LOCUS       NM_001007231            2969 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens Rho GTPase activating protein 25 (ARHGAP25),
            transcript variant 1, mRNA.
ACCESSION   NM_001007231
VERSION     NM_001007231.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2969)
  AUTHORS   Han,S., Jin,X., Hu,T. and Chi,F.
  TITLE     ARHGAP25 suppresses the development of breast cancer by an
            ARHGAP25/Wnt/ASCL2 feedback loop
  JOURNAL   Carcinogenesis 44 (5), 369-382 (2023)
   PUBMED   37326327
  REMARK    GeneRIF: ARHGAP25 suppresses the development of breast cancer by an
            ARHGAP25/Wnt/ASCL2 feedback loop.
REFERENCE   2  (bases 1 to 2969)
  AUTHORS   Wisniewski,E., Czaran,D., Kovacs,F., Bahurek,E., Nemeth,A.,
            Sasvari,P., Szanda,G., Pettko-Szandtner,A., Klement,E., Ligeti,E.
            and Csepanyi-Komi,R.
  TITLE     A novel BRET-Based GAP assay reveals phosphorylation-dependent
            regulation of the RAC-specific GTPase activating protein ARHGAP25
  JOURNAL   FASEB J 36 (11), e22584 (2022)
   PUBMED   36190314
  REMARK    GeneRIF: A novel BRET-Based GAP assay reveals
            phosphorylation-dependent regulation of the RAC-specific GTPase
            activating protein ARHGAP25.
REFERENCE   3  (bases 1 to 2969)
  AUTHORS   Shi,F., Wu,J., Jia,Q., Li,K., Li,W., Shi,Y., Wang,Y. and Wu,S.
  TITLE     Relationship between the expression of ARHGAP25 and RhoA in
            non-small cell lung cancer and vasculogenic mimicry
  JOURNAL   BMC Pulm Med 22 (1), 377 (2022)
   PUBMED   36207695
  REMARK    GeneRIF: Relationship between the expression of ARHGAP25 and RhoA
            in non-small cell lung cancer and vasculogenic mimicry.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2969)
  AUTHORS   Huang,W.K., Chen,Y., Su,H., Chen,T.Y., Gao,J., Liu,Y., Yeh,C.N. and
            Li,S.
  TITLE     ARHGAP25 Inhibits Pancreatic Adenocarcinoma Growth by Suppressing
            Glycolysis via AKT/mTOR Pathway
  JOURNAL   Int J Biol Sci 17 (7), 1808-1820 (2021)
   PUBMED   33994864
  REMARK    GeneRIF: ARHGAP25 Inhibits Pancreatic Adenocarcinoma Growth by
            Suppressing Glycolysis via AKT/mTOR Pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2969)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 2969)
  AUTHORS   Tao,L., Zhu,Y., Gu,Y., Zheng,J. and Yang,J.
  TITLE     ARHGAP25: A negative regulator of colorectal cancer (CRC)
            metastasis via the Wnt/beta-catenin pathway
  JOURNAL   Eur J Pharmacol 858, 172476 (2019)
   PUBMED   31228451
  REMARK    GeneRIF: ARHGAP25 negatively regulates the metastatic potential of
            CRC cells via the Wnt/beta-catenin pathway
REFERENCE   7  (bases 1 to 2969)
  AUTHORS   Schlam,D., Bagshaw,R.D., Freeman,S.A., Collins,R.F., Pawson,T.,
            Fairn,G.D. and Grinstein,S.
  TITLE     Phosphoinositide 3-kinase enables phagocytosis of large particles
            by terminating actin assembly through Rac/Cdc42 GTPase-activating
            proteins
  JOURNAL   Nat Commun 6, 8623 (2015)
   PUBMED   26465210
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2969)
  AUTHORS   Seppala,I., Kleber,M.E., Lyytikainen,L.P., Hernesniemi,J.A.,
            Makela,K.M., Oksala,N., Laaksonen,R., Pilz,S., Tomaschitz,A.,
            Silbernagel,G., Boehm,B.O., Grammer,T.B., Koskinen,T., Juonala,M.,
            Hutri-Kahonen,N., Alfthan,G., Viikari,J.S., Kahonen,M.,
            Raitakari,O.T., Marz,W., Meinitzer,A. and Lehtimaki,T.
  CONSRTM   AtheroRemo Consortium
  TITLE     Genome-wide association study on dimethylarginines reveals novel
            AGXT2 variants associated with heart rate variability but not with
            overall mortality
  JOURNAL   Eur Heart J 35 (8), 524-531 (2014)
   PUBMED   24159190
REFERENCE   9  (bases 1 to 2969)
  AUTHORS   Takefuji,M., Asano,H., Mori,K., Amano,M., Kato,K., Watanabe,T.,
            Morita,Y., Katsumi,A., Itoh,T., Takenawa,T., Hirashiki,A.,
            Izawa,H., Nagata,K., Hirayama,H., Takatsu,F., Naoe,T., Yokota,M.
            and Kaibuchi,K.
  TITLE     Mutation of ARHGAP9 in patients with coronary spastic angina
  JOURNAL   J Hum Genet 55 (1), 42-49 (2010)
   PUBMED   19911011
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 2969)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of ARHGAP24 and ARHGAP25 genes
            in silico
  JOURNAL   Int J Mol Med 14 (2), 333-338 (2004)
   PUBMED   15254788
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD695161.1, AK290396.1, AC097495.3 and BC032222.1.
            
            On May 17, 2019 this sequence version replaced NM_001007231.2.
            
            Summary: ARHGAPs, such as ARHGAP25, encode negative regulators of
            Rho GTPases (see ARHA; MIM 165390), which are implicated in actin
            remodeling, cell polarity, and cell migration (Katoh and Katoh,
            2004 [PubMed 15254788]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.232243.1,
                                           SRR1803611.199095.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000409202.8/ ENSP00000386911.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-292               CD695161.1         54-345
            293-2058            AK290396.1         1-1766
            2059-2059           AC097495.3         120799-120799       c
            2060-2724           AK290396.1         1768-2432
            2725-2969           BC032222.1         2696-2940
FEATURES             Location/Qualifiers
     source          1..2969
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.3"
     gene            1..2969
                     /gene="ARHGAP25"
                     /gene_synonym="HEL-S-308; KAIA0053"
                     /note="Rho GTPase activating protein 25"
                     /db_xref="GeneID:9938"
                     /db_xref="HGNC:HGNC:28951"
                     /db_xref="MIM:610587"
     exon            1..450
                     /gene="ARHGAP25"
                     /gene_synonym="HEL-S-308; KAIA0053"
                     /inference="alignment:Splign:2.1.0"
     CDS             390..2330
                     /gene="ARHGAP25"
                     /gene_synonym="HEL-S-308; KAIA0053"
                     /note="isoform a is encoded by transcript variant 1; rho
                     GTPase-activating protein 25; rho-type GTPase-activating
                     protein 25; epididymis secretory protein Li 308;
                     epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="rho GTPase-activating protein 25 isoform a"
                     /protein_id="NP_001007232.2"
                     /db_xref="CCDS:CCDS33214.2"
                     /db_xref="GeneID:9938"
                     /db_xref="HGNC:HGNC:28951"
                     /db_xref="MIM:610587"
                     /translation="MSLKLPRNWDFNLKVEAAKIARSRSVMTGEQMAAFHPSSTPNPL
                     ERPIKMGWLKKQRSIVKNWQQRYFVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEIAT
                     NPEEAGKFVFEIIPASWDQNRMGQDSYVLMASSQAEMEEWVKFLRRVAGTPCGAVFGQ
                     RLDETVAYEQKFGPHLVPILVEKCAEFILEHGRNEEGIFRLPGQDNLVKQLRDAFDAG
                     ERPSFDRDTDVHTVASLLKLYLRDLPEPVVPWSQYEGFLLCGQLTNADEAKAQQELMK
                     QLSILPRDNYSLLSYICRFLHEIQLNCAVNKMSVDNLATVIGVNLIRSKVEDPAVIMR
                     GTPQIQRVMTMMIRDHEVLFPKSKDIPLSPPAQKNDPKKAPVARSSVGWDATEDLRIS
                     RTDSFSSMTSDSDTTSPTGQQPSDAFPEDSSKVPREKPGDWKMQSRKRTQTLPNRKCF
                     LTSAFQGANSSKMEIFKNEFWSPSSEAKAGEGHRRTMSQDLRQLSDSQRTSTYDNVPS
                     LPGSPGEEASALSSQACDSKGDTLASPNSETGPGKKNSGEEEIDSLQRMVQELRKEIE
                     TQKQMYEEQIKNLEKENYDVWAKVVRLNEELEKEKKKSAALEISLRNMERSREDVEKR
                     NKALEEEVKEFVKSMKEPKTEA"
     exon            451..650
                     /gene="ARHGAP25"
                     /gene_synonym="HEL-S-308; KAIA0053"
                     /inference="alignment:Splign:2.1.0"
     exon            651..738
                     /gene="ARHGAP25"
                     /gene_synonym="HEL-S-308; KAIA0053"
                     /inference="alignment:Splign:2.1.0"
     exon            739..855
                     /gene="ARHGAP25"
                     /gene_synonym="HEL-S-308; KAIA0053"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1063
                     /gene="ARHGAP25"
                     /gene_synonym="HEL-S-308; KAIA0053"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1196
                     /gene="ARHGAP25"
                     /gene_synonym="HEL-S-308; KAIA0053"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1270
                     /gene="ARHGAP25"
                     /gene_synonym="HEL-S-308; KAIA0053"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1392
                     /gene="ARHGAP25"
                     /gene_synonym="HEL-S-308; KAIA0053"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1589
                     /gene="ARHGAP25"
                     /gene_synonym="HEL-S-308; KAIA0053"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..2122
                     /gene="ARHGAP25"
                     /gene_synonym="HEL-S-308; KAIA0053"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2969
                     /gene="ARHGAP25"
                     /gene_synonym="HEL-S-308; KAIA0053"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2898..2903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP25"
                     /gene_synonym="HEL-S-308; KAIA0053"
                     /note="hexamer: AACAAA"
     polyA_site      2923
                     /gene="ARHGAP25"
                     /gene_synonym="HEL-S-308; KAIA0053"
                     /note="major polyA site"
ORIGIN      
        1 agttgtttat cacgacctca actcagtaag gcctgagatt ctttcgaaaa ggagctttgc
       61 ttcccatgac gcagagggaa gtgtcaactg ggatatttct ggtaaaactg aaagcaagaa
      121 aagcagggtg ctagcccctg tgggactgag ggtggaggct gggggagttt gggtgccatc
      181 ctccagtgac agatggatgg acctttcatc taagagaaag gaggagacac gttggcaaat
      241 cagcctcaag cctaagattg cttgtgaagc aatcataagg aggaacaaaa acagacacaa
      301 aaacagaggg aaagagtgaa aagacaagaa gggcgcaaac tgtgacagac tcaccgcttc
      361 actaactact cacttaaact ggaagcaaaa tgtccctaaa attgccaagg aactgggatt
      421 tcaacctgaa agtggaggct gcgaaaatag ctcggtcaag gagtgtgatg actggcgagc
      481 agatggctgc cttccatcca tcgtccaccc ccaacccgct ggagaggccc atcaagatgg
      541 gctggctgaa gaagcagagg tccatcgtga agaactggca gcagaggtac tttgtgctga
      601 gggcgcagca gctctactac tacaaggatg aagaggacac gaagccccag ggctgcatgt
      661 atctaccagg atgtacaatc aaggagatcg ccacaaaccc agaagaagct gggaagtttg
      721 tctttgaaat cattccagcc tcatgggacc agaatcgcat gggacaggac tcctatgtcc
      781 tcatggccag ctctcaggcg gagatggagg agtgggttaa attcctcagg agagttgctg
      841 gcacaccctg tggagcagtg tttggccagc gcttggatga gactgtggcc tatgaacaga
      901 aattcggccc ccatctggtg cccatcctgg tggagaaatg tgcagagttc atcctggagc
      961 acggccggaa tgaagagggc atcttccgtc tgcctgggca ggacaacctg gtgaagcagc
     1021 tgagagacgc ttttgatgct ggggagcggc cctcctttga cagagacaca gatgtgcaca
     1081 ctgtggcttc cctgttaaag ctctacctcc gagacctccc agagcccgtg gttccctgga
     1141 gccagtacga agggttcctg ctctgtgggc agctcacgaa tgcggatgag gcaaaggctc
     1201 agcaggagtt gatgaagcag ctctccatcc ttcctcgtga caactatagt ctcctgagct
     1261 acatctgcag gttcctacat gaaatacagc tgaactgtgc tgttaacaag atgagtgtgg
     1321 acaacctggc tactgtgatt ggtgtgaatc tcatcaggtc gaaggtcgaa gaccctgccg
     1381 tgatcatgag agggactcct cagatccaaa gagtgatgac tatgatgatc agagaccatg
     1441 aagtcctctt ccccaagtcc aaggatatac ccctgtcacc ccctgcccag aaaaatgacc
     1501 ccaagaaagc tccagtggcc cgaagctctg taggctggga tgccactgaa gacctccgaa
     1561 tttctaggac agacagcttc agtagcatga caagcgactc tgatacaacc agccccaccg
     1621 gacagcagcc gagcgatgcg tttccggagg acagcagcaa agtacccagg gaaaagccag
     1681 gagactggaa aatgcaatct cgtaaaagga ctcaaacact ccctaaccgg aaatgtttct
     1741 tgacatcagc ttttcagggt gccaacagca gcaaaatgga gatctttaaa aatgaattct
     1801 ggtcgccttc ctcagaggct aaggcagggg aagggcacag gagaacgatg tctcaagact
     1861 tgcgccaact ttctgactcc caacggactt ccacctacga taacgtccct tccctgccag
     1921 ggtcccctgg ggaggaagcc agtgcactct cttcccaagc ctgtgactcc aagggagata
     1981 ctcttgccag tccaaactct gaaactgggc ctggaaaaaa gaactctgga gaagaggaaa
     2041 ttgattcttt gcagaggatg gtccaagagc tacgaaagga aatagaaaca cagaagcaaa
     2101 tgtatgagga acagattaaa aaccttgaga aggaaaatta tgacgtttgg gctaaagtgg
     2161 tgaggctcaa tgaagaactg gagaaggaaa agaagaagtc tgcagcccta gagatcagcc
     2221 tccgcaacat ggagcgctcc cgggaggatg ttgagaagag gaacaaggcc ttggaagaag
     2281 aagtcaagga atttgtcaaa tccatgaagg aacccaagac cgaggcttaa gggtcccagg
     2341 agtactgcag ggacagcccc agagaggccc aactctggcc cctttctcag tgctatctga
     2401 tgacggggaa acaaaattat tctctgagag ggaaaggaca tttgagggaa acatcaaatt
     2461 tccccataaa taaatgaatg gagtttgcag gaaggtgagg gtgagcagag atgtgtgtgg
     2521 acatctctga ccatccatcg ctgtattcaa atggattgtt ttattccatt ctggtctcag
     2581 gcatgaccac gtccagtgaa gacatttgag gcagcacatc tcaggaccca ggcaatagac
     2641 tggccccaac tcaggctgga ctaaggtgtg attaattctt tgttttttgt gtggaacagc
     2701 tcaccttgtc agacagcctc agggcatctc tgagacacag gggcagaaaa tgacattcat
     2761 cttttgagtc ctcatccatg gagtgctgtg tttggggggc tgcatctgct gaagcgagaa
     2821 ccccattctg ccaccccacc aggatgccca ttctccagga cttctccaac ttactattag
     2881 actaaaccag aacaagcaac aaactgtatt tatgcaagca aaattgatga gaaaattata
     2941 ttcaaataaa gcaaaaatta aaaaaaaaa
//
