIQNSEDGVECKIHVIEQTEFIDDQ
                     TFLPHRSTNLQPYIKRAAASKLQSAEKLMYICTDQLGLEQDFEQKQMPEGKLNVDGFL
                     LCIDVSQGCNRKFDDQLKFVNNLFVQLSKSKKPVIIAATKCDECVDHYLREVQAFASN
                     KKNLLVVETSARFNVNIETCFTALVQMLDKTRSKPKIIPYLDAYKTQRQLVVTATDKF
                     EKLVQTVRDYHATWKTVSNKLKNHPDYEEYINLEGTRKARNTFSKHIEQLKQEHIRKR
                     REEYINTLPRAFNTLLPNLEEIEHLNWSEALKLMEKRADFQLCFVVLEKTPWDETDHI
                     DKINDRRIPFDLLSTLEAEKVYQNHVQHLISEKRRVEMKEKFKKTLEKIQFISPGQPW
                     EEVMCFVMEDEAYKYITEADSKEVYGRHQREIVEKAKEEFQEMLFEHSELFYDLDLNA
                     TPSSDKMSEIHTVLSEEPRYKALQKLAPDRESLLLKHIGFVYHPTKETCLSGQNCTDI
                     KVEQLLASSLLQLDHGRLRLYHDSTNIDKVNLFILGKDGLAQELANEIRTQSTDDEYA
                     LDGKIYELDLRPVDAKSPYFLSQLWTAAFKPHGCFCVFNSIESLSFIGEFIGKIRTEA
                     SQIRKDKYMANLPFTLILANQRDSISKNLPILRHQGQQLANKLQCPFVDVPAGTYPRK
                     FNETQIKQALRGVLESVKHNLDVVSPIPANKDLSEADLRIVMCAMCGDPFSVDLILSP
                     FLDSHSCSAAQAGQNNSLMLDKIIGEKRRRIQITILSYHSSIGVRKDELVHGYILVYS
                     AKRKASMGMLRAFLSEVQDTIPVQLVAVTDSQADFFENEAIKELMTEGEHIATEITAK
                     FTALYSLSQYHRQTEVFTLFFSDVLEKKNMIENSYLSDNTRESTHQSEDVFLPSPRDC
                     FPYNNYPDSDDDTEAPPPYSPIGDDVQLLPTPSDRSRYRLDLEGNEYPIHSTPNCHDH
                     ERNHKVPPPIKPKPVVPKTNVKKLDPNLLKTIEAGIGKNPRKQTSRVPLAHPEDMDPS
                     DNYAEPIDTIFKQKGYSDEIYVVPDDSQNRIKIRNSFVNNTQGDEENGFSDRTSKSHG
                     ERRPSKYKYKSKTLFSKAKSYYRRTHSDASDDEAFTTSKTKRKGRHRGSEEDPLLSPV
                     ETWKGGIDNPAITSDQELDDKKMKKKTHKVKEDKKQKKKTKNFNPPTRRNWESNYFGM
                     PLQDLVTAEKPIPLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQDHNINL
                     VSMEVTVNAVAGALKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKFH
                     PVNYDVFRYVITHLNRVSQQHKINLMTADNLSICFWPTLMRPDFENREFLSTTKIHQS
                     VVETFIQQCQFFFYNGEIVETTNIVAPPPPSNPGQLVEPMVPLQLPPPLQPQLIQPQL
                     QTDPLGII"
     exon            4018..4165
                     /gene="ARHGAP5"
                     /gene_synonym="GFI2; p190-B; p190BRhoGAP; RhoGAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            4166..4243
                     /gene="ARHGAP5"
                     /gene_synonym="GFI2; p190-B; p190BRhoGAP; RhoGAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            4244..4375
                     /gene="ARHGAP5"
                     /gene_synonym="GFI2; p190-B; p190BRhoGAP; RhoGAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            4376..4481
                     /gene="ARHGAP5"
                     /gene_synonym="GFI2; p190-B; p190BRhoGAP; RhoGAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            4482..9589
                     /gene="ARHGAP5"
                     /gene_synonym="GFI2; p190-B; p190BRhoGAP; RhoGAP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7056..7061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP5"
                     /gene_synonym="GFI2; p190-B; p190BRhoGAP; RhoGAP5"
                     /note="hexamer: ATTAAA"
     polyA_site      7078
                     /gene="ARHGAP5"
                     /gene_synonym="GFI2; p190-B; p190BRhoGAP; RhoGAP5"
                     /note="major polyA site"
     regulatory      7307..7312
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP5"
                     /gene_synonym="GFI2; p190-B; p190BRhoGAP; RhoGAP5"
                     /note="hexamer: AATAAA"
     polyA_site      7326
                     /gene="ARHGAP5"
                     /gene_synonym="GFI2; p190-B; p190BRhoGAP; RhoGAP5"
                     /note="major polyA site"
     regulatory      7841..7846
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP5"
                     /gene_synonym="GFI2; p190-B; p190BRhoGAP; RhoGAP5"
                     /note="hexamer: AATACA"
     polyA_site      7869
                     /gene="ARHGAP5"
                     /gene_synonym="GFI2; p190-B; p190BRhoGAP; RhoGAP5"
                     /note="major polyA site"
     regulatory      9565..9570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP5"
                     /gene_synonym="GFI2; p190-B; p190BRhoGAP; RhoGAP5"
                     /note="hexamer: AATAAA"
     polyA_site      9589
                     /gene="ARHGAP5"
                     /gene_synonym="GFI2; p190-B; p190BRhoGAP; RhoGAP5"
                     /note="major polyA site"
ORIGIN      
        1 gaggaagaga ggcgagcgga gagtggagga ggaggcggcg gcggcgggag cggtccccag
       61 gaatgtcgct gccgccgcca ccgccggggc cgctgccgtt gaggaggaga cggaggagac
      121 cgacgttgtt aggaagatga tccctatgat cttgaagatg tttctgcaca gaaatgaggg
      181 aaatacaaag aaccaaatac agttctgaaa tttgggatct gtattttgag atgattttat
      241 tttcagaatg agaagcatat ctggttacct ttatgaatgt agagacatga gaagagagtt
      301 atgatggcaa aaaacaaaga gcctcgtccc ccatcctata ccatcagtat agttggactc
      361 tctgggactg aaaaagacaa aggtaactgt ggagttggaa agtcttgttt gtgcaataga
      421 tttgtacgct caaaagcaga tgaatattat ccagagcata cttctgtgct tagcaccatt
      481 gactttggag gacgagtagt aaacaatgat cactttttgt actggggtga cataatacaa
      541 aatagtgaag atggagtaga atgcaaaatt catgtcattg aacaaacaga gttcattgat
      601 gaccagactt tcttgcctca tcggagtacg aatttgcaac catatataaa acgtgcagct
      661 gcatctaaat tgcagtcagc agaaaaacta atgtacattt gcactgatca gctaggctta
      721 gaacaagact ttgaacagaa gcaaatgcct gaagggaagc tcaacgtaga tggattttta
      781 ttatgcattg atgtaagtca aggatgcaat aggaagtttg atgatcaact taaatttgtg
      841 aataaccttt ttgtccagtt atcaaaatca aaaaaacctg taataatagc agcaactaaa
      901 tgtgatgaat gcgtggatca ttatcttaga gaagttcagg catttgcttc aaataaaaag
      961 aaccttcttg tagtggaaac atcagcacga tttaatgtca acattgaaac atgttttact
     1021 gcactggtac aaatgttgga taaaactcgt agcaagccta aaattattcc ctatttggat
     1081 gcttataaaa cacagagaca acttgttgtc acagcaacag ataagtttga aaaacttgtg
     1141 cagactgtga gagattatca tgcaacttgg aaaactgtta gtaataaatt aaaaaatcat
     1201 cctgattatg aagaatacat caacttagag ggaacaagaa aggccagaaa tacattctca
     1261 aaacatatag aacaacttaa acaggaacat ataagaaaaa ggagagaaga gtatataaat
     1321 actttaccaa gagcttttaa cactcttttg ccaaatctag aagagattga acatttgaat
     1381 tggtcagaag ctttgaagtt aatggaaaag agagcagatt tccagttatg ttttgtggtg
     1441 ctagaaaaaa ctccttggga tgaaactgac catatagaca aaattaatga taggcggatt
     1501 ccatttgacc tcctgagcac tttagaagct gaaaaagtct atcagaacca tgtacagcat
     1561 ctgatatccg agaagaggag ggtggaaatg aaggaaaaat tcaaaaagac tttggaaaaa
     1621 attcaattca tttcaccagg gcagccatgg gaggaagtta tgtgctttgt tatggaggat
     1681 gaagcctaca aatatatcac tgaggctgat agcaaagagg tatatggtag gcatcagcga
     1741 gaaatagttg aaaaagccaa agaagagttt caagaaatgc tttttgagca ttctgaactt
     1801 ttttatgatt tagatcttaa tgcaacacct agttcagata aaatgagtga aattcataca
     1861 gttctgagtg aagaacctag atataaagct ttacagaaac ttgcacctga tagggaatcc
     1921 cttctactta agcatatagg atttgtttat catcccacta aagaaacatg tcttagtggc
     1981 caaaattgta cagacattaa agtggagcag ttacttgcta gtagtctttt acagttggat
     2041 catggccgct taagattata tcacgatagt accaatatag ataaagttaa cctttttatt
     2101 ttagggaagg atggccttgc ccaagaacta gcaaatgaga taaggacaca atccactgat
     2161 gatgagtatg ccttagatgg aaaaatttat gaacttgatc ttcggccggt tgatgccaaa
     2221 tcgccttact ttttgagtca gttatggact gccgccttta aaccacatgg gtgcttctgt
     2281 gtatttaatt ccattgagtc attgagtttt attggggaat ttattgggaa aataagaact
     2341 gaagcttctc agatcagaaa agataaatac atggctaatc ttccatttac attaattctg
     2401 gctaatcaga gagattccat tagtaagaat ctaccaattc tcaggcacca agggcagcag
     2461 ttggcaaaca agttgcaatg tccttttgta gatgtacctg ctggtacata tcctcgtaaa
     2521 tttaatgaaa cccaaataaa gcaagctctc agaggagtat tggaatcagt taaacacaat
     2581 ttggatgtgg tgagcccaat tcctgccaat aaggacttat cagaagctga cttgagaatt
     2641 gtcatgtgcg ccatgtgtgg agatccattt agtgtggatc ttattctttc acccttcctt
     2701 gattctcatt cttgcagtgc tgctcaagct ggacagaata attccctaat gcttgataaa
     2761 atcattggtg aaaaaaggag gcgaatacag atcacaatat tatcatacca ctcttcaatt
     2821 ggagtaagaa aagatgaact agttcatggg tatatattag tttactctgc aaaacggaaa
     2881 gcttcgatgg gaatgcttcg agcatttcta tcagaagttc aagacaccat tcctgtacag
     2941 ctggtggcag ttactgacag ccaagcagat ttttttgaaa atgaggctat caaagagtta
     3001 atgactgaag gagaacacat tgcaactgag atcactgcta aatttacagc actgtattct
     3061 ttatctcagt atcatcggca aactgaggtc tttactctgt tttttagtga tgttctagag
     3121 aaaaaaaata tgatagaaaa ttcttatttg tctgataata caagggaatc aacccatcaa
     3181 agtgaagatg tttttctacc atctcccaga gactgttttc cctataataa ctaccctgat
     3241 tcagatgatg acacagaagc accacctcct tatagtccaa ttggggatga tgtacagttg
     3301 cttccaacac ctagtgaccg ttccagatat agattagatt tggaaggaaa tgagtatcct
     3361 attcatagta ccccaaactg tcatgaccat gaacgcaacc ataaagtgcc tccacctatt
     3421 aaacctaaac cagttgtacc taagacaaat gtgaaaaaac tcgatccaaa ccttttaaaa
     3481 acaattgaag ctggtattgg taaaaatcca agaaagcaga cttcccgggt gcctttggca
     3541 catcctgaag atatggatcc ttcagataac tatgcggaac ccattgatac aattttcaaa
     3601 cagaagggct attctgatga gatttatgtt gtcccagatg atagtcaaaa tcgtattaaa
     3661 attcgaaact catttgtaaa taacacccaa ggagatgaag aaaatgggtt ttctgataga
     3721 acctcaaaaa gtcatgggga acggaggcct tcaaaataca aatataaatc taaaaccttg
     3781 tttagtaaag ccaagtcata ctatagaaga acacattcag atgccagtga tgatgaggct
     3841 ttcaccactt ctaaaacaaa aagaaaagga agacatcgtg gaagtgaaga agatccactt
     3901 ctttctcctg ttgaaacttg gaaaggtggt attgataatc ctgcaatcac ttctgaccag
     3961 gagttagatg ataagaagat gaagaagaaa acccacaaag tgaaagaaga taaaaagcag
     4021 aaaaagaaaa ctaagaactt caatccacca acacgtagaa attgggaaag taattacttt
     4081 gggatgcccc tccaggatct ggttacagct gagaagccca taccactatt tgttgagaaa
     4141 tgtgtggaat ttattgaaga tacagggtta tgtaccgaag gactctaccg tgtcagcggg
     4201 aataaaactg accaagacaa tattcaaaag cagtttgatc aagatcataa tatcaatcta
     4261 gtgtcaatgg aagtaacagt aaatgctgta gctggagccc ttaaagcttt ctttgcagat
     4321 ctgccagatc ctttaattcc atattctctt catccagaac tattggaagc agcaaaaatc
     4381 ccggataaaa cagaacgtct tcatgccttg aaagaaattg ttaagaaatt tcatcctgta
     4441 aactatgatg tattcagata cgtgataaca catctaaaca gggttagtca gcaacataaa
     4501 atcaacctaa tgacagcaga caacttatcc atctgttttt ggccaacctt gatgagacct
     4561 gattttgaaa atcgagagtt tctgtctact actaagattc atcaatctgt tgttgaaaca
     4621 ttcattcagc agtgtcagtt tttcttttac aatggagaaa ttgtagaaac gacaaacatt
     4681 gtggctcctc caccaccttc aaacccagga cagttggtgg aaccaatggt gccacttcag
     4741 ttgccgccac cattgcaacc tcagctgata caaccacaat tacaaacgga tcctcttggt
     4801 attatatgag taggaagtga ttgcaaacag gctggatttg gacaaaaagc aaatctagac
     4861 atgcatgttt cagggttcag tagtatactt catgtttcat acagataatt cacattcaaa
     4921 attacatttt ctctttgaac tagatggtat tccttattca cttacattac aaatctaaga
     4981 ccatgtgata agcatgactg gagaggttta atttttataa acaaaaatag ctataaagta
     5041 caaagctgct gctgcatgca accttattgc aatcagtata tcattcctgt ggcaatttct
     5101 gtcaccttat attgtgaata aaatttttct atagaaatta aatgatttaa aaactcacct
     5161 atatgaaaca tttaatgctt ttcagcctgc tttctggctg attttgttat ttgatgtgct
     5221 aatttgggca acttaattta cattctggca gtcggtgtag ataactaaaa gcccagttaa
     5281 gtattttata atttcaggct actgaggcca tgcttgggat gttgtttgaa agaaagaaaa
     5341 aatacacttg acatatttca catttctgta ccttcatctt tacttccaag taaacccgtg
     5401 gatgatttga tgagggataa atgaacctat ttcttttaca cacataccaa ggacatgctt
     5461 gtggctaaag tgagttgata atgttgtgca aaggatagtt gtcaccaact catttcttta
     5521 tggtccataa tgaaataaaa attttgtata ctgttaattc tgtaaacaga tgcatgttca
     5581 aaagatctat gatggtcttg taatcttaat ctaatatatt ttagatattt taattttttc
     5641 cctcttgggg aacacattta gtatagtgta gaaaatactt ccatgacatt ttcatataag
     5701 gttatataac ttttcataca taaacatgaa atttgttgta gaaaattctt taaaccaaac
     5761 atttaaatct aggacttcaa tttaatttgt tccttgaatc tatttttatg tggcccttaa
     5821 aaaatatcca aaaaacccat tgctaatata gcaataaaaa tactttgggt actgacagac
     5881 tctttggagt gtttatatta caaatttgta ttcatattct tttctgtgat gtgttgtact
     5941 aaaatccaaa atggcttttg caccattttt aagccaattt tttcctttga tgttggtacc
     6001 agaattacta taagtgactg ctgcttttgg gggtaaacat tttgttagtg aagataaaac
     6061 cagaacacta aattatggat aaaattttca gaataggtgg cacaggtaaa tttcactagg
     6121 ttatattttg tgtagtaaag aaaaaaatta tttggtcaat gttatcttaa ttcatactac
     6181 aatttaagat tatcttatgt gtattatagt aaatagatga ttttcagatt caaggctcct
     6241 aagagtttga tttgctctgt tttttcctaa aataaatatt gtctctccca actgttaagt
     6301 tctaggtatt gtacttccaa ttttaacttc agaaccaaga tgttggcatg aaccaggctg
     6361 ctgttgaagt acatgtatat tataaattat cttatttgtg ttatactctt acatgttatc
     6421 ttttctaaga aaacaaagtc cctattattc ctattgcaaa gcacacagga attaagaaag
     6481 tacagtaatt tttaaaaaaa aatccggtaa atgtagtatt cttaacctgt tctatattac
     6541 ttatacctat tgtctatata gctttaattt atagttgtca gtttaactat tggcatgtct
     6601 ggcaaagaaa attaaacttt aagagtttta taaactgttt ctaggttgct aaagaattta
     6661 tttttctact atatatggta tagacaaagc atcaaactat gtacaggaaa aaagcctgac
     6721 tatttctatt tggaagtagg ctgaaaagag aattttcaaa actgttcgtg tcttcagttc
     6781 attctgtcat aactttgcta ttgtaatatg tgaataccag tttatttaag ctgttctctt
     6841 ttatactgta ttaatttaat gttcatctgc gtttagtacc atttttgtta ttaaaactgg
     6901 catttaccgt ttttcacatt aacccacctt gcaccttccc ccaaacttat ctccactttt
     6961 ctatgcattc tatcattgat ttgacacact tcatagtgag tcatttaaat actctacgtt
     7021 tggttcaatt aaccagtagg ttacagttat tgaaaattaa agtacagttt aaagctcagt
     7081 ctgttacact gaattgattg tgtttgtttt tgccaagggt ttagatatgc ttttaaatat
     7141 tagaaacatc taagaacaga ataacataat taaacttttt tctggtaagt tactggaagg
     7201 tttcactgtt tagggaccta tcatatgaga cttcttaaag gattaaaaga ataggatagt
     7261 ctcataattg tgagtaaaca tcaaggcatt atattttaca atactgaata aaatttcatc
     7321 tacacacatg ttgccattgt ttcatttaag gttcagtgct tatagttaac tacaatattg
     7381 gacctaacag gatctagatt agcaatataa agaagcatag tggtactctg tttcacactt
     7441 tcagtagatt tattagaagt caaattctat tcaacagaca cttattagga tatacaacta
     7501 atttaagaat aaaattccag gcacaatata ttttttttaa atggtatttg ttagtagtgc
     7561 ttcttcccct taacatttac agtgtaaata ctgcaggtaa ccgcaatcta agttagccaa
     7621 aaagcagctt tttttcccat actgtatgta aataatgtag acctgggttt ttttgtttat
     7681 ttgggtttgt tttttttttt gaggtactgg aatctaatta atatctctta ggtatcaaca
     7741 aaagggaaca attggaatga gaatttaggc cttagcttcc atggtgattt ttagtttttt
     7801 atacagtaat aattgtgatg ctatttgtca actggatata aatacacata taattttaaa
     7861 aagtcaaaag tgcttttgtt tctttgttta atgtaatttt tgtgcttcac ctacaggatg
     7921 ctgcagtaaa ttaaatatca gtgaagcttc tgatgtataa agaatgctat gaataaaaca
     7981 ttaagaagct gtgtaatttt aagttatagt tgcctctatt tttaccattt cattggtaaa
     8041 aattagctaa tttttttcaa gtgaaatgaa aaataaaaat ataaatttat caatatgatg
     8101 gaaatcttat taaggagatg tattattgaa ttttcactgt acctgaaaag gagattcaaa
     8161 attttttctg gggatgtata taggtgaaaa tttgattttt taaattatca ggaaaacaag
     8221 ataatgcaca gatttctaag actaagatct tacctggatg tgatttttga gctgtggcta
     8281 gacattcttt agagccactg gaaatatttt gaaaactatt ctagttatag cagagctgct
     8341 aatattaacg aatatatttg tgtcttcatg gtttgtgact attaggccaa attttgtggt
     8401 atatgttgtc agtctggatc tggtgaggtc tgttcaacat gaatctttgt gttatcttga
     8461 atttagtagt ttcaaggtac ttaaattctt aacagtttct aatttgtttc aatacatatg
     8521 ggacatggtt gattttttta ctgtattaga actcttggaa gttcttagcc ttttcaggtt
     8581 atgaaatacc tgaaagtaaa attttctaag atttaataag ggaagatact attcaaatca
     8641 ttttcttagg atagcatctt tacatacaat gagaggattg tacaagcatt aatctcatat
     8701 tccaacatcc agttacttga tgtgatccaa gtaccctggt ctttttgaag cagttaaaat
     8761 ctaattaatt aactttggga gtcttcacta ttcaattgat cctcatcatt gtcctatttg
     8821 catgactcca ttttttcctc cactatatga gttttctttg tcagggggag aggagtggga
     8881 agagtcacag aatctcatat tcacatctta attaaattgt gtgaaattag tcttttgtgg
     8941 aaattctgta ggcagtatga ttttgaaaag ctaaccaatg ataattagca ttttagttaa
     9001 tactaaatgc ataaaattat aacccttgaa attaatttgg tgctggcagt tctggtttag
     9061 tcatttttac cagtagttag tagtattaag acctgcagta tatgcacttt ttgagtagct
     9121 gtcaaataat tgtagttgag aaacaacttg tttattctca caattcagat tttctattca
     9181 gttttgtctc aaatagtaag ttattgtgaa caatttaata acggccctcc tgttctagtt
     9241 tgcctaatat tttagttaag atttagtgtt ttaacctatt tttttaagtt tattttttgt
     9301 attagatttt atttgaataa gttatgtggg tttagtaatt gacctattta ttcattgctt
     9361 cactaattca tccagattag ttttaagtgt gtatatgtat ttgctcacca gatcattttc
     9421 ttgggacctt gaactgtgaa tgttttgtcc taaccattta atattttcta ggtacttgct
     9481 gcaagttctt gaactatttt accagcttta actttggggc tcttagtttc ttttctccag
     9541 attcttgtta ttttatttta tccaaataaa tatttaggtg ttctaagaa
//
