LOCUS       NM_032900               5438 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens Rho GTPase activating protein 19 (ARHGAP19),
            transcript variant 1, mRNA.
ACCESSION   NM_032900
VERSION     NM_032900.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5438)
  AUTHORS   Vajen,B., Greiwe,L., Schaffer,V., Eilers,M., Huge,N., Stalke,A.,
            Schlegelberger,B., Illig,T. and Skawran,B.
  TITLE     MicroRNA-192-5p inhibits migration of triple negative breast cancer
            cells and directly regulates Rho GTPase activating protein 19
  JOURNAL   Genes Chromosomes Cancer 60 (11), 733-742 (2021)
   PUBMED   34296808
  REMARK    GeneRIF: MicroRNA-192-5p inhibits migration of triple negative
            breast cancer cells and directly regulates Rho GTPase activating
            protein 19.
REFERENCE   2  (bases 1 to 5438)
  AUTHORS   Liang,J., Li,K., Chen,K., Liang,J., Qin,T., He,J., Shi,S., Tan,Q.
            and Wang,Z.
  TITLE     Regulation of ARHGAP19 in the endometrial epithelium: a possible
            role in the establishment of uterine receptivity
  JOURNAL   Reprod Biol Endocrinol 19 (1), 2 (2021)
   PUBMED   33407571
  REMARK    GeneRIF: Regulation of ARHGAP19 in the endometrial epithelium: a
            possible role in the establishment of uterine receptivity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5438)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 5438)
  AUTHORS   Marceaux,C., Petit,D., Bertoglio,J. and David,M.D.
  TITLE     Phosphorylation of ARHGAP19 by CDK1 and ROCK regulates its
            subcellular localization and function during mitosis
  JOURNAL   J Cell Sci 131 (5) (2018)
   PUBMED   29420299
  REMARK    GeneRIF: The docking of 14-3-3 proteins to phosphorylated S422
            protects ARHGAP19 from dephosphorylation of the threonine sites and
            prevents ARHGAP19 from relocating to the plasma membrane during
            prophase and metaphase, thus allowing RhoA to become activated
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5438)
  AUTHORS   David,M.D., Petit,D. and Bertoglio,J.
  TITLE     The RhoGAP ARHGAP19 controls cytokinesis and chromosome segregation
            in T lymphocytes
  JOURNAL   J Cell Sci 127 (Pt 2), 400-410 (2014)
   PUBMED   24259668
REFERENCE   6  (bases 1 to 5438)
  AUTHORS   Lv,L., Xu,J., Zhao,S., Chen,C., Zhao,X., Gu,S., Ji,C., Xie,Y. and
            Mao,Y.
  TITLE     Sequence analysis of a human RhoGAP domain-containing gene and
            characterization of its expression in human multiple tissues
  JOURNAL   DNA Seq 18 (3), 184-189 (2007)
   PUBMED   17454002
  REMARK    GeneRIF: sequence analysis of the ARHGAP19 gene and its genomic
            structure, expression profile and sub-cellular localization
REFERENCE   7  (bases 1 to 5438)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   8  (bases 1 to 5438)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL359385.28.
            
            On Nov 23, 2018 this sequence version replaced NM_032900.5.
            
            Summary: Members of the ARHGAP family, such as ARHGAP19, encode
            negative regulators of Rho GTPases (see RHOA; MIM 165390), which
            are involved in cell migration, proliferation, and differentiation,
            actin remodeling, and G1 cell cycle progression (Lv et al., 2007
            [PubMed 17454002]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648189.1, SRR1803616.136619.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358531.9/ ENSP00000351333.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                AL359385.28        91857-91922         c
            67-332              AL359385.28        65145-65410         c
            333-413             AL359385.28        64111-64191         c
            414-623             AL359385.28        62705-62914         c
            624-850             AL359385.28        58687-58913         c
            851-937             AL359385.28        55603-55689         c
            938-1003            AL359385.28        45557-45622         c
            1004-1195           AL359385.28        43253-43444         c
            1196-1294           AL359385.28        34502-34600         c
            1295-1405           AL359385.28        29049-29159         c
            1406-1484           AL359385.28        28432-28510         c
            1485-5438           AL359385.28        21464-25417         c
FEATURES             Location/Qualifiers
     source          1..5438
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.1"
     gene            1..5438
                     /gene="ARHGAP19"
                     /note="Rho GTPase activating protein 19"
                     /db_xref="GeneID:84986"
                     /db_xref="HGNC:HGNC:23724"
                     /db_xref="MIM:611587"
     exon            1..66
                     /gene="ARHGAP19"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..1495
                     /gene="ARHGAP19"
                     /note="isoform 1 is encoded by transcript variant 1;
                     putative RhoGAP protein; rho-type GTPase-activating
                     protein 19"
                     /codon_start=1
                     /product="rho GTPase-activating protein 19 isoform 1"
                     /protein_id="NP_116289.4"
                     /db_xref="CCDS:CCDS7454.2"
                     /db_xref="GeneID:84986"
                     /db_xref="HGNC:HGNC:23724"
                     /db_xref="MIM:611587"
                     /translation="MATEAQSEGEVPARESGRSDAICSFVICNDSSLRGQPIIFNPDF
                     FVEKLRHEKPEIFTELVVSNITRLIDLPGTELAQLMGEVDLKLPGGAGPASGFFRSLM
                     SLKRKEKGVIFGSPLTEEGIAQIYQLIEYLHKNLRVEGLFRVPGNSVRQQILRDALNN
                     GTDIDLESGEFHSNDVATLLKMFLGELPEPLLTHKHFNAHLKIADLMQFDDKGNKTNI
                     PDKDRQIEALQLLFLILPPPNRNLLKLLLDLLYQTAKKQDKNKMSAYNLALMFAPHVL
                     WPKNVTANDLQENITKLNSGMAFMIKHSQKLFKAPAYIRECARLHYLGSRTQASKDDL
                     DLIASCHTKSFQLAKSQKRNRVDSCPHQEETQHHTEEALRELFQHVHDMPESAKKKQL
                     IRQFNKQSLTQTPGREPSTSQVQKRARSRSFSGLIKRKVLGNQMMSEKKKKNPTPESV
                     AIGELKGTSKENRNLLFSGSPAVTMTPTRLKWSEGKKEGKKGFL"
     exon            67..332
                     /gene="ARHGAP19"
                     /inference="alignment:Splign:2.1.0"
     exon            333..413
                     /gene="ARHGAP19"
                     /inference="alignment:Splign:2.1.0"
     exon            414..623
                     /gene="ARHGAP19"
                     /inference="alignment:Splign:2.1.0"
     exon            624..850
                     /gene="ARHGAP19"
                     /inference="alignment:Splign:2.1.0"
     exon            851..937
                     /gene="ARHGAP19"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1003
                     /gene="ARHGAP19"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1195
                     /gene="ARHGAP19"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1294
                     /gene="ARHGAP19"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1405
                     /gene="ARHGAP19"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1484
                     /gene="ARHGAP19"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..5438
                     /gene="ARHGAP19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5417..5422
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP19"
                     /note="hexamer: ATTAAA"
     polyA_site      5438
                     /gene="ARHGAP19"
                     /note="major polyA site"
ORIGIN      
        1 gctgacgaag atggcgactg aggcacagag tgaaggggag gtgccagccc gcgaatccgg
       61 ccggagtgat gccatctgca gttttgtgat ctgcaatgat tcttcccttc gaggtcagcc
      121 cattatcttt aatcctgact tttttgtgga gaaactccga catgagaaac ctgagatttt
      181 cactgagttg gtggtcagca atatcacaag gctcatcgat ttacctggaa ctgagttggc
      241 tcagctgatg ggggaagtgg accttaagtt gcctggcggg gctggcccag catcaggatt
      301 cttccggtct ctcatgtctc tcaagcgaaa ggaaaaagga gtgatatttg ggtccccact
      361 gacggaggaa ggcattgccc agatatacca actgattgag tatctacaca aaaacttgcg
      421 agtagagggt ttgtttagag taccgggtaa tagtgtccga cagcagattt taagggatgc
      481 tctcaataat ggaactgaca ttgacttgga atcaggggaa tttcactcaa atgatgttgc
      541 cactttgctg aagatgtttc taggagagtt gccggagcct ctgctgacac ataaacactt
      601 caatgcacac ctcaaaatcg ctgatttgat gcagtttgat gataaaggaa acaagaccaa
      661 tataccagac aaggaccggc aaattgaggc tctccagttg ctcttcctca ttctccctcc
      721 tcctaatcgt aatttgctga agttattgct tgatctccta taccagacag caaagaaaca
      781 agacaagaac aagatgtcag cctataacct tgcccttatg tttgcacccc atgtcctgtg
      841 gccaaaaaat gtcactgcaa atgaccttca ggagaatatc acaaagttaa acagtgggat
      901 ggcttttatg attaaacact cccagaaact ttttaaggct cctgcttaca ttcgggagtg
      961 tgcgagattg cactatttgg gatccagaac tcaggcatca aaggatgacc ttgacctcat
     1021 agcttcatgt catactaagt cctttcagct ggcaaagtct cagaaacgga accgggtaga
     1081 ttcctgccct caccaggagg agacccagca ccatacggaa gaggcactga gagagctgtt
     1141 tcaacacgtt catgatatgc cagagtcagc aaagaagaaa caacttatta gacagtttaa
     1201 taagcaatca ttgacccaga caccagggcg agaaccttct acttcccagg tacaaaagag
     1261 ggctcgttcg cgctccttca gtgggcttat taagcggaag gtcctgggaa atcagatgat
     1321 gtcagaaaag aaaaagaaga accctactcc agaatctgtg gccattggtg aattgaaggg
     1381 aaccagcaaa gaaaatagga acttattatt ttctggctct ccagctgtca cgatgacacc
     1441 aacaagattg aagtggtctg aagggaagaa agaggggaaa aaaggatttc tctgaaggat
     1501 ccagagttgt ctcctatggt ccatgcagaa ttttctgttt agtgggcagg tgttattcct
     1561 gcccacagca aagcttggac ttgcagcttg cttgctgcat tttgaattgt caaagccaac
     1621 taataccgtg acccgactga tacctctaac cccactcact ggatgatgtt tgcaagctgt
     1681 gccttctgag agagtgctta ggccctgtct ctctttttta atattatggg gaaaccacta
     1741 actatccaac cagcttatac agcacactaa ggtgggcttc agtgctcact caatgtgttt
     1801 aggcagattc cacttttgaa aaaaaatatg aaatgtgtgc tcaactgcca gtaatttttt
     1861 aaaaagcact gtcccagtgg attgatgttg tttttaatgg atattttggg tttttctctg
     1921 ttttgatagt attgggtatt tggttgtttt tgtttgttta tttctttgtt ttaaaagcca
     1981 tgtttttggt tgggctctaa gctagatatc tttccctctt tttcactttg agctttggga
     2041 aaactcttta tcttatgagg ctgtattcct caatacctaa tttgtgtcca aagaatttat
     2101 agcttttctg gacatttttt attatttctt gggtgtgaca tcagagtatt tgacctgcag
     2161 tattgaaaaa ggagaattca gaatgataca gtattttaac aaatcttaat tattaaactc
     2221 ttttccttcc ttccatttct ccctcccttg tccatctctc tctctctttc cctttcctca
     2281 gtgatgtgaa aataattgtg ttttgctgaa cttgttatct tcattcaatt tcctcttgac
     2341 taaaacatct ctggtgccaa cgtaatactt ctgaaccaaa tcactgtgac tcaaggaaag
     2401 tcactgacag cataagagaa gtttgctaaa atatttgtat gtgggggaag ctctggagtg
     2461 tgcctaggag ggggctggct gcctttatgt cccaggatga ctctttatgg gtgggattac
     2521 attgcaccct ctgagggtgc aggctagacc gtctcctgag aggaagttag gatcagaaag
     2581 aagaagcaag cagcaacctc tgcagggctg acaggattta aaggagagaa tgttcttatt
     2641 tggaagcagc tgtggcttgt caccaatgtt caaggagtgt tactgttccg ccctctcttt
     2701 gtcagaaggg acacaggtgg taatttggag atggggccag agcttctggc ttttggattt
     2761 ggtgtgttca cttgtgttgg atagagcagt ggcatggctt tgacctagta tgaactggtg
     2821 tctgcccaga gagcagcatg tagcaggggg gaatgctcag gtttgtgcct ggctctgtgg
     2881 agctgtacaa cccttctcac cctgtgggtt ggagccgagt caggccacta tggggaagca
     2941 gttgccccac aaaatgtggt ttgctgacct atttctaaac tgttgaatat gctgcaccat
     3001 tgctgaaatg aaagatgact ctgggggagc agagcttggc cttgtgccca gctggcagcc
     3061 ccctctgcca gcctttctgc tgcttttgct gctgtaacag caatagtgga gaaaaatgta
     3121 aaatttggtc ttccagctta atgcagtgtg aacaatagat ggttaggaaa acaaaactgc
     3181 ttagaagccc ctttctctag agcagtttta tgtcatttgt aaaaacacat attagcaaat
     3241 tcgtttgcgt aggtttctat taaatatttg actttttttt tcttattaag aaaatgaaat
     3301 cccttacacc agatatcagt taattcaaac agaaaaccct ttgggtatca ccaaattgaa
     3361 atggtattct tccttaactc ttccttcttt cctttatttg tttagacgtg cttcatcccg
     3421 aagtggtgct atggtctgtt aaacagggct ggcatcaggt agagggagca gagtggtgac
     3481 ctgatagctc ctgtcatcgt gttagttttt gattctattt aagggaagta gctgagattt
     3541 agacggatgt agatgctctt tgggtgaatg gaatcataag caaaggttgt gttctggggt
     3601 gaggatcatg agagagatat ttatcacatg cacatgcctt tatatagctg gtctccttgg
     3661 gtggtttatg tgtgttttgt ttatttattg aatatgtttt cccttgcttt aggggtttta
     3721 taggtcattt ttcttaatag aagctgtgat cgacttagaa tccaaatttg aggagtaagc
     3781 agcataacct tctaccttgt aatatgtaac tattctaatc cagtggaatc ttacggaaaa
     3841 cacagagaaa acccctttta tcatttgcca cagaaggctg ctgtctccct tctgatttgg
     3901 tgggcaggta ttgtttttga gccagtattt aacagagttt tttaatctat aagatttttt
     3961 ttgaatctat ttcattgtgt ttgtttttca tgttggaaca atctctctgg aagtgcctct
     4021 tcttgtggct tttacaactt catttctttc tggggtcacc tgtgatgggc tttgatgtgg
     4081 tgtcaatttg gggccttgtg tttgtgccag agggatacac atattaaact gcaggccacc
     4141 ttcctggtcc agactgtact gtgtgaaccc cactgactaa attagtgaga accataggcg
     4201 ttggaatttc tcacctttta caatgataga cttttgcatt gggaccaatg aatctggtgt
     4261 gaaaaaccct gctgtagtag tgaaagagca tcaggagata ctgactgtac ctgagggcca
     4321 aaacaggagc aggtaacgaa ccgtaaaaaa aggagcaggt aatgaatcgt aaccaaaact
     4381 acagttgatc ctccgcaaag gaaagctctt tacccagaat gtccttccag agtcattcag
     4441 gaaggacaag ggaacaccct tgggaaatgg gctagtggag ggctgttgac tgcagtgaca
     4501 cctgggtgct ccggaggtat ctgttctgtt gacctgtaag gaagcagtcg atcctagagt
     4561 gtcagaacag agccattctc tcctcctgag taggaacgtt tctgttcagt ttccctcaca
     4621 gcagcctgtg ttagcatgca gttgaaaata ctgccgtcta ggagaacctg tggtcactgg
     4681 gaacgtgccc cacagtgact ggccatgcaa ccaggtgatt tttaggaata gatgtctcta
     4741 gactctgtct cctttcctac aaggcctcac acagatgctt gaggctaatg gcccccattc
     4801 tgaggtcatt tttgtgtaga actcctttcc ccaggagaga gccttatctc tgccctcctt
     4861 taccctgaag gcttcaaacg gaagacagga cctagatcta aacctagata ctagcatttt
     4921 gtgggattgt ctagaatttg gggaagattt gggttcctaa gatgcacaag cgttttacac
     4981 cagtggtgat taactcaact aaaacccact gtaggaagtt agcttcccca gacagctaat
     5041 gccgagatct tctaccagcg tagagttgac agaagcaggc cagcgaggag gtgtgggaca
     5101 taatagcctg agtgcttggg ttaccatgga gactggagtg tgtgaggcca cagcctgtgc
     5161 taaagagcca tggagccctc ccctggccat gtctggggac agatagaacc tgttggggga
     5221 aatattccct caccccaggg ttctttctgc agagcaaggg ttgcctttgt cctatccctg
     5281 agcttgctca acaagagaaa caaggtttct taagtgtttt ggttaaagtt ttcattctta
     5341 tttgactatg tatatgtaat tgtaaagaaa cgatcctatg cattgtcttt cttttatatt
     5401 cttgtaatat tctgaaatta aaattgtttt gtttcata
//
