LOCUS       NM_001025598            4342 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens Rho GTPase activating protein 30 (ARHGAP30),
            transcript variant 1, mRNA.
ACCESSION   NM_001025598
VERSION     NM_001025598.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4342)
  AUTHORS   Guo,W., Wang,T., Huai,Q., Guo,L., Wang,X. and He,J.
  TITLE     KIAA1429 regulates lung adenocarcinoma proliferation and metastasis
            through the PI3K/AKT pathway by modulating ARHGAP30 expression
  JOURNAL   Thorac Cancer 15 (18), 1397-1409 (2024)
   PUBMED   38717936
  REMARK    GeneRIF: KIAA1429 regulates lung adenocarcinoma proliferation and
            metastasis through the PI3K/AKT pathway by modulating ARHGAP30
            expression.
REFERENCE   2  (bases 1 to 4342)
  AUTHORS   Chu,X., Lou,J., Yi,Y., Zhong,L. and Huang,O.
  TITLE     Knockdown of ARHGAP30 inhibits ovarian cancer cell proliferation,
            migration, and invasiveness by suppressing the PI3K/AKT/mTOR
            signaling pathway
  JOURNAL   Eur J Histochem 67 (2), 3653 (2023)
   PUBMED   37170915
  REMARK    GeneRIF: Knockdown of ARHGAP30 inhibits ovarian cancer cell
            proliferation, migration, and invasiveness by suppressing the
            PI3K/AKT/mTOR signaling pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4342)
  AUTHORS   Wu,A., Lin,L., Li,X., Xu,Q., Xu,W., Zhu,X., Teng,Y., Yang,X.M. and
            Ai,Z.
  TITLE     Overexpression of ARHGAP30 suppresses growth of cervical cancer
            cells by downregulating ribosome biogenesis
  JOURNAL   Cancer Sci 112 (11), 4515-4525 (2021)
   PUBMED   34490691
  REMARK    GeneRIF: Overexpression of ARHGAP30 suppresses growth of cervical
            cancer cells by downregulating ribosome biogenesis.
REFERENCE   4  (bases 1 to 4342)
  AUTHORS   Chen,S., Liu,Z., Li,M., Huang,Y., Wang,M., Zeng,W., Wei,W.,
            Zhang,C., Gong,Y. and Guo,L.
  TITLE     Potential Prognostic Predictors and Molecular Targets for Skin
            Melanoma Screened by Weighted Gene Co-expression Network Analysis
  JOURNAL   Curr Gene Ther 20 (1), 5-14 (2020)
   PUBMED   32416689
  REMARK    GeneRIF: Potential Prognostic Predictors and Molecular Targets for
            Skin Melanoma Screened by Weighted Gene Co-expression Network
            Analysis.
REFERENCE   5  (bases 1 to 4342)
  AUTHORS   Wang,J., Qian,J., Hu,Y., Kong,X., Chen,H., Shi,Q., Jiang,L., Wu,C.,
            Zou,W., Chen,Y., Xu,J. and Fang,J.Y.
  TITLE     ArhGAP30 promotes p53 acetylation and function in colorectal cancer
  JOURNAL   Nat Commun 5, 4735 (2014)
   PUBMED   25156493
  REMARK    GeneRIF: ArhGAP30 is required for p53 acetylation and functional
            activation in colorectal cancer.Down-regulation of ArhGAP30 in
            colorectal cancer is associated with poor survival.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4342)
  AUTHORS   Jostins,L., Ripke,S., Weersma,R.K., Duerr,R.H., McGovern,D.P.,
            Hui,K.Y., Lee,J.C., Schumm,L.P., Sharma,Y., Anderson,C.A.,
            Essers,J., Mitrovic,M., Ning,K., Cleynen,I., Theatre,E.,
            Spain,S.L., Raychaudhuri,S., Goyette,P., Wei,Z., Abraham,C.,
            Achkar,J.P., Ahmad,T., Amininejad,L., Ananthakrishnan,A.N.,
            Andersen,V., Andrews,J.M., Baidoo,L., Balschun,T., Bampton,P.A.,
            Bitton,A., Boucher,G., Brand,S., Buning,C., Cohain,A., Cichon,S.,
            D'Amato,M., De Jong,D., Devaney,K.L., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Ferguson,L.R., Franchimont,D., Fransen,K.,
            Gearry,R., Georges,M., Gieger,C., Glas,J., Haritunians,T., Hart,A.,
            Hawkey,C., Hedl,M., Hu,X., Karlsen,T.H., Kupcinskas,L.,
            Kugathasan,S., Latiano,A., Laukens,D., Lawrance,I.C., Lees,C.W.,
            Louis,E., Mahy,G., Mansfield,J., Morgan,A.R., Mowat,C., Newman,W.,
            Palmieri,O., Ponsioen,C.Y., Potocnik,U., Prescott,N.J.,
            Regueiro,M., Rotter,J.I., Russell,R.K., Sanderson,J.D., Sans,M.,
            Satsangi,J., Schreiber,S., Simms,L.A., Sventoraityte,J.,
            Targan,S.R., Taylor,K.D., Tremelling,M., Verspaget,H.W., De Vos,M.,
            Wijmenga,C., Wilson,D.C., Winkelmann,J., Xavier,R.J., Zeissig,S.,
            Zhang,B., Zhang,C.K., Zhao,H., Silverberg,M.S., Annese,V.,
            Hakonarson,H., Brant,S.R., Radford-Smith,G., Mathew,C.G.,
            Rioux,J.D., Schadt,E.E., Daly,M.J., Franke,A., Parkes,M.,
            Vermeire,S., Barrett,J.C. and Cho,J.H.
  CONSRTM   International IBD Genetics Consortium (IIBDGC)
  TITLE     Host-microbe interactions have shaped the genetic architecture of
            inflammatory bowel disease
  JOURNAL   Nature 491 (7422), 119-124 (2012)
   PUBMED   23128233
REFERENCE   7  (bases 1 to 4342)
  AUTHORS   Naji,L., Pacholsky,D. and Aspenstrom,P.
  TITLE     ARHGAP30 is a Wrch-1-interacting protein involved in actin dynamics
            and cell adhesion
  JOURNAL   Biochem Biophys Res Commun 409 (1), 96-102 (2011)
   PUBMED   21565175
  REMARK    GeneRIF: A screen for Wrch-1 binding-partners identified the novel
            RhoGAP protein, ARHGAP30, as a Wrch-1 interactor.
REFERENCE   8  (bases 1 to 4342)
  AUTHORS   Brill,L.M., Salomon,A.R., Ficarro,S.B., Mukherji,M.,
            Stettler-Gill,M. and Peters,E.C.
  TITLE     Robust phosphoproteomic profiling of tyrosine phosphorylation sites
            from human T cells using immobilized metal affinity chromatography
            and tandem mass spectrometry
  JOURNAL   Anal Chem 76 (10), 2763-2772 (2004)
   PUBMED   15144186
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK160366.1 and AL591806.16.
            
            On Nov 22, 2018 this sequence version replaced NM_001025598.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK160366.1, SRR1803614.7560.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368013.8/ ENSP00000356992.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2037              AK160366.1         55-2091
            2038-4342           AL591806.16        100948-103252       c
FEATURES             Location/Qualifiers
     source          1..4342
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..4342
                     /gene="ARHGAP30"
                     /note="Rho GTPase activating protein 30"
                     /db_xref="GeneID:257106"
                     /db_xref="HGNC:HGNC:27414"
                     /db_xref="MIM:614264"
     exon            1..364
                     /gene="ARHGAP30"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..3573
                     /gene="ARHGAP30"
                     /note="isoform 1 is encoded by transcript variant 1; rho
                     GTPase-activating protein 30; rho-type GTPase-activating
                     protein 30"
                     /codon_start=1
                     /product="rho GTPase-activating protein 30 isoform 1"
                     /protein_id="NP_001020769.1"
                     /db_xref="CCDS:CCDS30918.1"
                     /db_xref="GeneID:257106"
                     /db_xref="HGNC:HGNC:27414"
                     /db_xref="MIM:614264"
                     /translation="MKSRQKGKKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFV
                     EEYGVVDGIYRLSGVSSNIQKLRQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELP
                     DPLLTYRLYDKFAEAVGVQLEPERLVKILEVLRELPVPNYRTLEFLMRHLVHMASFSA
                     QTNMHARNLAIVWAPNLLRSKDIEASGFNGTAAFMEVRVQSIVVEFILTHVDQLFGGA
                     ALSGGEVESGWRSLPGTRASGSPEDLMPRPLPYHLPSILQAGDGPPQMRPYHTIIEIA
                     EHKRKGSLKVRKWRSIFNLGRSGHETKRKLPRGAEDREDKSNKGTLRPAKSMDSLSAA
                     AGASDEPEGLVGPSSPRPSPLLPESLENDSIEAAEGEQEPEAEALGGTNSEPGTPRAG
                     RSAIRAGGSSRAERCAGVHISDPYNVNLPLHITSILSVPPNIISNVSLARLTRGLECP
                     ALQHRPSPASGPGPGPGLGPGPPDEKLEASPASSPLADSGPDDLAPALEDSLSQEVQD
                     SFSFLEDSSSSEPEWVGAEDGEVAQAEAAGAAFSPGEDDPGMGYLEELLGVGPQVEEF
                     SVEPPLDDLSLDEAQFVLAPSCCSLDSAGPRPEVEEENGEEVFLSAYDDLSPLLGPKP
                     PIWKGSGSLEGEAAGCGRQALGQGGEEQACWEVGEDKQAEPGGRLDIREEAEGSPETK
                     VEAGKASEDRGEAGGSQETKVRLREGSREETEAKEEKSKGQKKADSMEAKGVEEPGGD
                     EYTDEKEKEIEREEDEQREEAQVEAGRDLEQGAQEDQVAEEKWEVVQKQEAEGVREDE
                     DKGQREKGYHEARKDQGDGEDSRSPEAATEGGAGEVSKERESGDGEAEGDQRAGGYYL
                     EEDTLSEGSGVASLEVDCAKEGNPHSSEMEEVAPQPPQPEEMEPEGQPSPDGCLCPCS
                     LGLGGVGMRLASTLVQVQQVRSVPVVPPKPQFAKMPSAMCSKIHVAPANPCPRPGRLD
                     GTPGERAWGSRASRSSWRNGGSLSFDAAVALARDRQRTEAQGVRRTQTCTEGGDYCLI
                     PRTSPCSMISAHSPRPLSCLELPSEGAEGSGSRSRLSLPPREPQVPDPLLSSQRRSYA
                     FETQANPGKGEGL"
     exon            365..467
                     /gene="ARHGAP30"
                     /inference="alignment:Splign:2.1.0"
     exon            468..612
                     /gene="ARHGAP30"
                     /inference="alignment:Splign:2.1.0"
     exon            613..695
                     /gene="ARHGAP30"
                     /inference="alignment:Splign:2.1.0"
     exon            696..803
                     /gene="ARHGAP30"
                     /inference="alignment:Splign:2.1.0"
     exon            804..931
                     /gene="ARHGAP30"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1103
                     /gene="ARHGAP30"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1207
                     /gene="ARHGAP30"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1285
                     /gene="ARHGAP30"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1687
                     /gene="ARHGAP30"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1953
                     /gene="ARHGAP30"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..4342
                     /gene="ARHGAP30"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4322..4327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP30"
                     /note="hexamer: AATAAA"
     polyA_site      4342
                     /gene="ARHGAP30"
                     /note="major polyA site"
ORIGIN      
        1 gagtgccagg ctgggccacg agacacagga cacaatttct tgccagggtc ctggtagctt
       61 cctcttcaac agccacttcc gtgtggccgg ggccccaggg gcaggagctg ctgcccgttg
      121 cccaggccac cctccacccc caattgggag ccctgccccc ctggggccgg gccaagccca
      181 gcagctggct gggatcccat gggggactgg tagggcacag gtcttggggg atagaggtga
      241 ccgggccagt gccctggggc tctggccatg aagtctcggc agaaaggaaa gaagaagggc
      301 agcgcaaagg agcgggtttt tgggtgcgac ttgcaggagc acctgcagca ctcaggccag
      361 gaggtgcccc aggtgctaaa gagctgtgca gaatttgtgg aggagtatgg agtggtggat
      421 gggatctacc gcctctcagg ggtctcctcc aacatccaga agcttcggca ggaatttgag
      481 tcagagcgga agccagacct gcgtcgggat gtttacctcc aagacattca ctgcgtctcc
      541 tccctgtgca aggcctattt cagagaactg ccggatcccc tgctcactta ccggctctat
      601 gacaagtttg ctgaggctgt aggagtgcaa ttggaacctg agcgcttggt caagatccta
      661 gaggtgcttc gggaactccc tgtcccaaac tacaggaccc tggagttcct catgaggcac
      721 ttggtacaca tggcctcatt cagtgcccag accaacatgc atgctcgcaa cctggccatc
      781 gtgtgggctc ccaacctgct gaggtctaag gacatagagg cctcaggctt caatgggaca
      841 gcggccttca tggaggtgcg ggtacaatcc atcgtcgtgg agttcatcct cacacacgtg
      901 gaccagctct ttgggggtgc tgccctctct ggtggtgagg tggagagtgg gtggcgatcg
      961 cttccaggga cccgggcatc aggcagcccc gaggacctta tgcccaggcc actgccttat
     1021 cacctgccta gcatactgca ggctggcgat ggacccccac agatgcggcc ctaccatact
     1081 atcatcgaga ttgcagagca caagaggaag gggtctttga aggtcaggaa gtggaggtct
     1141 atcttcaatt taggtcgctc tggccatgag actaagcgta aacttccacg gggggctgag
     1201 gacagggagg ataaatccaa caaggggaca ctgcggccag ccaaaagcat ggactcactg
     1261 agtgctgcag ctggggccag tgatgagcca gaggggctgg tggggcccag cagcccccgg
     1321 ccaagcccat tgctgcctga gagcttggag aacgattcta tagaggcagc agagggtgaa
     1381 caggagcctg aggcagaagc actgggtggc acaaactctg aaccaggcac accacgagct
     1441 gggcggtcag ccatccgggc tgggggcagc agccgtgcag aacgctgtgc tggtgtccac
     1501 atctcagacc cctacaatgt caacctcccg ctacacatca cctctatcct cagtgtgccc
     1561 ccgaacatca tctctaacgt ttccttggcc aggctcaccc gtggccttga gtgccctgct
     1621 ctacagcacc ggccaagccc tgcctctggc cctggccctg gccctggcct tggccctggc
     1681 cccccagatg aaaagttgga agcaagtcca gcctcaagtc ccctggcaga ctcaggccca
     1741 gacgacttgg ctcctgccct ggaggactcg ctgtcccagg aggtgcagga ctccttctcc
     1801 ttcctagagg actcaagcag ctcagaacct gagtgggtgg gggcagagga tggggaggtg
     1861 gcccaggcag aagcagcagg agcagccttc tcccctgggg aggacgaccc tgggatgggc
     1921 tacctggagg agctcctggg agttgggcct caggtggagg agttctctgt ggagccaccc
     1981 ctggatgacc tgtctctgga tgaggcacag tttgtcttgg cccccagctg ctgttccctg
     2041 gactccgctg gccccaggcc tgaagttgag gaggaaaatg gggaggaagt tttcctgagt
     2101 gcctatgatg acctaagtcc ccttctggga cctaaacccc caatctggaa gggttcaggg
     2161 agtctggagg gagaggcagc aggatgtgga aggcaggctc tgggacaggg tggggaagag
     2221 caggcatgct gggaagttgg ggaggacaag caggctgagc ctggaggcag gctagacatc
     2281 agggaagagg cagagggaag tccagagacc aaggtggagg ctggaaaggc cagtgaggat
     2341 agaggggagg ctgggggaag ccaagagaca aaagtcagat tgagagaagg gagtagggaa
     2401 gagacagagg ccaaggaaga gaagtccaaa ggtcagaaga aggctgacag tatggaggct
     2461 aaaggtgtgg aggaaccagg aggagatgag tatacagatg agaaggaaaa agaaattgag
     2521 agagaagagg atgaacaaag agaggaagcc caggtagaag ctggaaggga cctagagcaa
     2581 ggggcccagg aagatcaagt tgctgaggag aaatgggaag ttgtacagaa acaagaggct
     2641 gagggagtca gagaggatga ggacaaagga cagagggaga aggggtacca tgaagcaaga
     2701 aaagaccaag gagatggtga agacagcaga agcccagaag cagcaactga aggaggagca
     2761 ggggaggtca gcaaggaacg ggagagtggg gatggagagg ctgagggaga ccagagggct
     2821 ggagggtact atttagaaga ggacaccctc tctgaaggtt caggtgtagc gtccctggag
     2881 gttgactgtg ccaaagaggg caatcctcac tcttctgaga tggaagaggt agccccacag
     2941 ccacctcagc cagaggagat ggagcctgag gggcagccca gtccagacgg ctgtctatgc
     3001 ccctgttctc ttggcctggg tggcgtgggc atgcgtctag cttccactct ggttcaggtc
     3061 caacaggtcc gctctgtgcc tgtggtgccc cccaagccac agtttgccaa gatgcccagt
     3121 gcaatgtgta gcaagattca tgtggcacct gcaaatccat gcccgaggcc tggccggctt
     3181 gatgggactc ctggagaaag ggcttggggg tcccgagctt ctcgatcctc ttggaggaat
     3241 gggggtagtc tttcctttga tgctgctgtg gccctagccc gggaccgcca aaggactgag
     3301 gctcaaggag ttcggcgaac ccagacctgt actgagggtg gggattactg cctcatcccc
     3361 agaacctccc cttgtagcat gatctctgcc cattctcctc ggccccttag ctgcctggag
     3421 ctcccatctg aaggtgcaga agggtctgga tcccggagtc gtcttagtct gccccccaga
     3481 gaaccccagg ttcctgaccc cctgttgtcc tctcagcgca ggtcatatgc atttgaaaca
     3541 caggctaacc ctgggaaagg tgaaggactg tgattaggac cacagccctg ggcaaagggg
     3601 accagcaagt tgtcttgaat ctccagggtt cctgactagc tgtctcctct gcagcatgag
     3661 cagctgtagt gcccaactct ataggctttg gccctccagc ttctctcttt gactgtggga
     3721 ggcactgcct tggttggttt acctgaactt gtctccgaca caaagcactt atctcttagg
     3781 agattcccaa gaaagtcaac aagatcttgt tcccagggag tgggtcattg gccaaaggga
     3841 acataaggta ggcagaaaac ttaaaagagt ttgttaaagt gaagactgga gaaattcctc
     3901 ccttcctctg agctgtgaat ctctcttcat gaaagccaaa ggtagagaca gggaggacag
     3961 ggccaggtta gggccttcca cacacaaaca cttctagagt tgcccattcc tgttatgttc
     4021 ttggacccta agatacctcc tgtccctttt aaatccagat taagagaaac gtccaggaag
     4081 agctctttga agccctcaat atttgttgga gggactggac tcctctccag ctccccaccc
     4141 tctgcctcca gtcaccatgt gcaagagagg tcctgtacag atctctctgg gctctccttt
     4201 ctcctttgga ataacttgtt cctatttcag gaaagggaaa tggtgtcact caggccctgg
     4261 gactgcttct ccagccaggc tggggccaca ggtcccactc tagtgaaggt caatgtctca
     4321 gaataaaagc tgtattttta ca
//
