LOCUS       NM_001384657            6109 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens Rho GTPase activating protein 20 (ARHGAP20),
            transcript variant 6, mRNA.
ACCESSION   NM_001384657 XM_006718893
VERSION     NM_001384657.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6109)
  AUTHORS   Foster,M.C., Yang,Q., Hwang,S.J., Hoffmann,U. and Fox,C.S.
  TITLE     Heritability and genome-wide association analysis of renal sinus
            fat accumulation in the Framingham Heart Study
  JOURNAL   BMC Med Genet 12, 148 (2011)
   PUBMED   22044751
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6109)
  AUTHORS   Herold,T., Jurinovic,V., Mulaw,M., Seiler,T., Dufour,A.,
            Schneider,S., Kakadia,P.M., Feuring-Buske,M., Braess,J.,
            Spiekermann,K., Mansmann,U., Hiddemann,W., Buske,C. and
            Bohlander,S.K.
  TITLE     Expression analysis of genes located in the minimally deleted
            regions of 13q14 and 11q22-23 in chronic lymphocytic
            leukemia-unexpected expression pattern of the RHO GTPase activator
            ARHGAP20
  JOURNAL   Genes Chromosomes Cancer 50 (7), 546-558 (2011)
   PUBMED   21500311
  REMARK    GeneRIF: The similar expression profiles of ARHGAP20 in 13q14 and
            11q22-23 deleted CLL cases suggest a molecular connection and an
            intriguing mechanism of regulation
REFERENCE   3  (bases 1 to 6109)
  AUTHORS   Yamada,T., Sakisaka,T., Hisata,S., Baba,T. and Takai,Y.
  TITLE     RA-RhoGAP, Rap-activated Rho GTPase-activating protein implicated
            in neurite outgrowth through Rho
  JOURNAL   J Biol Chem 280 (38), 33026-33034 (2005)
   PUBMED   16014623
  REMARK    GeneRIF: RA-RhoGAP transduces a signal from Rap1 to Rho and
            regulates the neurite outgrowth
REFERENCE   4  (bases 1 to 6109)
  AUTHORS   Kalla,C., Nentwich,H., Schlotter,M., Mertens,D., Wildenberger,K.,
            Dohner,H., Stilgenbauer,S. and Lichter,P.
  TITLE     Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic
            leukemia disrupts two novel genes
  JOURNAL   Genes Chromosomes Cancer 42 (2), 128-143 (2005)
   PUBMED   15543602
REFERENCE   5  (bases 1 to 6109)
  AUTHORS   Curry,B.J., Su,H., Law,E.G., McLaughlin,E.A., Nixon,B. and
            Aitken,R.J.
  TITLE     Identification of RARhoGAP, a novel putative RhoGAP gene expressed
            in male germ cells
  JOURNAL   Genomics 84 (2), 406-418 (2004)
   PUBMED   15234003
REFERENCE   6  (bases 1 to 6109)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human KIAA1391 and mouse
            Kiaa1391 genes encoding novel RhoGAP family proteins with RA domain
            and ANXL repeats
  JOURNAL   Int J Oncol 23 (5), 1471-1476 (2003)
   PUBMED   14532992
  REMARK    GeneRIF: human KIAA1391 gene and mouse Kiaa1391 gene encode RhoGAP
            proteins with RA domain and two ANXL repeats
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP003460.3, AP001980.6 and
            AP001883.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 23, 2020 this sequence version replaced XM_006718893.3.
            
            Summary: The protein encoded by this gene is an activator of
            RHO-type GTPases, transducing a signal from RAP1 to RHO and
            impacting neurite outgrowth. [provided by RefSeq, Sep 2016].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB037812.1, SRR1660803.88308.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683387.1/ ENSP00000507405.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-311               AP003460.3         44105-44415         c
            312-394             AP003460.3         22525-22607         c
            395-559             AP001980.6         39932-40096         c
            560-709             AP001980.6         33467-33616         c
            710-751             AP001980.6         24858-24899         c
            752-836             AP001980.6         23866-23950         c
            837-914             AP001980.6         20614-20691         c
            915-981             AP001980.6         18289-18355         c
            982-1170            AP001980.6         15866-16054         c
            1171-1349           AP001980.6         1282-1460           c
            1350-1453           AP001980.6         11-114              c
            1454-1511           AP001883.6         112172-112229       c
            1512-1621           AP001883.6         107740-107849       c
            1622-1811           AP001883.6         105072-105261       c
            1812-1926           AP001883.6         103845-103959       c
            1927-6109           AP001883.6         98567-102749        c
FEATURES             Location/Qualifiers
     source          1..6109
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.3-q23.1"
     gene            1..6109
                     /gene="ARHGAP20"
                     /gene_synonym="RARHOGAP"
                     /note="Rho GTPase activating protein 20"
                     /db_xref="GeneID:57569"
                     /db_xref="HGNC:HGNC:18357"
                     /db_xref="MIM:609568"
     exon            1..311
                     /gene="ARHGAP20"
                     /gene_synonym="RARHOGAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..3782
                     /gene="ARHGAP20"
                     /gene_synonym="RARHOGAP"
                     /note="isoform 1 is encoded by transcript variant 6; RA
                     and RhoGAP domain containing protein; rho-type
                     GTPase-activating protein 20"
                     /codon_start=1
                     /product="rho GTPase-activating protein 20 isoform 1"
                     /protein_id="NP_001371586.1"
                     /db_xref="CCDS:CCDS31673.1"
                     /db_xref="GeneID:57569"
                     /db_xref="HGNC:HGNC:18357"
                     /db_xref="MIM:609568"
                     /translation="MEAMSPQQETLGGQPGRSSSLTGVSRLAGGSCTKKKMKTLAERR
                     RSAPSLILDKALQKRPTTRDSPSASVDTCTFLSSLVCSNRTLLIDGRAELKRGLQRQE
                     RHLFLFNDLFVVAKIKYNNNFKIKNKIKLTDMWTASCVDEVGEGNTNAMKSFVLGWPT
                     VNFVATFSSPEQKDKWLSLLQRYINLEKEKDYPKSIPLKIFAKDIGNCAYSKTITVMN
                     SDTANEVINMSLPMLGITGSERDYQLWVNSGKEEAPYPLIGHEYPYGIKMSHLRDSAL
                     LTPGSKDSTTPFNLQEPFLMEQLPREMQCQFILKPSRLAAAQQLSDSGHKTFKRRRSI
                     INWAFWRGSSTHLDNLPSSPTSPMPGQLFGISLPNICENDNLPKPVLDMLFFLNQKGP
                     LTKGIFRQSANVKSCRELKEKLNSGVEVHLDCESIFVIASVLKDFLRNIPGSIFSSDL
                     YDHWVSVMDQGNDEEKINTVQRLLDQLPRANVVLLRYLFGVLHNIEQHSSSNQMTAFN
                     LAVCVAPSILWPPASSSPELENEFTKKVSLLIQFLIENCLRIFGEEITSLFREVSVRC
                     DTRENASDISCFQLNDSSYDSLENELNEDVDAPCSDLVKKLGQGSRSMDSVLTLSDYD
                     LDQPEVEGLLTLSDFDLAHSKDEDVQMKRPLESKPVNILVYTKIPLRDHARAPSAMCT
                     PSYLSTAAANAAKSLRRHRRCSEPSIDYLDSKLSYLREFYQKKLRKSSCDAILSQKDE
                     DYLKQNQPLQEEGKTCFKQSLVTGTDVSKKNATTQNTKKKSLSGSEGNHVKLFPKSKP
                     VAISVASYSPMSSQDHSKNQPFDVNTSGYSPPHTADALKGPRTHRRCSEPNIEDQNRK
                     LTYLRGIYSKKQHKTSCEAGLLHGEEDYLKRHKSLQMEGQKLINQSLVMGIEVGKSSA
                     TNQNTEKVLPPRLNLCPRTSYSSLSSPGTSPSGSSVSSQDSAFSQISEHSVFTPTETS
                     SPIDCTFQAQRKREDLSPDFSNASHVSGMPGPSSGQACSRPAYTKKDTMEWHSQMHSV
                     TLHPSTWLRNGVASLKNWSLKKKAKAARPEEEKIASPKGPLEPPPHASGVPEANSLQE
                     EQKDLPLRAAEGLSPVQSAQRCSSSPFQDSERHCSSPFSLVESRLKLCMKSHEEIEPG
                     SQSSSGSLPWERASASSWTLEDATSPDSGPTVVCDIEDRYLTKDI"
     exon            312..394
                     /gene="ARHGAP20"
                     /gene_synonym="RARHOGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            395..559
                     /gene="ARHGAP20"
                     /gene_synonym="RARHOGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            560..709
                     /gene="ARHGAP20"
                     /gene_synonym="RARHOGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            710..751
                     /gene="ARHGAP20"
                     /gene_synonym="RARHOGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            752..836
                     /gene="ARHGAP20"
                     /gene_synonym="RARHOGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            837..914
                     /gene="ARHGAP20"
                     /gene_synonym="RARHOGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            915..981
                     /gene="ARHGAP20"
                     /gene_synonym="RARHOGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1170
                     /gene="ARHGAP20"
                     /gene_synonym="RARHOGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1349
                     /gene="ARHGAP20"
                     /gene_synonym="RARHOGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1511
                     /gene="ARHGAP20"
                     /gene_synonym="RARHOGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1621
                     /gene="ARHGAP20"
                     /gene_synonym="RARHOGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1811
                     /gene="ARHGAP20"
                     /gene_synonym="RARHOGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1926
                     /gene="ARHGAP20"
                     /gene_synonym="RARHOGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..6109
                     /gene="ARHGAP20"
                     /gene_synonym="RARHOGAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6079..6084
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP20"
                     /gene_synonym="RARHOGAP"
                     /note="hexamer: AATAAA"
     polyA_site      6109
                     /gene="ARHGAP20"
                     /gene_synonym="RARHOGAP"
                     /note="major polyA site"
ORIGIN      
        1 gcactcgcct ccagcccgcg gtgtcgagcg caggcggagg tacatggccc cgacgggagg
       61 cgcgcggcga gcacccggag ctcggctccc tgcctgagca cggcagccgc gcctccgccc
      121 gcgcgtcctc gcccctccgg ccggcagccc gcggacatga tcgtgtagcc tcctcctggg
      181 ctgggatttg tttgaagatt ttcttcatgg aagcgatgtc cccccagcag gagactctag
      241 ggggacagcc ggggcgctcc tcttccctga caggagtgtc tcggctcgcg ggaggcagct
      301 gcaccaagaa gaaaatgaaa acactagcag aaaggaggag gagcgctcca tctcttatcc
      361 tggataaagc cctacaaaaa cggcctacta ccagggacag tccttctgct agtgttgaca
      421 catgcacatt tctgtcatca ttagtgtgct ccaataggac tctgctgatt gatggccggg
      481 cagaactcaa aagaggcctc cagaggcagg agcggcatct tttcctattc aatgatctgt
      541 ttgttgtggc caaaatcaaa tataacaata actttaagat aaaaaataaa attaaattaa
      601 ctgatatgtg gacagcaagc tgtgtggatg aagtgggaga aggcaacacc aatgccatga
      661 aatcctttgt tttgggctgg cccacagtga actttgtggc cactttcagt tctccagaac
      721 aaaaggacaa atggctctct ctccttcaga gatacatcaa tctagagaaa gaaaaggact
      781 acccgaagag cattcccctc aaaatcttcg ccaaggacat tgggaattgt gcctactcta
      841 aaactataac agtaatgaat tcagatacag cgaatgaagt tatcaacatg tcattaccaa
      901 tgctagggat aactggctct gagagagatt accagttgtg ggtcaattct ggcaaagaag
      961 aggctccata cccactcatt gggcatgaat atccatatgg aattaaaatg agccatcttc
     1021 gagactctgc actcctgaca ccgggatcaa aggactctac cacccctttc aacctccagg
     1081 agcccttcct tatggaacag ctcccccgag agatgcagtg ccagttcatc ctgaagccca
     1141 gccgcctggc tgcagcccag caactgagtg attcaggtca taagacattt aaaaggagaa
     1201 gatctatcat aaactgggcc ttctggcgag gttctagcac tcacctggac aacttgccct
     1261 catcgccaac atcacctatg ccaggacagc tctttggaat ttctctgcca aatatttgtg
     1321 agaatgacaa tctgcccaaa cctgtcttgg atatgctttt ctttcttaat caaaaaggac
     1381 ctctcaccaa aggtatcttc aggcaatcag ccaatgtgaa atcctgcaga gaactaaaag
     1441 agaaattgaa ttctggagtc gaagtacacc tagactgtga atctattttt gtgatagcat
     1501 ctgtcttaaa ggattttctg cgaaatattc caggaagtat tttttcatca gatctctatg
     1561 atcactgggt ctctgtaatg gatcaaggaa atgatgaaga gaaaataaat actgttcaaa
     1621 ggctattaga ccagcttccg agagccaatg ttgttctcct aaggtatctt tttggggtgt
     1681 tacacaacat tgagcaacat tcctcatcca atcagatgac tgcatttaat ttagctgtgt
     1741 gtgtcgctcc aagtattctt tggcctcctg cttcctccag cccagaacta gaaaacgaat
     1801 ttacaaaaaa ggtttccctg cttatacaat ttctgattga gaattgcctt aggatatttg
     1861 gagaagaaat cacttccctc ttcagagagg tttcagtgag atgtgacact agagagaatg
     1921 cctcagatat ttcttgcttt caactgaatg actcctccta tgacagcttg gaaaatgagc
     1981 taaatgagga tgttgatgca ccatgcagtg acttggtaaa gaaacttggc caggggagca
     2041 gaagcatgga ctctgtctta accctcagtg actatgatct tgaccagccc gaggtggaag
     2101 gccttttaac cctaagcgac tttgacttgg cccattctaa agatgaagat gttcaaatga
     2161 aacggcctct tgaatccaag ccggtgaaca ttttagtgta cacaaagatc ccactgcggg
     2221 atcatgccag ggccccatct gccatgtgca cacccagcta cctgtccaca gctgcagcaa
     2281 atgctgcaaa aagcctgagg cgacaccggc gttgctcaga gcccagcatc gactatctgg
     2341 attcaaagct ttcctacctc agggagtttt atcagaaaaa gctacgcaag tccagctgtg
     2401 atgcaattct ttctcaaaaa gatgaagact atctgaagca gaatcaaccc ctccaggagg
     2461 aaggaaagac atgttttaaa cagagtttag tcacaggcac tgatgtcagc aagaaaaatg
     2521 ccactactca aaacactaag aagaaaagct tgtctggtag tgaaggaaat cacgtgaaac
     2581 ttttccctaa gtctaagcca gtggccattt ctgtggcatc ttatagtcct atgtcctcac
     2641 aggatcattc caagaaccag ccctttgatg tgaatacatc tggatactcc ccaccacaca
     2701 cagcagatgc cctcaagggt ccaaggacac atcggcgctg ctcagagccc aacatagaag
     2761 accagaaccg caagctgacc tatctcaggg gaatttattc aaagaaacaa cataaaacca
     2821 gctgtgaagc tggtctcttg catggagagg aggattatct caaacggcat aagtctttgc
     2881 aaatggaggg gcagaagctc attaatcaga gtttagtcat ggggattgag gtgggcaaga
     2941 gtagtgccac aaaccaaaac actgagaagg ttttaccccc aagattaaac ctttgcccaa
     3001 ggaccagcta ttccagctta tcctccccag gcacttcccc atccggctca tcagtaagct
     3061 cccaagacag tgctttttct cagatttctg aacactctgt gtttacaccc actgagactt
     3121 cctctccaat agattgcact tttcaggctc agagaaaacg ggaagacctt tctcctgact
     3181 ttagcaatgc cagccatgtt tccggaatgc ccggtccctc atcagggcag gcttgcagcc
     3241 gcccagccta tacaaagaag gacaccatgg agtggcattc acaaatgcat tctgtaactc
     3301 ttcatcccag cacatggttg agaaatggtg tggccagttt gaaaaactgg tccctcaaaa
     3361 agaaagcaaa ggcagccaga ccagaggaag agaaaatagc ttctccaaaa ggacccttag
     3421 agccaccccc acatgcttct ggtgttccag aagccaactc actgcaagag gaacaaaaag
     3481 acttgccctt aagggcagct gaaggactgt cccctgtgca gtcagcccaa aggtgtagtt
     3541 cttctccctt ccaggactca gagagacact gtagctctcc attcagcctg gtggagagca
     3601 gacttaagct gtgcatgaag tcacatgagg aaatagagcc tggtagtcag agctcttctg
     3661 gttctctgcc ttgggaaaga gcctcagcca gctcttggac tctagaggat gcgaccagcc
     3721 cagactcagg gcctacagtg gtctgcgaca ttgaggacag gtatttaacc aaagacattt
     3781 aagcatagta agaatctgat gtccacaaga acaggaactg ggttaataat aatagacaat
     3841 aattattatg acccctttgt ataagatacc tgggagaggt agcataagga ttatcattgc
     3901 taatacttag gacaacgaaa taattctctt tattgagact acttgacaaa tactttatgc
     3961 taaaaatttt gtcacctaag tgtttgggag gctttttctt attaaaggtt gggattggtc
     4021 ctgtcatgtg gttttagaga tactaacaga gggctagaga aagcatcttc tgcagaggaa
     4081 gcacttatgg gaacagtctg tgagattgat gtcctgagaa gaccaagata tcaggaatga
     4141 ggaatagggg cctgaggaga gaggggaagg gtacagagaa accatctaca ttccatggaa
     4201 tgtttttaat aagtaggcaa gaaaaatgcc actaatcaaa gcattaagtg tgtccagtaa
     4261 tgaagaacat catataaaat ctttccctaa atctaagcca gtggccattt ttgtgggatc
     4321 ttactaatca cgtgtcctta cagaatcatt ccaagaacca gcccattgct acagctagag
     4381 tggagaaaaa cagagtgact caaaagccat gggtaccatg atatcagttt tgttggttgt
     4441 atttgtcggt ttgttttttc attcatgttg aagtgctttg caaggcttca ggaaacagag
     4501 ttgtgaggag aaagaagaaa atggctgccc atttcagtac cctttcaaag gtatctctgc
     4561 ctaggaacat tcttcagaaa tgcaacttct tctatttaga aggtgacctc ctgacagcgt
     4621 tcactctcaa tatggaggaa aagaccacaa caactgtcct ttctcaatta cacaaatgct
     4681 gttaaaatgt gatcaaacca tggcatcact ttgctgaaat gtttctgcac agtcctgcct
     4741 cttagattac agtcagccag aaaaacatac ttataaatca tcccttttct gatttttgta
     4801 gtttggcaat tgagagagca atattgaggt tggccggtta taaggagtcc cacaatagaa
     4861 tacccaacaa agtggctgcc aggccttctc agacagccat ttgctttggg ttttgcttcc
     4921 agacgttgtt ccatattttt gccccaaatg tttcatggct tataccccat tggtttattt
     4981 tatatccatg gacctttctt tctctgcttt cttgacttaa aggttgcagc agtacatctc
     5041 gtcacctagg aatagattat caggccttgc caactagtat gcagggatgg cactaaaaat
     5101 ggatgtgcat cttctttcac attaactact aacctataag aagttgctct gagcccattt
     5161 atttaaactc tttagttcac catcagatgg acctttctct cacaagctag cttattccaa
     5221 attatttgtc ttattaatca ccagaaaatg gtcatatcaa atgttctttc ttttttgttc
     5281 taaaggttgc attttcagtt ataggggaaa aaatattttc tctaagatag aagaagttat
     5341 ttcagtatta gctataggtg ctacctacct cttggggaca tggccctgtt tgcgctaacc
     5401 attacaatga tcttttagaa ctctgtatcc aaagagctac ttcgtgacac tggccatctg
     5461 agtcacagat gtgaagtcga tttcacttta taactaacca gtcctacata ttaagacttc
     5521 taagtgtcca tatgcatctt ttttggtata atatataaag tcagcaggga ctcccctttc
     5581 ccttagggca tactactgtc agtcagaact gcaagatgtg aatgaagctc ttaacggctt
     5641 ggagtgtctt tctggaagaa attgcctttt tttttttttt catgttagca ggtaaaaaat
     5701 cattcaccca atttgaagca tagaagaaaa tagttgctga ggttttttaa taaccattcc
     5761 tactatctgt gttcccttag atactcctgt aattcttaat gtgaatagtt tgttaatatt
     5821 gctgtaaagt attatattgt atgatttgaa gacagactat atgtcatttt attatactcc
     5881 atcaatctat aatatattag actgatgctt tatctaaaat gctttgagtt tgtataatat
     5941 atcttgacaa attttactac catatgttat gtaataaatg tgtatttttg tacttgcaga
     6001 aactgctgct aacttttaaa gttgtttggt tttcaaggca ctgataatgg atatgtatga
     6061 agtccatgct gtctgttaaa taaaatgcca ttctgcagaa ttaaccatc
//
