LOCUS       NM_001164431            2967 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens Rho GTPase activating protein 40 (ARHGAP40), mRNA.
ACCESSION   NM_001164431 XM_001715877 XM_293123 XM_937379
VERSION     NM_001164431.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2967)
  AUTHORS   Yu,N., Yuan,B., Cai,J., Liu,J., Zhang,W., Bao,W. and Wang,J.
  TITLE     Loss of ARHGAP40 expression in basal cell carcinoma via CpG island
            hypermethylation
  JOURNAL   Exp Dermatol 32 (12), 2094-2101 (2023)
   PUBMED   37822129
  REMARK    GeneRIF: Loss of ARHGAP40 expression in basal cell carcinoma via
            CpG island hypermethylation.
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from AL035419.12.
            
            On Apr 26, 2022 this sequence version replaced NM_001164431.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.1728741.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2147596
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000373345.9/
                                                ENSP00000362442.5
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-271               AL035419.12        36300-36570
            272-471             AL035419.12        57850-58049
            472-692             AL035419.12        61486-61706
            693-768             AL035419.12        63418-63493
            769-917             AL035419.12        63993-64141
            918-1083            AL035419.12        69111-69276
            1084-1175           AL035419.12        72199-72290
            1176-1253           AL035419.12        73252-73329
            1254-1413           AL035419.12        73718-73877
            1414-1496           AL035419.12        76217-76299
            1497-1703           AL035419.12        78195-78401
            1704-1844           AL035419.12        80538-80678
            1845-2014           AL035419.12        81448-81617
            2015-2070           AL035419.12        83134-83189
            2071-2967           AL035419.12        84248-85144
FEATURES             Location/Qualifiers
     source          1..2967
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.23"
     gene            1..2967
                     /gene="ARHGAP40"
                     /gene_synonym="C20orf95; dJ1100H13.4"
                     /note="Rho GTPase activating protein 40"
                     /db_xref="GeneID:343578"
                     /db_xref="HGNC:HGNC:16226"
     exon            1..271
                     /gene="ARHGAP40"
                     /gene_synonym="C20orf95; dJ1100H13.4"
                     /inference="alignment:Splign:2.1.0"
     CDS             135..2162
                     /gene="ARHGAP40"
                     /gene_synonym="C20orf95; dJ1100H13.4"
                     /note="rho-type GTPase-activating protein 40"
                     /codon_start=1
                     /product="rho GTPase-activating protein 40"
                     /protein_id="NP_001157903.2"
                     /db_xref="GeneID:343578"
                     /db_xref="HGNC:HGNC:16226"
                     /translation="MAEPALLPAAQMERLAPGPLASPCPRIPRARIARRCAQRWADLG
                     CSSGPSSGRMDQLPQKNLLRLHPAGSAGCSTGVESSSMDGFWMEVEQIQQRDELREED
                     SGGNEGQLPEEGEAESQWLQDTGLSGLLGGLGLDGDHQELLSTLTQTQVAAVCRRLDI
                     YARSVRRQHKTPVRDVRDVFGVFNSGKMSSENGDSGMKGAQLSSGASKFPPAAEPGGL
                     QEQAGREEAFNMDSAYSEQAAVLLQRSRPSRGGTSAWGKCSLPKFTVPKGRLGVTRIG
                     DLSLQDMRKVPSLALIELTALCDILGLDLKRSKAGKWKAAETRLFGVPLDSLLEADHK
                     VLPSTQVPLVLQALLSCLEKRGLDMEGILRVPGSQARVKGLEQKLERDFYAGLFSWDE
                     VHHNDASDLLKRFIRKLPTPLLTAEYLPAFAVVPNIPNLKQRLQVLHLLILILPEPNR
                     NALKALLEFLRKVVAREQHNKMTLRNVSTVMAPNLFLHQGRPPKLPKGKEKQLAEGAA
                     EVVQIMVHYQDLLWTVASFLVAQVRKLNDSSSRRPQLCDAGLKTWLRRMHADRDKAGD
                     GLEATPKVAKIQVVWPIKDPLKVPLTPSTKVAHVLRQFTEHLSPGSKGQEDSEDMDSL
                     LLHHRSMESANILLYEVGGNINEHRLDPDAYLLDLYRANPHGEWVLKQNPT"
     exon            272..471
                     /gene="ARHGAP40"
                     /gene_synonym="C20orf95; dJ1100H13.4"
                     /inference="alignment:Splign:2.1.0"
     exon            472..692
                     /gene="ARHGAP40"
                     /gene_synonym="C20orf95; dJ1100H13.4"
                     /inference="alignment:Splign:2.1.0"
     exon            693..768
                     /gene="ARHGAP40"
                     /gene_synonym="C20orf95; dJ1100H13.4"
                     /inference="alignment:Splign:2.1.0"
     exon            769..917
                     /gene="ARHGAP40"
                     /gene_synonym="C20orf95; dJ1100H13.4"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1083
                     /gene="ARHGAP40"
                     /gene_synonym="C20orf95; dJ1100H13.4"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1175
                     /gene="ARHGAP40"
                     /gene_synonym="C20orf95; dJ1100H13.4"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1253
                     /gene="ARHGAP40"
                     /gene_synonym="C20orf95; dJ1100H13.4"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1413
                     /gene="ARHGAP40"
                     /gene_synonym="C20orf95; dJ1100H13.4"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1496
                     /gene="ARHGAP40"
                     /gene_synonym="C20orf95; dJ1100H13.4"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1703
                     /gene="ARHGAP40"
                     /gene_synonym="C20orf95; dJ1100H13.4"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1844
                     /gene="ARHGAP40"
                     /gene_synonym="C20orf95; dJ1100H13.4"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..2014
                     /gene="ARHGAP40"
                     /gene_synonym="C20orf95; dJ1100H13.4"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2070
                     /gene="ARHGAP40"
                     /gene_synonym="C20orf95; dJ1100H13.4"
                     /inference="alignment:Splign:2.1.0"
     exon            2071..2967
                     /gene="ARHGAP40"
                     /gene_synonym="C20orf95; dJ1100H13.4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2941..2946
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP40"
                     /gene_synonym="C20orf95; dJ1100H13.4"
                     /note="hexamer: AGTAAA"
     polyA_site      2967
                     /gene="ARHGAP40"
                     /gene_synonym="C20orf95; dJ1100H13.4"
                     /note="major polyA site"
ORIGIN      
        1 agtcctgcat gagggtgtct gggaactggg tgcgccacgg gggccctacc tcactcctcc
       61 ctctcacatt gccgatcgag tcagccccac ggcggcagca ccacgaccga ccgggatcct
      121 cgaggtgcca gcccatggcc gagcctgccc tcctccccgc cgcccagatg gagaggctgg
      181 ccccagggcc cctagcctca ccgtgtcctc ggatcccgcg ggcccgcatt gccaggcgct
      241 gcgcccagcg ctgggccgac ctgggctgca gctctggccc ctcctcaggc cgaatggatc
      301 agcttcccca gaagaatctc ctgcgactac accctgctgg ctctgctggc tgttccactg
      361 gagtggagag ctccagcatg gatggctttt ggatggaggt ggaacagatc caacagagag
      421 atgagctgag ggaagaggac agtggcggga atgaaggcca gcttccagag gaaggggaag
      481 ctgaatccca gtggctgcag gacacaggcc tgtcgggcct ccttggtggc ctgggcttgg
      541 atggtgatca ccaggagctc ctgtccaccc tgacacagac ccaggtggcc gctgtgtgcc
      601 gccggctgga catctatgct cgctcagtgc gaagacaaca caagacacct gtcagagatg
      661 tcagggatgt ctttggggtc ttcaattcag ggaaaatgtc gtcagagaat ggcgactccg
      721 gtatgaaggg ggcccagctc agttccgggg cctctaagtt tcctccagca gcagagcctg
      781 gggggctgca ggagcaggct gggagggaag aagccttcaa catggactct gcctactcag
      841 aacaagctgc ggtgctcctg cagaggagca ggccatcccg gggaggcacc tctgcctggg
      901 gcaagtgttc cctgccgaag tttaccgtcc ccaaaggcag acttggcgtg acgaggatag
      961 gagacttgtc cctgcaggat atgaggaagg taccttctct ggccctcata gagctgaccg
     1021 cgctctgtga catcctcggc ttggacctga agaggagcaa ggcggggaag tggaaagcgg
     1081 cagaaactcg cctctttggt gtgccccttg acagcctgct agaagctgac cacaaagtcc
     1141 tccccagcac acaggtcccg ctggtccttc aagccctgct gtcctgtttg gaaaagagag
     1201 gactggacat ggaaggcatt ctcagggtgc ccggatccca ggccagggtc aaggggctgg
     1261 aacagaaact ggagagagac ttctatgctg gcctttttag ctgggacgag gttcatcaca
     1321 atgacgcctc tgatttgctc aaaaggttca tccggaagct gccgacacct ttgctcacgg
     1381 ctgagtacct cccggccttc gccgtggtgc ctaacatccc caacctgaag cagcgcctgc
     1441 aggttcttca cctgctcatc ctcatcctcc cagaacccaa cagaaatgcc ttaaaggcac
     1501 tgctggaatt cctcaggaag gtggtggccc gggaacagca caacaagatg actctgagga
     1561 atgtttccac cgtgatggcc cctaacctct ttctgcacca agggcggccc cccaagctcc
     1621 ccaaaggcaa ggagaagcag ctggcagaag gggcagccga ggtggtgcag ataatggtgc
     1681 actaccagga tctgctgtgg acggtcgcct ctttcctggt cgcccaggtg cgaaaactga
     1741 acgacagtag cagcaggcgc ccccagctct gcgacgcagg cctcaagact tggctgcgga
     1801 ggatgcacgc agacagggac aaggcggggg acggcctcga ggcgactccc aaggtggcaa
     1861 agatccaggt ggtctggcct atcaaggacc ccttgaaggt gcctctcacc cccagcacca
     1921 aagtggccca cgtcctgagg cagttcacag agcacctcag ccctggttcc aagggtcaag
     1981 aagacagtga ggacatggac agcctccttc tacaccatag gtccatggag tcagccaaca
     2041 tcctcctcta tgaagttgga gggaatatca atgagcatcg cctggaccca gatgcctacc
     2101 tcttagatct gtaccgtgcc aacccgcatg gtgagtgggt ccttaaacag aaccccacct
     2161 aaaccctgcg agtctcagga gcagcctgga tgcctcctcc tctcccctgc tggctctgtg
     2221 tccatgtacc cagcatgaga acaaagctat tccaggggag ggtctgagtt ttattccaag
     2281 gcttcctttt ctgaaatgcc tctcagaccc ctcagaaata gactcagggg tggtgctctc
     2341 tccactcaga ggggatgagg ggctagggcc tcagggaggg gaggccaaca ctgtagccat
     2401 gatcagccct ggaagaactg gacagaggaa gaacttccct tcacagctct catgttttaa
     2461 ccgtgcacac aatgccctca ctcccctcca ccctccagcc ctccagagag ttgcttccta
     2521 caccaagctt gctgtatgac gccaccactt ggggcgcttg gatctccatg ggcttctgtc
     2581 tgtggcttcc agactggagg aaaattaaaa atgcagtacc tttatcaaga ggtagttggg
     2641 gtcttttccc cccaggcaaa attgtttcga aagtggccct acaatgtgta gtagcagcag
     2701 caccagagac aaaaccagga gagctctgtg accttggaca agccccttgc cctctcagaa
     2761 tcctttcagg atgaggggct agggcctcag ggagaggaag ccaagattgt agccatgacc
     2821 agccccggga gaaatggaca gaggaagact ttgcttcaca gctctcatgc tttacatgtt
     2881 gatttgtaca atcttgtcat tttgtaatat gatataatat gtaaacgtaa ttgtttaaac
     2941 agtaaaggca caacaagttc aatgtca
//
