LOCUS       NM_152432               8156 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens Rho GTPase activating protein 42 (ARHGAP42),
            transcript variant 1, mRNA.
ACCESSION   NM_152432 XM_001127597 XM_001725369 XM_001725431 XM_001725432
            XM_001726122 XM_001726124
VERSION     NM_152432.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8156)
  AUTHORS   Li,Q., Dibus,M., Casey,A., Yee,C.S.K., Vargas,S.O., Luo,S.,
            Rosen,S.M., Madden,J.A., Genetti,C.A., Brabek,J., Brownstein,C.A.,
            Kazerounian,S., Raby,B.A., Schmitz-Abe,K., Kennedy,J.C.,
            Fishman,M.P., Mullen,M.P., Taylor,J.M., Rosel,D. and Agrawal,P.B.
  TITLE     A homozygous stop-gain variant in ARHGAP42 is associated with
            childhood interstitial lung disease, systemic hypertension, and
            immunological findings
  JOURNAL   PLoS Genet 17 (7), e1009639 (2021)
   PUBMED   34232960
  REMARK    GeneRIF: A homozygous stop-gain variant in ARHGAP42 is associated
            with childhood interstitial lung disease, systemic hypertension,
            and immunological findings.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8156)
  AUTHORS   Lei,Y., Ludorf,K.L., Yu,X., Benjamin,R.H., Gu,X., Lin,Y.,
            Finnell,R.H., Mitchell,L.E., Musfee,F.I., Malik,S., Canfield,M.A.,
            Morrison,A.C., Hobbs,C.A., Van Zutphen,A.R., Fisher,S. and
            Agopian,A.J.
  TITLE     Maternal Hypertension-Related Genotypes and Congenital Heart
            Defects
  JOURNAL   Am J Hypertens 34 (1), 82-91 (2021)
   PUBMED   32710738
  REMARK    GeneRIF: Maternal Hypertension-Related Genotypes and Congenital
            Heart Defects.
REFERENCE   3  (bases 1 to 8156)
  AUTHORS   Bai,X., Mangum,K., Kakoki,M., Smithies,O., Mack,C.P. and
            Taylor,J.M.
  TITLE     GRAF3 serves as a blood volume-sensitive rheostat to control smooth
            muscle contractility and blood pressure
  JOURNAL   Small GTPases 11 (3), 194-203 (2020)
   PUBMED   29099324
  REMARK    GeneRIF: GRAF3 serves as a blood volume-sensitive rheostat to
            control smooth muscle contractility and blood pressure.
REFERENCE   4  (bases 1 to 8156)
  AUTHORS   Mangum,K.D., Freeman,E.J., Magin,J.C., Taylor,J.M. and Mack,C.P.
  TITLE     Transcriptional and posttranscriptional regulation of the
            SMC-selective blood pressure-associated gene, ARHGAP42
  JOURNAL   Am J Physiol Heart Circ Physiol 318 (2), H413-H424 (2020)
   PUBMED   31886719
  REMARK    GeneRIF: ARHGAP42 expression was inhibited by micro-RNA 505
            (miR505) which interacted with the ARHGAP42 3'-untranslated region
            (UTR) to facilitate its degradation and by AK124326, a long
            noncoding RNA that overlaps with the ARHGAP42 transcription start
            site on the opposite DNA strand
REFERENCE   5  (bases 1 to 8156)
  AUTHORS   Fjorder,A.S., Rasmussen,M.B., Mehrjouy,M.M., Nazaryan-Petersen,L.,
            Hansen,C., Bak,M., Grarup,N., Norremolle,A., Larsen,L.A.,
            Vestergaard,H., Hansen,T., Tommerup,N. and Bache,I.
  TITLE     Haploinsufficiency of ARHGAP42 is associated with hypertension
  JOURNAL   Eur J Hum Genet 27 (8), 1296-1303 (2019)
   PUBMED   30903111
  REMARK    GeneRIF: A decreased expression level of Rho GTPase-activating
            protein 42 gene (ARHGAP42) mRNA in the blood was found in the
            translocation carriers relative to controls.
REFERENCE   6  (bases 1 to 8156)
  AUTHORS   Tanikawa,C., Okada,Y., Takahashi,A., Oda,K., Kamatani,N., Kubo,M.,
            Nakamura,Y. and Matsuda,K.
  TITLE     Genome wide association study of age at menarche in the Japanese
            population
  JOURNAL   PLoS One 8 (5), e63821 (2013)
   PUBMED   23667675
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 8156)
  AUTHORS   Bai,X., Lenhart,K.C., Bird,K.E., Suen,A.A., Rojas,M., Kakoki,M.,
            Li,F., Smithies,O., Mack,C.P. and Taylor,J.M.
  TITLE     The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of
            vascular tone and hypertension
  JOURNAL   Nat Commun 4, 2910 (2013)
   PUBMED   24335996
  REMARK    GeneRIF: The smooth muscle-selective GRAF3 is a critical regulator
            of vascular tone and hypertension.
REFERENCE   8  (bases 1 to 8156)
  AUTHORS   Ehret,G.B., Munroe,P.B., Rice,K.M., Bochud,M., Johnson,A.D.,
            Chasman,D.I., Smith,A.V., Tobin,M.D., Verwoert,G.C., Hwang,S.J.,
            Pihur,V., Vollenweider,P., O'Reilly,P.F., Amin,N.,
            Bragg-Gresham,J.L., Teumer,A., Glazer,N.L., Launer,L., Zhao,J.H.,
            Aulchenko,Y., Heath,S., Sober,S., Parsa,A., Luan,J., Arora,P.,
            Dehghan,A., Zhang,F., Lucas,G., Hicks,A.A., Jackson,A.U.,
            Peden,J.F., Tanaka,T., Wild,S.H., Rudan,I., Igl,W., Milaneschi,Y.,
            Parker,A.N., Fava,C., Chambers,J.C., Fox,E.R., Kumari,M., Go,M.J.,
            van der Harst,P., Kao,W.H., Sjogren,M., Vinay,D.G., Alexander,M.,
            Tabara,Y., Shaw-Hawkins,S., Whincup,P.H., Liu,Y., Shi,G.,
            Kuusisto,J., Tayo,B., Seielstad,M., Sim,X., Nguyen,K.D.,
            Lehtimaki,T., Matullo,G., Wu,Y., Gaunt,T.R., Onland-Moret,N.C.,
            Cooper,M.N., Platou,C.G., Org,E., Hardy,R., Dahgam,S., Palmen,J.,
            Vitart,V., Braund,P.S., Kuznetsova,T., Uiterwaal,C.S., Adeyemo,A.,
            Palmas,W., Campbell,H., Ludwig,B., Tomaszewski,M., Tzoulaki,I.,
            Palmer,N.D., Aspelund,T., Garcia,M., Chang,Y.P., O'Connell,J.R.,
            Steinle,N.I., Grobbee,D.E., Arking,D.E., Kardia,S.L.,
            Morrison,A.C., Hernandez,D., Najjar,S., McArdle,W.L., Hadley,D.,
            Brown,M.J., Connell,J.M., Hingorani,A.D., Day,I.N., Lawlor,D.A.,
            Beilby,J.P., Lawrence,R.W., Clarke,R., Hopewell,J.C., Ongen,H.,
            Dreisbach,A.W., Li,Y., Young,J.H., Bis,J.C., Kahonen,M.,
            Viikari,J., Adair,L.S., Lee,N.R., Chen,M.H., Olden,M., Pattaro,C.,
            Bolton,J.A., Kottgen,A., Bergmann,S., Mooser,V., Chaturvedi,N.,
            Frayling,T.M., Islam,M., Jafar,T.H., Erdmann,J., Kulkarni,S.R.,
            Bornstein,S.R., Grassler,J., Groop,L., Voight,B.F., Kettunen,J.,
            Howard,P., Taylor,A., Guarrera,S., Ricceri,F., Emilsson,V.,
            Plump,A., Barroso,I., Khaw,K.T., Weder,A.B., Hunt,S.C., Sun,Y.V.,
            Bergman,R.N., Collins,F.S., Bonnycastle,L.L., Scott,L.J.,
            Stringham,H.M., Peltonen,L., Perola,M., Vartiainen,E., Brand,S.M.,
            Staessen,J.A., Wang,T.J., Burton,P.R., Soler Artigas,M., Dong,Y.,
            Snieder,H., Wang,X., Zhu,H., Lohman,K.K., Rudock,M.E.,
            Heckbert,S.R., Smith,N.L., Wiggins,K.L., Doumatey,A., Shriner,D.,
            Veldre,G., Viigimaa,M., Kinra,S., Prabhakaran,D., Tripathy,V.,
            Langefeld,C.D., Rosengren,A., Thelle,D.S., Corsi,A.M.,
            Singleton,A., Forrester,T., Hilton,G., McKenzie,C.A., Salako,T.,
            Iwai,N., Kita,Y., Ogihara,T., Ohkubo,T., Okamura,T., Ueshima,H.,
            Umemura,S., Eyheramendy,S., Meitinger,T., Wichmann,H.E., Cho,Y.S.,
            Kim,H.L., Lee,J.Y., Scott,J., Sehmi,J.S., Zhang,W., Hedblad,B.,
            Nilsson,P., Smith,G.D., Wong,A., Narisu,N., Stancakova,A.,
            Raffel,L.J., Yao,J., Kathiresan,S., O'Donnell,C.J., Schwartz,S.M.,
            Ikram,M.A., Longstreth,W.T. Jr., Mosley,T.H., Seshadri,S.,
            Shrine,N.R., Wain,L.V., Morken,M.A., Swift,A.J., Laitinen,J.,
            Prokopenko,I., Zitting,P., Cooper,J.A., Humphries,S.E., Danesh,J.,
            Rasheed,A., Goel,A., Hamsten,A., Watkins,H., Bakker,S.J., van
            Gilst,W.H., Janipalli,C.S., Mani,K.R., Yajnik,C.S., Hofman,A.,
            Mattace-Raso,F.U., Oostra,B.A., Demirkan,A., Isaacs,A.,
            Rivadeneira,F., Lakatta,E.G., Orru,M., Scuteri,A., Ala-Korpela,M.,
            Kangas,A.J., Lyytikainen,L.P., Soininen,P., Tukiainen,T., Wurtz,P.,
            Ong,R.T., Dorr,M., Kroemer,H.K., Volker,U., Volzke,H., Galan,P.,
            Hercberg,S., Lathrop,M., Zelenika,D., Deloukas,P., Mangino,M.,
            Spector,T.D., Zhai,G., Meschia,J.F., Nalls,M.A., Sharma,P.,
            Terzic,J., Kumar,M.V., Denniff,M., Zukowska-Szczechowska,E.,
            Wagenknecht,L.E., Fowkes,F.G., Charchar,F.J., Schwarz,P.E.,
            Hayward,C., Guo,X., Rotimi,C., Bots,M.L., Brand,E., Samani,N.J.,
            Polasek,O., Talmud,P.J., Nyberg,F., Kuh,D., Laan,M., Hveem,K.,
            Palmer,L.J., van der Schouw,Y.T., Casas,J.P., Mohlke,K.L.,
            Vineis,P., Raitakari,O., Ganesh,S.K., Wong,T.Y., Tai,E.S.,
            Cooper,R.S., Laakso,M., Rao,D.C., Harris,T.B., Morris,R.W.,
            Dominiczak,A.F., Kivimaki,M., Marmot,M.G., Miki,T., Saleheen,D.,
            Chandak,G.R., Coresh,J., Navis,G., Salomaa,V., Han,B.G., Zhu,X.,
            Kooner,J.S., Melander,O., Ridker,P.M., Bandinelli,S.,
            Gyllensten,U.B., Wright,A.F., Wilson,J.F., Ferrucci,L., Farrall,M.,
            Tuomilehto,J., Pramstaller,P.P., Elosua,R., Soranzo,N.,
            Sijbrands,E.J., Altshuler,D., Loos,R.J., Shuldiner,A.R., Gieger,C.,
            Meneton,P., Uitterlinden,A.G., Wareham,N.J., Gudnason,V.,
            Rotter,J.I., Rettig,R., Uda,M., Strachan,D.P., Witteman,J.C.,
            Hartikainen,A.L., Beckmann,J.S., Boerwinkle,E., Vasan,R.S.,
            Boehnke,M., Larson,M.G., Jarvelin,M.R., Psaty,B.M., Abecasis,G.R.,
            Chakravarti,A., Elliott,P., van Duijn,C.M., Newton-Cheh,C.,
            Levy,D., Caulfield,M.J. and Johnson,T.
  CONSRTM   International Consortium for Blood Pressure Genome-Wide Association
            Studies; CARDIoGRAM consortium; CKDGen Consortium; KidneyGen
            Consortium; EchoGen consortium; CHARGE-HF consortium
  TITLE     Genetic variants in novel pathways influence blood pressure and
            cardiovascular disease risk
  JOURNAL   Nature 478 (7367), 103-109 (2011)
   PUBMED   21909115
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 8156)
  AUTHORS   Wain,L.V., Verwoert,G.C., O'Reilly,P.F., Shi,G., Johnson,T.,
            Johnson,A.D., Bochud,M., Rice,K.M., Henneman,P., Smith,A.V.,
            Ehret,G.B., Amin,N., Larson,M.G., Mooser,V., Hadley,D., Dorr,M.,
            Bis,J.C., Aspelund,T., Esko,T., Janssens,A.C., Zhao,J.H., Heath,S.,
            Laan,M., Fu,J., Pistis,G., Luan,J., Arora,P., Lucas,G., Pirastu,N.,
            Pichler,I., Jackson,A.U., Webster,R.J., Zhang,F., Peden,J.F.,
            Schmidt,H., Tanaka,T., Campbell,H., Igl,W., Milaneschi,Y.,
            Hottenga,J.J., Vitart,V., Chasman,D.I., Trompet,S.,
            Bragg-Gresham,J.L., Alizadeh,B.Z., Chambers,J.C., Guo,X.,
            Lehtimaki,T., Kuhnel,B., Lopez,L.M., Polasek,O., Boban,M.,
            Nelson,C.P., Morrison,A.C., Pihur,V., Ganesh,S.K., Hofman,A.,
            Kundu,S., Mattace-Raso,F.U., Rivadeneira,F., Sijbrands,E.J.,
            Uitterlinden,A.G., Hwang,S.J., Vasan,R.S., Wang,T.J., Bergmann,S.,
            Vollenweider,P., Waeber,G., Laitinen,J., Pouta,A., Zitting,P.,
            McArdle,W.L., Kroemer,H.K., Volker,U., Volzke,H., Glazer,N.L.,
            Taylor,K.D., Harris,T.B., Alavere,H., Haller,T., Keis,A.,
            Tammesoo,M.L., Aulchenko,Y., Barroso,I., Khaw,K.T., Galan,P.,
            Hercberg,S., Lathrop,M., Eyheramendy,S., Org,E., Sober,S., Lu,X.,
            Nolte,I.M., Penninx,B.W., Corre,T., Masciullo,C., Sala,C.,
            Groop,L., Voight,B.F., Melander,O., O'Donnell,C.J., Salomaa,V.,
            d'Adamo,A.P., Fabretto,A., Faletra,F., Ulivi,S., Del Greco,F.,
            Facheris,M., Collins,F.S., Bergman,R.N., Beilby,J.P., Hung,J.,
            Musk,A.W., Mangino,M., Shin,S.Y., Soranzo,N., Watkins,H., Goel,A.,
            Hamsten,A., Gider,P., Loitfelder,M., Zeginigg,M., Hernandez,D.,
            Najjar,S.S., Navarro,P., Wild,S.H., Corsi,A.M., Singleton,A., de
            Geus,E.J., Willemsen,G., Parker,A.N., Rose,L.M., Buckley,B.,
            Stott,D., Orru,M., Uda,M., van der Klauw,M.M., Zhang,W., Li,X.,
            Scott,J., Chen,Y.D., Burke,G.L., Kahonen,M., Viikari,J., Doring,A.,
            Meitinger,T., Davies,G., Starr,J.M., Emilsson,V., Plump,A.,
            Lindeman,J.H., Hoen,P.A., Konig,I.R., Felix,J.F., Clarke,R.,
            Hopewell,J.C., Ongen,H., Breteler,M., Debette,S., Destefano,A.L.,
            Fornage,M., Mitchell,G.F., Smith,N.L., Holm,H., Stefansson,K.,
            Thorleifsson,G., Thorsteinsdottir,U., Samani,N.J., Preuss,M.,
            Rudan,I., Hayward,C., Deary,I.J., Wichmann,H.E., Raitakari,O.T.,
            Palmas,W., Kooner,J.S., Stolk,R.P., Jukema,J.W., Wright,A.F.,
            Boomsma,D.I., Bandinelli,S., Gyllensten,U.B., Wilson,J.F.,
            Ferrucci,L., Schmidt,R., Farrall,M., Spector,T.D., Palmer,L.J.,
            Tuomilehto,J., Pfeufer,A., Gasparini,P., Siscovick,D.,
            Altshuler,D., Loos,R.J., Toniolo,D., Snieder,H., Gieger,C.,
            Meneton,P., Wareham,N.J., Oostra,B.A., Metspalu,A., Launer,L.,
            Rettig,R., Strachan,D.P., Beckmann,J.S., Witteman,J.C., Erdmann,J.,
            van Dijk,K.W., Boerwinkle,E., Boehnke,M., Ridker,P.M.,
            Jarvelin,M.R., Chakravarti,A., Abecasis,G.R., Gudnason,V.,
            Newton-Cheh,C., Levy,D., Munroe,P.B., Psaty,B.M., Caulfield,M.J.,
            Rao,D.C., Tobin,M.D., Elliott,P. and van Duijn,C.M.
  CONSRTM   LifeLines Cohort Study; EchoGen consortium; AortaGen Consortium;
            CHARGE Consortium Heart Failure Working Group; KidneyGen
            consortium; CKDGen consortium; Cardiogenics consortium; CardioGram
  TITLE     Genome-wide association study identifies six new loci influencing
            pulse pressure and mean arterial pressure
  JOURNAL   Nat Genet 43 (10), 1005-1011 (2011)
   PUBMED   21909110
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 8156)
  AUTHORS   Eberth,A., Lundmark,R., Gremer,L., Dvorsky,R., Koessmeier,K.T.,
            McMahon,H.T. and Ahmadian,M.R.
  TITLE     A BAR domain-mediated autoinhibitory mechanism for RhoGAPs of the
            GRAF family
  JOURNAL   Biochem J 417 (1), 371-377 (2009)
   PUBMED   18954304
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001351.5, HY036401.1,
            AI672473.1, AI677857.1, DA800121.1, AP000872.5, EG328683.1,
            AK057372.1, BU146672.1, BM014001.1, CK824101.1 and AV690946.1.
            
            On Nov 23, 2018 this sequence version replaced NM_152432.3.
            
            Summary: This gene encodes a Rho GTPase-activating protein
            (RhoGAP), and member of the GRAF or BAR-PH family of proteins.
            Expression of this gene is enriched in vascular smooth muscle cells
            and the encoded protein inhibits RhoA activity to regulate vascular
            tone and control blood pressure. A mutation in the first intron of
            this gene modulates its expression and is associated with reduced
            blood pressure in human patients with borderline hypertension.
            [provided by RefSeq, Jul 2017].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. There are no human full-length
            transcripts representing this gene; the RefSeq is predicted based
            on tiled partial transcript alignments, but it is unclear if this
            exon combination exists in vivo.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.138267.1,
                                           DRR138513.418230.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298815.13/ ENSP00000298815.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-302               AP001351.5         2679-2980
            303-403             HY036401.1         1-101
            404-747             AI672473.1         17-360
            748-823             AI677857.1         26-101              c
            824-987             DA800121.1         1-164
            988-988             AP000872.5         45749-45749
            989-1368            DA800121.1         166-545
            1369-1434           AP000872.5         67948-68013
            1435-1500           AP000872.5         72602-72667
            1501-1553           EG328683.1         267-319             c
            1554-2101           AK057372.1         36-583
            2102-2624           BU146672.1         220-742
            2625-2700           AK057372.1         1107-1182
            2701-3338           BM014001.1         1-638
            3339-7554           AP000872.5         113269-117484
            7555-8124           CK824101.1         53-622              c
            8125-8156           AV690946.1         403-434
FEATURES             Location/Qualifiers
     source          1..8156
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.1"
     gene            1..8156
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /note="Rho GTPase activating protein 42"
                     /db_xref="GeneID:143872"
                     /db_xref="HGNC:HGNC:26545"
                     /db_xref="MIM:615936"
     exon            1..545
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     CDS             392..3016
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /note="isoform 1 is encoded by transcript variant 1; rho
                     GTPase-activating protein 42; rho-type GTPase-activating
                     protein 42; transmembrane protein 133"
                     /codon_start=1
                     /product="rho GTPase-activating protein 42 isoform 1"
                     /protein_id="NP_689645.2"
                     /db_xref="GeneID:143872"
                     /db_xref="HGNC:HGNC:26545"
                     /db_xref="MIM:615936"
                     /translation="MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGS
                     LLIGALRNLSMAVQKFSQSLQDFQFECIGDAETDDEISIAQSLKEFARLLIAVEEERR
                     RLIQNANDVLIAPLEKFRKEQIGAAKDGKKKFDKESEKYYSILEKHLNLSAKKKESHL
                     QEADTQIDREHQNFYEASLEYVFKIQEVQEKKKFEFVEPLLSFLQGLFTFYHEGYELA
                     QEFAPYKQQLQFNLQNTRNNFESTRQEVERLMQRMKSANQDYRPPSQWTMEGYLYVQE
                     KRPLGFTWIKHYCTYDKGSKTFTMSVSEMKSSGKMNGLVTSSPEMFKLKSCIRRKTDS
                     IDKRFCFDIEVVERHGIITLQAFSEANRKLWLEAMDGKEPIYTLPAIISKKEEMYLNE
                     AGFNFVRKCIQAVETRGITILGLYRIGGVNSKVQKLMNTTFSPKSPPDIDIDIELWDN
                     KTITSGLKNYLRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHALVHKLPEKNREML
                     DILIKHLVKVSLHSQQNLMTVSNLGVIFGPTLMRAQEETVAAMMNIKFQNIVVEILIE
                     HYEKIFHTAPDPSIPLPQPQSRSGSRRTRAICLSTGSRKPRGRYTPCLAEPDSDSYSS
                     SPDSTPMGSIESLSSHSSEQNSTTKSASCQPREKSGGIPWIATPSSSNGQKSLGLWTT
                     SPESSSREDATKTDAESDCQSVASVTSPGDVSPPIDLVKKEPYGLSGLKRASASSLRS
                     ISAAEGNKSYSGSIQSLTSVGSKETPKASPNPDLPPKMCRRLRLDTASSNGYQRPGSV
                     VAAKAQLFENVGSPKPVSSGRQAKAMYSCKAEHSHELSFPQGAIFSNVYPSVEPGWLK
                     ATYEGKTGLVPENYVVFL"
     exon            546..641
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            642..703
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            704..775
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            776..877
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            878..988
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1093
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1223
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1324
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1434
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1513
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1553
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1616
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1691
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1776
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1835
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1941
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2101
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2246
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2627
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2784
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            2785..2847
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            2848..2927
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            2928..8156
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8132..8137
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /note="hexamer: AATAAA"
     polyA_site      8156
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /note="major polyA site"
ORIGIN      
        1 acaacgccga cgactgtcaa gagagttggg gagtggaact gccggaagtg tctgcgcgcc
       61 gtgagagaaa ctttcctgct ccggccgcgg cccggagcct cgccgccccc gcgttccgaa
      121 cgacgatgcg tccagatgac aacaacctga ggggactcgc gcctcggccc gccgcccgcg
      181 cctgcgctcg cctagcctcg ggggaggaag actgagcccg gcgcaggcgg cgcggcgctc
      241 ggggcccgtt tcctccgcgc aatcagtccc ctcgcgtccc ggcgccttcc ccgcgatcgc
      301 gcgaccccag cgcccgccgc ggccgccggc tgcccccgcc ctgacctccg gcccggacgt
      361 gtccgcggcc gccgctggca gcgcctgtgc catggggctg cccactctgg agttcagcga
      421 ttcctacttg gacagcccag atttcaggga gcgcttgcag tgtcacgaga ttgagctgga
      481 gcgaaccaac aagttcatca aggagctcat taaggacggc tctctgctca ttggggcgtt
      541 gaggaatctg tctatggcag tgcagaaatt ttcccagtca ttgcaagatt tccagtttga
      601 atgtattggt gatgctgaaa cagatgatga aattagtatt gctcagtcac taaaagaatt
      661 tgcaagacta ctcattgcag tagaagaaga aaggcgaaga ctgatccaaa acgctaacga
      721 tgtattaatt gcaccacttg agaaatttcg aaaagaacag ataggtgcag caaaagatgg
      781 aaagaagaag tttgacaaag agagtgaaaa atattactct atccttgaaa agcatttaaa
      841 tttgtccgca aagaaaaagg agtctcattt acaagaggca gatacacaaa ttgaccgaga
      901 acatcagaac ttctatgaag catcattaga atatgtcttt aaaattcaag aggtccaaga
      961 aaaaaagaag tttgaatttg ttgaaccgct tttgtcattt cttcagggct tatttacttt
     1021 ttaccatgag ggatatgaac ttgcccagga atttgcaccg tataagcaac agctgcagtt
     1081 caacttgcag aatacaagga ataattttga aagtactcga caagaggtag agcggttgat
     1141 gcaaaggatg aaatctgcta accaggacta cagaccaccc agccagtgga cgatggaagg
     1201 ctatctgtat gtccaggaga aacgaccgct tggttttaca tggattaaac attattgtac
     1261 atatgataag ggaagtaaaa catttacaat gagtgtttca gaaatgaaat ccagtgggaa
     1321 aatgaatggc cttgttacta gctcaccgga aatgtttaaa ttaaaatctt gtatccgacg
     1381 aaagacagat tcaattgaca aacgattctg ctttgacata gaagtagttg aaaggcatgg
     1441 gatcatcacg ttacaggcct tctcagaagc taataggaaa ctctggcttg aagccatgga
     1501 tgggaaggaa ccgatttata ctctgcctgc cattataagc aagaaagaag aaatgtattt
     1561 gaatgaagca gggttcaact ttgtgagaaa atgcattcaa gctgtggaaa caagaggtat
     1621 caccatttta ggactctacc gaataggagg agtgaactcc aaagttcaaa aactcatgaa
     1681 taccacattt tctcctaaat cccctcctga tattgatatt gatattgaac tgtgggacaa
     1741 taagacgata acaagtgggc tgaaaaacta cctcaggtgc cttgcagaac cactgatgac
     1801 ttacaagttg cacaaagatt ttatcattgc tgttaaatct gatgatcaaa actacagggt
     1861 ggaggctgta catgcattgg tgcacaaatt gccggagaaa aacagagaga tgctggacat
     1921 cttaataaag catctggtca aagtatcact acacagccaa caaaatctca tgactgtctc
     1981 aaatcttggt gtcatatttg gcccaactct aatgagagca caggaagaaa ctgtggctgc
     2041 tatgatgaat attaaatttc agaatattgt ggtagaaatt ctgatagagc actatgaaaa
     2101 gatttttcat actgctccag acccaagcat tcctcttcct cagcctcagt ctcgatctgg
     2161 atcccgaagg acacgagcaa tctgcctctc tacagggtct aggaagccca gagggaggta
     2221 tactccatgc ctggccgaac ctgatagtga ctcctatagc agcagcccag acagcacacc
     2281 tatggggagc attgagtcac tctcttctca ttcctctgaa caaaatagca ctacaaagtc
     2341 agcttcctgc cagcccaggg agaaatctgg agggattcct tggattgcaa ccccatcatc
     2401 ttccaatgga cagaaaagcc ttggtctgtg gacaactagt cctgaatcaa gttccagaga
     2461 agatgcaacc aagacagatg cagaatcaga ctgccagagt gttgcttcag tcactagccc
     2521 aggagacgtt tccccaccca tagacctagt caagaaagag ccttatgggc tttcaggact
     2581 gaaaagagct tctgcttctt ctctcagatc catctctgca gctgaaggaa acaagagcta
     2641 cagtggatct attcaaagct taacttctgt aggttccaag gagacaccca aagcttcacc
     2701 aaacccagac ctgcctccga aaatgtgcag gagattaaga ctagacactg cctcaagcaa
     2761 tggctatcag cggcctggct cagtagtggc agcaaaagct caactgtttg aaaatgttgg
     2821 ttcacctaaa ccagtttctt ctgggcgcca agccaaagcc atgtactcct gtaaagcaga
     2881 gcacagtcat gagctttcct tcccacaagg agcaatattt tctaatgtgt acccatcagt
     2941 ggaaccagga tggttaaagg caacttatga aggcaaaaca ggactagttc cagaaaatta
     3001 tgttgtcttc ctctaatact atttagtgga tggcagtatc ttcatggtat ccatggtaac
     3061 gaataaatgc tatgatttta tctgacacag atacacgggg atcagcccac taagtgaaaa
     3121 cagtcaattt ctatcaagtt cttcaccagc agactatgta gctccttatt aatggaaaaa
     3181 aagatttaaa ttgttggcca ttcttttttg gttggtttct tattttaaaa tatcttactt
     3241 gtgaaaaatg tgtttttgga taatatgtaa ctctccacaa tgtcgcttcc gtagcaattg
     3301 tagagtttca aatactgtgt taaatactgt atcccagaaa tttggaaacc agaaatctgc
     3361 tatatggatt ttgagatctg tcctttactg cctggcattc tctgaggatc tctgaaattg
     3421 ttacttaaaa atgtaattta aattgttcat ttattgtttt ttttttctta gaaatatact
     3481 gcttttatat atgattgttt tgctggtcct aaacatttca aggatgtaag tctttgtttt
     3541 aatataactt tatttgtttt ccaagtagat gataatattc aaaagcaata atgtatatga
     3601 tatctataaa ggaagcaaaa ttaagtcata cactgattcc actgtaaaca atctgtccag
     3661 aattccagac accttcagca aactttttct gtaaaggcct gatagcaaat atttttgtgg
     3721 tgggttgaat ttggcttatg ggttatagtt tgctgacacc tagtttagag ggtgtgtaaa
     3781 actatcttca taactttgag atttttataa aattttacat gaaaatatac tgataaatta
     3841 tatgcacata ttttctacca gtagcattat agtggcatca tagaagaata tttaccaatg
     3901 atggggaaac tgtaaaacta cagtatcaag gcatacaact taaattccac ttggaagatt
     3961 gtaaagtgtc aaagtatttt aatgataatt taatttgggc ttttgaaatg ttcttctaca
     4021 aatgaaaaag atgtttaaaa acgttacaag ggaagctatg ccttctgaag tctatcctta
     4081 gttgaaacag aaaataaaca caaaggtaca agatccttaa attattttga accacagagg
     4141 ttgaaattgt tttgtgatct tcagcagaaa taaaatctgt acatgatttt cttttatgcc
     4201 ttttagttta cagtctttat tagcaatttc agtgaatttg tagagcatag taataggtat
     4261 ttactgtcca cttatatata tcagcatctg gtcatgcacg aaccattaat tctatatttc
     4321 tatttcaata attctaatat attatttcta taaatgtaat atctgtatgt ggcaaagagc
     4381 ctttcttctc aagatcctga aaagctggtt acctgccctt tgagtgccac agtcctgaac
     4441 tgcttgttct tgacatcttg catattactt cagagttccc cactgtgcag actctcaggt
     4501 attaactgta aaaaactctt tacatgccat tattatctgt aatctctatc tcttctactt
     4561 taaattaatg tttctagaat taataggtta aatacacata cacacacaca actatgcctc
     4621 agaaaagtta ggcttttaca aataaaaaga ataagattag aattaacaag tagagagaat
     4681 aacggtaggc agagtcagaa tcaggaataa atatcagtga atcaaaagaa tgaaaaatat
     4741 tatgtaataa aaattagcaa tgtaatgtaa acgtttgata aaagagtatc tttttctttt
     4801 atctcttact gttgacctct gtgcactgta ataaggtgtg ttgctggatc ttcttggtcg
     4861 aggtccttgg tgaccttagt agtaataaca gcattgctga caccctaatt gccctctgct
     4921 ggaacagaag gtagttttcc agtgtaccag tcccttagtc tatacagcac ccttggttta
     4981 agcacacttg ccatcatctg gtatcctgct agactagaat ctcttaaaag caaattggtt
     5041 ttctttcaaa gaccaacttg actccaaaga gagattcaga atcctacttc tcctgctgct
     5101 gcataaagaa tctcaacctt cattttattt gaacacggac caaagtgttc ctgcttctga
     5161 gttgtctgta agctaattct gcagatgttc cattcagatt taaagctttt ttactgcata
     5221 ggatgtggat aggaagccta actattgtat ctgatggcaa ggcatatgtt gcagccacag
     5281 tactggctat ggtccctttg ctgaaacaag ctacagaagc actgattcaa gttgtgcttg
     5341 tgcttgaact tttaatcttc tagatttgtg aggatggctc tttttccttc ataatggatt
     5401 acaatgtaag caagtcatgg ccatatactg gagacgggct aaagctgctt ttcccttaaa
     5461 gtaagtttcc tacagataag gtatttatga gcactgagaa agtcaggaca tgtactctaa
     5521 atcacacaga atgttaattc cacaggaagg caatgccaga cattgaaaga ggatcacatt
     5581 caacttttaa tagtagttca ataacaaaac cttagctttt caggaacaat gtgaagatac
     5641 attagaattg ccacatccat atcttcaaaa cacgcaacct ctgcacccta ataactgctt
     5701 acggtataat cagtatgatg atgagattga gggggtctaa atttaagttc cttatctcct
     5761 gagttatgtg aaaatatccc tcagtacaaa acatttgtgt gtttcacaga tgactctctt
     5821 gttttgccgt aatgctacca agtttatgga aactagtcaa ctgaaggatt tttctgttgt
     5881 gttatgtgta aatgtctgaa cagtaaaatc atctgtgtat tcctgtaaca ttcacgaagt
     5941 atgaggaagt gggtttctcc ttgtttgatg tgagtggttt tgcttgttgc atgggttccc
     6001 tgtgctttgt aacttgcatg aacacaacca ggtttctcaa caatgatttg tctgctgact
     6061 cttttcagag atagtgaagg aaaaaaaatg tattaaaacc ccaaattatc taggtttcca
     6121 agtaggaaaa ataaagatac atatgacttt tattattatt cgatgataat tagctttata
     6181 taatgtggca tccttcataa aaattcacta tgttgtgagg caaacagatt tctcactatc
     6241 atccagtgta ccctgctcac cttctcactc ctagcaccgt tcttctggtc tgtgttgaaa
     6301 agggtatcat tcatgtggtt tcagtttaga agagtccctc agagctttgc ctcaagcaat
     6361 ttcaaattgt agtgatacct taaatcatgt attcaggatg ccttctttag catttagaac
     6421 cccaactaga cttatacttt gactaaagtc agaggcagac caatttaggg aacagatttt
     6481 gttctttgct tttatgatac atttgtaact cacagctgtt agcatgacct cacatcactg
     6541 cgtaggaccc ggaaatcaca tctcctggtc aggtcacgaa aaagaacaca ggcttgacta
     6601 ttgtccagaa gttactttcc ccttgactaa aggtttcccc ttagggtaca cattgctatt
     6661 taactttgcc tcctaccctt ttttgttacc ttccaaaatc aagacacttt taagaaacaa
     6721 agatagtttt ctgaacattc tgtgtcctgc ctgtctcctg ttgattcgca gatgtaatat
     6781 cgagtattca tcaactggtc tcaatttcct gaacacattc actgtatccc tcattgtcac
     6841 cgttatcccc ctgcttcaaa atgtgccagt tccacttggt aataacgttg ggaaaatgca
     6901 ggtttatgaa tgatgtggac ttttagagga tcaaatcaat aaattggatt ttttattttt
     6961 tgagggcagc tgccctcact gttttaaata aagaatctta cataagaatg ttgacaacat
     7021 tcacagtaag ccattggcag aaaattgatc tgcatgtcct agaccaatga ttacaaggtg
     7081 tctgtggttt agggggccca gcccatcatt ccttttcccc ttggcactca tgagagagat
     7141 gccaagttca gtgtggattt ttcttggtgc tctatggaga aatggagtct gtgtgcttac
     7201 tgaagagtcc caaaaaccag agaccatttt catttactgc catcataaat attctccacc
     7261 attcaagatg cctgtgtaca cggctatttg ggaaacttaa gtgttggagg aggcaggggc
     7321 tgaaggtgtc aaaacctcct cagtaggata acccctttct cccctttgga ccatctgcca
     7381 tctttcatga gtgtttccca tggtgttttt gcatccagag ttgacaacaa ctcaattttg
     7441 ccttgaattt actcagtctt ataaattaaa aatgtgcatt ttatataaag atgcatttta
     7501 tataaaaatg cacaccttta atctctatat ggcagcatat acatatatat atataaaatg
     7561 cacactttta atctctatat ggcagcattt ttgaggcttt atatctgccc gtgtaccctc
     7621 aactgcctcc tttttgcaga gaacgatccc cacaggaact ggtctaagaa cactgtctgc
     7681 acatgattga tgcttaaaat ccaatatacc accacatatc aaaggttggg attttcagag
     7741 tccttcttga tttctgagct gaaaccttaa caaataggga atttggcagg gaagacacct
     7801 gggtttttaa ttcagaaccc tatttatata ctgttaaaat ttgaggtact gtagtttata
     7861 taaaagtcgg atgttaagat attatatttc agtactagga gcttctttgc agtcattaac
     7921 atgacaaatt aagtaataaa tataaaagtg attgtccata aattatcatt gaattttttg
     7981 tttattttgt agtgttctgt atttatctgc actttgtgta tatatacaca catacatatg
     8041 ccaacatgta aataacctca tgtttattcc taatctaaat tgccacaata tttttaatgt
     8101 atggttacac tgtgttttaa attactttaa aaataaactt tgtaagcaga ttttaa
//
