LOCUS       NM_001366178            4352 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens Rho GTPase activating protein 33 (ARHGAP33),
            transcript variant 3, mRNA.
ACCESSION   NM_001366178 XM_005258488
VERSION     NM_001366178.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4352)
  AUTHORS   Nakazawa,T., Hashimoto,R., Sakoori,K., Sugaya,Y., Tanimura,A.,
            Hashimotodani,Y., Ohi,K., Yamamori,H., Yasuda,Y., Umeda-Yano,S.,
            Kiyama,Y., Konno,K., Inoue,T., Yokoyama,K., Inoue,T., Numata,S.,
            Ohnuma,T., Iwata,N., Ozaki,N., Hashimoto,H., Watanabe,M.,
            Manabe,T., Yamamoto,T., Takeda,M. and Kano,M.
  TITLE     Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and
            pathophysiology of neuropsychiatric disorders
  JOURNAL   Nat Commun 7, 10594 (2016)
   PUBMED   26839058
  REMARK    GeneRIF: ARHGAP33 is associated with brain phenotypes of patients
            with schizophrenia.
            Erratum:[Nat Commun. 2016 Apr 20;7:11466. doi:
            10.1038/ncomms11466.. PMID: 27095349]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4352)
  AUTHORS   Vaz Meirelles,G., Ferreira Lanza,D.C., da Silva,J.C., Santana
            Bernachi,J., Paes Leme,A.F. and Kobarg,J.
  TITLE     Characterization of hNek6 interactome reveals an important role for
            its short N-terminal domain and colocalization with proteins at the
            centrosome
  JOURNAL   J Proteome Res 9 (12), 6298-6316 (2010)
   PUBMED   20873783
REFERENCE   3  (bases 1 to 4352)
  AUTHORS   Lu,Y., Dolle,M.E., Imholz,S., van 't Slot,R., Verschuren,W.M.,
            Wijmenga,C., Feskens,E.J. and Boer,J.M.
  TITLE     Multiple genetic variants along candidate pathways influence plasma
            high-density lipoprotein cholesterol concentrations
  JOURNAL   J Lipid Res 49 (12), 2582-2589 (2008)
   PUBMED   18660489
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 4352)
  AUTHORS   Rosario,M., Franke,R., Bednarski,C. and Birchmeier,W.
  TITLE     The neurite outgrowth multiadaptor RhoGAP, NOMA-GAP, regulates
            neurite extension through SHP2 and Cdc42
  JOURNAL   J Cell Biol 178 (3), 503-516 (2007)
   PUBMED   17664338
  REMARK    GeneRIF: Results show that neurite outgrowth multiadaptor RhoGAP
            protein, NOMA-GAP, plays an essential role downstream of NGF in
            promoting neurite outgrowth and extension by recruiting SHP2 and
            activating Cdc42.
REFERENCE   5  (bases 1 to 4352)
  AUTHORS   Liu,H., Nakazawa,T., Tezuka,T. and Yamamoto,T.
  TITLE     Physical and functional interaction of Fyn tyrosine kinase with a
            brain-enriched Rho GTPase-activating protein TCGAP
  JOURNAL   J Biol Chem 281 (33), 23611-23619 (2006)
   PUBMED   16777849
  REMARK    GeneRIF: TCGAP interacts with Fyn and is phosphorylated by Fyn,
            with tyrosine-406 in the GTPase-activating protein (GAP) domain as
            a major Fyn-mediated phosphorylation site.
REFERENCE   6  (bases 1 to 4352)
  AUTHORS   Chiang,S.H., Hwang,J., Legendre,M., Zhang,M., Kimura,A. and
            Saltiel,A.R.
  TITLE     TCGAP, a multidomain Rho GTPase-activating protein involved in
            insulin-stimulated glucose transport
  JOURNAL   EMBO J 22 (11), 2679-2691 (2003)
   PUBMED   12773384
REFERENCE   7  (bases 1 to 4352)
  AUTHORS   Worby,C.A. and Dixon,J.E.
  TITLE     Sorting out the cellular functions of sorting nexins
  JOURNAL   Nat Rev Mol Cell Biol 3 (12), 919-931 (2002)
   PUBMED   12461558
  REMARK    Review article
            Erratum:[Nat Rev Mol Cell Biol. 2003 Feb;4(2):156.]
REFERENCE   8  (bases 1 to 4352)
  AUTHORS   Peck,J., Douglas,G. 4th, Wu,C.H. and Burbelo,P.D.
  TITLE     Human RhoGAP domain-containing proteins: structure, function and
            evolutionary relationships
  JOURNAL   FEBS Lett 528 (1-3), 27-34 (2002)
   PUBMED   12297274
  REMARK    Review article
REFERENCE   9  (bases 1 to 4352)
  AUTHORS   Xu,Y., Seet,L.F., Hanson,B. and Hong,W.
  TITLE     The Phox homology (PX) domain, a new player in phosphoinositide
            signalling
  JOURNAL   Biochem J 360 (Pt 3), 513-530 (2001)
   PUBMED   11736640
  REMARK    Review article
REFERENCE   10 (bases 1 to 4352)
  AUTHORS   Teasdale,R.D., Loci,D., Houghton,F., Karlsson,L. and Gleeson,P.A.
  TITLE     A large family of endosome-localized proteins related to sorting
            nexin 1
  JOURNAL   Biochem J 358 (Pt 1), 7-16 (2001)
   PUBMED   11485546
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC002398.1.
            
            On Sep 25, 2018 this sequence version replaced XM_005258488.2.
            
            Summary: This gene encodes a member of the sorting nexin family.
            Members of this family contain a phox (PX) domain, which is a
            phosphoinositide binding domain, and are involved in intracellular
            trafficking. Alternative splice variants encoding different
            isoforms have been identified in this gene. [provided by RefSeq,
            Feb 2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2145743 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000007510.9/ ENSP00000007510.6
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               AC002398.1         25169-25269
            102-199             AC002398.1         27250-27347
            200-284             AC002398.1         27429-27513
            285-365             AC002398.1         27885-27965
            366-503             AC002398.1         28069-28206
            504-596             AC002398.1         28637-28729
            597-719             AC002398.1         29816-29938
            720-797             AC002398.1         30026-30103
            798-864             AC002398.1         30187-30253
            865-924             AC002398.1         30362-30421
            925-1077            AC002398.1         30525-30677
            1078-1180           AC002398.1         30755-30857
            1181-1325           AC002398.1         31978-32122
            1326-1408           AC002398.1         32202-32284
            1409-1516           AC002398.1         32367-32474
            1517-1662           AC002398.1         33777-33922
            1663-1816           AC002398.1         34558-34711
            1817-1962           AC002398.1         34794-34939
            1963-2037           AC002398.1         35014-35088
            2038-2697           AC002398.1         36018-36677
            2698-4352           AC002398.1         36773-38427
FEATURES             Location/Qualifiers
     source          1..4352
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..4352
                     /gene="ARHGAP33"
                     /gene_synonym="NOMA-GAP; SNX26; TCGAP"
                     /note="Rho GTPase activating protein 33"
                     /db_xref="GeneID:115703"
                     /db_xref="HGNC:HGNC:23085"
                     /db_xref="MIM:614902"
     exon            1..101
                     /gene="ARHGAP33"
                     /gene_synonym="NOMA-GAP; SNX26; TCGAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..3959
                     /gene="ARHGAP33"
                     /gene_synonym="NOMA-GAP; SNX26; TCGAP"
                     /note="isoform 3 is encoded by transcript variant 3;
                     sorting nexin 26; tc10/CDC42 GTPase-activating protein;
                     neurite outgrowth multiadaptor RhoGAP protein; rho
                     GTPase-activating protein 33; rho-type GTPase-activating
                     protein 33"
                     /codon_start=1
                     /product="rho GTPase-activating protein 33 isoform 3"
                     /protein_id="NP_001353107.1"
                     /db_xref="CCDS:CCDS92599.1"
                     /db_xref="GeneID:115703"
                     /db_xref="HGNC:HGNC:23085"
                     /db_xref="MIM:614902"
                     /translation="MVARSTDSLDGPGEGSVQPLPTAGGPSVKGKPGKRLSAPRGPFP
                     RLADCAHFHYENVDFGHIQLLLSPDREGPSLSGENELVFGVQVTCQGRSWPVLRSYDD
                     FRSLDAHLHRCIFDRRFSCLPELPPPPEGARAAQMLVPLLLQYLETLSGLVDSNLNCG
                     PVLTWMELDNHGRRLLLSEEASLNIPAVAAAHVIKRYTAQAPDELSFEVGDIVSVIDM
                     PPTEDRSWWRGKRGFQVGFFPSECVELFTERPGPGLKADADGPPCGIPAPQGISSLTS
                     AVPRPRGKLAGLLRTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRC
                     CSEFIEAHGVVDGIYRLSGVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLY
                     FRELPNPLLTYQLYGKFSEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARM
                     ARHSANTSMHARNLAIVWAPNLLRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDV
                     LFSDTFTSAGLDPAGRCLLPRPKSLAGSCPSTRLLTLEEAQARTQGRLGTPTEPTTPK
                     APASPAERRKGERGEKQRKPGGSSWKTFFALGRGPSVPRKKPLPWLGGTRAPPQPSGS
                     RPDTVTLRSAKSEESLSSQASGAGLQRLHRLRRPHSSSDAFPVGPAPAGSCESLSSSS
                     SSESSSSESSSSSSESSAAGLGALSGSPSHRTSAWLDDGDELDFSPPRCLEGLRGLDF
                     DPLTFRCSSPTPGDPAPPASPAPPAPASAFPPRVTPQAISPRGPTSPASPAALDISEP
                     LAVSVPPAVLELLGAGGAPASATPTPALSPGRSLRPHLIPLLLRGAEAPLTDACQQEM
                     CSKLRGAQGPLGPDMESPLPPPPLSLLRPGGAPPPPPKNPARLMALALAERAQQVAEQ
                     QSQQECGGTPPASQSPFHRSLSLEVGGEPLGTSGSGPPPNSLAHPGAWVPGPPPYLPR
                     QQSDGSLLRSQRPMGTSRRGLRGPAQVSAQLRAGGGGRDAPEAAAQSPCSVPSQVPTP
                     GFFSPAPRECLPPFLGVPKPGLYPLGPPSFQPSSPAPVWRSSLGPPAPLDRGENLYYE
                     IGASEGSPYSGPTRSWSPFRSMPPDRLNASYGMLGQSPPLHRSPDFLLSYPPAPSCFP
                     PDHLGYSAPQHPARRPTPPEPLYVNLALGPRGPSPASSSSSSPPAHPRSRSDPGPPVP
                     RLPQKQRAPWGPRTPHRVPGPWGPPEPLLLYRAAPPAYGRGGELHRGSLYRNGGQRGE
                     GAGPPPPYPTPSWSLHSEGQTRSYC"
     exon            102..199
                     /gene="ARHGAP33"
                     /gene_synonym="NOMA-GAP; SNX26; TCGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            200..284
                     /gene="ARHGAP33"
                     /gene_synonym="NOMA-GAP; SNX26; TCGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            285..365
                     /gene="ARHGAP33"
                     /gene_synonym="NOMA-GAP; SNX26; TCGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            366..503
                     /gene="ARHGAP33"
                     /gene_synonym="NOMA-GAP; SNX26; TCGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            504..596
                     /gene="ARHGAP33"
                     /gene_synonym="NOMA-GAP; SNX26; TCGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            597..719
                     /gene="ARHGAP33"
                     /gene_synonym="NOMA-GAP; SNX26; TCGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            720..797
                     /gene="ARHGAP33"
                     /gene_synonym="NOMA-GAP; SNX26; TCGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            798..864
                     /gene="ARHGAP33"
                     /gene_synonym="NOMA-GAP; SNX26; TCGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            865..924
                     /gene="ARHGAP33"
                     /gene_synonym="NOMA-GAP; SNX26; TCGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1077
                     /gene="ARHGAP33"
                     /gene_synonym="NOMA-GAP; SNX26; TCGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1180
                     /gene="ARHGAP33"
                     /gene_synonym="NOMA-GAP; SNX26; TCGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1325
                     /gene="ARHGAP33"
                     /gene_synonym="NOMA-GAP; SNX26; TCGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1408
                     /gene="ARHGAP33"
                     /gene_synonym="NOMA-GAP; SNX26; TCGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1516
                     /gene="ARHGAP33"
                     /gene_synonym="NOMA-GAP; SNX26; TCGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1662
                     /gene="ARHGAP33"
                     /gene_synonym="NOMA-GAP; SNX26; TCGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1816
                     /gene="ARHGAP33"
                     /gene_synonym="NOMA-GAP; SNX26; TCGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1962
                     /gene="ARHGAP33"
                     /gene_synonym="NOMA-GAP; SNX26; TCGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1963..2037
                     /gene="ARHGAP33"
                     /gene_synonym="NOMA-GAP; SNX26; TCGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2697
                     /gene="ARHGAP33"
                     /gene_synonym="NOMA-GAP; SNX26; TCGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2698..4352
                     /gene="ARHGAP33"
                     /gene_synonym="NOMA-GAP; SNX26; TCGAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4333..4338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP33"
                     /gene_synonym="NOMA-GAP; SNX26; TCGAP"
                     /note="hexamer: AATAAA"
     polyA_site      4352
                     /gene="ARHGAP33"
                     /gene_synonym="NOMA-GAP; SNX26; TCGAP"
                     /note="major polyA site"
ORIGIN      
        1 gccctcccct ttgtgtcgcc atggcggcgg cagcggcgac gagaacggcg agcgaggggt
       61 cgagcgcggc cggggcctga ggaggctacg cgaccatggt ggcacgcagc actgacagcc
      121 tggatggccc aggggagggc tcggtgcagc ctctacccac tgctgggggg cccagtgtga
      181 aggggaagcc tgggaagagg ctctcagctc ctcgaggccc cttcccgcgg ctggctgact
      241 gcgcccattt ccactacgag aacgttgact ttggccacat tcagctcctg ctgtctccag
      301 accgtgaagg gcccagcctc tctggagaga atgagctggt gttcggggtg caggtgacct
      361 gtcagggccg ttcctggccg gttctccgga gttacgatga ctttcgttcc ctggatgccc
      421 acctccaccg gtgcatattt gaccggaggt tctcctgcct tccggagctt cccccgcccc
      481 ccgagggtgc cagggctgcc cagatgctgg tgccactgct gctgcagtac ctggagacac
      541 tgtcaggact ggtggacagt aacctcaact gcgggcctgt gctcacctgg atggagctgg
      601 acaatcacgg ccggcgactg ctcctcagtg aggaggcgtc actcaatatc cctgcagtgg
      661 cggccgccca tgtgatcaaa cggtatacag cccaggcgcc agatgagctg tcctttgagg
      721 tgggagacat tgtctcggtg atcgacatgc cacccacaga ggatcggagc tggtggcggg
      781 gcaagcgagg cttccaggtc gggttcttcc ccagtgagtg tgtggaactc ttcacagagc
      841 ggccaggtcc gggcctgaag gcggatgccg atggcccccc atgtggcatc ccggctcccc
      901 agggtatctc gtctctgacc tcagctgtgc cacggcctcg tgggaagctg gccggcctgc
      961 tccgcacctt catgcgctcc cgcccttctc ggcagcggct gcggcagcgg ggaatcctgc
     1021 gacagagggt gtttggctgc gatcttggcg agcacctcag caactcaggc caggatgtgc
     1081 cccaggtgct gcgctgctgc tccgagttca ttgaggccca cggggtggtg gatgggatct
     1141 accggctctc aggcgtgtct tccaacatcc agaggcttcg gcacgagttt gacagtgaga
     1201 ggatcccgga gctgtctggc cctgcattcc tgcaggacat ccacagcgtg tcctccctct
     1261 gcaagctcta cttccgagag cttccgaacc ctctgctcac ctaccagctc tatgggaagt
     1321 tcagtgaggc catgtcagtg cctggggagg aggagcgtct ggtgcgggtg cacgatgtca
     1381 tccagcagct gcccccacca cattacagga ccctggagta cctgctgagg cacctggccc
     1441 gcatggcgag acacagtgcc aacaccagca tgcatgcccg caacctggcc attgtctggg
     1501 cacccaacct gctacggtcc atggagctgg agtcagtggg aatgggtggc gcggcggcgt
     1561 tccgggaagt tcgggtgcag tcggtggtgg tggagtttct gctcacccat gtggacgtcc
     1621 tgttcagcga caccttcacc tccgccggcc tcgaccctgc aggccgctgc ctgctcccca
     1681 ggcccaagtc ccttgcgggc agctgcccct ccacccgcct gctgacgctg gaggaagccc
     1741 aggcacgcac ccagggccgg ctggggacgc ccacggagcc cacaactccc aaggccccgg
     1801 cctcacctgc ggaaaggagg aaaggggaga gaggggagaa gcagcggaag ccagggggca
     1861 gcagctggaa gacgttcttt gcactgggcc ggggccccag tgtccctcga aagaagcccc
     1921 tgccctggct ggggggcacc cgtgccccac cgcagccttc aggcagcaga cccgacaccg
     1981 tcacactgag atctgccaag agcgaggagt ctctgtcatc gcaggccagc ggggctggcc
     2041 tccagaggct gcacaggctg cggcgacccc actccagcag cgacgctttc cctgtgggcc
     2101 cagcacctgc tggctcctgc gagagcctgt cctcgtcctc ctcctccgag tcctcctcct
     2161 ctgagtcctc ctcttcctcc tctgagtcct cagcagctgg gctgggggca ctctctgggt
     2221 ctccctcaca ccgtacctca gcctggctag atgatggtga tgagctggac ttcagcccac
     2281 cccgctgcct ggagggactc cgggggctgg actttgatcc cttaaccttc cgctgcagca
     2341 gccccacccc aggggatccc gcacctcccg ccagcccagc accccccgcc cctgcctctg
     2401 ccttcccacc cagggtgacc ccccaggcca tctcgccccg ggggcccacc agccccgcct
     2461 cgcctgctgc cctagacatc tcagagcccc tggctgtatc agtgccaccc gctgtcctag
     2521 aactgctggg ggctggggga gcacctgcct cagccacccc aacaccagct ctcagccccg
     2581 gccggagcct gcgcccccat ctcatacccc tgctgctgcg aggagccgag gccccgctga
     2641 ctgacgcctg ccagcaggag atgtgcagca agctccgggg agcccagggc ccactcggtc
     2701 ctgatatgga gtcaccactg ccaccccctc ccctgtctct cctgcgccct gggggtgccc
     2761 cacccccgcc ccctaagaac ccagcacgcc tcatggccct ggccctggct gagcgggctc
     2821 agcaggtggc cgagcaacag agccagcagg agtgtggggg caccccacct gcttcccaat
     2881 cccccttcca ccgctcgctg tctctggagg tgggcgggga gcccctgggg acctcaggga
     2941 gtgggccacc tcccaactcc ctagcacacc cgggtgcctg ggtcccggga cccccaccct
     3001 acttaccaag gcaacaaagt gatgggagcc tgctgaggag ccagcggccc atggggacct
     3061 caaggagggg actccgaggc cctgcccagg tcagtgccca gctcagggca ggtggcgggg
     3121 gcagggatgc gccagaggca gcagcccagt ccccatgttc tgtcccctca caggttccta
     3181 cccccggctt cttctcccca gcccccaggg agtgcctgcc acccttcctc ggggtcccca
     3241 agccaggctt gtaccccctg ggccccccat ccttccagcc cagttcccca gccccagtct
     3301 ggaggagctc tctgggcccc cctgcaccac tcgacagggg agagaacctg tactatgaga
     3361 tcggggcaag tgaggggtcc ccctattctg gccccacccg ctcctggagt ccctttcgct
     3421 ccatgccccc cgacaggctc aatgcctcct acggcatgct tggccaatca cccccactcc
     3481 acaggtcccc cgacttcctg ctcagctacc cgccagcccc ctcctgcttt ccccctgacc
     3541 accttggcta ctcagccccc cagcaccctg ctcggcgccc tacaccgcct gagcccctct
     3601 acgtcaacct agctctaggg cccaggggtc cctcacctgc ctcttcctcc tcctcttccc
     3661 ctcctgccca cccccgaagc cgttcagatc ccggtccccc agtcccccgc cttccccaga
     3721 aacaacgggc accctgggga ccccgtaccc ctcatagggt gccgggtccc tggggccctc
     3781 ctgagcctct cctgctctac agggcagccc cgccagccta cggaaggggg ggcgagctcc
     3841 accgagggtc cttgtacaga aatggagggc aaagagggga gggggctggt cccccacccc
     3901 cttaccccac tcccagctgg tccctccact ctgagggcca gacccgaagc tactgctgag
     3961 caccagctgg gaggggccgt ccttccttcc cttcaccctc actggatctt ggcccaacca
     4021 aatcccttgt tttgtatttt cttgaacccc gaccactacc ccaggtttct aactttgtaa
     4081 cttgcttctg atgtgggtcc ctaacctata atctcagctt ccctaccctg gactgaaggg
     4141 tctgcccatc cccccaccac cctccatcct gggggccctc gcacaaatct ggggtgggag
     4201 gggctaggct gaccccatcc tcctctccct ccaggagccc ccagcatgtc ctgacctgtg
     4261 cacggggatg gggggacaac tcctaccctt ctttccccac atgccccact aaaccatctg
     4321 acaacattaa tgaataaaat ggtgaaaatg tg
//
