LOCUS       NM_020754               9307 bp    mRNA    linear   PRI 10-OCT-2024
DEFINITION  Homo sapiens Rho GTPase activating protein 31 (ARHGAP31), mRNA.
ACCESSION   NM_020754 XM_291085
VERSION     NM_020754.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9307)
  AUTHORS   Santaniello,C., Faversani,A., Corsaro,L., Melloni,G., Motta,S.,
            Mandorino,E., Sacco,D., Stioui,S., Ferrara,F., Barteselli,D., De
            Vita,D., Manuelli,D. and Costantino,L.
  TITLE     Characterization of a New Variant in ARHGAP31 Probably Involved in
            Adams-Oliver Syndrome in a Family with a Variable Phenotypic
            Spectrum
  JOURNAL   Genes (Basel) 15 (5), 536 (2024)
   PUBMED   38790165
  REMARK    GeneRIF: Characterization of a New Variant in ARHGAP31 Probably
            Involved in Adams-Oliver Syndrome in a Family with a Variable
            Phenotypic Spectrum.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9307)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   3  (bases 1 to 9307)
  AUTHORS   Muller,P.M., Rademacher,J., Bagshaw,R.D., Wortmann,C., Barth,C.,
            van Unen,J., Alp,K.M., Giudice,G., Eccles,R.L., Heinrich,L.E.,
            Pascual-Vargas,P., Sanchez-Castro,M., Brandenburg,L., Mbamalu,G.,
            Tucholska,M., Spatt,L., Czajkowski,M.T., Welke,R.W., Zhang,S.,
            Nguyen,V., Rrustemi,T., Trnka,P., Freitag,K., Larsen,B., Popp,O.,
            Mertins,P., Gingras,A.C., Roth,F.P., Colwill,K., Bakal,C.,
            Pertz,O., Pawson,T., Petsalaki,E. and Rocks,O.
  TITLE     Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals
            spatially organized RAC1 signalling from integrin adhesions
  JOURNAL   Nat Cell Biol 22 (4), 498-511 (2020)
   PUBMED   32203420
REFERENCE   4  (bases 1 to 9307)
  AUTHORS   He,Y., Northey,J.J., Pelletier,A., Kos,Z., Meunier,L.,
            Haibe-Kains,B., Mes-Masson,A.M., Cote,J.F., Siegel,P.M. and
            Lamarche-Vane,N.
  TITLE     The Cdc42/Rac1 regulator CdGAP is a novel E-cadherin
            transcriptional co-repressor with Zeb2 in breast cancer
  JOURNAL   Oncogene 36 (24), 3490-3503 (2017)
   PUBMED   28135249
  REMARK    GeneRIF: Study demonstrate that CdGAP acts as a novel
            co-transcriptional repressor with Zeb2 to suppress E-cadherin
            expression in breast cancer cells.
REFERENCE   5  (bases 1 to 9307)
  AUTHORS   Isrie,M., Wuyts,W., Van Esch,H. and Devriendt,K.
  TITLE     Isolated terminal limb reduction defects: extending the clinical
            spectrum of Adams-Oliver syndrome and ARHGAP31 mutations
  JOURNAL   Am J Med Genet A 164A (6), 1576-1579 (2014)
   PUBMED   24668619
  REMARK    GeneRIF: a four-generation pedigree with isolated terminal limb
            defects and a truncating mutation in ARHGAP31 underscores the
            relevance of sequencing ARHGAP31 in cases of isolated limb defects,
            irrespective of presence of a complete Adams-Oliver syndrome
            phenotype
REFERENCE   6  (bases 1 to 9307)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   7  (bases 1 to 9307)
  AUTHORS   Zhao,C., Ma,H., Bossy-Wetzel,E., Lipton,S.A., Zhang,Z. and
            Feng,G.S.
  TITLE     GC-GAP, a Rho family GTPase-activating protein that interacts with
            signaling adapters Gab1 and Gab2
  JOURNAL   J Biol Chem 278 (36), 34641-34653 (2003)
   PUBMED   12819203
REFERENCE   8  (bases 1 to 9307)
  AUTHORS   Jenna,S., Hussain,N.K., Danek,E.I., Triki,I., Wasiak,S.,
            McPherson,P.S. and Lamarche-Vane,N.
  TITLE     The activity of the GTPase-activating protein CdGAP is regulated by
            the endocytic protein intersectin
  JOURNAL   J Biol Chem 277 (8), 6366-6373 (2002)
   PUBMED   11744688
REFERENCE   9  (bases 1 to 9307)
  AUTHORS   Lamarche-Vane,N. and Hall,A.
  TITLE     CdGAP, a novel proline-rich GTPase-activating protein for Cdc42 and
            Rac
  JOURNAL   J Biol Chem 273 (44), 29172-29177 (1998)
   PUBMED   9786927
REFERENCE   10 (bases 1 to 9307)
  AUTHORS   Lehman,A., Wuyts,W. and Patel,M.S.
  TITLE     Adams-Oliver Syndrome - RETIRED CHAPTER, FOR HISTORICAL REFERENCE
            ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   27077170
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB033030.1, BC112163.1,
            KF457672.1, AC092981.3 and BM970175.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_020754.3.
            
            Summary: This gene encodes a GTPase-activating protein (GAP). A
            variety of cellular processes are regulated by Rho GTPases which
            cycle between an inactive form bound to GDP and an active form
            bound to GTP. This cycling between inactive and active forms is
            regulated by guanine nucleotide exchange factors and GAPs. The
            encoded protein is a GAP shown to regulate two GTPases involved in
            protein trafficking and cell growth. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB033030.1, SRR1803617.207276.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264245.9/ ENSP00000264245.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-495               AB033030.1         11-505
            496-1586            BC112163.1         1-1091
            1587-1587           KF457672.1         187-187
            1588-2928           BC112163.1         1093-2433
            2929-2929           AC092981.3         9304-9304           c
            2930-4881           BC112163.1         2435-4386
            4882-7601           AC092981.3         4632-7351           c
            7602-8069           BM970175.1         18-485              c
            8070-9307           AC092981.3         2926-4163           c
FEATURES             Location/Qualifiers
     source          1..9307
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.32-q13.33"
     gene            1..9307
                     /gene="ARHGAP31"
                     /gene_synonym="AOS; AOS1; CDGAP"
                     /note="Rho GTPase activating protein 31"
                     /db_xref="GeneID:57514"
                     /db_xref="HGNC:HGNC:29216"
                     /db_xref="MIM:610911"
     exon            1..622
                     /gene="ARHGAP31"
                     /gene_synonym="AOS; AOS1; CDGAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             523..4857
                     /gene="ARHGAP31"
                     /gene_synonym="AOS; AOS1; CDGAP"
                     /note="Cdc42 GTPase-activating protein"
                     /codon_start=1
                     /product="rho GTPase-activating protein 31"
                     /protein_id="NP_065805.2"
                     /db_xref="CCDS:CCDS43135.1"
                     /db_xref="GeneID:57514"
                     /db_xref="HGNC:HGNC:29216"
                     /db_xref="MIM:610911"
                     /translation="MKNKGAKQKLKRKGAASAFGCDLTEYLESSGQDVPYVLKSCAEF
                     IETHGIVDGIYRLSGVTSNIQRLRQEFGSDQCPDLTREVYLQDIHCVGSLCKLYFREL
                     PNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAHIASFS
                     SKTNMHARNLALVWAPNLLRSKEIEATGCNGDAAFLAVRVQQVVIEFILNHVDQIFNN
                     GAPGSLENDENRPIMKSLTLPALSLPMKLVSLEEAQARSLATNHPARKERRENSLPEI
                     VPPMGTLFHTVLELPDNKRKLSSKSKKWKSIFNLGRSGSDSKSKLSRNGSVFVRGQRL
                     SVEKATIRPAKSMDSLCSVPVEGKETKGNFNRTVTTGGFFIPATKMHSTGTGSSCDLT
                     KQEGEWGQEGMPPGAEGGFDVSSDRSHLQGAQARPPPEQLKVFRPVEDPESEQTAPKM
                     LGMFYTSNDSPSKSVFTSSLFQMEPSPRNQRKALNISEPFAVSVPLRVSAVISTNSTP
                     CRTPPKELQSLSSLEEFSFHGSESGGWPEEEKPLGAETSAASVPKKAGLEDAKAVPEA
                     PGTVECSKGLSQEPGAHLEEKKTPESSLSSQHLNELEKRPNPEKVVEEGREAGEMESS
                     TLQESPRARAEAVLLHEMDEDDLANALIWPEIQQELKIIESEEELSSLPPPALKTSPI
                     QPILESSLGPFIPSEPPGSLPCGSFPAPVSTPLEVWTRDPANQSTQGASTAASREKPE
                     PEQGLHPDLASLAPLEIVPFEKASPQATVEVGGPGNLSPPLPPAPPPPTPLEESTPVL
                     LSKGGPEREDSSRKLRTDLYIDQLKSQDSPEISSLCQGEEATPRHSDKQNSKNAASEG
                     KGCGFPSPTREVEIVSQEEEDVTHSVQEPSDCDEDDTVTDIAQHGLEMVEPWEEPQWV
                     TSPLHSPTLKDAHKAQVQGLQGHQLEKRLSHRPSLRQSHSLDSKPTVKSQWTLEVPSS
                     SSCANLETERNSDPLQPQAPRREITGWDEKALRSFREFSGLKGAEAPPNQKGPSGVQP
                     NPAETSPISLAEGKELGTHLGHSSPQIRQGGVPGPESSKESSPSVQDSTSPGEHPAKL
                     QLKSTECGPPKGKNRPSSLNLDPAIPIADLFWFENVASFSSPGMQVSEPGDPKVTWMT
                     SSYCKADPWRVYSQDPQDLDIVAHALTGRRNSAPVSVSAVRTSFMVKMCQARAVPVIP
                     PKIQYTQIPQPLPSQSSGENGVQPLERSQEGPSSTSGTTQKPAKDDSPSSLESSKEEK
                     PKQDPGAIKSSPVDATAPCMCEGPTLSPEPGSSNLLSTQDAVVQCRKRMSETEPSGDN
                     LLSSKLERPSGGSKPFHRSRPGRPQSLILFSPPFPIMDHLPPSSTVTDSKVLLSPIRS
                     PTQTVSPGLLCGELAENTWVTPEGVTLRNKMTIPKNGQRLETSTSCFYQPQRRSVILD
                     GRSGRQIE"
     exon            623..725
                     /gene="ARHGAP31"
                     /gene_synonym="AOS; AOS1; CDGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            726..870
                     /gene="ARHGAP31"
                     /gene_synonym="AOS; AOS1; CDGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            871..953
                     /gene="ARHGAP31"
                     /gene_synonym="AOS; AOS1; CDGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1061
                     /gene="ARHGAP31"
                     /gene_synonym="AOS; AOS1; CDGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1204
                     /gene="ARHGAP31"
                     /gene_synonym="AOS; AOS1; CDGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1403
                     /gene="ARHGAP31"
                     /gene_synonym="AOS; AOS1; CDGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1528
                     /gene="ARHGAP31"
                     /gene_synonym="AOS; AOS1; CDGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1591
                     /gene="ARHGAP31"
                     /gene_synonym="AOS; AOS1; CDGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..2167
                     /gene="ARHGAP31"
                     /gene_synonym="AOS; AOS1; CDGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2448
                     /gene="ARHGAP31"
                     /gene_synonym="AOS; AOS1; CDGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2449..9307
                     /gene="ARHGAP31"
                     /gene_synonym="AOS; AOS1; CDGAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6286..6291
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP31"
                     /gene_synonym="AOS; AOS1; CDGAP"
                     /note="hexamer: AATAAA"
     polyA_site      6312
                     /gene="ARHGAP31"
                     /gene_synonym="AOS; AOS1; CDGAP"
                     /note="major polyA site"
     regulatory      7274..7279
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP31"
                     /gene_synonym="AOS; AOS1; CDGAP"
                     /note="hexamer: TATAAA"
     polyA_site      7293
                     /gene="ARHGAP31"
                     /gene_synonym="AOS; AOS1; CDGAP"
     regulatory      8051..8056
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP31"
                     /gene_synonym="AOS; AOS1; CDGAP"
                     /note="hexamer: ATTAAA"
     polyA_site      8072
                     /gene="ARHGAP31"
                     /gene_synonym="AOS; AOS1; CDGAP"
     regulatory      9286..9291
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP31"
                     /gene_synonym="AOS; AOS1; CDGAP"
                     /note="hexamer: AGTAAA"
     polyA_site      9307
                     /gene="ARHGAP31"
                     /gene_synonym="AOS; AOS1; CDGAP"
ORIGIN      
        1 gaaggcgtga gggcgggcag cagcgacagg atgcttgttt ttcgctctac caaagtcgtc
       61 tgaaggcgag acagcgggcc cagggcgcag gacccaccgc agccccctgg gcagtctcct
      121 cgccccgcgt ccgcgtcgtc tccggggcac ttagtaaggg gtggggagag cttgccctcc
      181 ctcttaagct gaggagaaac acccgaagac accgcaggag cctgtgaaag tccctaggac
      241 tccaagtgag gaagtgacac tcccaggcga gccggcccgc ggctgccagt ctgcacggcc
      301 tcggcacggc ggccccggag cggcgcgggg tggatctcag gctctgccgg cccgcggccc
      361 gcggggtcca tgcgcagggc ccccagccca agttcttcca tcttccgatg cggcccccca
      421 gagccgcggg gcagccggtg atctagcccg ggagcccatc ttacagcggt gccaagcaga
      481 ggggcggcag agacggaggg gcagcctctt tgggactaac tcatgaagaa caagggtgct
      541 aagcagaagc tgaaacgaaa gggagccgcc agcgcgtttg gctgtgacct gacggagtat
      601 ctggaaagct cgggacagga tgttccatac gttttgaaga gctgtgcaga atttatagag
      661 actcacggca tcgtggatgg aatctatcgg ctttcaggag tcacctcaaa catacaacgg
      721 ctaaggcaag agtttggctc agatcaatgt ccagatctga caagggaagt gtacctccag
      781 gacatccact gtgtgggctc gctttgcaag ctctacttta gggagctgcc caaccccctc
      841 ctgacttatg agctctatga gaaattcacg gaggcagtgt cgcattgccc tgaagaaggc
      901 caactggccc gaatccaaaa tgttatccag gagcttcctc catcccacta taggaccttg
      961 gaatacctga ttcgacacct ggcccatatc gcctccttca gcagcaagac caacatgcac
     1021 gcccggaacc tggccctggt gtgggcgcca aacctcctca ggtctaaaga aattgaagcc
     1081 actggttgca atggagatgc agccttcctt gcagtccggg tccagcaggt ggtgattgag
     1141 ttcatattga atcatgtaga tcaaatcttt aacaacggtg cacctgggtc tctggagaat
     1201 gatgaaaacc ggcccatcat gaagagcctg accttgccag ccctctccct gcccatgaag
     1261 ctggtgagcc ttgaggaagc tcaagcccgc agcctggcca ctaaccatcc tgctcgcaag
     1321 gaaaggaggg agaacagcct gcctgagatt gtccctccca tgggcaccct cttccacact
     1381 gtccttgagt taccagacaa caagcgaaag ctctccagta aatcaaagaa gtggaaatca
     1441 atatttaacc tgggacgttc tggatcagac tccaaatcaa aactgagtag aaatgggagt
     1501 gtatttgtga gaggacagag gctctcggtg gaaaaggcta ctatccgacc agctaaaagc
     1561 atggactcac tatgttcagt gcctgtggaa ggaaaagaaa ccaagggaaa tttcaatcga
     1621 acagttacca ccggtggatt tttcattcca gcaacaaaga tgcactccac cggcaccggc
     1681 agctcatgtg acctcaccaa gcaggagggc gaatggggcc aggaggggat gcctcccggg
     1741 gctgagggtg gctttgatgt gagcagtgat cgcagccatc tccagggcgc tcaggcccgg
     1801 cccccaccgg aacagctgaa ggttttccgg cctgttgagg atccggagag cgagcaaaca
     1861 gccccaaaga tgttgggtat gttctacact tcgaacgaca gccctagcaa atccgtcttc
     1921 accagcagcc tcttccagat ggagccctcg ccgcgtaacc agcgcaaggc gctgaacatc
     1981 tccgagccct ttgcggtatc tgtgccgctc cgcgtgtccg cagtcatcag caccaacagc
     2041 acgccgtgca gaacaccccc gaaggagctg cagtctcttt ccagcctgga agagttttct
     2101 tttcatggat cagagagcgg aggctggcca gaagaagaga aaccgctggg agctgagact
     2161 tctgcagctt ctgtacctaa gaaggcaggt cttgaggatg ccaaggcagt acctgaagca
     2221 ccggggacag tggaatgcag caaaggcctg tcccaggagc caggcgccca cctggaggag
     2281 aagaaaaccc cagaaagctc cttgagctct caacatttaa atgaattaga gaagaggcca
     2341 aatccggaga aggtggtgga ggagggacga gaggctggtg agatggagtc cagcaccctg
     2401 caggagagcc ccagggccag agccgaagct gtgcttctcc atgagatgga tgaagatgat
     2461 ctggccaatg ccctgatctg gcctgagatt caacaggagc tgaaaatcat tgaatctgag
     2521 gaggagctct catcgttgcc acctcctgct ctgaagacca gcccaattca gcctattctc
     2581 gagtcgagtc tggggccctt tattccctca gagcctcctg ggagcttgcc ttgtggctcc
     2641 ttccctgctc cagtctccac ccctctggag gtgtggacta gggatccagc caatcagagc
     2701 acacaggggg cttccacagc agccagcaga gagaagccgg aacctgagca gggcctgcac
     2761 ccagacctcg ccagcctggc tcctctggaa atagttcctt ttgagaaggc atctccacaa
     2821 gcaacagtgg aagtaggagg cccaggcaat ctgtctcctc cactcccacc tgctcctccc
     2881 cctccaactc ctctggagga gtcaactcca gtcctgcttt caaagggcgg cccggaaaga
     2941 gaagactcat ccaggaaatt gaggacagat ctctacatag accagctgaa gtcccaagac
     3001 agccctgaga tctctagcct ctgtcaggga gaggaggcaa ccccaagaca cagtgacaag
     3061 caaaattcaa agaatgctgc ttctgagggg aaaggctgtg gttttccaag cccaaccagg
     3121 gaggttgaga tcgtctcaca agaagaggag gatgtaaccc attcagtaca ggagccttca
     3181 gactgtgacg aagatgacac tgtgacagac attgcccagc atggcctgga gatggtggag
     3241 ccctgggagg aaccccagtg ggtgacgagt ccccttcact ctcccaccct gaaagacgcg
     3301 cacaaggccc aggtacaggg ccttcagggt caccagttgg agaagaggct ttcccacagg
     3361 cccagccttc gccagagcca ttctctagat agcaaaccca cggttaaaag ccagtggact
     3421 ctcgaggttc cctcctccag cagctgtgct aatcttgaaa cagagaggaa ttctgaccct
     3481 cttcagcccc aggcacccag gagagagatt actggatggg atgagaaagc cctgaggtcc
     3541 ttcagagagt tctctggcct gaaaggggca gaggctcctc ccaaccagaa gggaccaagt
     3601 ggtgtgcaac ccaacccagc agaaaccagc cccatcagcc tagcagaggg aaaggagcta
     3661 gggacacacc tggggcacag cagtccacag attaggcaag gtggtgttcc tgggccagag
     3721 agcagcaagg agagttcacc cagcgtgcag gacagcactt cgcctggaga gcaccccgca
     3781 aagttacagc taaagagcac agagtgtggg cccccaaaag ggaaaaacag gccttcttcc
     3841 ctcaacttgg accctgccat tcccattgct gacctcttct ggtttgagaa tgtggcctca
     3901 tttagttcac ctggaatgca ggtctctgag ccaggagacc caaaggtcac atggatgacc
     3961 tcatcttact gtaaagcaga cccctggagg gtttactccc aggaccccca ggacctggac
     4021 attgttgctc atgcactgac aggccgccgt aactcagctc ctgtgagtgt gtcagctgtg
     4081 agaacctcct tcatggtcaa aatgtgccag gccagggcgg tcccagtcat ccctcccaag
     4141 attcagtaca cccagatccc acagcccctg ccctctcaga gctcagggga gaatggggtt
     4201 cagcctctgg agaggagcca ggagggaccc agctcaacca gtgggaccac tcagaaacct
     4261 gccaaagatg attctccctc ctccctggaa agctcaaagg aagaaaaacc aaagcaagat
     4321 cccggagcca ttaagtcctc accagtggat gccactgcac cctgcatgtg cgagggacct
     4381 accctttctc cagaaccagg ctcgtctaac ctgctctcca cccaggatgc agtagtgcaa
     4441 tgcagaaagc gcatgtcaga gacagagcca tctggggaca accttctttc ttcaaaacta
     4501 gagcgaccat ctgggggttc taagcctttc cacaggtcaa ggccaggaag acctcagagc
     4561 ctaatcttat tcagtcctcc tttccccatt atggaccacc tgcccccttc atccacagtg
     4621 acagattcca aggtcctgct gtcccctatc agaagtccca cccagacagt ttcccctggc
     4681 cttctttgtg gagagttggc agaaaacaca tgggtcacac cagaaggggt tacacttagg
     4741 aataaaatga ccatccctaa gaatggccag agactagaga cctcaaccag ctgtttttac
     4801 cagcctcagc ggagatcagt aattctggat ggaagaagtg ggaggcaaat agaatgattt
     4861 cggttcacct gctggtgtct gaaaaaaacc gtgattcatc tggaagttat tacagggcca
     4921 gcttgccata ttccaggcac acgttatcaa gtttgggcct attgtggcct ctgacttctc
     4981 tttcttcagc cttttgacca cttattaatt agtccatttg ctagaagagt ggtcaaggga
     5041 aaaacgagag atgaaattta gttaagtcta tgtgagcaag tgagagaagg ttaggtaagg
     5101 ggagaggatg gaatgcttgc ctccaatgaa ctttggagct tgtatgtgag tcagattgct
     5161 cccctattgc tattatctat tactcttgag agctggctgt cctttgaaag aaagaagtaa
     5221 tgttctttga aagaaagaaa aatctcttgc tgtgtcaaac ctcaaaatgt tgctattggg
     5281 gttagaaggc ctcctcttta tgctttttaa tgctctttca aacgtgttct tttagaccag
     5341 ttttctaata agctttgtaa aatgtactat ccaaattaga agcggatttg gaaatgcaaa
     5401 ctaacgtgca cttagatatc caagtgggtg agcttagcca ctcttaccca tgctctttcc
     5461 ctggaatccc tggagacctg tccaagatga tttccatata ccagcataga aaatcagaat
     5521 caagagcaaa ctctgagact ggcacaatcc aagaagattt cctggctctg gcttttagta
     5581 atttgggact ccaactgcca ctgtactgga ctgtaattta taaatccagt agctacgcag
     5641 ggtggaggct gggctgagga ttaccataat gaaatgtact aaatcttcat ttaggtatgc
     5701 aattgtgaag tgaaggcatc tgctttcttt acagtatcag agtccaagaa caggatgtca
     5761 ccatagataa aagcctcata caaaggcaga actacactcc aaatttaatg tgtttaaatt
     5821 ggtggggcac cagcagaaaa tattctagct cagctttact cttcttccac actaggctgg
     5881 gcccagcaat acaggagagg atgaagggag gagctccagg aggcgaggga agagccctag
     5941 cagggcggcc atcacaacca ctcactgaga gttgcccttc ttaaaaatgt attttatttt
     6001 agccagtggg tcccttcctt tctcctttcc tctctactgc tcaagaacag atttgaggcc
     6061 aggtgcggtg cctcacatct gtaatcccaa cactttggga ggctgagatg ggtggattgc
     6121 ttgagcccag gagttcaaga ccagcctggg caacacagcg agaccccatc tcttaaaaaa
     6181 taacagactt gaggaacccc tctcccttcc ataattcccc tcatccaccg cccactccag
     6241 gcactcactc aaacttgctc ttcaactctg tatacaagca gaagcaataa accaatctga
     6301 ttttcttttc aattatttat aactttcaat ggttctttcc tttccagctg gcgagagaaa
     6361 ggagaactaa tatacctgct ggcagatttt tggtgctgcc caaaaaagga cttcacaggg
     6421 catctcttct caggttcaag cctggctgaa ttctgcccag aagctcagtc attgcagaaa
     6481 tttctctaag ggctgatagt acctctgggt aggcgtcaca accaaggctg gttctgggct
     6541 tagtgggggc tgagatgaag ttacctcctc caatgagaaa ttgggagctg atgccctgca
     6601 acagatatat attcctctct ctctctgtct ctctatctct ctcctccctc tccctccctc
     6661 cctccccgcc aataagcctt acaaacagtt ttgaaatctt gttctgtacc ttttaagcca
     6721 gtgtctgtgg cgagggtgac tggcaagtca gctgatgagt tctgccttct gagagcactg
     6781 agtgagcaag gcctttcatc agtgttttgg ccttctcatt gggtgaggaa gacattgaac
     6841 caacagccaa cgagatatga acctgtaaga aaaaagtcct agaatatagt atttttcccc
     6901 aggccagcaa agtgaagaaa tacagtggtg acagatgaga aaggccatgt tcaagagatc
     6961 tgaaaagtac attcctgcct tatcagaaaa tgtgtcagac aggttttatg tcagcctcag
     7021 tgctcctgcg gtgtcgacgc tctgataagg accatgttcc agttagaatg cgagggaggg
     7081 aaagagctgc actttgcttc accatcagaa ctctgagcca aataatgaat atgtaaacta
     7141 ttttatgatt attttaaatg tttgtttggt aacatttata agatctattt ttatttgggg
     7201 atagactgag aagccaccat ttacatatta acaagtgact tcagttctaa gggttgagat
     7261 gcctgtgtgg atttataaaa tggttgcaag atcttttaga ctctgacatt tatagcatca
     7321 ccttcaggaa cacagttctg gggatgtcat catgagacac actgacagct gtggagatag
     7381 tccctactct cagctttcct tgctagtcaa gtccaaaagg ccttagaagc tgactcacct
     7441 tctcagccag agtcctgctg ctcaagtgtg gacctccact ttgactctca cccagcctgc
     7501 cagccatcac aaaggctttc ataaacttcc tgtggtctgg gctagcctgg cactgatgaa
     7561 attccattct aaagaaagaa aactcatatt cctccccccc acaaattgtt cccccaaatg
     7621 ctctgggatt acctatttca ccactcattt gagtctccga aaaatgaact ccctgagaat
     7681 ggctggatgg gaatcagata gtctgcttcc attcaggaga gggacagaac aggagctgct
     7741 gtgtttagga ggatttacct ggtgccctag aaagggctat gcaatcaaat tctcaagggc
     7801 tccttcaaat cagctatcag tcctcaaaat gggggttgct gatgttaaat gatggatttg
     7861 cagtgaaacg catgcatgta ctgacgtttt ctttcagcat tagtggttgc ttaagaaaat
     7921 agtaacctat attttctgct acacttggaa tatgaagaaa tctgaacaag aaccccatta
     7981 agacacctaa cctaatctaa accctaaaat tcaaaatatt gtccaagtca aaagtctaga
     8041 ctctgaggac attaaaaatg taaatatcat catccttagc aaatatttat tgggagctta
     8101 gtaatagtgc actgggtacc ttagcactcc caaatcattc aagagtctag tgaaaaaggg
     8161 ggagggatgg cagcaaataa aacaccccca taaacaacca ggagcaaggt tgagaaccat
     8221 taagttgcca aacaaaagca gaaggggaaa aagtgtggca acaagcatct tttaatagga
     8281 tagttgacgg tattcaagtg acctactgac tccaaataat caaattgaac acaattgcaa
     8341 atccaataga acatcccagt gagacactcg ggtatttgag aactttgctt gatttagaaa
     8401 actggaaagt ggcaactagg ctagaatagt ggcaactagg ttcggaggtt tcgtgtggtc
     8461 ataattggtt tggtgaagtg tgagatctct gcaaatgagc caggtaagat cagtattcca
     8521 tagtgcttga aaaggggatt ttagagactt ctgtcatcac aaagcagatt aactcctagt
     8581 taatgatgaa gcagtaggcc caagataaac tgttcaattc aagataaatt gttcttgtca
     8641 gtgtttggca tatgataatc acatttggct aaaattggat gggacagtca tttgtctaca
     8701 caggccttcc attcctgcat gaagagatac tggggagcat acaattattt tgtccagtat
     8761 tagagtggga gaagttctca gtaagtccag tcccaccagg atttatttgg gccacattct
     8821 accacggcca gtccaatctg atgaccacat gaattggggt taagtgttgc taagactatg
     8881 attttagaca tgtctggcag gaaggtcagc tcaaaatgtg gcatgacaaa gaatatgtgc
     8941 tctactacca aaacctttcc tagcaaaaca aggccagaag agggagcaag catctttcca
     9001 agcatggaga ggagggggca atggtggaag ggtgattgcc tgaaatcagt gccagtacag
     9061 atagcataaa attgggggcc accacagatt ggctggctac tgtgtagatc atttagtaat
     9121 cttgaggtac attaataatg cagagattac ttttctgtga gggtaagggg gacgtagcta
     9181 aatataagaa gcttacaagg tccatagcca tgtattttac tggataaatc acaatgcttt
     9241 gcaataactt aatgtcatag tactttctgg cttataattc tgcaaagtaa agcacttttt
     9301 caaagga
//
