LOCUS       NM_001006634            3495 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens Rho GTPase activating protein 17 (ARHGAP17),
            transcript variant 1, mRNA.
ACCESSION   NM_001006634
VERSION     NM_001006634.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3495)
  AUTHORS   Kreider-Letterman,G., Castillo,A., Mahlandt,E.K., Goedhart,J.,
            Rabino,A., Goicoechea,S. and Garcia-Mata,R.
  TITLE     ARHGAP17 regulates the spatiotemporal activity of Cdc42 at
            invadopodia
  JOURNAL   J Cell Biol 222 (2) (2023)
   PUBMED   36571786
  REMARK    GeneRIF: ARHGAP17 regulates the spatiotemporal activity of Cdc42 at
            invadopodia.
REFERENCE   2  (bases 1 to 3495)
  AUTHORS   Pan,S.L., Deng,Y.Y., Fu,J., Zhang,Y.H., Zhang,Z.J. and Qin,X.J.
  TITLE     ARHGAP17 enhances 5-Fluorouracil-induced apoptosis in colon cancer
            cells by suppressing Rac1
  JOURNAL   Neoplasma 69 (3), 640-647 (2022)
   PUBMED   35293764
  REMARK    GeneRIF: ARHGAP17 enhances 5-Fluorouracil-induced apoptosis in
            colon cancer cells by suppressing Rac1.
REFERENCE   3  (bases 1 to 3495)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 3495)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3495)
  AUTHORS   Wang,L., Yang,X., Wan,L., Wang,S., Pan,J. and Liu,Y.
  TITLE     ARHGAP17 inhibits pathological cyclic strain-induced apoptosis in
            human periodontal ligament fibroblasts via Rac1/Cdc42
  JOURNAL   Clin Exp Pharmacol Physiol 47 (9), 1591-1599 (2020)
   PUBMED   32391922
  REMARK    GeneRIF: ARHGAP17 inhibits pathological cyclic strain-induced
            apoptosis in human periodontal ligament fibroblasts via Rac1/Cdc42.
REFERENCE   6  (bases 1 to 3495)
  AUTHORS   Yi,C., Troutman,S., Fera,D., Stemmer-Rachamimov,A., Avila,J.L.,
            Christian,N., Persson,N.L., Shimono,A., Speicher,D.W.,
            Marmorstein,R., Holmgren,L. and Kissil,J.L.
  TITLE     A tight junction-associated Merlin-angiomotin complex mediates
            Merlin's regulation of mitogenic signaling and tumor suppressive
            functions
  JOURNAL   Cancer Cell 19 (4), 527-540 (2011)
   PUBMED   21481793
REFERENCE   7  (bases 1 to 3495)
  AUTHORS   Wells,C.D., Fawcett,J.P., Traweger,A., Yamanaka,Y., Goudreault,M.,
            Elder,K., Kulkarni,S., Gish,G., Virag,C., Lim,C., Colwill,K.,
            Starostine,A., Metalnikov,P. and Pawson,T.
  TITLE     A Rich1/Amot complex regulates the Cdc42 GTPase and apical-polarity
            proteins in epithelial cells
  JOURNAL   Cell 125 (3), 535-548 (2006)
   PUBMED   16678097
  REMARK    GeneRIF: We propose that Rich1 and Amot maintain TJ integrity by
            the coordinate regulation of Cdc42 and by linking specific
            components of the TJ to intracellular protein trafficking.
REFERENCE   8  (bases 1 to 3495)
  AUTHORS   Richnau,N. and Aspenstrom,P.
  TITLE     Rich, a rho GTPase-activating protein domain-containing protein
            involved in signaling by Cdc42 and Rac1
  JOURNAL   J Biol Chem 276 (37), 35060-35070 (2001)
   PUBMED   11431473
REFERENCE   9  (bases 1 to 3495)
  AUTHORS   Reczek,D. and Bretscher,A.
  TITLE     Identification of EPI64, a TBC/rabGAP domain-containing microvillar
            protein that binds to the first PDZ domain of EBP50 and E3KARP
  JOURNAL   J Cell Biol 153 (1), 191-206 (2001)
   PUBMED   11285285
REFERENCE   10 (bases 1 to 3495)
  AUTHORS   Harada,A., Furuta,B., Takeuchi,K., Itakura,M., Takahashi,M. and
            Umeda,M.
  TITLE     Nadrin, a novel neuron-specific GTPase-activating protein involved
            in regulated exocytosis
  JOURNAL   J Biol Chem 275 (47), 36885-36891 (2000)
   PUBMED   10967100
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU187683.1 and BC080195.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001006634.2.
            
            Summary: RICH1 is a GTPase-activating protein (GAP). GAPs stimulate
            the intrinsic GTP hydrolysis of small G proteins, such as RHOA (MIM
            165390), RAC1 (MIM 602048), and CDC42 (MIM 116952).[supplied by
            OMIM, Apr 2004].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC080195.1, AK291691.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000289968.11/ ENSP00000289968.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                BU187683.1         10-47
            39-3495             BC080195.1         1-3457
FEATURES             Location/Qualifiers
     source          1..3495
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.1"
     gene            1..3495
                     /gene="ARHGAP17"
                     /gene_synonym="MST066; MST110; MSTP038; MSTP066; MSTP110;
                     NADRIN; PP367; PP4534; RICH-1; RICH1; WBP15"
                     /note="Rho GTPase activating protein 17"
                     /db_xref="GeneID:55114"
                     /db_xref="HGNC:HGNC:18239"
                     /db_xref="MIM:608293"
     exon            1..161
                     /gene="ARHGAP17"
                     /gene_synonym="MST066; MST110; MSTP038; MSTP066; MSTP110;
                     NADRIN; PP367; PP4534; RICH-1; RICH1; WBP15"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..2754
                     /gene="ARHGAP17"
                     /gene_synonym="MST066; MST110; MSTP038; MSTP066; MSTP110;
                     NADRIN; PP367; PP4534; RICH-1; RICH1; WBP15"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RhoGAP interacting with CIP4 homologs 1; neuron-associated
                     developmentally regulated protein; rho-type
                     GTPase-activating protein 17"
                     /codon_start=1
                     /product="rho GTPase-activating protein 17 isoform 1"
                     /protein_id="NP_001006635.1"
                     /db_xref="CCDS:CCDS32409.1"
                     /db_xref="GeneID:55114"
                     /db_xref="HGNC:HGNC:18239"
                     /db_xref="MIM:608293"
                     /translation="MKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSICH
                     HSHKRLVACFQGQHGTDAERRHKKLPLTALAQNMQEASTQLEDSLLGKMLETCGDAEN
                     QLALELSQHEVFVEKEIVDPLYGIAEVEIPNIQKQRKQLARLVLDWDSVRARWNQAHK
                     SSGTNFQGLPSKIDTLKEEMDEAGNKVEQCKDQLAADMYNFMAKEGEYGKFFVTLLEA
                     QADYHRKALAVLEKTLPEMRAHQDKWAEKPAFGTPLEEHLKRSGREIALPIEACVMLL
                     LETGMKEEGLFRIGAGASKLKKLKAALDCSTSHLDEFYSDPHAVAGALKSYLRELPEP
                     LMTFNLYEEWTQVASVQDQDKKLQDLWRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVN
                     KMTPSNIAIVLGPNLLWARNEGTLAEMAAATSVHVVAVIEPIIQHADWFFPEEVEFNV
                     SEAFVPLTTPSSNHSFHTGNDSDSGTLERKRPASMAVMEGDLVKKESFGVKLMDFQAH
                     RRGGTLNRKHISPAFQPPLPPTDGSTVVPAGPEPPPQSSRAESSSGGGTVPSSAGILE
                     QGPSPGDGSPPKPKDPVSAAVPAPGRNNSQIASGQNQPQAAAGSHQLSMGQPHNAAGP
                     SPHTLRRAVKKPAPAPPKPGNPPPGHPGGQSSSGTSQHPPSLSPKPPTRSPSPPTQHT
                     GQPPGQPSAPSQLSAPRRYSSSLSPIQAPNHPPPQPPTQATPLMHTKPNSQGPPNPMA
                     LPSEHGLEQPSHTPPQTPTPPSTPPLGKQNPSLPAPQTLAGGNPETAQPHAGTLPRPR
                     PVPKPRNRPSVPPPPQPPGVHSAGDSSLTNTAPTASKIVTDSNSRVSEPHRSIFPEMH
                     SDSASKDVPGRILLDIDNDTESTAL"
     exon            162..201
                     /gene="ARHGAP17"
                     /gene_synonym="MST066; MST110; MSTP038; MSTP066; MSTP110;
                     NADRIN; PP367; PP4534; RICH-1; RICH1; WBP15"
                     /inference="alignment:Splign:2.1.0"
     exon            202..306
                     /gene="ARHGAP17"
                     /gene_synonym="MST066; MST110; MSTP038; MSTP066; MSTP110;
                     NADRIN; PP367; PP4534; RICH-1; RICH1; WBP15"
                     /inference="alignment:Splign:2.1.0"
     exon            307..380
                     /gene="ARHGAP17"
                     /gene_synonym="MST066; MST110; MSTP038; MSTP066; MSTP110;
                     NADRIN; PP367; PP4534; RICH-1; RICH1; WBP15"
                     /inference="alignment:Splign:2.1.0"
     exon            381..492
                     /gene="ARHGAP17"
                     /gene_synonym="MST066; MST110; MSTP038; MSTP066; MSTP110;
                     NADRIN; PP367; PP4534; RICH-1; RICH1; WBP15"
                     /inference="alignment:Splign:2.1.0"
     exon            493..569
                     /gene="ARHGAP17"
                     /gene_synonym="MST066; MST110; MSTP038; MSTP066; MSTP110;
                     NADRIN; PP367; PP4534; RICH-1; RICH1; WBP15"
                     /inference="alignment:Splign:2.1.0"
     exon            570..681
                     /gene="ARHGAP17"
                     /gene_synonym="MST066; MST110; MSTP038; MSTP066; MSTP110;
                     NADRIN; PP367; PP4534; RICH-1; RICH1; WBP15"
                     /inference="alignment:Splign:2.1.0"
     exon            682..750
                     /gene="ARHGAP17"
                     /gene_synonym="MST066; MST110; MSTP038; MSTP066; MSTP110;
                     NADRIN; PP367; PP4534; RICH-1; RICH1; WBP15"
                     /inference="alignment:Splign:2.1.0"
     exon            751..832
                     /gene="ARHGAP17"
                     /gene_synonym="MST066; MST110; MSTP038; MSTP066; MSTP110;
                     NADRIN; PP367; PP4534; RICH-1; RICH1; WBP15"
                     /inference="alignment:Splign:2.1.0"
     exon            833..960
                     /gene="ARHGAP17"
                     /gene_synonym="MST066; MST110; MSTP038; MSTP066; MSTP110;
                     NADRIN; PP367; PP4534; RICH-1; RICH1; WBP15"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1072
                     /gene="ARHGAP17"
                     /gene_synonym="MST066; MST110; MSTP038; MSTP066; MSTP110;
                     NADRIN; PP367; PP4534; RICH-1; RICH1; WBP15"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1154
                     /gene="ARHGAP17"
                     /gene_synonym="MST066; MST110; MSTP038; MSTP066; MSTP110;
                     NADRIN; PP367; PP4534; RICH-1; RICH1; WBP15"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1235
                     /gene="ARHGAP17"
                     /gene_synonym="MST066; MST110; MSTP038; MSTP066; MSTP110;
                     NADRIN; PP367; PP4534; RICH-1; RICH1; WBP15"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1349
                     /gene="ARHGAP17"
                     /gene_synonym="MST066; MST110; MSTP038; MSTP066; MSTP110;
                     NADRIN; PP367; PP4534; RICH-1; RICH1; WBP15"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1441
                     /gene="ARHGAP17"
                     /gene_synonym="MST066; MST110; MSTP038; MSTP066; MSTP110;
                     NADRIN; PP367; PP4534; RICH-1; RICH1; WBP15"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1598
                     /gene="ARHGAP17"
                     /gene_synonym="MST066; MST110; MSTP038; MSTP066; MSTP110;
                     NADRIN; PP367; PP4534; RICH-1; RICH1; WBP15"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1832
                     /gene="ARHGAP17"
                     /gene_synonym="MST066; MST110; MSTP038; MSTP066; MSTP110;
                     NADRIN; PP367; PP4534; RICH-1; RICH1; WBP15"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..2002
                     /gene="ARHGAP17"
                     /gene_synonym="MST066; MST110; MSTP038; MSTP066; MSTP110;
                     NADRIN; PP367; PP4534; RICH-1; RICH1; WBP15"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2623
                     /gene="ARHGAP17"
                     /gene_synonym="MST066; MST110; MSTP038; MSTP066; MSTP110;
                     NADRIN; PP367; PP4534; RICH-1; RICH1; WBP15"
                     /inference="alignment:Splign:2.1.0"
     exon            2624..3495
                     /gene="ARHGAP17"
                     /gene_synonym="MST066; MST110; MSTP038; MSTP066; MSTP110;
                     NADRIN; PP367; PP4534; RICH-1; RICH1; WBP15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3466..3471
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP17"
                     /gene_synonym="MST066; MST110; MSTP038; MSTP066; MSTP110;
                     NADRIN; PP367; PP4534; RICH-1; RICH1; WBP15"
                     /note="hexamer: ATTAAA"
     regulatory      3470..3475
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP17"
                     /gene_synonym="MST066; MST110; MSTP038; MSTP066; MSTP110;
                     NADRIN; PP367; PP4534; RICH-1; RICH1; WBP15"
                     /note="hexamer: AATATA"
     polyA_site      3487
                     /gene="ARHGAP17"
                     /gene_synonym="MST066; MST110; MSTP038; MSTP066; MSTP110;
                     NADRIN; PP367; PP4534; RICH-1; RICH1; WBP15"
                     /note="major polyA site"
     polyA_site      3495
                     /gene="ARHGAP17"
                     /gene_synonym="MST066; MST110; MSTP038; MSTP066; MSTP110;
                     NADRIN; PP367; PP4534; RICH-1; RICH1; WBP15"
                     /note="major polyA site"
ORIGIN      
        1 gagccaccgc cgcgccgccg tttgggccgg gaagcgatgt agtagctgcc aggctgtccc
       61 ccgccctgcc cggcccgagc cccgcgggcc gccgccgcca ccgccgccat gaagaagcag
      121 ttcaaccgca tgaagcagct ggctaaccag accgtgggca gagctgagaa aacagaagtc
      181 cttagtgaag atctattaca gattgagaga cgcctggaca cggtgcggtc aatatgccac
      241 cattcccata agcgcttggt ggcatgtttc cagggccagc atggcaccga tgccgagagg
      301 agacacaaaa aactgcctct gacagctctt gctcaaaata tgcaagaagc atcgactcag
      361 ctggaagact ctctcctggg gaagatgctg gagacgtgtg gagatgctga gaatcagctg
      421 gctctcgagc tctcccagca cgaagtcttt gttgagaagg agatcgtgga ccctctgtac
      481 ggcatagctg aggtggagat tcccaacatc cagaagcaga ggaagcagct tgcaagattg
      541 gtgttagact gggattcagt cagagccagg tggaaccaag ctcacaaatc ctcaggaacc
      601 aactttcagg ggcttccatc aaaaatagat actctaaagg aagagatgga tgaagctgga
      661 aataaagtag aacagtgcaa ggatcaactt gcagcagaca tgtacaactt tatggccaaa
      721 gaaggggagt atggcaaatt ctttgttacg ttattagaag cccaagcaga ttaccataga
      781 aaagcattag cagtcttaga aaagaccctc cccgaaatgc gagcccatca agataagtgg
      841 gcggaaaaac cagcctttgg gactccccta gaagaacacc tgaagaggag cgggcgcgag
      901 attgcgctgc ccattgaagc ctgtgtcatg ctgcttctgg agacaggcat gaaggaggag
      961 ggccttttcc gaattggggc tggggcctcc aagttaaaga agctgaaagc tgctttggac
     1021 tgttctactt ctcacctgga tgagttctat tcagaccccc atgctgtagc aggtgcttta
     1081 aaatcctatt tacgggaatt gcctgaacct ttgatgactt ttaatctgta tgaagaatgg
     1141 acacaagttg caagtgtgca ggatcaagac aaaaaacttc aagacttgtg gagaacatgt
     1201 cagaagttgc caccacaaaa ttttgttaac tttagatatt tgatcaagtt ccttgcaaag
     1261 cttgctcaga ccagcgatgt gaataaaatg actcccagca acattgcgat tgtgttaggc
     1321 cctaacttgt tatgggccag aaatgaagga acacttgctg aaatggcagc agccacatcc
     1381 gtccatgtgg ttgcagtgat tgaacccatc attcagcatg ccgactggtt cttccctgaa
     1441 gaggtggaat ttaatgtatc agaagcattt gtacctctca ccaccccgag ttctaatcac
     1501 tcattccaca ctggaaacga ctctgactcg gggaccctgg agaggaagcg gcctgctagc
     1561 atggcggtga tggaaggaga cttggtgaag aaggaaagct ttggtgtgaa gcttatggac
     1621 ttccaggccc accggcgggg tggcactcta aatagaaagc acatatcccc cgctttccag
     1681 ccgccacttc cgcccacaga tggcagcacc gtggtgcccg ctggcccaga gccccctccc
     1741 cagagctcta gggctgaaag cagctctggg ggtgggactg tcccctcttc cgcgggcata
     1801 ctggagcagg ggccgagccc aggcgacggc agtcctccca aaccgaagga ccctgtatct
     1861 gcagctgtgc cagcaccagg gagaaacaac agtcagatag catctggcca aaatcagccc
     1921 caggcagctg ctggctccca ccagctctcc atgggccaac ctcacaatgc tgcagggccc
     1981 agcccgcata cactgcgccg agctgttaaa aaacccgctc cagcaccccc gaaaccgggc
     2041 aacccacctc ctggccaccc cgggggccag agttcttcag gaacatctca gcatccaccc
     2101 agtctgtcac caaagccacc cacccgaagc ccctctcctc ccacccagca cacgggccag
     2161 cctccaggcc agccctccgc cccctcccag ctctcagcac cccggaggta ctccagcagc
     2221 ttgtctccaa tccaagctcc caatcaccca ccgccgcagc cccctacgca ggccacgcca
     2281 ctgatgcaca ccaaacccaa tagccagggc cctcccaacc ccatggcatt gcccagtgag
     2341 catggacttg agcagccatc tcacacccct ccccagactc caacgccccc cagtactccg
     2401 cccctaggaa aacagaaccc cagtctgcca gctcctcaga ccctggcagg gggtaaccct
     2461 gaaactgcac agccacatgc tggaacctta ccgagaccga gaccagtacc aaagccaagg
     2521 aaccggccca gcgtgccccc acccccccaa cctcctggtg tccactcagc tggggacagc
     2581 agcctcacca acacagcacc aacagcttcc aagatagtaa cagactccaa ttccagggtt
     2641 tcagaaccgc atcgcagcat ctttcctgaa atgcactcag actcagccag caaagacgtg
     2701 cctggccgca tcctgctgga tatagacaat gataccgaga gcactgccct gtgaagaaag
     2761 ccctttccca gccctccacc acttccaccc tggcgagtgg agcaggggca ggcgaacctc
     2821 tttctttgca gaccgaacag tgaaaagctt tcagtggagg acaaaggagg gcctcactgt
     2881 gcgggacctg gccttctgca cggcccaagg agaacctgga ggccaccact aaagctgaat
     2941 gacctgtgtc ttgaagaagt tggctttctt tacatgggaa ggaaatcatg ccaaaaaaat
     3001 ccaaaacaaa gaagtacctg gagtggagag agtattcctg ctgaaacgcg cataggaagc
     3061 ttttgtccct gctgttaatg cgggcagcac ctacagcaac ttggaatgag taagaagcag
     3121 tgcgttaact atctatttaa taaaatgcgc tcattatgca agtcgcctac tctctgctac
     3181 ctggacgttc attcttatgt attaggaggg aggctgcgct ccttcagact tgctgcagaa
     3241 tcattttgta tcatgtatgg tctgtgtctc cccagtcccc tcagaaccat gcccatggat
     3301 ggtgactgct ggctctgtca cctcatcaaa ctggatgtga cccatgccgc ctcgttggat
     3361 tgtcggaatg tagacagaaa tgtactgttc tttttttttt ttttaaacaa tgtaattgct
     3421 acttgataag gaccgaacat tattctagtt tcatgtttaa tttgaattaa atatattctg
     3481 tggtttatat gaaaa
//
