LOCUS       NM_014859               4270 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens Rho GTPase activating protein 44 (ARHGAP44),
            transcript variant 1, mRNA.
ACCESSION   NM_014859 XM_375408
VERSION     NM_014859.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4270)
  AUTHORS   Li,S., Xue,J., Zhang,H. and Shang,G.
  TITLE     ARHGAP44-mediated regulation of the p53/C-myc/Cyclin D1 pathway in
            modulating the malignant biological behavior of osteosarcoma cells
  JOURNAL   J Orthop Surg Res 18 (1), 910 (2023)
   PUBMED   38031136
  REMARK    GeneRIF: ARHGAP44-mediated regulation of the p53/C-myc/Cyclin D1
            pathway in modulating the malignant biological behavior of
            osteosarcoma cells.
            Erratum:[J Orthop Surg Res. 2023 Dec 18;18(1):972. doi:
            10.1186/s13018-023-04454-5.. PMID: 38105224]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4270)
  AUTHORS   Zhang,J., Gong,L., Zhu,H., Sun,W., Tian,J., Zhang,Y., Liu,Q.,
            Li,X., Zhang,F., Wang,S., Zhu,S., Ding,D., Zhang,W. and Yang,C.
  TITLE     RICH2 decreases the mitochondrial number and affects mitochondrial
            localization in diffuse low-grade glioma-related epilepsy
  JOURNAL   Neurobiol Dis 188, 106344 (2023)
   PUBMED   37926169
  REMARK    GeneRIF: RICH2 decreases the mitochondrial number and affects
            mitochondrial localization in diffuse low-grade glioma-related
            epilepsy.
REFERENCE   3  (bases 1 to 4270)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4270)
  AUTHORS   Cheng,J., Liu,Z., Deng,T., Lu,Z., Liu,M., Lu,X., Adeshakin,F.O.,
            Yan,D., Zhang,G. and Wan,X.
  TITLE     CD317 mediates immunocytolysis resistance by
            RICH2/cytoskeleton-dependent membrane protection
  JOURNAL   Mol Immunol 129, 94-102 (2021)
   PUBMED   33223223
  REMARK    GeneRIF: CD317 mediates immunocytolysis resistance by
            RICH2/cytoskeleton-dependent membrane protection.
REFERENCE   5  (bases 1 to 4270)
  AUTHORS   Zhang,J., Yang,C., Gong,L., Zhu,S., Tian,J., Zhang,F., Zhu,Q.,
            Wang,J., Lan,M., Li,Y. and Zhang,W.
  TITLE     RICH2, a potential tumor suppressor in hepatocellular carcinoma
  JOURNAL   Front Biosci (Landmark Ed) 24 (8), 1363-1376 (2019)
   PUBMED   31136984
  REMARK    GeneRIF: Rho GTPase-activating protein RICH2 (RICH2) is
            downregulated in hepatocellular carcinoma (HCC).
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4270)
  AUTHORS   Galic,M., Jeong,S., Tsai,F.C., Joubert,L.M., Wu,Y.I., Hahn,K.M.,
            Cui,Y. and Meyer,T.
  TITLE     External push and internal pull forces recruit curvature-sensing
            N-BAR domain proteins to the plasma membrane
  JOURNAL   Nat Cell Biol 14 (8), 874-881 (2012)
   PUBMED   22750946
REFERENCE   7  (bases 1 to 4270)
  AUTHORS   Benjamin,D.J., Cesarini,D., van der Loos,M.J., Dawes,C.T.,
            Koellinger,P.D., Magnusson,P.K., Chabris,C.F., Conley,D.,
            Laibson,D., Johannesson,M. and Visscher,P.M.
  TITLE     The genetic architecture of economic and political preferences
  JOURNAL   Proc Natl Acad Sci U S A 109 (21), 8026-8031 (2012)
   PUBMED   22566634
REFERENCE   8  (bases 1 to 4270)
  AUTHORS   Le Clerc,S., Coulonges,C., Delaneau,O., Van Manen,D., Herbeck,J.T.,
            Limou,S., An,P., Martinson,J.J., Spadoni,J.L., Therwath,A.,
            Veldink,J.H., van den Berg,L.H., Taing,L., Labib,T., Mellak,S.,
            Montes,M., Delfraissy,J.F., Schachter,F., Winkler,C., Froguel,P.,
            Mullins,J.I., Schuitemaker,H. and Zagury,J.F.
  TITLE     Screening low-frequency SNPS from genome-wide association study
            reveals a new risk allele for progression to AIDS
  JOURNAL   J Acquir Immune Defic Syndr 56 (3), 279-284 (2011)
   PUBMED   21107268
  REMARK    GeneRIF: Besides the already known chromosome 6 associations, the
            analysis of low-frequency single nucleotide polymorphisms brought
            up a new association in the RICH2 gene for progression to AIDS.
REFERENCE   9  (bases 1 to 4270)
  AUTHORS   Rollason,R., Korolchuk,V., Hamilton,C., Jepson,M. and Banting,G.
  TITLE     A CD317/tetherin-RICH2 complex plays a critical role in the
            organization of the subapical actin cytoskeleton in polarized
            epithelial cells
  JOURNAL   J Cell Biol 184 (5), 721-736 (2009)
   PUBMED   19273615
  REMARK    GeneRIF: Knocking down expression of RICH 2 causes loss of the
            apical actin network and apical microvilli, an increase in actin
            bundles at the basal surface, and a reduction in cell height. (RICH
            2 protein)
REFERENCE   10 (bases 1 to 4270)
  AUTHORS   Richnau,N. and Aspenstrom,P.
  TITLE     Rich, a rho GTPase-activating protein domain-containing protein
            involved in signaling by Cdc42 and Rac1
  JOURNAL   J Biol Chem 276 (37), 35060-35070 (2001)
   PUBMED   11431473
  REMARK    GeneRIF: Demonstrates that the RhoGAP domains of RICH-1 and RICH-2
            can catalyze GTP hydrolysis of both Rac1 and Cdc42, but not of
            RhoA.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005274.1, DB461035.1, DA403021.1, BC117416.1, AL080100.1 and
            BM993036.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014859.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB014572.1, BC117412.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379672.10/ ENSP00000368994.5
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC005274.1         190209-190222       c
            15-232              DB461035.1         4-221
            233-262             DA403021.1         191-220
            263-3211            BC117416.1         1-2949
            3212-3757           AL080100.1         464-1009
            3758-4270           BM993036.1         18-530              c
FEATURES             Location/Qualifiers
     source          1..4270
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p12"
     gene            1..4270
                     /gene="ARHGAP44"
                     /gene_synonym="NPC-A-10; RICH2"
                     /note="Rho GTPase activating protein 44"
                     /db_xref="GeneID:9912"
                     /db_xref="HGNC:HGNC:29096"
                     /db_xref="MIM:617716"
     exon            1..394
                     /gene="ARHGAP44"
                     /gene_synonym="NPC-A-10; RICH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             342..2798
                     /gene="ARHGAP44"
                     /gene_synonym="NPC-A-10; RICH2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RhoGAP interacting with CIP4 homologs protein 2; Rho-type
                     GTPase-activating protein RICH2; rho GTPase-activating
                     protein RICH2; rho GTPase-activating protein 44"
                     /codon_start=1
                     /product="rho GTPase-activating protein 44 isoform 1"
                     /protein_id="NP_055674.4"
                     /db_xref="CCDS:CCDS45616.1"
                     /db_xref="GeneID:9912"
                     /db_xref="HGNC:HGNC:29096"
                     /db_xref="MIM:617716"
                     /translation="MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSH
                     STHKKLTACLQGQQGAEADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETE
                     DKLAQELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTS
                     KSSGLSSSLQPAGAKADALREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTL
                     IEVQAEYHRKSLTLLQAVLPQIKAQQEAWVEKPSFGKPLEEHLTISGREIAFPIEACV
                     TMLLECGMQEEGLFRVAPSASKLKKLKAALDCCVVDVQEYSADPHAIAGALKSYLREL
                     PEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIRYLIKFLSKLSEYQ
                     DVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVSLQIVGIIEPIIQHADWFFPGEIE
                     FNITGNYGSPVHVNHNANYSSMPSPDMDPADRRQPEQARRPLSVATDNMMLEFYKKDG
                     LRKIQSMGVRVMDTNWVARRGSSAGRKVSCAPPSMQPPAPPAELAAPLPSPLPEQPLD
                     SPAAPALSPSGLGLQPGPERTSTTKSKELSPGSAQKGSPGSSQGTACAGTQPGAQPGA
                     QPGASPSPSQPPADQSPHTLRKVSKKLAPIPPKVPFGQPGAMADQSAGQPSPVSLSPT
                     PPSTPSPYGLSYPQGYSLASGQLSPAAAPPLASPSVFTSTLSKSRPTPKPRQRPTLPP
                     PQPPTVNLSASSPQSTEAPMLDGMSPGESMSTDLVHFDIPSIHIELGSTLRLSPLEHM
                     RRHSVTDKRDSEEESESTAL"
     exon            395..434
                     /gene="ARHGAP44"
                     /gene_synonym="NPC-A-10; RICH2"
                     /inference="alignment:Splign:2.1.0"
     exon            435..539
                     /gene="ARHGAP44"
                     /gene_synonym="NPC-A-10; RICH2"
                     /inference="alignment:Splign:2.1.0"
     exon            540..616
                     /gene="ARHGAP44"
                     /gene_synonym="NPC-A-10; RICH2"
                     /inference="alignment:Splign:2.1.0"
     exon            617..728
                     /gene="ARHGAP44"
                     /gene_synonym="NPC-A-10; RICH2"
                     /inference="alignment:Splign:2.1.0"
     exon            729..805
                     /gene="ARHGAP44"
                     /gene_synonym="NPC-A-10; RICH2"
                     /inference="alignment:Splign:2.1.0"
     exon            806..923
                     /gene="ARHGAP44"
                     /gene_synonym="NPC-A-10; RICH2"
                     /inference="alignment:Splign:2.1.0"
     exon            924..992
                     /gene="ARHGAP44"
                     /gene_synonym="NPC-A-10; RICH2"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1074
                     /gene="ARHGAP44"
                     /gene_synonym="NPC-A-10; RICH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1202
                     /gene="ARHGAP44"
                     /gene_synonym="NPC-A-10; RICH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1314
                     /gene="ARHGAP44"
                     /gene_synonym="NPC-A-10; RICH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1396
                     /gene="ARHGAP44"
                     /gene_synonym="NPC-A-10; RICH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1477
                     /gene="ARHGAP44"
                     /gene_synonym="NPC-A-10; RICH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..1591
                     /gene="ARHGAP44"
                     /gene_synonym="NPC-A-10; RICH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1683
                     /gene="ARHGAP44"
                     /gene_synonym="NPC-A-10; RICH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1864
                     /gene="ARHGAP44"
                     /gene_synonym="NPC-A-10; RICH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1882
                     /gene="ARHGAP44"
                     /gene_synonym="NPC-A-10; RICH2"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2104
                     /gene="ARHGAP44"
                     /gene_synonym="NPC-A-10; RICH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2280
                     /gene="ARHGAP44"
                     /gene_synonym="NPC-A-10; RICH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2658
                     /gene="ARHGAP44"
                     /gene_synonym="NPC-A-10; RICH2"
                     /inference="alignment:Splign:2.1.0"
     exon            2659..4270
                     /gene="ARHGAP44"
                     /gene_synonym="NPC-A-10; RICH2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4246..4251
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP44"
                     /gene_synonym="NPC-A-10; RICH2"
                     /note="hexamer: ATTAAA"
     polyA_site      4270
                     /gene="ARHGAP44"
                     /gene_synonym="NPC-A-10; RICH2"
                     /note="major polyA site"
ORIGIN      
        1 agccagcctg cggagactcc cgggtccccg cgccggactg ggactgggag caggcagccc
       61 gggcggagcg ggccggtgcc gaggacggcc ccaggcattg ctctgccccg ggcattgcgc
      121 ggcgcgcgtg agggggatgc ggcaggaggc ggcgcggcgg gaggagtagg cggcggcgcc
      181 ctcgggaggg agctgcgcgc gggccagacg gcgcccggag gctccgcagt gccgccgccg
      241 tcgcccggga ggctccgcgc gggagccatg taaccctgcg gcgggctccg ggctgctccg
      301 tccttcccca gctcccgggc tagcgcggca gcggggccac gatgaagaag cagttcaatc
      361 gcatgcgcca gctggccaac cagacggtgg gcagggctga aaagacagaa gttttgagtg
      421 aagaccttct tcaggtggag aagcgtctgg agctggtgaa acaggtgtcc cacagcacgc
      481 acaagaagct caccgcatgt ctgcagggcc agcaaggggc agaggctgac aagcgctcca
      541 aaaagttgcc tttgacaaca ctggctcagt gtctgatgga ggggtcagct atcctgggag
      601 atgacacact tcttgggaag atgctgaaac tctgtggaga gacggaggac aagctggctc
      661 aggagctgat acattttgag ttgcaagtag agagagacgt gattgagccc ctgtttttgc
      721 tggcggaggt ggaaatccca aatattcaaa agcagaggaa acacttagcc aagttggtgc
      781 tggacatgga ttcctcacga accaggtggc agcagacttc caagtcttca ggtttgtcca
      841 gcagcttaca gcctgcgggt gccaaggctg atgccctcag ggaagaaatg gaagaggctg
      901 ccaacagagt ggagatttgc agggaccagc tctcagctga tatgtacagt tttgtggcca
      961 aagaaattga ctatgcaaac tactttcaaa cgctaataga agtgcaagct gaataccaca
     1021 ggaagtccct gacactattg caggctgtat tgcctcagat caaagcacaa caggaggcct
     1081 gggtagagaa gccttccttc gggaagccgc tggaggagca cctcaccatc agcggccggg
     1141 agatcgcctt ccccatcgag gcgtgtgtga ccatgctgct tgagtgtggg atgcaggagg
     1201 agggactctt ccgagtagcc ccctctgcct ccaaactgaa gaagctgaaa gcggccctgg
     1261 actgctgcgt ggtggatgtg caggagtact cggcagaccc ccacgcaatt gcaggagctt
     1321 tgaaatctta cctccgagag ttgccagaac ctcttatgac ctttgaactc tatgatgagt
     1381 ggatccaggc ttccaatgtc caggagcaag acaagaagct tcaggctcta tggaatgctt
     1441 gtgaaaagtt gcccaaggcc aatcacaaca acatccgata cttgataaaa tttttatcca
     1501 agctgtcaga atatcaagat gtaaacaaga tgactcccag taatatggca attgttttag
     1561 gacccaacct cctatggcca caagcagaag ggaacattac agagatgatg accacagtgt
     1621 cgctgcaaat tgttgggatc attgaaccta tcatccagca tgcagactgg ttcttccctg
     1681 gggagataga gttcaacatt actggcaatt atgggagtcc agtacacgtg aaccataatg
     1741 ccaactacag ctcaatgccc tccccagaca tggaccctgc tgaccggcgc cagcccgagc
     1801 aggcccgccg gcccctcagc gtcgccacgg ataatatgat gctggagttt tacaaaaagg
     1861 atggccttag gaaaatccaa agcatgggtg tgagggtcat ggacacaaac tgggtggctc
     1921 gaagaggctc ctcggccggt cggaaagtgt cctgcgcccc gccctccatg cagcctcccg
     1981 ccccgcccgc cgagctggct gcgcccctgc cttcgccgct gccggagcag cccctggaca
     2041 gccccgcggc ccccgcgctc tctccatccg gcctgggcct ccagcctggg cccgagcgca
     2101 ccagcacaac aaaaagcaag gaactttctc caggctctgc acagaaagga agtccaggct
     2161 ccagccaggg cacagcctgt gcagggactc aaccaggggc tcaacctgga gctcagccgg
     2221 gcgccagccc cagccccagc cagccgcctg cagaccagag tcctcacacc ctccggaaag
     2281 tttcaaagaa gctggcaccg attccaccca aggtcccctt tggccagccg ggggctatgg
     2341 cagaccagtc cgctggccag ccgtccccag tcagcctgtc ccccaccccg cccagcaccc
     2401 cgtcacccta tggactgagc taccctcagg ggtactcctt ggcctcgggc cagctctccc
     2461 cagctgcagc tcctcccctg gcctctcctt ctgtctttac aagcactttg agcaaatcgc
     2521 ggcccactcc taagccgcga cagagaccta ctctgccgcc tcctcagcct cccacagtaa
     2581 acctctcggc ctctagtcca cagtccacgg aggcccccat gctagatggc atgtcccctg
     2641 gggaaagcat gtctacagat cttgtccact ttgatattcc ctcgatccac atagagctcg
     2701 ggtcgacgct ccgcctgagt cccctggagc acatgcggcg acactcagta actgacaaga
     2761 gggactcgga ggaggagtct gagagcaccg ccctctgaca tgacaccgcc catcctgcct
     2821 cgcgtgtaca tacatcacgg gccctaggaa cgccgccagg agcagcgtcc atgagcttgc
     2881 caagtgttct ctgctggctc tttcctgcca ctgccaacac gaggttggaa tttggcagaa
     2941 aattgtgatc tccagtccgt gtggtgatgc tggtggtgca ggttttgttt gttcctttcg
     3001 ggtggtgact tcggcctttt gtttgacctt tgccttttga ctttgtgcct cttttgatcc
     3061 actttcagcc tccatgccag aaaacaccca cctctccatc caaggctggt caggaacgtc
     3121 ctttgcaggg tcggggtggt gcgggagagg ctcactttgc ctggttagac ccaagggctg
     3181 ctaccttttc cttggacggc tcatgtcagg tcttgcagga tcagtttaat ggccacagaa
     3241 aggaagcagg acagcagggc ccctctcacc cacaactgga ccaggtccag gattctagca
     3301 gtcctggggc actgaccttt gccagctacc tgggggaggg cttgccactg gaaaaccttt
     3361 caggccgccc ccatcagtgg gctccaaagt aaatggctga aaacaaaaat gtttcacttc
     3421 ctaacagttt tcctttttcc actgtgtgac tgaaagctcc tatatcattt tatatttctg
     3481 aatctataaa acaaaacaaa caagcctgac agtgtctgga ggagccaaag gtggcctccc
     3541 tgtccccaaa tatattggct atatgagagt aattttaccc ctctacgtac ctaaaggcac
     3601 ccagttcact agtctgtggg gtcctggagc ctgtctcttc tttctggagg ttcaaactga
     3661 atagcaataa ttacgttacc caaagcatgt ggaggaaaag tgaaaccagc cacggagacg
     3721 ctggcccacg ggctcggcct gcggtgtggc ctgctttgct caccagcgtc agccgctcat
     3781 ttccttctca tgaagtccca tctggtcatg gggacgaggg ccgggagggc accgggtagc
     3841 cttttcacac ttggggatta ggggagtgag aaaagatttg ggccatgcat gcaaagtcaa
     3901 agtttaaaat tttatccttt tcaaatagat gatataatat acctatacat gatataatat
     3961 ttgtatatat gaaatctctc tatatttgtt taatttgagc cattcaatct aaaccaatgt
     4021 acaggtgtac aatgaaaaat ttaaatgctt agttattttt cccaacacag tgtaaagtca
     4081 ccctcctctg agagtgggat gtgcagagtt ttgatgttgc agctttgctc acttcctggc
     4141 aagggcaggt catgcctcaa tttgtaatgg gagtctgggg taagggtggg ggttgaaagt
     4201 tgttatcttt aaatacatgt acaaatcgtt gtcaaaagta acgttattaa aatagattta
     4261 ttatccctga
//
