LOCUS       NM_001135608            9226 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens Rho GTPase activating protein 26 (ARHGAP26),
            transcript variant 2, mRNA.
ACCESSION   NM_001135608
VERSION     NM_001135608.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9226)
  AUTHORS   Zhu,Q. and Taylor,J.M.
  TITLE     ARHGAP26/GRAF1 orchestrates actin remodeling and membrane dynamics
            to drive mitochondrial clearance and promote fuel flexibility
  JOURNAL   Autophagy 20 (8), 1906-1908 (2024)
   PUBMED   38855880
  REMARK    GeneRIF: ARHGAP26/GRAF1 orchestrates actin remodeling and membrane
            dynamics to drive mitochondrial clearance and promote fuel
            flexibility.
REFERENCE   2  (bases 1 to 9226)
  AUTHORS   Zhu,Q., Combs,M.E., Liu,J., Bai,X., Wang,W.B., Herring,L.E.,
            Liu,J., Locasale,J.W., Bowles,D.E., Gross,R.T., Pla,M.M., Mack,C.P.
            and Taylor,J.M.
  TITLE     GRAF1 integrates PINK1-Parkin signaling and actin dynamics to
            mediate cardiac mitochondrial homeostasis
  JOURNAL   Nat Commun 14 (1), 8187 (2023)
   PUBMED   38081847
  REMARK    GeneRIF: GRAF1 integrates PINK1-Parkin signaling and actin dynamics
            to mediate cardiac mitochondrial homeostasis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9226)
  AUTHORS   Xu,G., Zhao,L., Hua,Q., Wang,L., Liu,H., Lin,Z., Jin,M., Wang,J.,
            Zhou,P., Yang,K., Wu,G., Yu,D., Zhang,D. and Zhang,T.
  TITLE     CEMIP, acting as a scaffold protein for bridging GRAF1 and MIB1,
            promotes colorectal cancer metastasis via activating CDC42/MAPK
            pathway
  JOURNAL   Cell Death Dis 14 (2), 167 (2023)
   PUBMED   36849460
  REMARK    GeneRIF: CEMIP, acting as a scaffold protein for bridging GRAF1 and
            MIB1, promotes colorectal cancer metastasis via activating
            CDC42/MAPK pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9226)
  AUTHORS   Al-Hamed,M.H., Sayer,J.A., Alsahan,N., Edwards,N., Ali,W.,
            Tulbah,M. and Imtiaz,F.
  TITLE     Missense Variants in GFRA1 and NPNT Are Associated with Congenital
            Anomalies of the Kidney and Urinary Tract
  JOURNAL   Genes (Basel) 13 (10), 1687 (2022)
   PUBMED   36292572
  REMARK    GeneRIF: Missense Variants in <i>GFRA1</i> and <i>NPNT</i> Are
            Associated with Congenital Anomalies of the Kidney and Urinary
            Tract.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9226)
  AUTHORS   Wang,K., Lu,Y., Morrow,D.F., Xiao,D. and Xu,C.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative
  TITLE     Associations of ARHGAP26 Polymorphisms with Alzheimer's Disease and
            Cardiovascular Disease
  JOURNAL   J Mol Neurosci 72 (5), 1085-1097 (2022)
   PUBMED   35171450
  REMARK    GeneRIF: Associations of ARHGAP26 Polymorphisms with Alzheimer's
            Disease and Cardiovascular Disease.
REFERENCE   6  (bases 1 to 9226)
  AUTHORS   Taylor,J.M., Macklem,M.M. and Parsons,J.T.
  TITLE     Cytoskeletal changes induced by GRAF, the GTPase regulator
            associated with focal adhesion kinase, are mediated by Rho
  JOURNAL   J Cell Sci 112 (Pt 2), 231-242 (1999)
   PUBMED   9858476
  REMARK    GeneRIF: GRAF is a negative regulator of RhoA in vivo, it acts as a
            GTP-ase activating protein (GAP) for RhoA and may be a downstream
            effector of RhoA in certain cell types.
REFERENCE   7  (bases 1 to 9226)
  AUTHORS   Billuart,P., Bienvenu,T., Ronce,N., des Portes,V., Vinet,M.C.,
            Zemni,R., Roest Crollius,H., Carrie,A., Fauchereau,F., Cherry,M.,
            Briault,S., Hamel,B., Fryns,J.P., Beldjord,C., Kahn,A., Moraine,C.
            and Chelly,J.
  TITLE     Oligophrenin-1 encodes a rhoGAP protein involved in X-linked mental
            retardation
  JOURNAL   Nature 392 (6679), 923-926 (1998)
   PUBMED   9582072
REFERENCE   8  (bases 1 to 9226)
  AUTHORS   Taylor,J.M., Hildebrand,J.D., Mack,C.P., Cox,M.E. and Parsons,J.T.
  TITLE     Characterization of graf, the GTPase-activating protein for rho
            associated with focal adhesion kinase. Phosphorylation and possible
            regulation by mitogen-activated protein kinase
  JOURNAL   J Biol Chem 273 (14), 8063-8070 (1998)
   PUBMED   9525907
REFERENCE   9  (bases 1 to 9226)
  AUTHORS   Hildebrand,J.D., Taylor,J.M. and Parsons,J.T.
  TITLE     An SH3 domain-containing GTPase-activating protein for Rho and
            Cdc42 associates with focal adhesion kinase
  JOURNAL   Mol Cell Biol 16 (6), 3169-3178 (1996)
   PUBMED   8649427
REFERENCE   10 (bases 1 to 9226)
  AUTHORS   Pillay,T.S., Sasaoka,T. and Olefsky,J.M.
  TITLE     Insulin stimulates the tyrosine dephosphorylation of pp125 focal
            adhesion kinase
  JOURNAL   J Biol Chem 270 (3), 991-994 (1995)
   PUBMED   7836419
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008533.9, BX342449.2,
            BC068555.1, AC012630.7, AC004782.1 and AI888512.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001135608.2.
            
            Summary: Interaction of a cell with the extracellular matrix
            triggers integrin cell surface receptors to begin signaling
            cascades that regulate the organization of the actin-cytoskeleton.
            One of the proteins involved in these cascades is focal adhesion
            kinase. The protein encoded by this gene is a GTPase activating
            protein that binds to focal adhesion kinase and mediates the
            activity of the GTP binding proteins RhoA and Cdc42. Defects in
            this gene are a cause of juvenile myelomonocytic leukemia (JMML).
            Multiple transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Mar 2017].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site compared to variant 1. The resulting isoform (b) has
            the same N- and C-termini but is shorter compared to isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068555.1, KU178561.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000645722.2/ ENSP00000495131.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AC008533.9         212382-212388       c
            8-30                BX342449.2         1-23
            31-639              BC068555.1         1-609
            640-640             AC008533.9         107651-107651       c
            641-1629            BC068555.1         611-1599
            1630-1630           AC012630.7         65442-65442
            1631-2574           BC068555.1         1601-2544
            2575-2575           AC004782.1         87087-87087         c
            2576-3413           BC068555.1         2546-3383
            3414-9080           AC004782.1         72313-77979         c
            9081-9226           AI888512.1         32-177              c
FEATURES             Location/Qualifiers
     source          1..9226
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.3"
     gene            1..9226
                     /gene="ARHGAP26"
                     /gene_synonym="GRAF; GRAF1; OPHN1L; OPHN1L1"
                     /note="Rho GTPase activating protein 26"
                     /db_xref="GeneID:23092"
                     /db_xref="HGNC:HGNC:17073"
                     /db_xref="MIM:605370"
     exon            1..539
                     /gene="ARHGAP26"
                     /gene_synonym="GRAF; GRAF1; OPHN1L; OPHN1L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             386..2665
                     /gene="ARHGAP26"
                     /gene_synonym="GRAF; GRAF1; OPHN1L; OPHN1L1"
                     /note="isoform b is encoded by transcript variant 2;
                     GTPase regulator associated with focal adhesion kinase
                     pp125(FAK); oligophrenin-1-like protein"
                     /codon_start=1
                     /product="rho GTPase-activating protein 26 isoform b"
                     /protein_id="NP_001129080.1"
                     /db_xref="CCDS:CCDS47297.1"
                     /db_xref="GeneID:23092"
                     /db_xref="HGNC:HGNC:17073"
                     /db_xref="MIM:605370"
                     /translation="MGLPALEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGK
                     SLISALKNLSSAKRKFADSLNEFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERI
                     RMIENASEVLITPLEKFRKEQIGAAKEAKKKYDKETEKYCGILEKHLNLSSKKKESQL
                     QEADSQVDLVRQHFYEVSLEYVFKVQEVQERKMFEFVEPLLAFLQGLFTFYHHGYELA
                     KDFGDFKTQLTISIQNTRNRFEGTRSEVESLMKKMKENPLEHKTISPYTMEGYLYVQE
                     KRHFGTSWVKHYCTYQRDSKQITMVPFDQKSGGKGGEDESVILKSCTRRKTDSIEKRF
                     CFDVEAVDRPGVITMQALSEEDRRLWMEAMDGREPVYNSNKDSQSEGTAQLDSIGFSI
                     IRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETETDICAEWEIKTIT
                     SALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLM
                     NHLANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEK
                     IFNTVPDMPLTNAQLHLSRKKSSDSKPPSCSERPLTLFHTVQSTEKQEQRNSIINSSL
                     ESVSSNPNSILNSSSSLQPNMNSSDPDLAVVKPTRPNSLPPNPSPTSPLSPSWPMFSA
                     PSSPMPTSSTSSDSSPVSTPFRKAKALYACKAEHDSELSFTAGTVFDNVHPSQEPGWL
                     EGTLNGKTGLIPENYVEFL"
     exon            540..635
                     /gene="ARHGAP26"
                     /gene_synonym="GRAF; GRAF1; OPHN1L; OPHN1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            636..697
                     /gene="ARHGAP26"
                     /gene_synonym="GRAF; GRAF1; OPHN1L; OPHN1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            698..769
                     /gene="ARHGAP26"
                     /gene_synonym="GRAF; GRAF1; OPHN1L; OPHN1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            770..871
                     /gene="ARHGAP26"
                     /gene_synonym="GRAF; GRAF1; OPHN1L; OPHN1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            872..982
                     /gene="ARHGAP26"
                     /gene_synonym="GRAF; GRAF1; OPHN1L; OPHN1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1087
                     /gene="ARHGAP26"
                     /gene_synonym="GRAF; GRAF1; OPHN1L; OPHN1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1217
                     /gene="ARHGAP26"
                     /gene_synonym="GRAF; GRAF1; OPHN1L; OPHN1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1318
                     /gene="ARHGAP26"
                     /gene_synonym="GRAF; GRAF1; OPHN1L; OPHN1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1413
                     /gene="ARHGAP26"
                     /gene_synonym="GRAF; GRAF1; OPHN1L; OPHN1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1492
                     /gene="ARHGAP26"
                     /gene_synonym="GRAF; GRAF1; OPHN1L; OPHN1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1529
                     /gene="ARHGAP26"
                     /gene_synonym="GRAF; GRAF1; OPHN1L; OPHN1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1595
                     /gene="ARHGAP26"
                     /gene_synonym="GRAF; GRAF1; OPHN1L; OPHN1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1670
                     /gene="ARHGAP26"
                     /gene_synonym="GRAF; GRAF1; OPHN1L; OPHN1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1758
                     /gene="ARHGAP26"
                     /gene_synonym="GRAF; GRAF1; OPHN1L; OPHN1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1817
                     /gene="ARHGAP26"
                     /gene_synonym="GRAF; GRAF1; OPHN1L; OPHN1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1923
                     /gene="ARHGAP26"
                     /gene_synonym="GRAF; GRAF1; OPHN1L; OPHN1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..2083
                     /gene="ARHGAP26"
                     /gene_synonym="GRAF; GRAF1; OPHN1L; OPHN1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2084..2222
                     /gene="ARHGAP26"
                     /gene_synonym="GRAF; GRAF1; OPHN1L; OPHN1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2373
                     /gene="ARHGAP26"
                     /gene_synonym="GRAF; GRAF1; OPHN1L; OPHN1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2484
                     /gene="ARHGAP26"
                     /gene_synonym="GRAF; GRAF1; OPHN1L; OPHN1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..2576
                     /gene="ARHGAP26"
                     /gene_synonym="GRAF; GRAF1; OPHN1L; OPHN1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..9226
                     /gene="ARHGAP26"
                     /gene_synonym="GRAF; GRAF1; OPHN1L; OPHN1L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9200..9205
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP26"
                     /gene_synonym="GRAF; GRAF1; OPHN1L; OPHN1L1"
                     /note="hexamer: ATTAAA"
     polyA_site      9226
                     /gene="ARHGAP26"
                     /gene_synonym="GRAF; GRAF1; OPHN1L; OPHN1L1"
                     /note="major polyA site"
ORIGIN      
        1 agacaccggc ggggcggccg aggctgctgt gagagggcgc tcgaggctgc cgagagctag
       61 ctagcgaagg aggcggggag gcggcgtctg cactcgctcg cccgctcgct cgcttcccgg
      121 cgccgctgcg ggtccgcgct gcgtttcctg ctcgcgatcc gctccgttgc ccgcgcccgg
      181 aacagcagca cctcggccgg gtccgagctc ggttcgggag tcttgcgcgc cggcggacac
      241 cgcgcgcgga gtgagccagc gccacacctg tggagccggc ggccgtcggg ggagccggcc
      301 ggggtcccgc cgcgtgagtg ctctgggcgg cgggcggccc gggccccggc ggaggcgcgc
      361 cccccggctg ggcgccgcgc gcaccatggg gctcccagcg ctcgagttca gcgactgctg
      421 cctcgatagt ccgcacttcc gagagacgct caagtcgcac gaagcagagc tggacaagac
      481 caacaaattc atcaaggagc tcatcaagga cgggaagtca ctcataagcg cgctcaagaa
      541 tttgtcttca gcgaagcgga agtttgcaga ttccttaaat gaatttaaat ttcagtgcat
      601 aggagatgca gaaacagatg atgagatgtg tatagcaaga tctttgcagg agtttgccac
      661 tgtcctcagg aatcttgaag atgaacggat acggatgatt gagaatgcca gcgaggtgct
      721 catcactccc ttggagaagt ttcgaaagga acagatcggg gctgccaagg aagccaaaaa
      781 gaagtatgac aaagagacag aaaagtattg tggcatctta gaaaaacact tgaatttgtc
      841 ttccaaaaag aaagaatctc agcttcagga ggcagacagc caagtggacc tggtccggca
      901 gcatttctat gaagtatccc tggaatatgt cttcaaggtg caggaagtcc aagagagaaa
      961 gatgtttgag tttgtggagc ctctgctggc cttcctgcaa ggactcttca ctttctatca
     1021 ccatggttac gaactggcca aggatttcgg ggacttcaag acacagttaa ccattagcat
     1081 acagaacaca agaaatcgct ttgaaggcac tagatcagaa gtggaatcac tgatgaaaaa
     1141 gatgaaggag aatccccttg agcacaagac catcagtccc tacaccatgg agggatacct
     1201 ctacgtgcag gagaaacgtc actttggaac ttcttgggtg aagcactact gtacatatca
     1261 acgggattcc aaacaaatca ccatggtacc atttgaccaa aagtcaggag gaaaaggggg
     1321 agaagatgaa tcagttatcc tcaaatcctg cacacggcgg aaaacagact ccattgagaa
     1381 gaggttttgc tttgatgtgg aagcagtaga caggccaggg gttatcacca tgcaagcttt
     1441 gtcggaagag gaccggaggc tctggatgga agccatggat ggccgggaac ctgtctacaa
     1501 ctcgaacaaa gacagccaga gtgaagggac tgcgcagttg gacagcattg gcttcagcat
     1561 aatcaggaaa tgcatccatg ctgtggaaac cagagggatc aacgagcaag ggctgtatcg
     1621 aattgtgggt gtcaactcca gagtgcagaa gttgctgagt gtcctgatgg accccaagac
     1681 tgcttctgag acagaaacag atatctgtgc tgaatgggag ataaagacca tcactagtgc
     1741 tctgaagacc tacctaagaa tgcttccagg accactcatg atgtaccagt ttcaaagaag
     1801 tttcatcaaa gcagcaaaac tggagaacca ggagtctcgg gtctctgaaa tccacagcct
     1861 tgttcatcgg ctcccagaga aaaatcggca gatgttacag ctgctcatga accacttggc
     1921 aaatgttgct aacaaccaca agcagaattt gatgacggtg gcaaaccttg gtgtggtgtt
     1981 tggacccact ctgctgaggc ctcaggaaga aacagtagca gccatcatgg acatcaaatt
     2041 tcagaacatt gtcattgaga tcctaataga aaaccacgaa aagatattta acaccgtgcc
     2101 cgatatgcct ctcaccaatg cccagctgca cctgtctcgg aagaagagca gtgactccaa
     2161 gcccccgtcc tgcagcgaga ggcccctgac gctcttccac accgttcagt caacagagaa
     2221 acaggaacaa aggaacagca tcatcaactc cagtttggaa tctgtctcat caaatccaaa
     2281 cagcatcctt aattccagca gcagcttaca gcccaacatg aactccagtg acccagacct
     2341 ggctgtggtc aaacccaccc ggcccaactc actccccccg aatccaagcc caacttcacc
     2401 cctctcgcca tcttggccca tgttctcggc gccatccagc cctatgccca cctcatccac
     2461 gtccagcgac tcatcccccg tcagcacacc gttccggaag gcaaaagcct tgtatgcctg
     2521 caaagctgaa catgactcag aactttcgtt cacagcaggc acggtcttcg ataacgttca
     2581 cccatctcag gagcctggct ggttggaggg gactctgaac ggaaagactg gcctcatccc
     2641 tgagaattac gtggagttcc tctaaccgtg ggccccagca gaactgctga gctttacatg
     2701 gtatccatga caactgctga ttccagtgtc gaggccattt ctctttgcca ctgagaaatg
     2761 cagcgtgact gactctgttg ctacctgtca acatgaatgt ttctgtgagc tctggtgtca
     2821 ctcatctcca tgatcatctc agccaacatg catcagtact gcaagaaaag aagtcaatca
     2881 gcagaggaga gcatttgata actaagagga agacttgcaa agccgttttc tcatgagtac
     2941 cctgaatagg gggcactcat tttgtttcaa cggtccaaac gcccaacctt cagaaagagg
     3001 aagtcagata gaaatagtcc ctgagagcac actgtgtagc taagcctgct ggggctgggt
     3061 gaagaaattg gcgctgagat ccaggctgga tccattgctt ttgtttacaa taggcactct
     3121 ctctacccca cctctcagta cttgagactt aaagtgctac aggcagctgg atctgtttgc
     3181 atgcaggatg aagagggtta aaacactgtt tatataagat ccaatctctc accatctcta
     3241 aagcagccgt tggcctgtca tcagtgagat acaatccagt cttctcatgc acgggaacac
     3301 acacaccctg cgtttctccc tcccaggcta ggaacctctc tgccaccaag ggctgccatc
     3361 catcgcctag taaccacggc aacccaacct actctaaaac caaaccaaaa aaataaaata
     3421 acacatcctc tttgcatgac acattttttt tctccccttt ttggtacact ttttttgaat
     3481 ggttttctaa caacttgaag cacaggatca aggaattagg gtggtctact tgaggcagat
     3541 gggatagtag ctgggaactg ttccctttct gattaatttc agcagcatcg gaatatattt
     3601 ggagcacacc ctagtaacct cttgagatta aattacatag tcttaatatt tctgttcctc
     3661 catgcaactg atgtttgttt tttaaagggt aagatgctgc ctcccaatgg gtgatgccat
     3721 ctgactggtt tccccatgtc ctcccattca cccatctctg ctcccaccct tgcctgcctc
     3781 taacccacca ctggccagcc cccttgccct actctgggct gctgaacact ggtgctgtgg
     3841 tggttttcaa ggttaattcc taggctaacc gtatggccta tagtttaaaa gcacatctat
     3901 gttcactgcc actctgaaaa agggaattat ttctcagtct ttcaaggctt gagactaata
     3961 taggccattg tgattcagga agaaacccaa ggttggaggg tgggatgagt accctctgaa
     4021 aaagggaatt tgctggtgaa aagaggctgg atcttgtgga agactgtctt ggatggggaa
     4081 gtactacctg gagatttcaa attcacttgg cctgcaaaca acagagttat ccgtatcttc
     4141 cacatgtgaa tgtcattgca agggtgactc tagacaaact acaaaccgat ggaccgtcaa
     4201 gctccccagg agccccttgg atggcagcgt tgcttcagag tgtttcctgt ttctggaatt
     4261 ccttgttagg gaactttaaa gaagaaaaga aaaacttgaa ttgtgttgaa ttactgtatc
     4321 ttttactttt ttttttttga aaagataaac ttgtaaatag agtgatttga aatactatat
     4381 ggcaaagttt tatatttgat attctttaag ttagttgctc acacacttag gctttgattg
     4441 ctgaagaagt atgtttaaga gggagagagg ggaggcaaag ctgaagagag tcaaggtcac
     4501 tgtccccgct tcggcctgaa ggaaagagaa gacatttcta tggccttgct ctctgctgtc
     4561 ctgttggtgg gcacgacaca tcagtggtgt tcagtcttta tgtgttttta agcatccctt
     4621 gggctttgga tttggagatg ggaagagcat ctccaggcaa tgagtttttc aaagaatgcc
     4681 tacttagtag taagatgaag ctcaggattt aaataagtgg ggtcaggcat tcgagttttt
     4741 gtctttcttc tcaggtgtat ttcttggtac ccccaagata tcaggccaga aagagatgag
     4801 tcagttgctg tgctctttac ttctttttct ccacatcttc tgaggcttta gaaatgtgga
     4861 caagctagtt ttcaaatttt gtgtgcgtct gtaagttctt aaagaaccag cttcttagaa
     4921 tgttcagttc tcaatgtgct gctgctttcc cttctcctaa acattttaaa actcttccct
     4981 ttcacctcca attcccgtga tcccaaaaga agaggaagac tccaggaggg gtatagattg
     5041 tgccgtcata gctttacagg tggttttaaa gttaacaggg gtttgtcatg gtgattcact
     5101 actcagttta tcagctcaag gattatacag ctcttttccg ggaactcacc caggagcaag
     5161 cgagacacta ccattgaatc agggaatgag aattaagaat ggacaggacc aagacagaac
     5221 tcaagaaagc cactggggaa aactcgagaa gaaagggagt atactagtag gttagatctg
     5281 tgaacctgag gacaagaaga ccttgggaaa tggaggcctc aggggatgtg cattcacata
     5341 ctattacgct tctcaaagag agaccaacat catgctttta acacatttga tgaggttttt
     5401 tatttgtgtt tttgtttgtt ttttgagatg gagtctcact ctgtggccca ggctggagtg
     5461 cagtggcgca atcttggctc actgcaacct ccacctccca ggttcaagtg attctcctgt
     5521 ctcagcctcc caagtagctg ggactacagg catgagccat cacacccagc tagttttttg
     5581 tatttttagt aaagatgggg ttttgccatg tttgccaggc tgatctcgaa ctcctgacct
     5641 caagtgatct gcccacttca gacccccaaa gtgctgggat tccaggtgtg agccgctgcg
     5701 gccgaccaca tttgatgttt gaagttgtaa tctgtcccat cataaactta cctggagctc
     5761 atgtggagga acagaaggcc aagatccttg ctttgggggt gcctcacgaa gcatccctgt
     5821 agacatttgg ccccagcttc actgcttgga agcatgtccc tccctcttga gttggctctg
     5881 atttgaaatc gggagaaaca gagctgctgc caatgggatc ttttaggtaa ctccctccct
     5941 agcttccgtg tgtctgtgca gtgcccatga gctgctgcca atgggatctt tcaggtaccc
     6001 cctccccagc ttccctgtgg ctgtgcggtg cccttgacag atggcttctc tgtttccctt
     6061 tgcccagcca ggctcccctc cttcctatta gctacaaaac tggataaact tcagaatatg
     6121 agccaatgag taggaaggaa cttgaagact aaagatttta ctctctcccc tatccatgcc
     6181 ccctacctct gactctctct gtgtgaacag gaaactttag ggcagatgag gagaatgaat
     6241 tggttatcag agtggaagac catggcccag gatccctgag ctttcccagt agcctccagt
     6301 ttcctttgta agacccaggg atcacttagc catagcctga atcttttagg ggtattaagg
     6361 tcagcctctc actcttcctt caggttacta acaaaatttc gtagctaaag aatgccatgg
     6421 ccgggtgcag tggctcacgc ctataatccc agcactttgg gaggccgagg cgggcggatc
     6481 acgaggtcag gagattgaga ccatcctggc tacgacggtg aaaccccgtc tctactaaaa
     6541 atacaaaaaa ttagccgggt gtggtggcgg gcgcctgtag tcccagctac tctggaggct
     6601 gaggcaggag aatggcatga acccaggagg cagagattgc agtgagccaa gatcacgccc
     6661 ctgcactcca gcctgggtga cagagccaga ctccgtctca aaggaaaaaa aaaaaaaaaa
     6721 aaaaagaatg ccatgccagg agaagacagc tggtttcaaa tccctgcccc caggcaagta
     6781 aaaccctgac ttgctcaaga cagaagatct tttctcctgt ttttcaaaat aaacatatat
     6841 agggatggac cctgtgcatt gtggcctgcc ttggtgtcct agaattggag ccagtcttta
     6901 gcttaatgtc tgaagtattt atacggccaa tatgtgtttt cttatgtcag accacactgt
     6961 ctttttgaat atcagttcat ttcctctcac cgagtgcttt tcggtgagag gcaaagagaa
     7021 agaatgaaca atcaagtatt gacagactgg cattagcagg acagagccat actagtgaca
     7081 agggcatccc aaggcacttg cccagagctg cagagttgtg tgtgccatac ctgcggctca
     7141 aagggaaggc cttctatccc ctgagtttct atcagctgaa aatggcaact gctgtctcag
     7201 taaaagctct gtcttgactg cagaggctcc aaaagcattc acagttgagg gggagaaaga
     7261 cagaaagaag aagccaaaga taacctgatc cctgcctgtc tgttggcacc tgtcatcctc
     7321 tggcttctgc tcccaaaagc aagtctggat gactgagttt tgtggacatg gcactcccgg
     7381 agacagcagt ggccaccatg gcacccagag tttgcccaag tactgaatgt tttgtgagca
     7441 accatgttcc ccaagtaggt agccagcgct gcagaaacca aacagcctct tagctacctg
     7501 actttaaaag gaatgaccta ggtgttctgc caaaggagtt atctatcatc tctggcaaac
     7561 ttgacaatca tcacttacct cgacaaccct gccccacatc actttataaa gtcagcagga
     7621 tgtcttctca cccaccctgt gctggtgtct aacaaattta tcttgtcatg ctcaaatgtg
     7681 tttggcagcc acaccgatcg gctgggtgct gaaccgcctc tctgtaattg tagcatcaaa
     7741 atgacaacag cagcagagca gcgaatcttg cacagcccca cagcatgcct gagacaagac
     7801 tccaacaagt aataattagc tttttttctc ctgccgccta cagtacctgt ctaactaaag
     7861 agcttcccaa agtggaggga aaggccatag aatccaggtg tcattcagag ccagtccttg
     7921 ctgaaatgtg gtcttccagt ggaagcacct gtattattga gaggaaaaag tgttggatgc
     7981 aaagtaacac caggactaga gagaaagaga aaggtgaacc atcctaagga gctttggata
     8041 cttttttaga aggataaata ttatgcttac tgaggagaaa aaaaaaagcg atcacagaaa
     8101 aatttcacag ctaatatttt tacaaaagtt gtgccagaca ttacagagtg aaaacgtctc
     8161 tcaaggtgga atgctttaga gagcaaaggc ttagcataga cctagaccct tgtgtgggta
     8221 tgacatgaca tgacatgtcc atgtcaaaat tcactttagt cagaaccaga gtattgataa
     8281 acaaaatgtc agttacctgg agcagtcctg gagaggttaa gacattctat actgttctac
     8341 gtcaaccatt tctacaaagt tgtccagaca cctaaaagca gctttcttgg ttatccagat
     8401 gccagaatca accttgtatc tgacaatgca catctgttga ttctaaagta tatttatgtg
     8461 tgtgtgtatg tgtgtgtata cagcacatat ttacatctat gaagacatag acacttacag
     8521 agacccacat gagctggcac tttctgagcc tttacagcct ttaagactcg gaggttgaga
     8581 attagagaca caagagaggc tgtggatggc ctattaaaat gattaaagat gtaaattcag
     8641 tgccatttta aaactgttca tatttatcaa acaattactg tctacagcta cattttttgt
     8701 taacttactt aaagtcatgt cgcaagaaag atcaaaccca tgaatgctta gtagctaagg
     8761 ctagtgttca aaagcactct aaaagacatt ttgtccacat tttggaaaag aaaatatttg
     8821 catgtttaat tcataattta ggctatcttt gagtatactg taaagtgctg tgtgatataa
     8881 tatcaataaa gtacttatta aatggcactt taatgttttc ttttaaaata acgcactgtt
     8941 ctaaacttca gtattgacta ttgactcgtg catagaatcc aatgctgtaa ttagaaagta
     9001 atctgtgact agaatagacc tttgtccctg ttagtagccc tgttgccatg ttcaggcttt
     9061 taaaaaatgc ttttgtgtca ccaaatatat ctataaagaa aacaaaattt ctgttcagag
     9121 gcctctgaaa cttggctttc ttacatgtgg ttggtttatg tgacaatccc tatgaaatga
     9181 gtggacgtat gatttttgaa ttaaatgact tttccatttg gtggta
//
