LOCUS       NM_012292               4272 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens Rho GTPase activating protein 45 (ARHGAP45),
            transcript variant 1, mRNA.
ACCESSION   NM_012292 XM_037574
VERSION     NM_012292.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4272)
  AUTHORS   Lee,P.W.T., Suwa,T., Kobayashi,M., Yang,H., Koseki,L.R.,
            Takeuchi,S., Chow,C.C.T., Yasuhara,T. and Harada,H.
  TITLE     Hypoxia- and Postirradiation reoxygenation-induced HMHA1/ARHGAP45
            expression contributes to cancer cell invasion in a HIF-dependent
            manner
  JOURNAL   Br J Cancer 131 (1), 37-48 (2024)
   PUBMED   38740970
  REMARK    GeneRIF: Hypoxia- and Postirradiation reoxygenation-induced
            HMHA1/ARHGAP45 expression contributes to cancer cell invasion in a
            HIF-dependent manner.
REFERENCE   2  (bases 1 to 4272)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4272)
  AUTHORS   Amado-Azevedo,J., Reinhard,N.R., van Bezu,J., van Nieuw
            Amerongen,G.P., van Hinsbergh,V.W.M. and Hordijk,P.L.
  TITLE     The minor histocompatibility antigen 1 (HMHA1)/ArhGAP45 is a RacGAP
            and a novel regulator of endothelial integrity
  JOURNAL   Vascul Pharmacol 101, 38-47 (2018)
   PUBMED   29174013
  REMARK    GeneRIF: ArhGAP45 acts as a Rac-GAP contributing to the balance
            between formation and disruption of endothelial junctions, which is
            required for the dynamic regulation of vascular permeability.
REFERENCE   4  (bases 1 to 4272)
  AUTHORS   Xu,P., Ma,J., Ma,J., Zhang,W., Guo,S., Jian,Z., Liu,L., Wang,G.,
            Gao,T., Zhu,G. and Li,C.
  TITLE     Multiple pro-tumorigenic functions of the human minor
            Histocompatibility Antigen-1 (HA-1) in melanoma progression
  JOURNAL   J Dermatol Sci 88 (2), 216-224 (2017)
   PUBMED   28939173
  REMARK    GeneRIF: HMHA1 significantly promotes melanoma cells proliferation,
            invasion and migration, and prevents cell apoptosis.
REFERENCE   5  (bases 1 to 4272)
  AUTHORS   Linscheid,C., Heitmann,E., Singh,P., Wickstrom,E., Qiu,L.,
            Hodes,H., Nauser,T. and Petroff,M.G.
  TITLE     Trophoblast expression of the minor histocompatibility antigen HA-1
            is regulated by oxygen and is increased in placentas from
            preeclamptic women
  JOURNAL   Placenta 36 (8), 832-838 (2015)
   PUBMED   26095815
  REMARK    GeneRIF: Placental HA-1 expression is regulated by oxygen and is
            increased in the syncytial nuclear aggregates and
            syncytiotrophoblast of preeclamptic as compared to control
            placentas.
REFERENCE   6  (bases 1 to 4272)
  AUTHORS   Kaminski,W.E., Piehler,A. and Schmitz,G.
  TITLE     Genomic organization of the human cholesterol-responsive ABC
            transporter ABCA7: tandem linkage with the minor histocompatibility
            antigen HA-1 gene
  JOURNAL   Biochem Biophys Res Commun 278 (3), 782-789 (2000)
   PUBMED   11095984
REFERENCE   7  (bases 1 to 4272)
  AUTHORS   Arostegui,J.I., Gallardo,D., Rodriguez-Luaces,M., Querol,S.,
            Madrigal,J.A., Garcia-Lopez,J. and Granena,A.
  TITLE     Genomic typing of minor histocompatibility antigen HA-1 by
            reference strand mediated conformation analysis (RSCA)
  JOURNAL   Tissue Antigens 56 (1), 69-76 (2000)
   PUBMED   10958358
REFERENCE   8  (bases 1 to 4272)
  AUTHORS   Wilke,M., Pool,J., den Haan,J.M. and Goulmy,E.
  TITLE     Genomic identification of the minor histocompatibility antigen HA-1
            locus by allele-specific PCR
  JOURNAL   Tissue Antigens 52 (4), 312-317 (1998)
   PUBMED   9820596
REFERENCE   9  (bases 1 to 4272)
  AUTHORS   den Haan,J.M., Meadows,L.M., Wang,W., Pool,J., Blokland,E.,
            Bishop,T.L., Reinhardus,C., Shabanowitz,J., Offringa,R., Hunt,D.F.,
            Engelhard,V.H. and Goulmy,E.
  TITLE     The minor histocompatibility antigen HA-1: a diallelic gene with a
            single amino acid polymorphism
  JOURNAL   Science 279 (5353), 1054-1057 (1998)
   PUBMED   9461441
REFERENCE   10 (bases 1 to 4272)
  AUTHORS   van Lochem,E., van der Keur,M., Mommaas,A.M., de Gast,G.C. and
            Goulmy,E.
  TITLE     Functional expression of minor histocompatibility antigens on human
            peripheral blood dendritic cells and epidermal Langerhans cells
  JOURNAL   Transpl Immunol 4 (2), 151-157 (1996)
   PUBMED   8843592
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB135747.1, D86976.1 and CX871629.1.
            
            On Aug 11, 2020 this sequence version replaced NM_012292.4.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D86976.1, BC065223.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313093.7/ ENSP00000316772.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               DB135747.1         1-151
            152-4164            D86976.1           1-4013
            4165-4272           CX871629.1         380-487             c
FEATURES             Location/Qualifiers
     source          1..4272
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..4272
                     /gene="ARHGAP45"
                     /gene_synonym="HA-1; HLA-HA1; HMHA1"
                     /note="Rho GTPase activating protein 45"
                     /db_xref="GeneID:23526"
                     /db_xref="HGNC:HGNC:17102"
                     /db_xref="MIM:601155"
     exon            1..329
                     /gene="ARHGAP45"
                     /gene_synonym="HA-1; HLA-HA1; HMHA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..3650
                     /gene="ARHGAP45"
                     /gene_synonym="HA-1; HLA-HA1; HMHA1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; minor histocompatibility antigen HA-1; minor
                     histocompatibility protein HA-1; histocompatibility
                     (minor) HA-1"
                     /codon_start=1
                     /product="rho GTPase-activating protein 45 isoform 1
                     precursor"
                     /protein_id="NP_036424.2"
                     /db_xref="CCDS:CCDS32863.1"
                     /db_xref="GeneID:23526"
                     /db_xref="HGNC:HGNC:17102"
                     /db_xref="MIM:601155"
                     /translation="MFSRKKRELMKTPSISKKNRAGSPSPQPSGELPRKDGADAVFPG
                     PSLEPPAGSSGVKATGTLKRPTSLSRHASAAGFPLSGAASWTLGRSHRSPLTAASPGE
                     LPTEGAGPDVVEDISHLLADVARFAEGLEKLKECVLRDDLLEARRPRAHECLGEALRV
                     MHQIISKYPLLNTVETLTAAGTLIAKVKAFHYESNNDLEKQEFEKALETIAVAFSSTV
                     SEFLMGEVDSSTLLAVPPGDSSQSMESLYGPGSEGTPPSLEDCDAGCLPAEEVDVLLQ
                     RCEGGVDAALLYAKNMAKYMKDLISYLEKRTTLEMEFAKGLQKIAHNCRQSVMQEPHM
                     PLLSIYSLALEQDLEFGHSMVQAVGTLQTQTFMQPLTLRRLEHEKRRKEIKEAWHRAQ
                     RKLQEAESNLRKAKQGYVQRCEDHDKARFLVAKAEEEQAGSAPGAGSTATKTLDKRRR
                     LEEEAKNKAEEAMATYRTCVADAKTQKQELEDTKVTALRQIQEVIRQSDQTIKSATIS
                     YYQMMHMQTAPLPVHFQMLCESSKLYDPGQQYASHVRQLQRDQEPDVHYDFEPHVSAN
                     AWSPVMRARKSSFNVSDVARPEAAGSPPEEGGCTEGTPAKDHRAGRGHQVHKSWPLSI
                     SDSDSGLDPGPGAGDFKKFERTSSSGTMSSTEELVDPDGGAGASAFEQADLNGMTPEL
                     PVAVPSGPFRHEGLSKAARTHRLRKLRTPAKCRECNSYVYFQGAECEECCLACHKKCL
                     ETLAIQCGHKKLQGRLQLFGQDFSHAARSAPDGVPFIVKKCVCEIERRALRTKGIYRV
                     NGVKTRVEKLCQAFENGKELVELSQASPHDISNVLKLYLRQLPEPLISFRLYHELVGL
                     AKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRLRELLRDLPPENRASLQYLLRHLR
                     RIVEVEQDNKMTPGNLGIVFGPTLLRPRPTEATVSLSSLVDYPHQARVIETLIVHYGL
                     VFEEEPEETPGGQDESSNQRAEVVVQVPYLEAGEAVVYPLQEAAADGCRESRVVSNDS
                     DSDLEEASELLSSSEASALGHLSFLEQQQSEASLEVASGSHSGSEEQLEATAREDGDG
                     DEDGPAQQLSGFNTNQSNNVLQAPLPPMRLRGGRMTLGSCRERQPEFV"
     exon            330..660
                     /gene="ARHGAP45"
                     /gene_synonym="HA-1; HLA-HA1; HMHA1"
                     /inference="alignment:Splign:2.1.0"
     exon            661..804
                     /gene="ARHGAP45"
                     /gene_synonym="HA-1; HLA-HA1; HMHA1"
                     /inference="alignment:Splign:2.1.0"
     exon            805..889
                     /gene="ARHGAP45"
                     /gene_synonym="HA-1; HLA-HA1; HMHA1"
                     /inference="alignment:Splign:2.1.0"
     exon            890..962
                     /gene="ARHGAP45"
                     /gene_synonym="HA-1; HLA-HA1; HMHA1"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1029
                     /gene="ARHGAP45"
                     /gene_synonym="HA-1; HLA-HA1; HMHA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1167
                     /gene="ARHGAP45"
                     /gene_synonym="HA-1; HLA-HA1; HMHA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1232
                     /gene="ARHGAP45"
                     /gene_synonym="HA-1; HLA-HA1; HMHA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1343
                     /gene="ARHGAP45"
                     /gene_synonym="HA-1; HLA-HA1; HMHA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1424
                     /gene="ARHGAP45"
                     /gene_synonym="HA-1; HLA-HA1; HMHA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1613
                     /gene="ARHGAP45"
                     /gene_synonym="HA-1; HLA-HA1; HMHA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1751
                     /gene="ARHGAP45"
                     /gene_synonym="HA-1; HLA-HA1; HMHA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1942
                     /gene="ARHGAP45"
                     /gene_synonym="HA-1; HLA-HA1; HMHA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2067
                     /gene="ARHGAP45"
                     /gene_synonym="HA-1; HLA-HA1; HMHA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2151
                     /gene="ARHGAP45"
                     /gene_synonym="HA-1; HLA-HA1; HMHA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2256
                     /gene="ARHGAP45"
                     /gene_synonym="HA-1; HLA-HA1; HMHA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2257..2429
                     /gene="ARHGAP45"
                     /gene_synonym="HA-1; HLA-HA1; HMHA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2430..2618
                     /gene="ARHGAP45"
                     /gene_synonym="HA-1; HLA-HA1; HMHA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2619..2756
                     /gene="ARHGAP45"
                     /gene_synonym="HA-1; HLA-HA1; HMHA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2757..2983
                     /gene="ARHGAP45"
                     /gene_synonym="HA-1; HLA-HA1; HMHA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2984..3194
                     /gene="ARHGAP45"
                     /gene_synonym="HA-1; HLA-HA1; HMHA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3195..3303
                     /gene="ARHGAP45"
                     /gene_synonym="HA-1; HLA-HA1; HMHA1"
                     /inference="alignment:Splign:2.1.0"
     exon            3304..4272
                     /gene="ARHGAP45"
                     /gene_synonym="HA-1; HLA-HA1; HMHA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4252..4257
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP45"
                     /gene_synonym="HA-1; HLA-HA1; HMHA1"
                     /note="hexamer: AATAAA"
     polyA_site      4272
                     /gene="ARHGAP45"
                     /gene_synonym="HA-1; HLA-HA1; HMHA1"
                     /note="major polyA site"
ORIGIN      
        1 actccgcaga gccgcaggct gaggccggga agggtcgggg gcgaggccgc gtcgccgcct
       61 ccccgaagcc ttttcctgtt ggggggaggg cccgccagtg acggccgggc ctgtcacgtg
      121 ggcctgacag ctggggaggg ggtggccggc gacaatgtgg tcccgaagcg gccagcgccg
      181 ggagctgcag cgctgagacc cccagcccgc cccctcgggc tcccggccgg ggccccatca
      241 tgttctccag gaagaaacga gagctcatga aaaccccttc catctcgaaa aagaaccgcg
      301 cgggaagccc cagcccgcag ccctcggggg agctgcccag gaaggatggg gctgacgcgg
      361 tgttccccgg accaagcctg gagccgcccg ctgggtcctc cggcgtcaag gccacaggga
      421 ccctcaagcg gcccaccagc ctgagccgcc acgccagcgc ggctggcttc cccctgtcgg
      481 gtgctgcctc ctggacactg ggccggagcc accggagccc actgacagcc gccagcccgg
      541 gcgagctgcc caccgagggt gccggcccgg acgtcgtcga ggacatctcc catctgctgg
      601 cggacgtggc ccgcttcgct gagggccttg agaaacttaa ggagtgtgtg ttgcgtgacg
      661 acctccttga ggcccgccgc ccgcgggccc acgagtgcct gggtgaggct ctgcgtgtca
      721 tgcatcagat catctccaag tacccgctgc tgaacaccgt ggagacgctc accgcagccg
      781 gcaccctcat tgccaaggtc aaagccttcc attatgagag caacaatgat ctggagaaac
      841 aggagttcga gaaggccctg gagacgattg ctgtggcctt cagtagcaca gtgtccgagt
      901 tcctcatggg tgaagtggac agcagcaccc tcctagcagt gcctcctggg gactcgagcc
      961 agtccatgga aagcctgtat ggaccgggca gtgagggcac gcctcccagc ctggaagact
     1021 gtgacgccgg ctgcctgccc gccgaggagg tggacgtgct gctacagcgc tgtgaggggg
     1081 gcgtggatgc cgcactgctg tatgccaaga acatggccaa gtacatgaag gacctcatca
     1141 gctacctgga gaagcggacg acgctggaga tggagtttgc caagggcctg cagaagatcg
     1201 ctcacaactg cagacagagc gtcatgcagg agccccacat gccgctcctg tccatctact
     1261 cgctggccct ggagcaggac ctggagttcg gccacagcat ggtgcaggcg gtgggcacct
     1321 tgcagaccca gaccttcatg cagcccctga ccctgcggcg gcttgaacac gagaagcgca
     1381 ggaaggagat caaggaggcc tggcaccgtg cccagaggaa gctgcaagag gcggagtcca
     1441 acctgcgcaa ggccaagcag ggttacgtgc agcgctgcga ggaccacgac aaggctcgct
     1501 tcctcgtggc caaggcggag gaggagcagg ctggcagcgc gccgggagca ggcagcacgg
     1561 ccaccaagac cctggacaag cggcggcggc tggaggagga ggccaagaac aaggcggagg
     1621 aagctatggc cacctaccgc acctgcgtgg ccgacgcgaa gacgcagaag caggagctgg
     1681 aggataccaa ggtgacggcg ctgcggcaga tccaggaggt catccggcag agcgaccaaa
     1741 ccatcaagtc ggccacgatc tcctactacc agatgatgca tatgcagacg gcgccgctgc
     1801 ccgtgcactt ccagatgctg tgtgagagca gcaagctgta tgacccaggc cagcagtacg
     1861 cctcccacgt gcgccagctg cagcgggacc aggagcccga tgtgcactac gactttgagc
     1921 cccacgtctc cgccaacgcc tggtcccccg tcatgcgtgc ccggaagagc agcttcaacg
     1981 tgagtgatgt ggcgcggccg gaggctgccg ggagcccccc agaagaaggc gggtgcactg
     2041 agggcacacc tgccaaggac cacagggccg ggcgaggaca ccaggttcac aagtcatggc
     2101 cgctctcgat ctcagactcg gacagtgggc tggaccccgg ccctggcgca ggggacttta
     2161 agaagttcga gcggacgtca tccagtggta ccatgtcgtc cacggaggag ctggtggacc
     2221 cagacggtgg agccggggct tcagcctttg agcaggctga cctcaacggc atgacccccg
     2281 agctgccggt ggccgtgccc agtggaccgt tccgccacga ggggctgtcc aaggcggccc
     2341 gtactcaccg gctccggaag ctccgcacgc ccgccaagtg ccgcgagtgc aacagctacg
     2401 tctacttcca gggtgctgag tgtgaagagt gctgcctggc ctgccacaag aaatgtctgg
     2461 agacgctggc catacagtgc gggcacaaga agctgcaagg ccgcctgcag ctgttcggcc
     2521 aggacttcag ccacgcggcc cgcagcgccc ccgacggcgt gcccttcatc gtcaagaagt
     2581 gcgtctgcga gatcgagcgg cgggcgctgc gcaccaaggg catctaccgg gtcaatgggg
     2641 taaagacacg cgtggagaag ctgtgccagg ccttcgagaa cggcaaggag ctggtcgagc
     2701 tgtcgcaggc ctcgccccac gacatcagca acgtcctcaa gctctacctg cgtcagcttc
     2761 ccgagccgct catctccttc cgcctctacc acgagctcgt agggctggcc aaggacagcc
     2821 tgaaggcaga ggccgaggcc aaggcggcgt cccggggccg gcaggacggc tcggagagcg
     2881 aggcagtggc ggtggccctg gcaggtcggc tgcgggagct cctgcgggac ctgccgcctg
     2941 agaaccgggc ctcgctgcag tacctgctgc gtcacctacg caggatcgtg gaggtggagc
     3001 aggacaacaa gatgaccccc gggaacctgg gcatcgtgtt cgggcccacg ctgcttcggc
     3061 cacggcccac cgaggccacc gtgtccctct cctccctggt ggattatccc catcaggccc
     3121 gcgtcatcga gactctcatc gtccactacg gcctggtctt cgaggaggag ccggaggaga
     3181 cccccggggg ccaggacgag tcatccaacc agcgagctga ggtagtcgtc caggtgccgt
     3241 acctggaggc gggcgaggcg gtggtctacc cgctgcagga ggcggcggcg gacgggtgca
     3301 gagaatcccg agttgtgtcc aacgattcgg actcggacct agaggaggcc tccgagctgc
     3361 tgtcctcatc ggaggccagt gccctgggcc acctcagctt cctggagcag cagcagagcg
     3421 aggccagcct agaggtggct tctggcagcc acagcggcag tgaggagcag ctggaggcca
     3481 cagcccggga ggacggggac ggggacgagg acggcccggc ccagcagctc tcaggattca
     3541 acaccaacca gtccaacaac gtgctgcagg ccccactgcc ccccatgagg ctccgtggcg
     3601 ggcggatgac actgggctcc tgcagggaaa ggcagccgga attcgtgtga gctggggtgg
     3661 ggctgggacc acaggtggct tctctcttgc ctgctcctgt ccctccagca cgtcccctgc
     3721 accacggcat agcttaggtg cgccgtcctg gggtcgctgc cgagagcgcc tggacttcga
     3781 cgtcccacca gcgggcgcct cctcccagag gcttccagga gcacgagggc cttgcggcac
     3841 aggactgtgc cctgtgctgt cccctgcacc ccggctcagc tgagctgggg aacactgctg
     3901 tcgtgtgaag tcacagtggc cttgttggtg cccacagggc tgtgtggatg gaggaagctg
     3961 tccctgccca gtgcatcccc caggtcatca cggggacgca ggaggcaggc cctgccctgc
     4021 cctctcctca caggtctgtt gcagggactc cagaaaccat tctgggagcc gtggatgggg
     4081 gcggagctgg ggtttggtgc agtttccagg gtgcagtaca gcagggcctg aatactggcc
     4141 ctggactccc ttttccagaa caccaggtgt ggccacctgg ggctcaggta cacagtgggg
     4201 tctctcggaa gccaccgtgt ggttctttca caggcacgtt tattttgctg aaataaaaag
     4261 tttttaatcg gg
//
