LOCUS       NM_001199417            5911 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens Rho GTPase activating protein 23 (ARHGAP23), mRNA.
ACCESSION   NM_001199417
VERSION     NM_001199417.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5911)
  AUTHORS   Pharoah,P.D., Tsai,Y.Y., Ramus,S.J., Phelan,C.M., Goode,E.L.,
            Lawrenson,K., Buckley,M., Fridley,B.L., Tyrer,J.P., Shen,H.,
            Weber,R., Karevan,R., Larson,M.C., Song,H., Tessier,D.C., Bacot,F.,
            Vincent,D., Cunningham,J.M., Dennis,J., Dicks,E., Aben,K.K.,
            Anton-Culver,H., Antonenkova,N., Armasu,S.M., Baglietto,L.,
            Bandera,E.V., Beckmann,M.W., Birrer,M.J., Bloom,G., Bogdanova,N.,
            Brenton,J.D., Brinton,L.A., Brooks-Wilson,A., Brown,R., Butzow,R.,
            Campbell,I., Carney,M.E., Carvalho,R.S., Chang-Claude,J.,
            Chen,Y.A., Chen,Z., Chow,W.H., Cicek,M.S., Coetzee,G., Cook,L.S.,
            Cramer,D.W., Cybulski,C., Dansonka-Mieszkowska,A., Despierre,E.,
            Doherty,J.A., Dork,T., du Bois,A., Durst,M., Eccles,D., Edwards,R.,
            Ekici,A.B., Fasching,P.A., Fenstermacher,D., Flanagan,J., Gao,Y.T.,
            Garcia-Closas,M., Gentry-Maharaj,A., Giles,G., Gjyshi,A., Gore,M.,
            Gronwald,J., Guo,Q., Halle,M.K., Harter,P., Hein,A., Heitz,F.,
            Hillemanns,P., Hoatlin,M., Hogdall,E., Hogdall,C.K., Hosono,S.,
            Jakubowska,A., Jensen,A., Kalli,K.R., Karlan,B.Y., Kelemen,L.E.,
            Kiemeney,L.A., Kjaer,S.K., Konecny,G.E., Krakstad,C.,
            Kupryjanczyk,J., Lambrechts,D., Lambrechts,S., Le,N.D., Lee,N.,
            Lee,J., Leminen,A., Lim,B.K., Lissowska,J., Lubinski,J.,
            Lundvall,L., Lurie,G., Massuger,L.F., Matsuo,K., McGuire,V.,
            McLaughlin,J.R., Menon,U., Modugno,F., Moysich,K.B., Nakanishi,T.,
            Narod,S.A., Ness,R.B., Nevanlinna,H., Nickels,S., Noushmehr,H.,
            Odunsi,K., Olson,S., Orlow,I., Paul,J., Pejovic,T., Pelttari,L.M.,
            Permuth-Wey,J., Pike,M.C., Poole,E.M., Qu,X., Risch,H.A.,
            Rodriguez-Rodriguez,L., Rossing,M.A., Rudolph,A., Runnebaum,I.,
            Rzepecka,I.K., Salvesen,H.B., Schwaab,I., Severi,G., Shen,H.,
            Shridhar,V., Shu,X.O., Sieh,W., Southey,M.C., Spellman,P.,
            Tajima,K., Teo,S.H., Terry,K.L., Thompson,P.J., Timorek,A.,
            Tworoger,S.S., van Altena,A.M., van den Berg,D., Vergote,I.,
            Vierkant,R.A., Vitonis,A.F., Wang-Gohrke,S., Wentzensen,N.,
            Whittemore,A.S., Wik,E., Winterhoff,B., Woo,Y.L., Wu,A.H.,
            Yang,H.P., Zheng,W., Ziogas,A., Zulkifli,F., Goodman,M.T., Hall,P.,
            Easton,D.F., Pearce,C.L., Berchuck,A., Chenevix-Trench,G.,
            Iversen,E., Monteiro,A.N., Gayther,S.A., Schildkraut,J.M. and
            Sellers,T.A.
  CONSRTM   Australian Cancer Study; Australian Ovarian Cancer Study Group
  TITLE     GWAS meta-analysis and replication identifies three new
            susceptibility loci for ovarian cancer
  JOURNAL   Nat Genet 45 (4), 362-370 (2013)
   PUBMED   23535730
REFERENCE   2  (bases 1 to 5911)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   3  (bases 1 to 5911)
  AUTHORS   Choy,K.W., Wang,C.C., Ogura,A., Lau,T.K., Rogers,M.S., Ikeo,K.,
            Gojobori,T., Lam,D.S. and Pang,C.P.
  TITLE     Genomic annotation of 15,809 ESTs identified from pooled early
            gestation human eyes
  JOURNAL   Physiol Genomics 25 (1), 9-15 (2006)
   PUBMED   16368877
REFERENCE   4  (bases 1 to 5911)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human ARHGAP23 gene in
            silico
  JOURNAL   Int J Oncol 25 (2), 535-540 (2004)
   PUBMED   15254754
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC244153.3.
            
            On Nov 23, 2018 this sequence version replaced NM_001199417.1.
            
            Summary: The RHO (see ARHA; MIM 165390) family of small GTPases are
            involved in signal transduction through transmembrane receptors,
            and they are inactive in the GDP-bound form and active in the
            GTP-bound form. GTPase-activating proteins, such as ARHGAP23,
            inactivate RHO family proteins by stimulating their hydrolysis of
            GTP (Katoh and Katoh, 2004 [PubMed 15254754]).[supplied by OMIM,
            Mar 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. There are no full-length transcripts
            representing this exon combination; it is predicted based on tiled
            alignments of partial transcripts.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1966682,
                              SAMEA1968189 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000622683.5/ ENSP00000481862.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                AC244153.3         164803-164887       c
            86-247              AC244153.3         135088-135249       c
            248-275             AC244153.3         132419-132446       c
            276-371             AC244153.3         130410-130505       c
            372-450             AC244153.3         130155-130233       c
            451-505             AC244153.3         129969-130023       c
            506-1670            AC244153.3         126020-127184       c
            1671-1826           AC244153.3         124052-124207       c
            1827-1938           AC244153.3         123716-123827       c
            1939-1996           AC244153.3         123447-123504       c
            1997-2140           AC244153.3         121345-121488       c
            2141-2458           AC244153.3         115455-115772       c
            2459-2520           AC244153.3         113854-113915       c
            2521-2651           AC244153.3         113468-113598       c
            2652-2773           AC244153.3         111208-111329       c
            2774-2929           AC244153.3         110673-110828       c
            2930-3008           AC244153.3         107211-107289       c
            3009-3082           AC244153.3         103176-103249       c
            3083-3172           AC244153.3         102800-102889       c
            3173-3298           AC244153.3         101819-101944       c
            3299-3340           AC244153.3         95525-95566         c
            3341-3437           AC244153.3         94841-94937         c
            3438-3469           AC244153.3         92723-92754         c
            3470-5911           AC244153.3         80966-83407         c
FEATURES             Location/Qualifiers
     source          1..5911
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..5911
                     /gene="ARHGAP23"
                     /note="Rho GTPase activating protein 23"
                     /db_xref="GeneID:57636"
                     /db_xref="HGNC:HGNC:29293"
                     /db_xref="MIM:610590"
     exon            1..85
                     /gene="ARHGAP23"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..4498
                     /gene="ARHGAP23"
                     /note="rho-type GTPase-activating protein 23"
                     /codon_start=1
                     /product="rho GTPase-activating protein 23"
                     /protein_id="NP_001186346.1"
                     /db_xref="CCDS:CCDS56027.1"
                     /db_xref="GeneID:57636"
                     /db_xref="HGNC:HGNC:29293"
                     /db_xref="MIM:610590"
                     /translation="MNGVAFCLVGIPPRPEPRPPQLPLGPRDGCSPRRPFPWQGPRTL
                     LLYKSPQDGFGFTLRHFIVYPPESAVHCSLKEEENGGRGGGPSPRYRLEPMDTIFVKN
                     VKEDGPAHRAGLRTGDRLVKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQ
                     LAYSQDAYLKGNEPYSGEARSIPEPPPICYPRKTYAPPARASTRATMVPEPTSALPSD
                     PRSPAAWSDPGLRVPPAARAHLDNSSLGMSQPRPSPGAFPHLSSEPRTPRAFPEPGSR
                     VPPSRLECQQALSHWLSNQVPRRAGERRCPAMAPRARSASQDRLEEVAAPRPWPCSTS
                     QDALSQLGQEGWHRARSDDYLSRATRSAEALGPGALVSPRFERCGWASQRSSARTPAC
                     PTRDLPGPQAPPPSGLQGLDDLGYIGYRSYSPSFQRRTGLLHALSFRDSPFGGLPTFN
                     LAQSPASFPPEASEPPRVVRPEPSTRALEPPAEDRGDEVVLRQKPPTGRKVQLTPARQ
                     MNLGFGDESPEPEASGRGERLGRKVAPLATTEDSLASIPFIDEPTSPSIDLQAKHVPA
                     SAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQDCSSIKAGRRSSYLLAITTERSKSC
                     DDGLNTFRDEGRVLRRLPNRIPSLRMLRSFFTDGSLDSWGTSEDADAPSKRHSTSDLS
                     DATFSDIRREGWLYYKQILTKKGKKAGSGLRQWKRVYAALRARSLSLSKERREPGPAA
                     AGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDRDDMLG
                     WIRAIRENSRAEGEDPGCANQALISKKLNDYRKVSHSSGPKADSSPKGSRGLGGLKSE
                     FLKQSAARGLRTQDLPAGSKDDSAAAPKTPWGINIIKKNKKAAPRAFGVRLEECQPAT
                     ENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQ
                     DLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYE
                     TLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVET
                     LIQHSDWFFSDEEDKGERTPVGDKEPQAVPNIEYLLPNIGRTVPPGDPGSDSTTCSSA
                     KSKGSWAPKKEPYAREMLAISFISAVNRKRKKRREARGLGSSTDDDSEQEAHKPGAGA
                     TAPGTQERPQGPLPGAVAPEAPGRLSPPAAPEERPAADTRSIVSGYSTLSTMDRSVCS
                     GASGRRAGAGDEADDERSELSHVETDTEGAAGAGPGGRLTRRPSFSSHHLMPCDTLAR
                     RRLARGRPDGEGAGRGGPRAPEPPGSASSSSQESLRPPAAALASRPSRMEALRLRLRG
                     TADDMLAVRLRRPLSPETRRRRSSWRRHTVVVQSPLTDLNFNEWKELGGGGPPEPAGA
                     RAHSDNKDSGLSSLESTKARAPSSAASQPPAPGDTGSLQSQPPRRSAASRLHQCL"
     exon            86..247
                     /gene="ARHGAP23"
                     /inference="alignment:Splign:2.1.0"
     exon            248..275
                     /gene="ARHGAP23"
                     /inference="alignment:Splign:2.1.0"
     exon            276..371
                     /gene="ARHGAP23"
                     /inference="alignment:Splign:2.1.0"
     exon            372..450
                     /gene="ARHGAP23"
                     /inference="alignment:Splign:2.1.0"
     exon            451..505
                     /gene="ARHGAP23"
                     /inference="alignment:Splign:2.1.0"
     exon            506..1670
                     /gene="ARHGAP23"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1826
                     /gene="ARHGAP23"
                     /inference="alignment:Splign:2.1.0"
     exon            1827..1938
                     /gene="ARHGAP23"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..1996
                     /gene="ARHGAP23"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2140
                     /gene="ARHGAP23"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2458
                     /gene="ARHGAP23"
                     /inference="alignment:Splign:2.1.0"
     exon            2459..2520
                     /gene="ARHGAP23"
                     /inference="alignment:Splign:2.1.0"
     exon            2521..2651
                     /gene="ARHGAP23"
                     /inference="alignment:Splign:2.1.0"
     exon            2652..2773
                     /gene="ARHGAP23"
                     /inference="alignment:Splign:2.1.0"
     exon            2774..2929
                     /gene="ARHGAP23"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..3008
                     /gene="ARHGAP23"
                     /inference="alignment:Splign:2.1.0"
     exon            3009..3082
                     /gene="ARHGAP23"
                     /inference="alignment:Splign:2.1.0"
     exon            3083..3172
                     /gene="ARHGAP23"
                     /inference="alignment:Splign:2.1.0"
     exon            3173..3298
                     /gene="ARHGAP23"
                     /inference="alignment:Splign:2.1.0"
     exon            3299..3340
                     /gene="ARHGAP23"
                     /inference="alignment:Splign:2.1.0"
     exon            3341..3437
                     /gene="ARHGAP23"
                     /inference="alignment:Splign:2.1.0"
     exon            3438..3469
                     /gene="ARHGAP23"
                     /inference="alignment:Splign:2.1.0"
     exon            3470..5911
                     /gene="ARHGAP23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5893..5898
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP23"
                     /note="hexamer: AATAAA"
     polyA_site      5911
                     /gene="ARHGAP23"
                     /note="major polyA site"
ORIGIN      
        1 gcagagccgc cgctgccacc cgatgaatgg agtcgccttc tgcctggtcg ggatcccgcc
       61 ccgcccggag ccccggcccc cacagctgcc actgggccca agagatgggt gctctcctag
      121 gcgccccttc ccctggcagg ggccgaggac gctgctgctg tacaaaagtc cccaggacgg
      181 ctttggcttc actctgcgcc acttcatcgt gtacccaccc gagtcggccg tgcactgcag
      241 cctgaaggag gaagagaatg gaggccgtgg aggaggaccc tccccccggt accgcctgga
      301 gcccatggac accatctttg tcaagaatgt gaaggaagac ggccctgccc atagggcggg
      361 gcttcgcaca ggagaccggc tggtaaaggt gaatggggaa agcgtcattg ggaagaccta
      421 ctctcaggtc atagctctga tccagaatag tgatgacact ctggagctgt ctatcatgcc
      481 caaggacgag gacatcctcc agctggccta ctcccaggat gcctacctga aagggaacga
      541 gccgtattct ggagaggccc gcagcatccc agagccaccc ccgatctgct acccccgcaa
      601 gacctacgcc cctcctgccc gggcctccac cagggccact atggtgcctg agcccacctc
      661 agcactgccc agtgaccccc ggagtcctgc tgcctggagt gacccggggc tccgtgtgcc
      721 acctgctgcc cgtgcccacc tggacaactc ttccttgggg atgagccagc cccgccccag
      781 ccctggtgcc ttcccccacc tctcctcgga gccccggacg ccccgtgcct tcccagagcc
      841 tggcagccgg gtgcccccca gcagactgga gtgccagcag gccttgtcac actggctgtc
      901 aaaccaggta ccccgccggg cgggggagag acggtgccca gccatggccc cccgggcccg
      961 cagcgcctcc caggaccggt tggaggaggt ggctgccccc cgcccgtggc cctgctccac
     1021 ctcccaggat gctttgagcc agctgggcca ggagggctgg caccgagctc gctcagatga
     1081 ctacttgagc cgggccaccc gttctgccga ggcactgggg ccaggggcac tggtgtcacc
     1141 ccgctttgag cggtgtggct gggcttccca gcgttcgtct gcccgcaccc ccgcctgccc
     1201 aactcgggac ctgccagggc cccaggcccc acccccgtct ggcctgcagg gcctggatga
     1261 cctcgggtac atcggctacc ggagctacag cccatcattc cagcgccgga ccggcctcct
     1321 ccatgcgctc tccttccggg actcaccctt tggggggctg cctaccttca acctggccca
     1381 gtcccctgcg tcattcccac cagaggcctc cgagccaccc agggttgtac ggccggaacc
     1441 cagcacccgg gccctggagc ctcctgcgga ggatcgcggc gatgaggtgg tcctgaggca
     1501 gaagcccccg acgggccgca aggttcagct gacccccgca agacagatga accttggatt
     1561 tggtgacgag tccccagagc cagaggccag tgggcgaggg gaacgcctgg gcaggaaggt
     1621 ggcccctttg gccaccaccg aagactctct ggcttccatc ccctttattg atgagcccac
     1681 cagccccagc attgacctcc aagccaagca cgtccctgcc tctgctgtgg tctccagtgc
     1741 catgaactca gcccctgtcc tgggcaccag cccatcttcc ccgaccttca ctttcaccct
     1801 cggacgccat tactcgcagg actgcagcag catcaaggct ggccgccgct cctcctacct
     1861 gctggccatc accacggagc gctccaagtc ctgcgatgat ggactcaaca ccttccgcga
     1921 cgagggccgg gttctgcggc gcctgccaaa ccgcataccc agcctgcgga tgctccggag
     1981 cttcttcacc gacgggtcct tggatagctg gggcacctct gaagatgctg acgctccttc
     2041 taagcgacac tcaacctctg acctctcaga tgcgaccttc agcgatatca ggagagaagg
     2101 ctggttgtat tataagcaga ttctcaccaa gaaggggaag aaagcgggca gcggcctgcg
     2161 ccagtggaag cgggtgtacg ccgcgctgcg ggcgcgctcg ctctcgctga gcaaggagcg
     2221 gcgggagccc gggccggcgg cggcgggggc tgcggcggcc ggcgcaggtg aggacgaggc
     2281 ggcgcccgtc tgcatcggct cctgcctcgt ggacatctcc tacagcgaga ccaagaggag
     2341 gcacgtgttc cggctgacca ccgctgactt ctgtgaatat ctctttcagg ctgaggaccg
     2401 ggatgacatg ctgggctgga tcagagcgat ccgggagaac agcagggccg agggcgagga
     2461 ccccggctgt gccaaccaag ctctgatcag caagaagctt aacgattatc gcaaagtgag
     2521 ccatagctct gggcccaaag ctgattcctc ccccaaaggc tctcgcggcc tggggggcct
     2581 caagtctgag ttcctcaagc agagtgcggc acgtggcctc aggactcagg acctgcccgc
     2641 agggagcaag gatgacagtg ctgcagcccc caaaaccccc tggggcatca acatcatcaa
     2701 gaaaaataag aaggccgctc cgagggcgtt tggggtcagg ctggaggagt gccagccagc
     2761 cacggagaac cagcgcgtcc ccttaatcgt ggctgcatgc tgtcgcattg tggaggcacg
     2821 agggctggag tccacaggca tttaccgagt gcccggcaac aatgcagtgg tgtccagcct
     2881 acaggagcag ctcaaccgcg ggcctggtga catcaacctg caggatgagc gctggcaaga
     2941 cctcaatgtg atcagcagcc tgctcaagtc cttcttccga aagctgcccg agcctctttt
     3001 cactgatgac aaatacaacg acttcatcga ggccaaccgc attgaggacg cgcgggagcg
     3061 aatgaggacg ctgcggaagc tgatccggga tctcccagga cactactatg aaacgctcaa
     3121 attccttgtg ggccatctca agaccatcgc tgaccactct gagaaaaaca agatggaacc
     3181 ccggaacctg gccctggtct ttgggccgac actggtgagg acgtctgagg acaacatgac
     3241 agacatggtg acccacatgc ctgaccgcta caagatcgtg gagacactga tccagcactc
     3301 agactggttc ttcagtgacg aagaggacaa gggagagaga acccctgtgg gcgacaagga
     3361 gcctcaggca gtgcccaaca ttgagtacct cctgcccaac attggcagga cagtgccccc
     3421 tggcgacccg gggtcagatt ctaccacctg tagttcagcc aagtccaagg gttcgtgggc
     3481 ccccaagaag gagccgtacg cccgggagat gctggcgatc tccttcatct cggccgtcaa
     3541 ccgcaagcgc aagaagcggc gggaggcgcg ggggctgggc agcagcaccg acgacgactc
     3601 ggagcaggag gcgcacaagc ctggggcggg ggccacagcg ccggggactc aggagcggcc
     3661 gcaggggccg ctgcctggcg ccgtcgcccc cgaggccccc ggacgcctca gtcccccggc
     3721 ggcgccggag gagcggccgg ccgcggacac gcgctccatt gtgtcgggct actccaccct
     3781 gtccaccatg gaccgcagcg tgtgctcggg cgctagcggt cggcgggcag gggcggggga
     3841 tgaggcggac gacgagcgta gcgagctgag ccacgtggag acggacactg agggcgcggc
     3901 gggcgcgggg cctggggggc gcctgacacg ccggccgtcc ttcagctcgc accacctcat
     3961 gccctgcgac actctggcgc gccgccgcct ggcccggggc cgcccagacg gcgagggcgc
     4021 gggccggggc ggtccccgcg ccccggagcc gcccggctcg gcgtcgtcca gcagccagga
     4081 gtcgctgcgg cccccggcgg cggcgctggc ctcccggccc tcgcgcatgg aggcgctgcg
     4141 tctaaggctc cgcggcacgg cggacgacat gctcgccgtg cgcctgcggc ggccgctgtc
     4201 gcccgagacc cggcggcgcc ggagcagctg gcgccgccac accgtggtgg tgcagagccc
     4261 gctgactgac ctcaacttca acgagtggaa ggagctgggc ggagggggcc ccccggagcc
     4321 tgcgggcgcg cgggcgcaca gtgacaacaa ggactccgga ctcagcagcc tggagtccac
     4381 caaggcgcgg gccccgtcgt ccgctgcctc gcagccgccc gcgcccgggg acacggggtc
     4441 cctgcagagc cagcccccgc gccgctcggc cgcctcccgc ctgcatcagt gtctgtgatc
     4501 cccacctccc gcgccgctcg ggcgccaccc ctccctagag cccctttgga accaggaggc
     4561 ttcaccagcc tgcacctcct cttctgtggc ccctgggtgc atggtgtggg tggagggcgc
     4621 agcaggcagt gtctctagtt ggtgtgctgg aactggcagg gcagaggaga aggctggggc
     4681 cggactaatt gaatggaagg gggttccaga ggtgatgagc agaagaggag ggggcgtggg
     4741 ctgctggggt ctgtgtccct gcacacatgc gcccgatagg tccttctgag cctttctgtg
     4801 gctgcacttg gggacccttg tggaccatgg ggtgtggcta gggaacccct aagtttcaga
     4861 ctaaaggaaa gatcctgggt gatgctggct ttttgcttct ttcttctgcc ctcccacctc
     4921 agcttgtaag cggggatgtg tgtatgtctg gggagaggag gtgtagggtg cgtatgtcca
     4981 tggggggagg ggcttgtgtg tgcagtcatt gtcccaaggt gtttccagta gcgacttctg
     5041 tccccctatc cccaccctgg tccccacttt gcgcccccgg gctccctgcc tttggtgcac
     5101 acaggatcct gcccgccccc cttgccagag ccagagaagg gggttggggc cattccaagg
     5161 aggcaggact gaaaccctca ccagggttac tccccaacat ccttttgcct gagtcaccct
     5221 ctaagcgctt taaccacggg cagctgcctg ttccccagac agtttttggt ggggggggtc
     5281 cagggtcccc cttgctggta cctccctcac ccctcttttt gtttttccat ctgtgcctgt
     5341 tccttccaca gcccaggcac acagaagccc accttcttcc ccttaggagg agggatagtc
     5401 aacacccctg ctgtctctct gtcactcaca cactgattta tggggtctga gctgggctgt
     5461 tcctgcagga tggacaggac ccagcgccct cttctcccca caggctgtaa atagacttcc
     5521 aatcaccagg ccagccccca cacaccctca ctcattccag ggaagcccag gtaggtggtg
     5581 aacccgctgc cacgtctatc agtcctcttg ttttatgcaa agatttactg taaagtagat
     5641 ttctttccct ccctccccca ttcttttatt gtaaatattg tctctaaatg tgtaacatat
     5701 tataaagaat ttataaggat ttttaaagat gttttgctca tttacaaaag tgttgtaaca
     5761 gtgttggaca aagccttcca ccccatgtcc gcatggctcc tttcactgtg tccttgacac
     5821 acctctctgg caacaactaa aatttcctgc ttctgaaaag tcctgtctta aaagtacagt
     5881 ctatatcttg gaaataaata gctttcctca a
//
