LOCUS       NM_001282290            4621 bp    mRNA    linear   PRI 15-FEB-2024
DEFINITION  Homo sapiens Rho GTPase activating protein 27 (ARHGAP27),
            transcript variant 4, mRNA.
ACCESSION   NM_001282290 XM_006721745
VERSION     NM_001282290.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4621)
  AUTHORS   Katoh,Y. and Katoh,M.
  TITLE     Identification and characterization of ARHGAP27 gene in silico
  JOURNAL   Int J Mol Med 14 (5), 943-947 (2004)
   PUBMED   15492870
REFERENCE   2  (bases 1 to 4621)
  AUTHORS   Sakakibara,T., Nemoto,Y., Nukiwa,T. and Takeshima,H.
  TITLE     Identification and characterization of a novel Rho GTPase
            activating protein implicated in receptor-mediated endocytosis
  JOURNAL   FEBS Lett 566 (1-3), 294-300 (2004)
   PUBMED   15147912
REFERENCE   3  (bases 1 to 4621)
  AUTHORS   Peck,J., Douglas,G. 4th, Wu,C.H. and Burbelo,P.D.
  TITLE     Human RhoGAP domain-containing proteins: structure, function and
            evolutionary relationships
  JOURNAL   FEBS Lett 528 (1-3), 27-34 (2002)
   PUBMED   12297274
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091132.16 and AC003070.2.
            
            On or before Jul 16, 2020 this sequence version replaced
            XM_006721745.2, NM_001282290.1.
            
            Summary: This gene encodes a member of a large family of proteins
            that activate Rho-type guanosine triphosphate (GTP) metabolizing
            enzymes. The encoded protein may pay a role in clathrin-mediated
            endocytosis. Alternatively spliced transcript variants encoding
            multiple isoforms have been observed for this gene. [provided by
            RefSeq, Aug 2013].
            
            Transcript Variant: This variant (4) represents the longest
            transcript and encodes the longest isoform (d).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.2845519.1,
                                           SRR14038194.1808655.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000685559.1/ ENSP00000509127.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-119               AC091132.16        140849-140967
            120-253             AC091132.16        141370-141503
            254-385             AC091132.16        141967-142098
            386-1060            AC091132.16        143422-144096
            1061-1468           AC003070.2         8633-9040
            1469-1651           AC003070.2         9610-9792
            1652-1732           AC003070.2         10035-10115
            1733-1816           AC003070.2         10188-10271
            1817-1882           AC003070.2         10382-10447
            1883-1950           AC003070.2         10620-10687
            1951-2041           AC003070.2         11007-11097
            2042-2146           AC003070.2         11898-12002
            2147-2245           AC003070.2         16669-16767
            2246-2354           AC003070.2         17692-17800
            2355-2477           AC003070.2         17926-18048
            2478-2576           AC003070.2         18131-18229
            2577-2654           AC003070.2         18432-18509
            2655-2789           AC003070.2         18599-18733
            2790-2895           AC003070.2         18867-18972
            2896-4621           AC003070.2         19083-20808
FEATURES             Location/Qualifiers
     source          1..4621
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..4621
                     /gene="ARHGAP27"
                     /gene_synonym="CAMGAP1; PP905; SH3D20; SH3P20"
                     /note="Rho GTPase activating protein 27"
                     /db_xref="GeneID:201176"
                     /db_xref="HGNC:HGNC:31813"
                     /db_xref="MIM:610591"
     exon            1..119
                     /gene="ARHGAP27"
                     /gene_synonym="CAMGAP1; PP905; SH3D20; SH3P20"
                     /inference="alignment:Splign:2.1.0"
     exon            120..253
                     /gene="ARHGAP27"
                     /gene_synonym="CAMGAP1; PP905; SH3D20; SH3P20"
                     /inference="alignment:Splign:2.1.0"
     exon            254..385
                     /gene="ARHGAP27"
                     /gene_synonym="CAMGAP1; PP905; SH3D20; SH3P20"
                     /inference="alignment:Splign:2.1.0"
     exon            386..1060
                     /gene="ARHGAP27"
                     /gene_synonym="CAMGAP1; PP905; SH3D20; SH3P20"
                     /inference="alignment:Splign:2.1.0"
     CDS             404..3073
                     /gene="ARHGAP27"
                     /gene_synonym="CAMGAP1; PP905; SH3D20; SH3P20"
                     /note="isoform d is encoded by transcript variant 4; SH3
                     domain containing 20; rho GTPase-activating protein 27;
                     CIN85-associated multi-domain-containing Rho
                     GTPase-activating protein 1; rho-type GTPase-activating
                     protein 27; SH3 domain-containing protein 20"
                     /codon_start=1
                     /product="rho GTPase-activating protein 27 isoform d"
                     /protein_id="NP_001269219.1"
                     /db_xref="CCDS:CCDS74082.1"
                     /db_xref="GeneID:201176"
                     /db_xref="HGNC:HGNC:31813"
                     /db_xref="MIM:610591"
                     /translation="MAADVVGDVYVLVEHPFEYTGKDGRRVAIRPNERYRLLRRSTEH
                     WWHVRREPGGRPFYLPAQYVRELPALGNPAAAAPPGPHPSPAAPEPLAYDYRFVSAAA
                     TAGPDGAPEESGGRASSLCGPAQRGAATQRSSLAPGLPACLYLRPAAPVRPAQSLNDL
                     ACAAVSPPAGLLGSSGSFKACSVAGSWVCPRPLARSDSENVYEVIQDLHVPPPEESAE
                     QVDDPPEPVYANIERQPRATSPGAAAAPLPSPVWETHTDAGTGRPYYYNPDTGVTTWE
                     SPFEAAEGAASPATSPASVDSHVSLETEWGQYWDEESRRVFFYNPLTGETAWEDEAEN
                     EPEEELEMQPGLSPGSPGDPRPPTPETDYPESLTSYPEEDYSPVGSFGEPGPTSPLTT
                     PPGWSCHVSQDKQMLYTNHFTQEQWVRLEDPHGKPYFYNPEDSSVRWELPQVPVPAPR
                     SIHKSSQDGDTPAQASPPEEKVPAELDEVGSWEEVSPATAAVRTKTLDKAGVLHRTKT
                     ADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFSTPEYTVELRGATL
                     SWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGIQELSAELPPEESE
                     SSRVDFGSSERLGSWQEKEEDARPNAAAPALGPVGLESDLSKVRHKLRKFLQRRPTLQ
                     SLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDIDGLYRISGNLAT
                     IQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQ
                     DQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLR
                     PEVEETSMPMTMVFQNQVVELILQQCADIFPPH"
     exon            1061..1468
                     /gene="ARHGAP27"
                     /gene_synonym="CAMGAP1; PP905; SH3D20; SH3P20"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1651
                     /gene="ARHGAP27"
                     /gene_synonym="CAMGAP1; PP905; SH3D20; SH3P20"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1732
                     /gene="ARHGAP27"
                     /gene_synonym="CAMGAP1; PP905; SH3D20; SH3P20"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1816
                     /gene="ARHGAP27"
                     /gene_synonym="CAMGAP1; PP905; SH3D20; SH3P20"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..1882
                     /gene="ARHGAP27"
                     /gene_synonym="CAMGAP1; PP905; SH3D20; SH3P20"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..1950
                     /gene="ARHGAP27"
                     /gene_synonym="CAMGAP1; PP905; SH3D20; SH3P20"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2041
                     /gene="ARHGAP27"
                     /gene_synonym="CAMGAP1; PP905; SH3D20; SH3P20"
                     /inference="alignment:Splign:2.1.0"
     exon            2042..2146
                     /gene="ARHGAP27"
                     /gene_synonym="CAMGAP1; PP905; SH3D20; SH3P20"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2245
                     /gene="ARHGAP27"
                     /gene_synonym="CAMGAP1; PP905; SH3D20; SH3P20"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2354
                     /gene="ARHGAP27"
                     /gene_synonym="CAMGAP1; PP905; SH3D20; SH3P20"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2477
                     /gene="ARHGAP27"
                     /gene_synonym="CAMGAP1; PP905; SH3D20; SH3P20"
                     /inference="alignment:Splign:2.1.0"
     exon            2478..2576
                     /gene="ARHGAP27"
                     /gene_synonym="CAMGAP1; PP905; SH3D20; SH3P20"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2654
                     /gene="ARHGAP27"
                     /gene_synonym="CAMGAP1; PP905; SH3D20; SH3P20"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2789
                     /gene="ARHGAP27"
                     /gene_synonym="CAMGAP1; PP905; SH3D20; SH3P20"
                     /inference="alignment:Splign:2.1.0"
     exon            2790..2895
                     /gene="ARHGAP27"
                     /gene_synonym="CAMGAP1; PP905; SH3D20; SH3P20"
                     /inference="alignment:Splign:2.1.0"
     exon            2896..4621
                     /gene="ARHGAP27"
                     /gene_synonym="CAMGAP1; PP905; SH3D20; SH3P20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4598..4603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP27"
                     /gene_synonym="CAMGAP1; PP905; SH3D20; SH3P20"
                     /note="hexamer: AATAAA"
     polyA_site      4621
                     /gene="ARHGAP27"
                     /gene_synonym="CAMGAP1; PP905; SH3D20; SH3P20"
                     /note="major polyA site"
ORIGIN      
        1 gttgaacagg aaacccggca gcgcgggagc cgcacagtcg aggagggagc gcgggacgcc
       61 gagcccacgc gcgcctgccg gggcaagtgg aggcgaagcc ggcgagcgga cgccccgagg
      121 gtcggggaag gaaccgaggt ccggtcccct tcttatccag cccgagacat cgagctccgg
      181 tgggcgtccc tgcgctggga atcccgctcg gagtttttcc aggcccggcc gggctgctcc
      241 gggaaaggcc ctgctcctgt tccgcgcagc ctctccggcc tcgcccctgg aaaccccgcc
      301 cagggcgatg gtaggggcct aacctgcagc caccgccggc tccgcccacc cagcccatgg
      361 gctccctgag gcccgcccag ccgacgaaaa cgccgcggct gcgatggcgg cggacgtggt
      421 gggggacgtg tacgtgctgg tggagcaccc cttcgagtac accggcaagg acgggcgccg
      481 cgtggccatc cggccgaatg agcgctaccg gctgctgcgg cgcagcaccg agcactggtg
      541 gcacgtgcgg cgtgagcccg gcggccgccc cttctacctg cctgcgcagt acgtgcgcga
      601 gctgcccgcg ctgggcaacc ctgccgccgc cgcgccgcca ggtccccacc cgagccccgc
      661 ggcccctgag ccgctcgcct acgactaccg gtttgtgagc gcggcggcga ccgcgggccc
      721 cgacggcgcc cccgaggagt ccggaggccg agccagctcc ctgtgcggcc ctgcgcaacg
      781 cggcgccgcg acccagcgca gcagcctggc gcccggcctg ccagcctgcc tgtacctgcg
      841 gcccgcggcg cccgtgcggc ccgcgcagtc cctgaacgac ctggcctgcg ccgccgtctc
      901 gcctcccgcc ggcctcctag gaagcagcgg cagcttcaag gcctgcagcg tggcgggctc
      961 ctgggtgtgc ccgcggcctc tggcgcgcag cgactcagag aacgtctacg aggtcatcca
     1021 ggacttgcac gtcccgccgc cggaggagag cgcagagcag gtggacgacc caccggagcc
     1081 cgtgtacgcg aacatagaga ggcagccccg ggccacttca ccgggcgccg ctgcagcccc
     1141 ccttcccagc ccggtgtggg agacgcacac ggacgcgggc accgggcgcc cctactacta
     1201 caacccagac acgggagtta ccacctggga gtcgcccttt gaggctgccg agggtgccgc
     1261 cagcccagcc acctcccctg cctcggtgga cagccacgtg agccttgaga ccgagtgggg
     1321 ccagtactgg gatgaggaga gccgcagggt gttcttctac aacccgctga cgggcgagac
     1381 ggcctgggag gacgaggccg agaacgagcc cgaggaggag ttggagatgc agccgggcct
     1441 gagccctggc agcccagggg acccgcggcc ccccactccc gagacggact accccgagtc
     1501 gctgaccagt taccccgagg aggactattc tcccgtgggc tctttcggtg agcccggccc
     1561 tacctctccc ttgaccacac cccccggctg gtcttgtcat gtcagccagg acaagcagat
     1621 gctctacacc aaccacttca ctcaggagca gtgggtgagg ctggaggacc cccacgggaa
     1681 gccatacttc tacaatccag aggactcctc tgttcgatgg gagctgcccc aggtccctgt
     1741 ccctgcccct cgaagcatcc ataaatccag ccaggatggt gacaccccag cccaggccag
     1801 ccctccagag gagaaggtcc cagcagagct ggatgaggtt gggagctggg aggaagtctc
     1861 tcctgccaca gctgctgtga ggaccaagac cttggacaag gcaggggtgc tccatcgcac
     1921 caagacggca gacaagggaa agcggctccg gaagaagcac tggagtgcct cctggactgt
     1981 gctggagggt ggcgtcctga cattcttcaa ggactcaaag acctcggctg caggcggcct
     2041 gaggcagcct tccaagtttt ccacccctga gtacacagtg gagctgaggg gggccactct
     2101 ctcctgggcc cccaaagaca aatccagtag gaagaatgtg ctggagctac ggagccgaga
     2161 tggctctgag tacctgatcc agcacgactc ggaggccatc atcagcacct ggcataaggc
     2221 cattgctcag ggcatccagg agctgtccgc agagctgccc ccagaggaga gcgagagcag
     2281 cagagtggac ttcgggtcga gcgagcgctt gggaagctgg caggagaaag aggaggacgc
     2341 gcgaccgaat gcagccgcgc ccgccctggg ccccgtgggc ctggagagcg acttgagcaa
     2401 ggtccggcac aagctccgca agttcctcca gaggcggccc acactgcagt cgctgcggga
     2461 gaagggctac atcaaagacc aggtgttcgg ctgcgcgctg gccgcgctgt gtgagcgcga
     2521 gaggagccgg gtgccacgct tcgtgcagca gtgcatccgc gccgtcgagg cccgcgggct
     2581 ggacatcgac gggctgtacc gcatcagtgg aaacctggcc accatccaga agctacgcta
     2641 taaggtggac cacgatgagc gccttgacct ggatgacggg cgctgggagg acgtccacgt
     2701 tatcaccgga gccctgaagc tcttctttcg ggagctgccc gagcccctct tccccttctc
     2761 gcacttccgc cagttcattg cggccatcaa gttgcaggac caggcccggc gcagccgctg
     2821 tgtgcgtgac ttggtgcgct cgctgcccgc tcccaaccac gacactctgc ggatgctctt
     2881 ccagcacctc tgccgggtga tcgagcacgg cgagcagaac cgcatgtcgg tgcagagcgt
     2941 ggccattgtg ttcgggccca cgctgctgcg gcccgaggtg gaagagacca gcatgcccat
     3001 gaccatggtg ttccagaacc aggtggtgga gctcatcctg cagcagtgcg cggacatctt
     3061 cccgccgcac tgactgctgg cctgtgactg gggcggcggc cgcggtcctg ccacacaagc
     3121 tgggcggcgg aggccacgca gccgggcctt cttctctctg ggaccctccg ccagcgcata
     3181 gccgcaggcc ggtgtgactt ctgcaccctc ggttctgagg gtacggtgac ccctagtggg
     3241 cagtttgcaa aatgtgattc cttcttccca actccccatc cccccttccc ttcccgtcac
     3301 gtcctgtttg ggggttaatt cggttttttc tctgttgcat cgcgcctact gtgcgtgtgc
     3361 gatagcgtgt gtgggggtga gagtttgttt tctggaatgg taggtgctgg gaggaggagt
     3421 ttgatggagg gcttcctggc tgcttctggc cctcacctcg tggaggcctt cacagagacc
     3481 ctgtgggccc tggccctgtg ctggcactgt gccagtcatg aggcagctct gatcacttcc
     3541 ccactgtgga aacaggactg acccagcctt cagtgtgggc tgctgaagct atcctcctca
     3601 ggcctcaggg atgacctcct gcctgagcct ctcacaggct ggctgtgggc cagtttcatc
     3661 tgctttcctg ttgggggtcc cgggcctctg ctgtccttga cccactggtg ttctgtgcaa
     3721 ggcttcttcc cattcaccaa gtgcacacct tgcatctgcc gctcggcatg caccagttcc
     3781 acacaccatc ccattttaca gacaaggacg ctgaggcctg cagcagcagt gtgacttgct
     3841 caaggtccag tgagtgacct cattccccag aaaaggctcc tcccacacca gagtacagcc
     3901 tgggtagggg gaaaatcagt tctttcagct accacccatc caacctttgg gcctatgtga
     3961 aaagaaagga actaagctgg gtgtgttctg tctggacctg gggaggcccc tgaaggcaaa
     4021 gagggaaact gtcccagctg ttctgtccta ggggaggggg acatagccct agcaggagct
     4081 cccagcccct cttggcactc tgacacacaa gtacacccat ctggggcccg ctttgccacg
     4141 aagagctggg caggcctgca gggtgtgggg aaggaggaca caacctcaag aaaggaagcg
     4201 tgaaccccag ggaacagcgg gtcccttccc tcctcagaca caagccacct cagcttgtgg
     4261 ctcttggccc ccagccccac caacccacct gttcatttat tcaacagaca atgacagctg
     4321 atatttattg gacatttgca ccatgccaag cattcggctt ggattatccc atttgtttct
     4381 cacagccggt atttattgtc tgctcctctg tgccaggtgc tgtgctctgg gcaggggcac
     4441 tgcatgggct gcctgccctg gtggagcttg tggtctgatg ggtgaggctg acccaagccc
     4501 accccattgc caacagggcc agggcaagag tacacacagg ggcctcatac catatgtcta
     4561 aatatttaaa agttatcaat caagctaaca actgttaaat aaaatatgtt ctattctcct
     4621 a
//
