LOCUS       NM_001367945            8456 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens Rho GTPase activating protein 42 (ARHGAP42),
            transcript variant 2, mRNA.
ACCESSION   NM_001367945 XM_011542617
VERSION     NM_001367945.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8456)
  AUTHORS   Li,Q., Dibus,M., Casey,A., Yee,C.S.K., Vargas,S.O., Luo,S.,
            Rosen,S.M., Madden,J.A., Genetti,C.A., Brabek,J., Brownstein,C.A.,
            Kazerounian,S., Raby,B.A., Schmitz-Abe,K., Kennedy,J.C.,
            Fishman,M.P., Mullen,M.P., Taylor,J.M., Rosel,D. and Agrawal,P.B.
  TITLE     A homozygous stop-gain variant in ARHGAP42 is associated with
            childhood interstitial lung disease, systemic hypertension, and
            immunological findings
  JOURNAL   PLoS Genet 17 (7), e1009639 (2021)
   PUBMED   34232960
  REMARK    GeneRIF: A homozygous stop-gain variant in ARHGAP42 is associated
            with childhood interstitial lung disease, systemic hypertension,
            and immunological findings.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8456)
  AUTHORS   Lei,Y., Ludorf,K.L., Yu,X., Benjamin,R.H., Gu,X., Lin,Y.,
            Finnell,R.H., Mitchell,L.E., Musfee,F.I., Malik,S., Canfield,M.A.,
            Morrison,A.C., Hobbs,C.A., Van Zutphen,A.R., Fisher,S. and
            Agopian,A.J.
  TITLE     Maternal Hypertension-Related Genotypes and Congenital Heart
            Defects
  JOURNAL   Am J Hypertens 34 (1), 82-91 (2021)
   PUBMED   32710738
  REMARK    GeneRIF: Maternal Hypertension-Related Genotypes and Congenital
            Heart Defects.
REFERENCE   3  (bases 1 to 8456)
  AUTHORS   Bai,X., Mangum,K., Kakoki,M., Smithies,O., Mack,C.P. and
            Taylor,J.M.
  TITLE     GRAF3 serves as a blood volume-sensitive rheostat to control smooth
            muscle contractility and blood pressure
  JOURNAL   Small GTPases 11 (3), 194-203 (2020)
   PUBMED   29099324
  REMARK    GeneRIF: GRAF3 serves as a blood volume-sensitive rheostat to
            control smooth muscle contractility and blood pressure.
REFERENCE   4  (bases 1 to 8456)
  AUTHORS   Mangum,K.D., Freeman,E.J., Magin,J.C., Taylor,J.M. and Mack,C.P.
  TITLE     Transcriptional and posttranscriptional regulation of the
            SMC-selective blood pressure-associated gene, ARHGAP42
  JOURNAL   Am J Physiol Heart Circ Physiol 318 (2), H413-H424 (2020)
   PUBMED   31886719
  REMARK    GeneRIF: ARHGAP42 expression was inhibited by micro-RNA 505
            (miR505) which interacted with the ARHGAP42 3'-untranslated region
            (UTR) to facilitate its degradation and by AK124326, a long
            noncoding RNA that overlaps with the ARHGAP42 transcription start
            site on the opposite DNA strand
REFERENCE   5  (bases 1 to 8456)
  AUTHORS   Fjorder,A.S., Rasmussen,M.B., Mehrjouy,M.M., Nazaryan-Petersen,L.,
            Hansen,C., Bak,M., Grarup,N., Norremolle,A., Larsen,L.A.,
            Vestergaard,H., Hansen,T., Tommerup,N. and Bache,I.
  TITLE     Haploinsufficiency of ARHGAP42 is associated with hypertension
  JOURNAL   Eur J Hum Genet 27 (8), 1296-1303 (2019)
   PUBMED   30903111
  REMARK    GeneRIF: A decreased expression level of Rho GTPase-activating
            protein 42 gene (ARHGAP42) mRNA in the blood was found in the
            translocation carriers relative to controls.
REFERENCE   6  (bases 1 to 8456)
  AUTHORS   Tanikawa,C., Okada,Y., Takahashi,A., Oda,K., Kamatani,N., Kubo,M.,
            Nakamura,Y. and Matsuda,K.
  TITLE     Genome wide association study of age at menarche in the Japanese
            population
  JOURNAL   PLoS One 8 (5), e63821 (2013)
   PUBMED   23667675
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 8456)
  AUTHORS   Bai,X., Lenhart,K.C., Bird,K.E., Suen,A.A., Rojas,M., Kakoki,M.,
            Li,F., Smithies,O., Mack,C.P. and Taylor,J.M.
  TITLE     The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of
            vascular tone and hypertension
  JOURNAL   Nat Commun 4, 2910 (2013)
   PUBMED   24335996
  REMARK    GeneRIF: The smooth muscle-selective GRAF3 is a critical regulator
            of vascular tone and hypertension.
REFERENCE   8  (bases 1 to 8456)
  AUTHORS   Ehret,G.B., Munroe,P.B., Rice,K.M., Bochud,M., Johnson,A.D.,
            Chasman,D.I., Smith,A.V., Tobin,M.D., Verwoert,G.C., Hwang,S.J.,
            Pihur,V., Vollenweider,P., O'Reilly,P.F., Amin,N.,
            Bragg-Gresham,J.L., Teumer,A., Glazer,N.L., Launer,L., Zhao,J.H.,
            Aulchenko,Y., Heath,S., Sober,S., Parsa,A., Luan,J., Arora,P.,
            Dehghan,A., Zhang,F., Lucas,G., Hicks,A.A., Jackson,A.U.,
            Peden,J.F., Tanaka,T., Wild,S.H., Rudan,I., Igl,W., Milaneschi,Y.,
            Parker,A.N., Fava,C., Chambers,J.C., Fox,E.R., Kumari,M., Go,M.J.,
            van der Harst,P., Kao,W.H., Sjogren,M., Vinay,D.G., Alexander,M.,
            Tabara,Y., Shaw-Hawkins,S., Whincup,P.H., Liu,Y., Shi,G.,
            Kuusisto,J., Tayo,B., Seielstad,M., Sim,X., Nguyen,K.D.,
            Lehtimaki,T., Matullo,G., Wu,Y., Gaunt,T.R., Onland-Moret,N.C.,
            Cooper,M.N., Platou,C.G., Org,E., Hardy,R., Dahgam,S., Palmen,J.,
            Vitart,V., Braund,P.S., Kuznetsova,T., Uiterwaal,C.S., Adeyemo,A.,
            Palmas,W., Campbell,H., Ludwig,B., Tomaszewski,M., Tzoulaki,I.,
            Palmer,N.D., Aspelund,T., Garcia,M., Chang,Y.P., O'Connell,J.R.,
            Steinle,N.I., Grobbee,D.E., Arking,D.E., Kardia,S.L.,
            Morrison,A.C., Hernandez,D., Najjar,S., McArdle,W.L., Hadley,D.,
            Brown,M.J., Connell,J.M., Hingorani,A.D., Day,I.N., Lawlor,D.A.,
            Beilby,J.P., Lawrence,R.W., Clarke,R., Hopewell,J.C., Ongen,H.,
            Dreisbach,A.W., Li,Y., Young,J.H., Bis,J.C., Kahonen,M.,
            Viikari,J., Adair,L.S., Lee,N.R., Chen,M.H., Olden,M., Pattaro,C.,
            Bolton,J.A., Kottgen,A., Bergmann,S., Mooser,V., Chaturvedi,N.,
            Frayling,T.M., Islam,M., Jafar,T.H., Erdmann,J., Kulkarni,S.R.,
            Bornstein,S.R., Grassler,J., Groop,L., Voight,B.F., Kettunen,J.,
            Howard,P., Taylor,A., Guarrera,S., Ricceri,F., Emilsson,V.,
            Plump,A., Barroso,I., Khaw,K.T., Weder,A.B., Hunt,S.C., Sun,Y.V.,
            Bergman,R.N., Collins,F.S., Bonnycastle,L.L., Scott,L.J.,
            Stringham,H.M., Peltonen,L., Perola,M., Vartiainen,E., Brand,S.M.,
            Staessen,J.A., Wang,T.J., Burton,P.R., Soler Artigas,M., Dong,Y.,
            Snieder,H., Wang,X., Zhu,H., Lohman,K.K., Rudock,M.E.,
            Heckbert,S.R., Smith,N.L., Wiggins,K.L., Doumatey,A., Shriner,D.,
            Veldre,G., Viigimaa,M., Kinra,S., Prabhakaran,D., Tripathy,V.,
            Langefeld,C.D., Rosengren,A., Thelle,D.S., Corsi,A.M.,
            Singleton,A., Forrester,T., Hilton,G., McKenzie,C.A., Salako,T.,
            Iwai,N., Kita,Y., Ogihara,T., Ohkubo,T., Okamura,T., Ueshima,H.,
            Umemura,S., Eyheramendy,S., Meitinger,T., Wichmann,H.E., Cho,Y.S.,
            Kim,H.L., Lee,J.Y., Scott,J., Sehmi,J.S., Zhang,W., Hedblad,B.,
            Nilsson,P., Smith,G.D., Wong,A., Narisu,N., Stancakova,A.,
            Raffel,L.J., Yao,J., Kathiresan,S., O'Donnell,C.J., Schwartz,S.M.,
            Ikram,M.A., Longstreth,W.T. Jr., Mosley,T.H., Seshadri,S.,
            Shrine,N.R., Wain,L.V., Morken,M.A., Swift,A.J., Laitinen,J.,
            Prokopenko,I., Zitting,P., Cooper,J.A., Humphries,S.E., Danesh,J.,
            Rasheed,A., Goel,A., Hamsten,A., Watkins,H., Bakker,S.J., van
            Gilst,W.H., Janipalli,C.S., Mani,K.R., Yajnik,C.S., Hofman,A.,
            Mattace-Raso,F.U., Oostra,B.A., Demirkan,A., Isaacs,A.,
            Rivadeneira,F., Lakatta,E.G., Orru,M., Scuteri,A., Ala-Korpela,M.,
            Kangas,A.J., Lyytikainen,L.P., Soininen,P., Tukiainen,T., Wurtz,P.,
            Ong,R.T., Dorr,M., Kroemer,H.K., Volker,U., Volzke,H., Galan,P.,
            Hercberg,S., Lathrop,M., Zelenika,D., Deloukas,P., Mangino,M.,
            Spector,T.D., Zhai,G., Meschia,J.F., Nalls,M.A., Sharma,P.,
            Terzic,J., Kumar,M.V., Denniff,M., Zukowska-Szczechowska,E.,
            Wagenknecht,L.E., Fowkes,F.G., Charchar,F.J., Schwarz,P.E.,
            Hayward,C., Guo,X., Rotimi,C., Bots,M.L., Brand,E., Samani,N.J.,
            Polasek,O., Talmud,P.J., Nyberg,F., Kuh,D., Laan,M., Hveem,K.,
            Palmer,L.J., van der Schouw,Y.T., Casas,J.P., Mohlke,K.L.,
            Vineis,P., Raitakari,O., Ganesh,S.K., Wong,T.Y., Tai,E.S.,
            Cooper,R.S., Laakso,M., Rao,D.C., Harris,T.B., Morris,R.W.,
            Dominiczak,A.F., Kivimaki,M., Marmot,M.G., Miki,T., Saleheen,D.,
            Chandak,G.R., Coresh,J., Navis,G., Salomaa,V., Han,B.G., Zhu,X.,
            Kooner,J.S., Melander,O., Ridker,P.M., Bandinelli,S.,
            Gyllensten,U.B., Wright,A.F., Wilson,J.F., Ferrucci,L., Farrall,M.,
            Tuomilehto,J., Pramstaller,P.P., Elosua,R., Soranzo,N.,
            Sijbrands,E.J., Altshuler,D., Loos,R.J., Shuldiner,A.R., Gieger,C.,
            Meneton,P., Uitterlinden,A.G., Wareham,N.J., Gudnason,V.,
            Rotter,J.I., Rettig,R., Uda,M., Strachan,D.P., Witteman,J.C.,
            Hartikainen,A.L., Beckmann,J.S., Boerwinkle,E., Vasan,R.S.,
            Boehnke,M., Larson,M.G., Jarvelin,M.R., Psaty,B.M., Abecasis,G.R.,
            Chakravarti,A., Elliott,P., van Duijn,C.M., Newton-Cheh,C.,
            Levy,D., Caulfield,M.J. and Johnson,T.
  CONSRTM   International Consortium for Blood Pressure Genome-Wide Association
            Studies; CARDIoGRAM consortium; CKDGen Consortium; KidneyGen
            Consortium; EchoGen consortium; CHARGE-HF consortium
  TITLE     Genetic variants in novel pathways influence blood pressure and
            cardiovascular disease risk
  JOURNAL   Nature 478 (7367), 103-109 (2011)
   PUBMED   21909115
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 8456)
  AUTHORS   Wain,L.V., Verwoert,G.C., O'Reilly,P.F., Shi,G., Johnson,T.,
            Johnson,A.D., Bochud,M., Rice,K.M., Henneman,P., Smith,A.V.,
            Ehret,G.B., Amin,N., Larson,M.G., Mooser,V., Hadley,D., Dorr,M.,
            Bis,J.C., Aspelund,T., Esko,T., Janssens,A.C., Zhao,J.H., Heath,S.,
            Laan,M., Fu,J., Pistis,G., Luan,J., Arora,P., Lucas,G., Pirastu,N.,
            Pichler,I., Jackson,A.U., Webster,R.J., Zhang,F., Peden,J.F.,
            Schmidt,H., Tanaka,T., Campbell,H., Igl,W., Milaneschi,Y.,
            Hottenga,J.J., Vitart,V., Chasman,D.I., Trompet,S.,
            Bragg-Gresham,J.L., Alizadeh,B.Z., Chambers,J.C., Guo,X.,
            Lehtimaki,T., Kuhnel,B., Lopez,L.M., Polasek,O., Boban,M.,
            Nelson,C.P., Morrison,A.C., Pihur,V., Ganesh,S.K., Hofman,A.,
            Kundu,S., Mattace-Raso,F.U., Rivadeneira,F., Sijbrands,E.J.,
            Uitterlinden,A.G., Hwang,S.J., Vasan,R.S., Wang,T.J., Bergmann,S.,
            Vollenweider,P., Waeber,G., Laitinen,J., Pouta,A., Zitting,P.,
            McArdle,W.L., Kroemer,H.K., Volker,U., Volzke,H., Glazer,N.L.,
            Taylor,K.D., Harris,T.B., Alavere,H., Haller,T., Keis,A.,
            Tammesoo,M.L., Aulchenko,Y., Barroso,I., Khaw,K.T., Galan,P.,
            Hercberg,S., Lathrop,M., Eyheramendy,S., Org,E., Sober,S., Lu,X.,
            Nolte,I.M., Penninx,B.W., Corre,T., Masciullo,C., Sala,C.,
            Groop,L., Voight,B.F., Melander,O., O'Donnell,C.J., Salomaa,V.,
            d'Adamo,A.P., Fabretto,A., Faletra,F., Ulivi,S., Del Greco,F.,
            Facheris,M., Collins,F.S., Bergman,R.N., Beilby,J.P., Hung,J.,
            Musk,A.W., Mangino,M., Shin,S.Y., Soranzo,N., Watkins,H., Goel,A.,
            Hamsten,A., Gider,P., Loitfelder,M., Zeginigg,M., Hernandez,D.,
            Najjar,S.S., Navarro,P., Wild,S.H., Corsi,A.M., Singleton,A., de
            Geus,E.J., Willemsen,G., Parker,A.N., Rose,L.M., Buckley,B.,
            Stott,D., Orru,M., Uda,M., van der Klauw,M.M., Zhang,W., Li,X.,
            Scott,J., Chen,Y.D., Burke,G.L., Kahonen,M., Viikari,J., Doring,A.,
            Meitinger,T., Davies,G., Starr,J.M., Emilsson,V., Plump,A.,
            Lindeman,J.H., Hoen,P.A., Konig,I.R., Felix,J.F., Clarke,R.,
            Hopewell,J.C., Ongen,H., Breteler,M., Debette,S., Destefano,A.L.,
            Fornage,M., Mitchell,G.F., Smith,N.L., Holm,H., Stefansson,K.,
            Thorleifsson,G., Thorsteinsdottir,U., Samani,N.J., Preuss,M.,
            Rudan,I., Hayward,C., Deary,I.J., Wichmann,H.E., Raitakari,O.T.,
            Palmas,W., Kooner,J.S., Stolk,R.P., Jukema,J.W., Wright,A.F.,
            Boomsma,D.I., Bandinelli,S., Gyllensten,U.B., Wilson,J.F.,
            Ferrucci,L., Schmidt,R., Farrall,M., Spector,T.D., Palmer,L.J.,
            Tuomilehto,J., Pfeufer,A., Gasparini,P., Siscovick,D.,
            Altshuler,D., Loos,R.J., Toniolo,D., Snieder,H., Gieger,C.,
            Meneton,P., Wareham,N.J., Oostra,B.A., Metspalu,A., Launer,L.,
            Rettig,R., Strachan,D.P., Beckmann,J.S., Witteman,J.C., Erdmann,J.,
            van Dijk,K.W., Boerwinkle,E., Boehnke,M., Ridker,P.M.,
            Jarvelin,M.R., Chakravarti,A., Abecasis,G.R., Gudnason,V.,
            Newton-Cheh,C., Levy,D., Munroe,P.B., Psaty,B.M., Caulfield,M.J.,
            Rao,D.C., Tobin,M.D., Elliott,P. and van Duijn,C.M.
  CONSRTM   LifeLines Cohort Study; EchoGen consortium; AortaGen Consortium;
            CHARGE Consortium Heart Failure Working Group; KidneyGen
            consortium; CKDGen consortium; Cardiogenics consortium; CardioGram
  TITLE     Genome-wide association study identifies six new loci influencing
            pulse pressure and mean arterial pressure
  JOURNAL   Nat Genet 43 (10), 1005-1011 (2011)
   PUBMED   21909110
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 8456)
  AUTHORS   Eberth,A., Lundmark,R., Gremer,L., Dvorsky,R., Koessmeier,K.T.,
            McMahon,H.T. and Ahmadian,M.R.
  TITLE     A BAR domain-mediated autoinhibitory mechanism for RhoGAPs of the
            GRAF family
  JOURNAL   Biochem J 417 (1), 371-377 (2009)
   PUBMED   18954304
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001351.5, AC015600.8 and
            AP000872.5.
            
            On Jan 1, 2019 this sequence version replaced XM_011542617.2.
            
            Summary: This gene encodes a Rho GTPase-activating protein
            (RhoGAP), and member of the GRAF or BAR-PH family of proteins.
            Expression of this gene is enriched in vascular smooth muscle cells
            and the encoded protein inhibits RhoA activity to regulate vascular
            tone and control blood pressure. A mutation in the first intron of
            this gene modulates its expression and is associated with reduced
            blood pressure in human patients with borderline hypertension.
            [provided by RefSeq, Jul 2017].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR1660809.159280.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-545               AP001351.5         2679-3223
            546-641             AC015600.8         153171-153266       c
            642-703             AC015600.8         128443-128504       c
            704-845             AC015600.8         106753-106894       c
            846-1003            AC015600.8         102464-102621       c
            1004-1075           AC015600.8         63984-64055         c
            1076-1177           AP000872.5         37597-37698
            1178-1288           AP000872.5         45639-45749
            1289-1393           AP000872.5         57301-57405
            1394-1523           AP000872.5         60348-60477
            1524-1624           AP000872.5         65929-66029
            1625-1734           AP000872.5         67904-68013
            1735-1813           AP000872.5         72602-72680
            1814-1853           AP000872.5         74062-74101
            1854-1916           AP000872.5         84028-84090
            1917-1991           AP000872.5         85060-85134
            1992-2076           AP000872.5         85829-85913
            2077-2135           AP000872.5         86554-86612
            2136-2241           AP000872.5         89816-89921
            2242-2401           AP000872.5         97320-97479
            2402-2546           AP000872.5         98604-98748
            2547-2927           AP000872.5         100202-100582
            2928-3084           AP000872.5         100960-101116
            3085-3147           AP000872.5         103132-103194
            3148-3227           AP000872.5         111658-111737
            3228-8456           AP000872.5         112858-118086
FEATURES             Location/Qualifiers
     source          1..8456
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.1"
     gene            1..8456
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /note="Rho GTPase activating protein 42"
                     /db_xref="GeneID:143872"
                     /db_xref="HGNC:HGNC:26545"
                     /db_xref="MIM:615936"
     exon            1..545
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            546..641
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            642..703
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            704..845
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            846..1003
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     CDS             974..3316
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /note="isoform 2 is encoded by transcript variant 2; rho
                     GTPase-activating protein 42; rho-type GTPase-activating
                     protein 42; transmembrane protein 133"
                     /codon_start=1
                     /product="rho GTPase-activating protein 42 isoform 2"
                     /protein_id="NP_001354874.1"
                     /db_xref="GeneID:143872"
                     /db_xref="HGNC:HGNC:26545"
                     /db_xref="MIM:615936"
                     /translation="MAWLNCDELPIQNANDVLIAPLEKFRKEQIGAAKDGKKKFDKES
                     EKYYSILEKHLNLSAKKKESHLQEADTQIDREHQNFYEASLEYVFKIQEVQEKKKFEF
                     VEPLLSFLQGLFTFYHEGYELAQEFAPYKQQLQFNLQNTRNNFESTRQEVERLMQRMK
                     SANQDYRPPSQWTMEGYLYVQEKRPLGFTWIKHYCTYDKGSKTFTMSVSEMKSSGKMN
                     GLVTSSPEMFKLKSCIRRKTDSIDKRFCFDIEVVERHGIITLQAFSEANRKLWLEAMD
                     GKEPIYTLPAIISKKEEMYLNEAGFNFVRKCIQAVETRGITILGLYRIGGVNSKVQKL
                     MNTTFSPKSPPDIDIDIELWDNKTITSGLKNYLRCLAEPLMTYKLHKDFIIAVKSDDQ
                     NYRVEAVHALVHKLPEKNREMLDILIKHLVKVSLHSQQNLMTVSNLGVIFGPTLMRAQ
                     EETVAAMMNIKFQNIVVEILIEHYEKIFHTAPDPSIPLPQPQSRSGSRRTRAICLSTG
                     SRKPRGRYTPCLAEPDSDSYSSSPDSTPMGSIESLSSHSSEQNSTTKSASCQPREKSG
                     GIPWIATPSSSNGQKSLGLWTTSPESSSREDATKTDAESDCQSVASVTSPGDVSPPID
                     LVKKEPYGLSGLKRASASSLRSISAAEGNKSYSGSIQSLTSVGSKETPKASPNPDLPP
                     KMCRRLRLDTASSNGYQRPGSVVAAKAQLFENVGSPKPVSSGRQAKAMYSCKAEHSHE
                     LSFPQGAIFSNVYPSVEPGWLKATYEGKTGLVPENYVVFL"
     exon            1004..1075
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1177
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1288
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1393
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1523
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1624
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1734
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1813
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1853
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            1854..1916
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..1991
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            1992..2076
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..2135
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            2136..2241
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2401
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            2402..2546
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..2927
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            2928..3084
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            3085..3147
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            3148..3227
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     exon            3228..8456
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8432..8437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /note="hexamer: AATAAA"
     polyA_site      8456
                     /gene="ARHGAP42"
                     /gene_synonym="AD031; GRAF3; TMEM133"
                     /note="major polyA site"
ORIGIN      
        1 acaacgccga cgactgtcaa gagagttggg gagtggaact gccggaagtg tctgcgcgcc
       61 gtgagagaaa ctttcctgct ccggccgcgg cccggagcct cgccgccccc gcgttccgaa
      121 cgacgatgcg tccagatgac aacaacctga ggggactcgc gcctcggccc gccgcccgcg
      181 cctgcgctcg cctagcctcg ggggaggaag actgagcccg gcgcaggcgg cgcggcgctc
      241 ggggcccgtt tcctccgcgc aatcagtccc ctcgcgtccc ggcgccttcc ccgcgatcgc
      301 gcgaccccag cgcccgccgc ggccgccggc tgcccccgcc ctgacctccg gcccggacgt
      361 gtccgcggcc gccgctggca gcgcctgtgc catggggctg cccactctgg agttcagcga
      421 ttcctacttg gacagcccag atttcaggga gcgcttgcag tgtcacgaga ttgagctgga
      481 gcgaaccaac aagttcatca aggagctcat taaggacggc tctctgctca ttggggcgtt
      541 gaggaatctg tctatggcag tgcagaaatt ttcccagtca ttgcaagatt tccagtttga
      601 atgtattggt gatgctgaaa cagatgatga aattagtatt gctcagtcac taaaagaatt
      661 tgcaagacta ctcattgcag tagaagaaga aaggcgaaga ctggcaatgt tttaagaggt
      721 tttgctgcca gcccccaaaa agcaggcgat aaaaatgaga atagcctgac atttccatgg
      781 caaacttctt ggtgttgttg taactggagc ttggatgagg atgagacaag ccacattgga
      841 gaatgtgctt ccctttccag ctgtccggct gtctggggag atgtaagaaa aggtatctga
      901 cttagccttg gaggaaggct tacaatctag ttaaatagaa aagcctatta taaacctgaa
      961 gcatttcaaa aacatggcct ggttgaattg tgatgagctc cctatccaaa acgctaacga
     1021 tgtattaatt gcaccacttg agaaatttcg aaaagaacag ataggtgcag caaaagatgg
     1081 aaagaagaag tttgacaaag agagtgaaaa atattactct atccttgaaa agcatttaaa
     1141 tttgtccgca aagaaaaagg agtctcattt acaagaggca gatacacaaa ttgaccgaga
     1201 acatcagaac ttctatgaag catcattaga atatgtcttt aaaattcaag aggtccaaga
     1261 aaaaaagaag tttgaatttg ttgaaccgct tttgtcattt cttcagggct tatttacttt
     1321 ttaccatgag ggatatgaac ttgcccagga atttgcaccg tataagcaac agctgcagtt
     1381 caacttgcag aatacaagga ataattttga aagtactcga caagaggtag agcggttgat
     1441 gcaaaggatg aaatctgcta accaggacta cagaccaccc agccagtgga cgatggaagg
     1501 ctatctgtat gtccaggaga aacgaccgct tggttttaca tggattaaac attattgtac
     1561 atatgataag ggaagtaaaa catttacaat gagtgtttca gaaatgaaat ccagtgggaa
     1621 aatgaatggc cttgttacta gctcaccgga aatgtttaaa ttaaaatctt gtatccgacg
     1681 aaagacagat tcaattgaca aacgattctg ctttgacata gaagtagttg aaaggcatgg
     1741 gatcatcacg ttacaggcct tctcagaagc taataggaaa ctctggcttg aagccatgga
     1801 tgggaaggaa ccgatttata ctctgcctgc cattataagc aagaaagaag aaatgtattt
     1861 gaatgaagca gggttcaact ttgtgagaaa atgcattcaa gctgtggaaa caagaggtat
     1921 caccatttta ggactctacc gaataggagg agtgaactcc aaagttcaaa aactcatgaa
     1981 taccacattt tctcctaaat cccctcctga tattgatatt gatattgaac tgtgggacaa
     2041 taagacgata acaagtgggc tgaaaaacta cctcaggtgc cttgcagaac cactgatgac
     2101 ttacaagttg cacaaagatt ttatcattgc tgttaaatct gatgatcaaa actacagggt
     2161 ggaggctgta catgcattgg tgcacaaatt gccggagaaa aacagagaga tgctggacat
     2221 cttaataaag catctggtca aagtatcact acacagccaa caaaatctca tgactgtctc
     2281 aaatcttggt gtcatatttg gcccaactct aatgagagca caggaagaaa ctgtggctgc
     2341 tatgatgaat attaaatttc agaatattgt ggtagaaatt ctgatagagc actatgaaaa
     2401 gatttttcat actgctccag acccaagcat tcctcttcct cagcctcagt ctcgatctgg
     2461 atcccgaagg acacgagcaa tctgcctctc tacagggtct aggaagccca gagggaggta
     2521 tactccatgc ctggccgaac ctgatagtga ctcctatagc agcagcccag acagcacacc
     2581 tatggggagc attgagtcac tctcttctca ttcctctgaa caaaatagca ctacaaagtc
     2641 agcttcctgc cagcccaggg agaaatctgg agggattcct tggattgcaa ccccatcatc
     2701 ttccaatgga cagaaaagcc ttggtctgtg gacaactagt cctgaatcaa gttccagaga
     2761 agatgcaacc aagacagatg cagaatcaga ctgccagagt gttgcttcag tcactagccc
     2821 aggagacgtt tccccaccca tagacctagt caagaaagag ccttatgggc tttcaggact
     2881 gaaaagagct tctgcttctt ctctcagatc catctctgca gctgaaggaa acaagagcta
     2941 cagtggatct attcaaagct taacttctgt aggttccaag gagacaccca aagcttcacc
     3001 aaacccagac ctgcctccga aaatgtgcag gagattaaga ctagacactg cctcaagcaa
     3061 tggctatcag cggcctggct cagtagtggc agcaaaagct caactgtttg aaaatgttgg
     3121 ttcacctaaa ccagtttctt ctgggcgcca agccaaagcc atgtactcct gtaaagcaga
     3181 gcacagtcat gagctttcct tcccacaagg agcaatattt tctaatgtgt acccatcagt
     3241 ggaaccagga tggttaaagg caacttatga aggcaaaaca ggactagttc cagaaaatta
     3301 tgttgtcttc ctctaatact atttagtgga tggcagtatc ttcatggtat ccatggtaac
     3361 gaataaatgc tatgatttta tctgacacag atacacgggg atcagcccac taagtgaaaa
     3421 cagtcaattt ctatcaagtt cttcaccagc agactatgta gctccttatt aatggaaaaa
     3481 aagatttaaa ttgttggcca ttcttttttg gttggtttct tattttaaaa tatcttactt
     3541 gtgaaaaatg tgtttttgga taatatgtaa ctctccacaa tgtcgcttcc gtagcaattg
     3601 tagagtttca aatactgtgt taaatactgt atcccagaaa tttggaaacc agaaatctgc
     3661 tatatggatt ttgagatctg tcctttactg cctggcattc tctgaggatc tctgaaattg
     3721 ttacttaaaa atgtaattta aattgttcat ttattgtttt ttttttctta gaaatatact
     3781 gcttttatat atgattgttt tgctggtcct aaacatttca aggatgtaag tctttgtttt
     3841 aatataactt tatttgtttt ccaagtagat gataatattc aaaagcaata atgtatatga
     3901 tatctataaa ggaagcaaaa ttaagtcata cactgattcc actgtaaaca atctgtccag
     3961 aattccagac accttcagca aactttttct gtaaaggcct gatagcaaat atttttgtgg
     4021 tgggttgaat ttggcttatg ggttatagtt tgctgacacc tagtttagag ggtgtgtaaa
     4081 actatcttca taactttgag atttttataa aattttacat gaaaatatac tgataaatta
     4141 tatgcacata ttttctacca gtagcattat agtggcatca tagaagaata tttaccaatg
     4201 atggggaaac tgtaaaacta cagtatcaag gcatacaact taaattccac ttggaagatt
     4261 gtaaagtgtc aaagtatttt aatgataatt taatttgggc ttttgaaatg ttcttctaca
     4321 aatgaaaaag atgtttaaaa acgttacaag ggaagctatg ccttctgaag tctatcctta
     4381 gttgaaacag aaaataaaca caaaggtaca agatccttaa attattttga accacagagg
     4441 ttgaaattgt tttgtgatct tcagcagaaa taaaatctgt acatgatttt cttttatgcc
     4501 ttttagttta cagtctttat tagcaatttc agtgaatttg tagagcatag taataggtat
     4561 ttactgtcca cttatatata tcagcatctg gtcatgcacg aaccattaat tctatatttc
     4621 tatttcaata attctaatat attatttcta taaatgtaat atctgtatgt ggcaaagagc
     4681 ctttcttctc aagatcctga aaagctggtt acctgccctt tgagtgccac agtcctgaac
     4741 tgcttgttct tgacatcttg catattactt cagagttccc cactgtgcag actctcaggt
     4801 attaactgta aaaaactctt tacatgccat tattatctgt aatctctatc tcttctactt
     4861 taaattaatg tttctagaat taataggtta aatacacata cacacacaca actatgcctc
     4921 agaaaagtta ggcttttaca aataaaaaga ataagattag aattaacaag tagagagaat
     4981 aacggtaggc agagtcagaa tcaggaataa atatcagtga atcaaaagaa tgaaaaatat
     5041 tatgtaataa aaattagcaa tgtaatgtaa acgtttgata aaagagtatc tttttctttt
     5101 atctcttact gttgacctct gtgcactgta ataaggtgtg ttgctggatc ttcttggtcg
     5161 aggtccttgg tgaccttagt agtaataaca gcattgctga caccctaatt gccctctgct
     5221 ggaacagaag gtagttttcc agtgtaccag tcccttagtc tatacagcac ccttggttta
     5281 agcacacttg ccatcatctg gtatcctgct agactagaat ctcttaaaag caaattggtt
     5341 ttctttcaaa gaccaacttg actccaaaga gagattcaga atcctacttc tcctgctgct
     5401 gcataaagaa tctcaacctt cattttattt gaacacggac caaagtgttc ctgcttctga
     5461 gttgtctgta agctaattct gcagatgttc cattcagatt taaagctttt ttactgcata
     5521 ggatgtggat aggaagccta actattgtat ctgatggcaa ggcatatgtt gcagccacag
     5581 tactggctat ggtccctttg ctgaaacaag ctacagaagc actgattcaa gttgtgcttg
     5641 tgcttgaact tttaatcttc tagatttgtg aggatggctc tttttccttc ataatggatt
     5701 acaatgtaag caagtcatgg ccatatactg gagacgggct aaagctgctt ttcccttaaa
     5761 gtaagtttcc tacagataag gtatttatga gcactgagaa agtcaggaca tgtactctaa
     5821 atcacacaga atgttaattc cacaggaagg caatgccaga cattgaaaga ggatcacatt
     5881 caacttttaa tagtagttca ataacaaaac cttagctttt caggaacaat gtgaagatac
     5941 attagaattg ccacatccat atcttcaaaa cacgcaacct ctgcacccta ataactgctt
     6001 acggtataat cagtatgatg atgagattga gggggtctaa atttaagttc cttatctcct
     6061 gagttatgtg aaaatatccc tcagtacaaa acatttgtgt gtttcacaga tgactctctt
     6121 gttttgccgt aatgctacca agtttatgga aactagtcaa ctgaaggatt tttctgttgt
     6181 gttatgtgta aatgtctgaa cagtaaaatc atctgtgtat tcctgtaaca ttcacgaagt
     6241 atgaggaagt gggtttctcc ttgtttgatg tgagtggttt tgcttgttgc atgggttccc
     6301 tgtgctttgt aacttgcatg aacacaacca ggtttctcaa caatgatttg tctgctgact
     6361 cttttcagag atagtgaagg aaaaaaaatg tattaaaacc ccaaattatc taggtttcca
     6421 agtaggaaaa ataaagatac atatgacttt tattattatt cgatgataat tagctttata
     6481 taatgtggca tccttcataa aaattcacta tgttgtgagg caaacagatt tctcactatc
     6541 atccagtgta ccctgctcac cttctcactc ctagcaccgt tcttctggtc tgtgttgaaa
     6601 agggtatcat tcatgtggtt tcagtttaga agagtccctc agagctttgc ctcaagcaat
     6661 ttcaaattgt agtgatacct taaatcatgt attcaggatg ccttctttag catttagaac
     6721 cccaactaga cttatacttt gactaaagtc agaggcagac caatttaggg aacagatttt
     6781 gttctttgct tttatgatac atttgtaact cacagctgtt agcatgacct cacatcactg
     6841 cgtaggaccc ggaaatcaca tctcctggtc aggtcacgaa aaagaacaca ggcttgacta
     6901 ttgtccagaa gttactttcc ccttgactaa aggtttcccc ttagggtaca cattgctatt
     6961 taactttgcc tcctaccctt ttttgttacc ttccaaaatc aagacacttt taagaaacaa
     7021 agatagtttt ctgaacattc tgtgtcctgc ctgtctcctg ttgattcgca gatgtaatat
     7081 cgagtattca tcaactggtc tcaatttcct gaacacattc actgtatccc tcattgtcac
     7141 cgttatcccc ctgcttcaaa atgtgccagt tccacttggt aataacgttg ggaaaatgca
     7201 ggtttatgaa tgatgtggac ttttagagga tcaaatcaat aaattggatt ttttattttt
     7261 tgagggcagc tgccctcact gttttaaata aagaatctta cataagaatg ttgacaacat
     7321 tcacagtaag ccattggcag aaaattgatc tgcatgtcct agaccaatga ttacaaggtg
     7381 tctgtggttt agggggccca gcccatcatt ccttttcccc ttggcactca tgagagagat
     7441 gccaagttca gtgtggattt ttcttggtgc tctatggaga aatggagtct gtgtgcttac
     7501 tgaagagtcc caaaaaccag agaccatttt catttactgc catcataaat attctccacc
     7561 attcaagatg cctgtgtaca cggctatttg ggaaacttaa gtgttggagg aggcaggggc
     7621 tgaaggtgtc aaaacctcct cagtaggata acccctttct cccctttgga ccatctgcca
     7681 tctttcatga gtgtttccca tggtgttttt gcatccagag ttgacaacaa ctcaattttg
     7741 ccttgaattt actcagtctt ataaattaaa aatgtgcatt ttatataaag atgcatttta
     7801 tataaaaatg cacaccttta atctctatat ggcagcatat acatatatat atataaaatg
     7861 cacactttta atctctatat ggcagcattt ttgaggcttt atatctgccc gtgtaccctc
     7921 aactgcctcc tttttgcaga gaacgatccc cacaggaact ggtctaagaa cactgtctgc
     7981 acatgattga tgcttaaaat ccaatatacc accacatatc aaaggttggg attttcagag
     8041 tccttcttga tttctgagct gaaaccttaa caaataggga atttggcagg gaagacacct
     8101 gggtttttaa ttcagaaccc tatttatata ctgttaaaat ttgaggtact gtagtttata
     8161 taaaagtcgg atgttaagat attatatttc agtactagga gcttctttgc agtcattaac
     8221 atgacaaatt aagtaataaa tataaaagtg attgtccata aattatcatt gaattttttg
     8281 tttattttgt agtgttctgt atttatctgc actttgtgta tatatacaca catacatatg
     8341 ccaacatgta aataacctca tgtttattcc taatctaaat tgccacaata tttttaatgt
     8401 atggttacac tgtgttttaa attactttaa aaataaactt tgtaagcaga ttttaa
//
