LOCUS       NM_001025616            4621 bp    mRNA    linear   PRI 09-JUL-2024
DEFINITION  Homo sapiens Rho GTPase activating protein 24 (ARHGAP24),
            transcript variant 1, mRNA.
ACCESSION   NM_001025616
VERSION     NM_001025616.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4621)
  AUTHORS   Luo,A., Liu,H., Huang,C. and Wei,S.
  TITLE     Exosome-transmitted circular RNA circ-LMO7 facilitates the
            progression of osteosarcoma by regulating miR-21-5p/ARHGAP24 axis
  JOURNAL   Cancer Biol Ther 25 (1), 2343450 (2024)
   PUBMED   38742566
  REMARK    GeneRIF: Exosome-transmitted circular RNA circ-LMO7 facilitates the
            progression of osteosarcoma by regulating miR-21-5p/ARHGAP24 axis.
REFERENCE   2  (bases 1 to 4621)
  AUTHORS   Tsutsumi,K., Nohara,A., Tanaka,T., Murano,M., Miyagaki,Y. and
            Ohta,Y.
  TITLE     FilGAP regulates tumor growth in Glioma through the regulation of
            mTORC1 and mTORC2
  JOURNAL   Sci Rep 13 (1), 20956 (2023)
   PUBMED   38065968
  REMARK    GeneRIF: FilGAP regulates tumor growth in Glioma through the
            regulation of mTORC1 and mTORC2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4621)
  AUTHORS   Yang,W., Wang,B., Yu,Q., Liu,T., Li,T., Tian,T., Jin,A., Ding,L.,
            Chen,W., Wang,H., Xian,J., Pan,B., Zhou,J., Fan,J., Yang,X. and
            Guo,W.
  TITLE     ARHGAP24 represses beta-catenin transactivation-induced
            invasiveness in hepatocellular carcinoma mainly by acting as a
            GTPase-independent scaffold
  JOURNAL   Theranostics 12 (14), 6189-6206 (2022)
   PUBMED   36168627
  REMARK    GeneRIF: ARHGAP24 represses beta-catenin transactivation-induced
            invasiveness in hepatocellular carcinoma mainly by acting as a
            GTPase-independent scaffold.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4621)
  AUTHORS   Saito,K., Mori,M., Kambara,N. and Ohta,Y.
  TITLE     FilGAP, a GAP protein for Rac, regulates front-rear polarity and
            tumor cell migration through the ECM
  JOURNAL   FASEB J 35 (4), e21508 (2021)
   PUBMED   33710706
  REMARK    GeneRIF: FilGAP, a GAP protein for Rac, regulates front-rear
            polarity and tumor cell migration through the ECM.
REFERENCE   5  (bases 1 to 4621)
  AUTHORS   Ehrlicher,A.J., Nakamura,F., Hartwig,J.H., Weitz,D.A. and
            Stossel,T.P.
  TITLE     Mechanical strain in actin networks regulates FilGAP and integrin
            binding to filamin A
  JOURNAL   Nature 478 (7368), 260-263 (2011)
   PUBMED   21926999
  REMARK    GeneRIF: Consistent with structural predictions, strain increases
            beta-integrin binding to FLNA, whereas it causes FilGAP to
            dissociate from FLNA, providing a direct and specific molecular
            basis for cellular mechanotransduction
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4621)
  AUTHORS   Ohta,Y., Hartwig,J.H. and Stossel,T.P.
  TITLE     FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to
            control actin remodelling
  JOURNAL   Nat Cell Biol 8 (8), 803-814 (2006)
   PUBMED   16862148
REFERENCE   7  (bases 1 to 4621)
  AUTHORS   Lavelin,I. and Geiger,B.
  TITLE     Characterization of a novel GTPase-activating protein associated
            with focal adhesions and the actin cytoskeleton
  JOURNAL   J Biol Chem 280 (8), 7178-7185 (2005)
   PUBMED   15611138
  REMARK    GeneRIF: propose that RC-GAP72 affects cellular morphology by
            targeting activated Cdc42 and Rac1 GTPases to specific subcellular
            sites, triggering local morphological changes
REFERENCE   8  (bases 1 to 4621)
  AUTHORS   Su,Z.J., Hahn,C.N., Goodall,G.J., Reck,N.M., Leske,A.F., Davy,A.,
            Kremmidiotis,G., Vadas,M.A. and Gamble,J.R.
  TITLE     A vascular cell-restricted RhoGAP, p73RhoGAP, is a key regulator of
            angiogenesis
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12212-12217 (2004)
   PUBMED   15302923
  REMARK    GeneRIF: p73, a vascular cell-specific GTPase-activating protein,
            is an important modulator of angiogenesis
REFERENCE   9  (bases 1 to 4621)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of ARHGAP24 and ARHGAP25 genes
            in silico
  JOURNAL   Int J Mol Med 14 (2), 333-338 (2004)
   PUBMED   15254788
REFERENCE   10 (bases 1 to 4621)
  AUTHORS   Lee,S.Y., Obata,Y., Yoshida,M., Stockert,E., Williamson,B.,
            Jungbluth,A.A., Chen,Y.T., Old,L.J. and Scanlan,M.J.
  TITLE     Immunomic analysis of human sarcoma
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2651-2656 (2003)
   PUBMED   12601173
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB109452.1, AK091196.1,
            DA815489.1, BC098580.1 and AC104059.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001025616.2.
            
            Summary: This gene encodes a Rho-GTPase activating protein, which
            is specific for the small GTPase family member Rac. Binding of the
            encoded protein by filamin A targets it to sites of membrane
            protrusion, where it antognizes Rac. This results in suppression of
            lamellae formation and promotion of retraction to regulate cell
            polarity. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK091196.1, SRR1803614.128891.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395184.6/ ENSP00000378611.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-509               DB109452.1         20-528
            510-732             AK091196.1         510-732
            733-888             DA815489.1         410-565
            889-3177            BC098580.1         451-2739
            3178-4621           AC104059.5         5495-6938
FEATURES             Location/Qualifiers
     source          1..4621
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.23-q21.3"
     gene            1..4621
                     /gene="ARHGAP24"
                     /gene_synonym="FILGAP; p73; p73RhoGAP; RC-GAP72; RCGAP72"
                     /note="Rho GTPase activating protein 24"
                     /db_xref="GeneID:83478"
                     /db_xref="HGNC:HGNC:25361"
                     /db_xref="MIM:610586"
     exon            1..410
                     /gene="ARHGAP24"
                     /gene_synonym="FILGAP; p73; p73RhoGAP; RC-GAP72; RCGAP72"
                     /inference="alignment:Splign:2.1.0"
     exon            411..610
                     /gene="ARHGAP24"
                     /gene_synonym="FILGAP; p73; p73RhoGAP; RC-GAP72; RCGAP72"
                     /inference="alignment:Splign:2.1.0"
     CDS             431..2677
                     /gene="ARHGAP24"
                     /gene_synonym="FILGAP; p73; p73RhoGAP; RC-GAP72; RCGAP72"
                     /note="isoform 1 is encoded by transcript variant 1; rho
                     GTPase-activating protein 24; sarcoma antigen NY-SAR-88;
                     rhoGAP of 73 kDa; filamin-A-associated RhoGAP; RAC1- and
                     CDC42-specific GTPase-activating protein of 72 kDa"
                     /codon_start=1
                     /product="rho GTPase-activating protein 24 isoform 1"
                     /protein_id="NP_001020787.2"
                     /db_xref="CCDS:CCDS34025.1"
                     /db_xref="GeneID:83478"
                     /db_xref="HGNC:HGNC:25361"
                     /db_xref="MIM:610586"
                     /translation="MEENNDSTENPQQGQGRQNAIKCGWLRKQGGFVKTWHTRWFVLK
                     GDQLYYFKDEDETKPLGTIFLPGNKVSEHPCNEENPGKFLFEVVPGGDRDRMTANHES
                     YLLMASTQNDMEDWVKSIRRVIWGPFGGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCV
                     DFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLREL
                     PEPVIPYAKYEDFLSCAKLLSKEEEAGVKELAKQVKSLPVVNYNLLKYICRFLDEVQS
                     YSGVNKMSVQNLATVFGPNILRPKVEDPLTIMEGTVVVQQLMSVMISKHDCLFPKDAE
                     LQSKPQDGVSNNNEIQKKATMGQLQNKENNNTKDSPSRQCSWDKSESPQRSSMNNGSP
                     TALSGSKTNSPKNSVHKLDVSRSPPLMVKKNPAFNKGSGIVTNGSFSSSNAEGLEKTQ
                     TTPNGSLQARRSSSLKVSGTKMGTHSVQNGTVRMGILNSDTLGNPTNVRNMSWLPNGY
                     VTLRDNKQKEQAGELGQHNRLSTYDNVHQQFSMMNLDDKQSIDSATWSTSSCEISLPE
                     NSNSCRSSTTTCPEQDFFGGNFEDPVLDGPPQDDLSHPRDYESKSDHRSVGGRSSRAT
                     SSSDNSETFVGNSSSNHSALHSLVSSLKQEMTKQKIEYESRIKSLEQRNLTLETEMMS
                     LHDELDQERKKFTMIEIKMRNAERAKEDAEKRNDMLQKEMEQFFSTFGELTVEPRRTE
                     RGNTIWIQ"
     exon            611..698
                     /gene="ARHGAP24"
                     /gene_synonym="FILGAP; p73; p73RhoGAP; RC-GAP72; RCGAP72"
                     /inference="alignment:Splign:2.1.0"
     exon            699..821
                     /gene="ARHGAP24"
                     /gene_synonym="FILGAP; p73; p73RhoGAP; RC-GAP72; RCGAP72"
                     /inference="alignment:Splign:2.1.0"
     exon            822..1029
                     /gene="ARHGAP24"
                     /gene_synonym="FILGAP; p73; p73RhoGAP; RC-GAP72; RCGAP72"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1162
                     /gene="ARHGAP24"
                     /gene_synonym="FILGAP; p73; p73RhoGAP; RC-GAP72; RCGAP72"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1236
                     /gene="ARHGAP24"
                     /gene_synonym="FILGAP; p73; p73RhoGAP; RC-GAP72; RCGAP72"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1358
                     /gene="ARHGAP24"
                     /gene_synonym="FILGAP; p73; p73RhoGAP; RC-GAP72; RCGAP72"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..2433
                     /gene="ARHGAP24"
                     /gene_synonym="FILGAP; p73; p73RhoGAP; RC-GAP72; RCGAP72"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..4621
                     /gene="ARHGAP24"
                     /gene_synonym="FILGAP; p73; p73RhoGAP; RC-GAP72; RCGAP72"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3161..3166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP24"
                     /gene_synonym="FILGAP; p73; p73RhoGAP; RC-GAP72; RCGAP72"
                     /note="hexamer: ATTAAA"
     polyA_site      3178
                     /gene="ARHGAP24"
                     /gene_synonym="FILGAP; p73; p73RhoGAP; RC-GAP72; RCGAP72"
     regulatory      3250..3255
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP24"
                     /gene_synonym="FILGAP; p73; p73RhoGAP; RC-GAP72; RCGAP72"
                     /note="hexamer: AATACA"
     polyA_site      3271
                     /gene="ARHGAP24"
                     /gene_synonym="FILGAP; p73; p73RhoGAP; RC-GAP72; RCGAP72"
     regulatory      4603..4608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP24"
                     /gene_synonym="FILGAP; p73; p73RhoGAP; RC-GAP72; RCGAP72"
                     /note="hexamer: AATAAA"
     polyA_site      4621
                     /gene="ARHGAP24"
                     /gene_synonym="FILGAP; p73; p73RhoGAP; RC-GAP72; RCGAP72"
                     /note="major polyA site"
ORIGIN      
        1 ctttctaact tctgggactc tttgcgcaac tgctaggatt tctcaagtgc atgtggcaac
       61 acagcccagc tccgggtgga aaccagcagg gctctggagg ggctcggaga ccaggggagc
      121 tgtcaaggct gcggcgggga ccagagagga gcctggcggg ggtggctggg tggctggggg
      181 aatcccccca acttcccatc gcaggcgcag ctctctcggc cgcctatttc ctccgaaacc
      241 cgcgctgcgg agcagcccag tgcatagagt tcaacacttc cccttgttgt ggaaagtaaa
      301 ggagcctcac taccaccttt ttttctttgc gttttcttac tgctggtcct gggagccttt
      361 tccttcggag cagcagccct gtccggcatc tgtcttgagc tcccagcaag gaaagtccat
      421 cagcttgata atggaggaga acaatgactc cacggagaac ccccaacaag gccaagggcg
      481 gcagaatgcc atcaagtgtg ggtggctgag gaagcaagga ggctttgtca agacttggca
      541 tactcgctgg tttgtgctca agggggatca gctctattat ttcaaagatg aagatgaaac
      601 caagcccttg ggtactattt ttctgcctgg aaataaagtt tctgagcatc cctgcaatga
      661 agagaaccca gggaagttcc tttttgaagt agttccagga ggcgatcgag atcggatgac
      721 agcaaatcat gaaagctacc tcctcatggc aagcacccag aatgatatgg aagactgggt
      781 gaagtcaatc cgccgagtca tatggggacc tttcggagga ggcatttttg gacagaaact
      841 ggaggatact gttcgttatg agaagagata tgggaaccgt ctggctccga tgttggtgga
      901 gcagtgcgtg gactttatcc gacaaagggg gctgaaagaa gagggtctct ttcgactgcc
      961 aggccaggct aatcttgtta aggagctcca agatgccttt gactgtgggg agaagccatc
     1021 atttgacagc aacacagatg tacacacggt ggcatcactt cttaagctgt acctccgaga
     1081 acttccagaa ccagttattc cttatgcgaa gtatgaagat tttttgtcat gtgccaaact
     1141 gctcagcaag gaagaggaag caggtgttaa ggaattagca aagcaggtga agagtttgcc
     1201 agtggtaaat tacaacctcc tcaagtatat ttgcagattc ttggatgaag tacagtccta
     1261 ctcgggagtt aacaaaatga gtgtgcagaa cttggcaacg gtctttggtc ctaatatcct
     1321 gcgccccaaa gtggaagatc ctttgactat catggagggc actgtggtgg tccagcagtt
     1381 gatgtcagtg atgattagca aacatgattg cctctttccc aaagatgcag aactacaaag
     1441 caagccccaa gatggagtga gcaacaacaa tgaaattcag aagaaagcca ccatggggca
     1501 gttacagaac aaggagaaca ataacaccaa ggacagccct agtaggcagt gctcctggga
     1561 caagtctgag tcaccccaga gaagcagcat gaacaatgga tcccccacag ctctatcagg
     1621 cagcaaaacc aacagcccaa agaacagtgt tcacaagcta gatgtgtcta gaagcccccc
     1681 tctcatggtc aaaaagaacc cagcctttaa taagggtagt gggatagtta ccaatgggtc
     1741 cttcagcagc agtaatgcag aaggtcttga gaaaacccaa accaccccca atgggagcct
     1801 acaggccaga aggagctctt cactgaaggt atctggtacc aaaatgggca cgcacagtgt
     1861 acagaatgga acggtgcgca tgggcatttt gaacagcgac acactcggga accccacaaa
     1921 tgttcgaaac atgagctggc tgccaaatgg ctatgtgacc ctgagggata acaagcagaa
     1981 agaacaagct ggagagttag gccagcacaa cagactgtcc acctatgata atgtccatca
     2041 acagttctcc atgatgaacc ttgatgacaa gcagagcatt gacagtgcta cctggtccac
     2101 ttcctcctgt gaaatctccc tccctgagaa ctccaactcc tgtcgctctt ctaccaccac
     2161 ctgcccagag caagactttt ttggggggaa ctttgaggac cctgttttgg atgggccccc
     2221 gcaggacgac ctttcccacc ccagggacta tgaaagcaaa agtgaccaca ggagtgtggg
     2281 aggtcgaagt agtcgtgcca ccagtagcag tgacaacagt gagacatttg tgggcaacag
     2341 cagcagcaac cacagtgcac tgcacagttt agtttccagc ctgaaacagg aaatgaccaa
     2401 acagaagata gagtatgagt ccaggataaa gagcttagaa cagcgaaact tgactttgga
     2461 aacagaaatg atgagcctcc atgatgaact ggatcaggag aggaaaaagt tcacaatgat
     2521 agaaataaaa atgcgaaatg ccgagcgagc aaaagaagat gccgagaaaa gaaatgacat
     2581 gctacagaaa gaaatggagc agtttttttc cacgtttgga gaactgacag tggaacccag
     2641 gagaaccgag agaggaaaca caatatggat tcagtgagcc tgctttcgcc tgctgtctct
     2701 gatggctctg gcaaggactc cagggattct ggtgggatat gacttagaac caggtggctg
     2761 gtcacctgga tgtacagaag tctaactggt gaaggaatat catttacaga cattaaacat
     2821 ccatatctgc aatgtgtacc aaagttatat catgccccat aatgctactg tcaagtgtta
     2881 caactggata tgtgtatata gagtagtttt tcaaaagtaa actaaaaatg agaagcatat
     2941 ttcaagaatt attttattgc aagtcttgta tttaaatgtt aaatcaatat gttgttgcaa
     3001 tttagcttgc tttcaagctt caccccttgc acttaacata agctattttt ggcattgtgt
     3061 tatcatcggc ttattttata gatcaatatt tttatttccc ttttttgctg aggaaatgaa
     3121 gataagcaaa aatataaata tatatataaa tatatgagtt attaaaatca gaagaatact
     3181 ttgtggctgt gctgtttgtg ccaatagact ttgtcatgac caaaaagaga aatgtaaata
     3241 gttttataaa atacagtcga atcaccagga acctttgagc tgcttttaaa attcttcccc
     3301 tggcaccact cagttttgct tttgcgaggc gatttgacat aggaactttg agactccatg
     3361 agaaagtccc tttctgaggc ccactgtcta ccttgccaga tcctcagtgc gtatcgccaa
     3421 tgcaggatgc tccttagaaa agaaaaaatg gtaaagaatg gcatttaacg attcaggctt
     3481 tgaattactc tgtccctctg gaccgaatct ctttaactgc tggatagttt tagaggaatt
     3541 ctcctgctac ttaggtactg ggaaacaatg cttgctaaac catgcccacg tgagcacctg
     3601 tctcccactc aaacctctcc catctcccaa caactgcact ttagaatacc agcagtgaaa
     3661 tggtattact gtttccctct gagtgaaact gctagagtat atgtcacgta gtgacatttt
     3721 tttctcactc aggctattgc catctgggat tctctcccta ctacagctgg caaagttggt
     3781 ttgcagcaag aagatagtgg gagggggcca ggctgcagga gaaggagaaa agtttagaag
     3841 aaacaaacca ttttgcttct aattttgaca gtatcacttt cctgttaaaa catacaataa
     3901 ttttaaaagg tgaatgccta aagttccaat tttagcaaat atgggaacct cagcaatgct
     3961 aattttctag aaaaacccag ggctctttgg agctagagtt ttgggagaac agttcttcac
     4021 aataaggcaa tggttttgag aggccaggca aataatcttt ctcaccgtag aacaaaaagt
     4081 tacaaaaggc ataatcggaa atagagacta catacttgag tttatggggt ttgtgttgtt
     4141 tgaaggttca atgcttgcat gtgtttattt attttcaaga gggaaagtgg tctgtactgc
     4201 tttcatcctt gccactgtct tgcttttatt ttttactctc ccactgagca agcgtctgtg
     4261 gtcctatggt atcaaccagt atctttatag caataatttc tttaattccc ttttctctct
     4321 ctttccaatt atttaaccag ttacttccac ctggacatac gataggaaat tcaaactcaa
     4381 aatatgaaaa ttgatcttaa taactctccc ttcatatctt ttcacctatt tccagtcctt
     4441 atcatagttg ataaaaacct cagactcatc cagaaagcta tatgatgcac tagtaaaaaa
     4501 aacaaagata ttcaaactgc ttgggttcaa atggtataca atttgccagc tgttactgaa
     4561 ccttctatgc ataacttttt ttttcctctg tgcaattgga ataataaaaa tactactccc
     4621 a
//
