LOCUS       NM_033515               4414 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens Rho GTPase activating protein 18 (ARHGAP18), mRNA.
ACCESSION   NM_033515
VERSION     NM_033515.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4414)
  AUTHORS   Chen,P., Liu,X., Liu,Y., Bao,X. and Wu,Q.
  TITLE     ARHGAP18 is Upregulated by Transcription Factor GATA1 Promotes the
            Proliferation and Invasion in Hepatocellular Carcinoma
  JOURNAL   Appl Biochem Biotechnol 196 (2), 679-689 (2024)
   PUBMED   37171759
  REMARK    GeneRIF: ARHGAP18 is Upregulated by Transcription Factor GATA1
            Promotes the Proliferation and Invasion in Hepatocellular
            Carcinoma.
REFERENCE   2  (bases 1 to 4414)
  AUTHORS   Dibus,M., Brabek,J. and Rosel,D.
  TITLE     A Screen for PKN3 Substrates Reveals an Activating Phosphorylation
            of ARHGAP18
  JOURNAL   Int J Mol Sci 21 (20), 7769 (2020)
   PUBMED   33092266
  REMARK    GeneRIF: A Screen for PKN3 Substrates Reveals an Activating
            Phosphorylation of ARHGAP18.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4414)
  AUTHORS   Coleman,P.R., Lay,A.J., Ting,K.K., Zhao,Y., Li,J., Jarrah,S.,
            Vadas,M.A. and Gamble,J.R.
  TITLE     YAP and the RhoC regulator ARHGAP18, are required to mediate
            flow-dependent endothelial cell alignment
  JOURNAL   Cell Commun Signal 18 (1), 18 (2020)
   PUBMED   32013974
  REMARK    GeneRIF: YAP and the RhoC regulator ARHGAP18, are required to
            mediate flow-dependent endothelial cell alignment.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4414)
  AUTHORS   Jomoui,W., Tepakhan,W., Yamsri,S., Srivorakun,H., Fucharoen,G. and
            Fucharoen,S.
  TITLE     A novel SNP rs11759328 on Rho GTPase-activating protein 18 gene is
            associated with the expression of Hb F in hemoglobin E-related
            disorders
  JOURNAL   Ann Hematol 99 (1), 23-29 (2020)
   PUBMED   31776727
  REMARK    GeneRIF: novel SNP rs11759328 on Rho GTPase-activating protein 18
            gene is associated with the expression of Hb F in hemoglobin
            E-related disorders.
REFERENCE   5  (bases 1 to 4414)
  AUTHORS   Chen,J., Huang,X., Wang,W., Xie,H., Li,J., Hu,Z., Zheng,Z., Li,H.
            and Teng,L.
  TITLE     LncRNA CDKN2BAS predicts poor prognosis in patients with
            hepatocellular carcinoma and promotes metastasis via the
            miR-153-5p/ARHGAP18 signaling axis
  JOURNAL   Aging (Albany NY) 10 (11), 3371-3381 (2018)
   PUBMED   30510148
  REMARK    GeneRIF: This study revealed that lncRNA CDKN2BAS promotes HCC
            metastasis by regulating the miR-153-5p/ARHGAP18 signaling.
REFERENCE   6  (bases 1 to 4414)
  AUTHORS   Cronin,S., Tomik,B., Bradley,D.G., Slowik,A. and Hardiman,O.
  TITLE     Screening for replication of genome-wide SNP associations in
            sporadic ALS
  JOURNAL   Eur J Hum Genet 17 (2), 213-218 (2009)
   PUBMED   18987618
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   7  (bases 1 to 4414)
  AUTHORS   Li,X., Liu,Q., Liu,S., Zhang,J. and Zhang,Y.
  TITLE     New member of the guanosine triphosphatase activating protein
            family in the human epididymis
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 40 (10), 855-863 (2008)
   PUBMED   18850050
REFERENCE   8  (bases 1 to 4414)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   9  (bases 1 to 4414)
  AUTHORS   Lehner,B. and Sanderson,C.M.
  TITLE     A protein interaction framework for human mRNA degradation
  JOURNAL   Genome Res 14 (7), 1315-1323 (2004)
   PUBMED   15231747
REFERENCE   10 (bases 1 to 4414)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB149638.1, BM557223.1, AB053293.1 and AL450310.18.
            
            On Nov 22, 2018 this sequence version replaced NM_033515.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.158316.1,
                                           SRR1803614.93837.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368149.3/ ENSP00000357131.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               CB149638.1         49-155
            108-786             BM557223.1         93-771
            787-3451            AB053293.1         633-3297
            3452-4414           AL450310.18        30892-31854         c
FEATURES             Location/Qualifiers
     source          1..4414
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q22.33"
     gene            1..4414
                     /gene="ARHGAP18"
                     /gene_synonym="bA307O14.2; MacGAP; SENEX"
                     /note="Rho GTPase activating protein 18"
                     /db_xref="GeneID:93663"
                     /db_xref="HGNC:HGNC:21035"
                     /db_xref="MIM:613351"
     exon            1..154
                     /gene="ARHGAP18"
                     /gene_synonym="bA307O14.2; MacGAP; SENEX"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..2033
                     /gene="ARHGAP18"
                     /gene_synonym="bA307O14.2; MacGAP; SENEX"
                     /note="rho-type GTPase-activating protein 18"
                     /codon_start=1
                     /product="rho GTPase-activating protein 18"
                     /protein_id="NP_277050.2"
                     /db_xref="CCDS:CCDS34535.1"
                     /db_xref="GeneID:93663"
                     /db_xref="HGNC:HGNC:21035"
                     /db_xref="MIM:613351"
                     /translation="MSWLSSSQGVVLTAYHPSGKDQTVGNSHAKAGEEATSSRRYGQY
                     TMNQESTTIKVMEKPPFDRSISQDSLDELSMEDYWIELENIKKSSENSQEDQEVVVVK
                     EPDEGELEEEWLKEAGLSNLFGESAGDPQESIVFLSTLTRTQAAAVQKRVETVSQTLR
                     KKNKQYQIPDVRDIFAQQRESKETAPGGTESQSLRTNENKYQGRDDEASNLVGEEKLI
                     PPEETPAPETDINLEVSFAEQALNQKESSKEKIQKSKGDDATLPSFRLPKDKTGTTRI
                     GDLAPQDMKKVCHLALIELTALYDVLGIELKQQKAVKIKTKDSGLFCVPLTALLEQDQ
                     RKVPGMRIPLIFQKLISRIEERGLETEGLLRIPGAAIRIKNLCQELEAKFYEGTFNWE
                     SVKQHDAASLLKLFIRELPQPLLSVEYLKAFQAVQNLPTKKQQLQALNLLVILLPDAN
                     RDTLKALLEFLQRVIDNKEKNKMTVMNVAMVMAPNLFMCHALGLKSSEQREFVMAAGT
                     ANTMHLLIKYQKLLWTIPKFIVNQVRKQNTENHKKDKRAMKKLLKKMAYDREKYEKQD
                     KSTNDADVPQGVIRVQAPHLSKVSMAIQLTEELKASDVLARFLSQESGVAQTLKKGEV
                     FLYEIGGNIGERCLDDDTYMKDLYQLNPNAEWVIKSKPL"
     exon            155..357
                     /gene="ARHGAP18"
                     /gene_synonym="bA307O14.2; MacGAP; SENEX"
                     /inference="alignment:Splign:2.1.0"
     exon            358..593
                     /gene="ARHGAP18"
                     /gene_synonym="bA307O14.2; MacGAP; SENEX"
                     /inference="alignment:Splign:2.1.0"
     exon            594..657
                     /gene="ARHGAP18"
                     /gene_synonym="bA307O14.2; MacGAP; SENEX"
                     /inference="alignment:Splign:2.1.0"
     exon            658..827
                     /gene="ARHGAP18"
                     /gene_synonym="bA307O14.2; MacGAP; SENEX"
                     /inference="alignment:Splign:2.1.0"
     exon            828..993
                     /gene="ARHGAP18"
                     /gene_synonym="bA307O14.2; MacGAP; SENEX"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1085
                     /gene="ARHGAP18"
                     /gene_synonym="bA307O14.2; MacGAP; SENEX"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1163
                     /gene="ARHGAP18"
                     /gene_synonym="bA307O14.2; MacGAP; SENEX"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1323
                     /gene="ARHGAP18"
                     /gene_synonym="bA307O14.2; MacGAP; SENEX"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1406
                     /gene="ARHGAP18"
                     /gene_synonym="bA307O14.2; MacGAP; SENEX"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1613
                     /gene="ARHGAP18"
                     /gene_synonym="bA307O14.2; MacGAP; SENEX"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1754
                     /gene="ARHGAP18"
                     /gene_synonym="bA307O14.2; MacGAP; SENEX"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1879
                     /gene="ARHGAP18"
                     /gene_synonym="bA307O14.2; MacGAP; SENEX"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..1941
                     /gene="ARHGAP18"
                     /gene_synonym="bA307O14.2; MacGAP; SENEX"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..4414
                     /gene="ARHGAP18"
                     /gene_synonym="bA307O14.2; MacGAP; SENEX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3186..3191
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP18"
                     /gene_synonym="bA307O14.2; MacGAP; SENEX"
                     /note="hexamer: AATAAA"
     polyA_site      3214
                     /gene="ARHGAP18"
                     /gene_synonym="bA307O14.2; MacGAP; SENEX"
                     /note="major polyA site"
     regulatory      3429..3434
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP18"
                     /gene_synonym="bA307O14.2; MacGAP; SENEX"
                     /note="hexamer: ATTAAA"
     polyA_site      3451
                     /gene="ARHGAP18"
                     /gene_synonym="bA307O14.2; MacGAP; SENEX"
                     /note="major polyA site"
     regulatory      4381..4386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP18"
                     /gene_synonym="bA307O14.2; MacGAP; SENEX"
                     /note="hexamer: AATAAA"
     regulatory      4391..4396
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP18"
                     /gene_synonym="bA307O14.2; MacGAP; SENEX"
                     /note="hexamer: AATATA"
     polyA_site      4401
                     /gene="ARHGAP18"
                     /gene_synonym="bA307O14.2; MacGAP; SENEX"
     polyA_site      4414
                     /gene="ARHGAP18"
                     /gene_synonym="bA307O14.2; MacGAP; SENEX"
ORIGIN      
        1 ctctgtgtca ggatcgcaga aagtatgtcc cttctctcac catgagctgg ctctccagtt
       61 cccagggagt ggtactaaca gcctaccacc ccagcggcaa ggaccagacc gtcgggaaca
      121 gccatgcaaa ggcaggggag gaagccacct cgagtcgcag atatggccag tacactatga
      181 accaggaaag caccaccatc aaagttatgg agaagcctcc atttgatcga tcaatttccc
      241 aggattcttt ggatgaacta tctatggaag actattggat agaactagaa aacatcaaga
      301 aatctagtga aaacagccaa gaagatcaag aggtggttgt tgtcaaagag cctgatgagg
      361 gagaattgga agaagagtgg cttaaagagg ccggtttatc caatctcttc ggagagtctg
      421 ctggagatcc acaggaaagc attgtgtttt tatcaacatt gacgcggacc caggcagcag
      481 cagttcagaa gcgagtagag acggtctccc agaccttgag gaaaaaaaac aaacagtacc
      541 agattcctga cgtcagagac atatttgctc aacagagaga atcaaaagaa acagctccag
      601 gtggcactga atcgcagtca cttagaacaa atgaaaacaa ataccaagga agagatgacg
      661 aggcatctaa ccttgttggt gaagagaagc tgatcccacc tgaggagacg cctgcccctg
      721 aaacagacat caacctggag gtatcatttg ccgagcaagc actcaatcag aaagagagct
      781 ccaaggagaa aatccagaag agcaaaggcg atgatgccac attacctagt ttcagattgc
      841 caaaagacaa aacgggtacc acaaggattg gtgacctcgc accccaggac atgaagaaag
      901 tttgccattt agccctaatt gagctgactg ccctctatga tgtattgggt attgagctga
      961 aacaacaaaa agctgtgaaa atcaaaacaa aagattctgg tcttttttgc gttccattga
     1021 cagcgctatt agaacaagat cagaggaaag taccaggaat gcgaataccc ttgatctttc
     1081 aaaaactgat ttctcgaatt gaagagagag gtttggaaac agaaggcctc ttacggatcc
     1141 ctggagctgc cattagaatc aagaatcttt gccaagaact agaagcaaag ttttatgaag
     1201 ggacttttaa ttgggaaagt gtcaaacagc atgatgccgc cagcctgctg aagctcttca
     1261 ttcgggagtt gccccagcca ctgctcagtg tggagtatct caaagccttt caggctgtcc
     1321 agaatcttcc aaccaagaag cagcaactac aggctttgaa ccttcttgtc atcctcctac
     1381 ctgatgcaaa cagggacaca ctgaaggccc ttcttgaatt tctccaaaga gtaatagata
     1441 ataaagaaaa aaataaaatg acagtcatga atgtagcaat ggtcatggcc ccgaatctct
     1501 ttatgtgtca tgcattggga ttgaagtcca gtgaacagcg agaatttgta atggcagctg
     1561 ggacagcaaa taccatgcac ttattgatta agtaccaaaa acttctgtgg acaattccca
     1621 agtttattgt aaaccaagtg aggaagcaaa acacggaaaa tcataaaaag gataaaagag
     1681 ccatgaagaa attgctgaag aaaatggctt atgaccgaga aaaatatgaa aagcaagata
     1741 agagtacaaa tgatgctgac gttcctcagg gagtgattcg agtgcaagct ccccatcttt
     1801 cgaaagtttc catggcaata cagctaactg aagaactaaa agccagtgat gtacttgcca
     1861 ggtttctcag ccaagaaagt ggggttgccc agactctcaa gaaaggagaa gtttttttgt
     1921 atgaaattgg aggaaatatt ggggaacgct gccttgatga tgacacttac atgaaggatt
     1981 tatatcagct taacccaaat gctgagtggg ttataaagtc aaagccattg tagaagactt
     2041 aacaagctgc agataaccat gtggacttct gtcataattc ttgctgagtc aagagtgtaa
     2101 ataaaagaaa tggcaggact catattattc agttgtaccc aagtatttaa aaatgactct
     2161 cttaagcctt aaaaagtcat agatttgtgc tgctgccaga attatattaa ttattattaa
     2221 tgttattatt agaaaaaaaa tttctggagt gagagtaaag aggcttaatt agtttgtggg
     2281 cagttttcat atgctctgtg aaatgtgtcc agatgtgaca tagttttttt ttttaatatg
     2341 tggaaatgtc ttctcttccc attcttttct cctaaaatca tatatactgt aatatatgct
     2401 ctctcacctc tattacctcc tcacatctac cctttcccag ttaggtttgc tttttgacca
     2461 aaaagataac aaataccagg tatggcaagt tgtgaagaca gcacattaaa acatacctaa
     2521 tttcacagta ttcctgtcac gacagaatgt tagtattcat ctctttgaat catttgctca
     2581 aataataaca ttccaccttt tcctgctgta tcacaggaag tgatttgcat tttttttcag
     2641 ttcatctgac ttatgttcac agaaccgtat cagcgaccaa gaaaatagga ctgtcagaag
     2701 ctgccagtta ttactgaacc attaaatact tatatactaa gaataaataa aatataccca
     2761 tgtgaaataa taattggatt atggataaca agagagtgaa agccaaagca ctttctgtct
     2821 actgtactct tctaaatgga attttaaaag tcatagctgg ctttacgtgt tgtcattatt
     2881 agcattataa atatgcatga tagtataatc cagtaatggt tgaagaatgt attttactta
     2941 aagagggatt ttttttttta agtcctgaat aagtctactg gaagaattat tcttctgggt
     3001 gaaaaagctt ttgtttgtgt tcttatttta aataatcgga gtcaatttat taaaatgttc
     3061 ttgaaagtac tattcccagg gattttaatg cacaaaccat attgtgacaa gagatgagcc
     3121 tctgtactgt aaataagaaa tgaagtagag aaatgttaaa tattttatga gtttagaata
     3181 tagtaaataa aaggtgatgt aaatgaatgc tgcacaaacg gtgttcatga tacttttagt
     3241 agtactttag gaaaaactac acattctcag aagctcttga tgtctctaat gaaggggggg
     3301 aatgctgtta atgagaacag tcataaattt ttagcatata attacaagaa cagcctgtgg
     3361 atatgatcac ttaaatgatt ttgtggtgat tcgtgccatt gcttttttat ttaaaagaaa
     3421 attttgtaat taaatgcctt tttctaaatt atcttctctt ggaatcatta cttttaatcc
     3481 tatgtgttta tgagtatttt tgcttttttt ttattaatat tgagaaatgg acttttttgt
     3541 tattaaaagt cacctctatt ttctattttc tttgtaattt ttaaagtagg aagatgtcag
     3601 agatgtaaat atgttttcgt ctttagtttt tttcctttta caaattttta ttcttcagga
     3661 ttttcaaaat acagtttagt ctgtttcttt gacaatatgt attaatttcc caattagcaa
     3721 aatggtactt attagtgggt tgaaaacaat taataatata aaagaaaaat taagtgctta
     3781 aaacatttta ggagtataca acttcaaaaa aaaagatagc agtgaggata atgatttaag
     3841 taaaaggttg tctgaagcat atgccaacta aatttcgcaa cgtttgctac ctacctgaaa
     3901 aggagggtca ggagggagac acaacatatt tttgatcatg aaaaagtatc ttaattttaa
     3961 aaaagtgaaa atgccatttt attttgaatc ccttttagaa ctcacgaccc aagttcatca
     4021 atgttgaata atatcacgtt taaataacaa aaaaatatgg actttaaaaa atctcaaatt
     4081 ttttagagac agggtcttgc tctgttttcc agattggagt acagcagtgc attcgcggct
     4141 aactgcagcc tcaagcactg gggctcaagc aaacctcctg cctcagcctc gtgagtagct
     4201 aggaccacag gtgcatgcca ccatgcctgg ctctaaagag aaaaaaaact tgataccata
     4261 gagccttgaa tataaatatc ctgatgttaa cctactgctt ttgctgtgat tttttttcct
     4321 tagtgagttt taaatctcag gctagatttt tatttgtttt tctgtgtgtg tatgagacaa
     4381 aataaaaata aatatatttg ccttgagttt aaaa
//
