LOCUS       NM_018460               1670 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens Rho GTPase activating protein 15 (ARHGAP15), mRNA.
ACCESSION   NM_018460
VERSION     NM_018460.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1670)
  AUTHORS   Kline,B.P., Yochum,G.S., Brinton,D.L., Schieffer,K.M., Weaver,T.,
            Harris,L., Deiling,S., Berg,A.S. and Koltun,W.A.
  TITLE     COLQ and ARHGAP15 are Associated with Diverticular Disease and are
            Expressed in the Colon
  JOURNAL   J Surg Res 267, 397-403 (2021)
   PUBMED   34225052
  REMARK    GeneRIF: COLQ and ARHGAP15 are Associated with Diverticular Disease
            and are Expressed in the Colon.
REFERENCE   2  (bases 1 to 1670)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1670)
  AUTHORS   Liu,Z.D., Mou,Z.X., Che,X.H., Wang,K., Li,H.X., Chen,X.Y. and
            Guo,X.M.
  TITLE     ARHGAP15 regulates lung cancer cell proliferation and metastasis
            via the STAT3 pathway
  JOURNAL   Eur Rev Med Pharmacol Sci 23 (13), 5840-5850 (2019)
   PUBMED   31298335
  REMARK    GeneRIF: ARHGAP15 regulates lung cancer cell proliferation and
            metastasis via the STAT3 pathway.
REFERENCE   4  (bases 1 to 1670)
  AUTHORS   Pan,S., Deng,Y., Fu,J., Zhang,Y., Zhang,Z., Ru,X. and Qin,X.
  TITLE     Decreased expression of ARHGAP15 promotes the development of
            colorectal cancer through PTEN/AKT/FOXO1 axis
  JOURNAL   Cell Death Dis 9 (6), 673 (2018)
   PUBMED   29867200
  REMARK    GeneRIF: ARHGAP15 might serve as a tumor suppressor during
            colorectal cancer progression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1670)
  AUTHORS   Takagi,K., Miki,Y., Onodera,Y., Ishida,T., Watanabe,M., Sasano,H.
            and Suzuki,T.
  TITLE     ARHGAP15 in Human Breast Carcinoma: A Potent Tumor Suppressor
            Regulated by Androgens
  JOURNAL   Int J Mol Sci 19 (3), 804 (2018)
   PUBMED   29534468
  REMARK    GeneRIF: ARHGAP15 immunoreactivity correlated with decreased risk
            of recurrence and improved prognosis in breast carcinoma. ARHGA15
            overexpression suppressed cell proliferation and migration of MCF-7
            cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1670)
  AUTHORS   Lowe,J.K., Maller,J.B., Pe'er,I., Neale,B.M., Salit,J., Kenny,E.E.,
            Shea,J.L., Burkhardt,R., Smith,J.G., Ji,W., Noel,M., Foo,J.N.,
            Blundell,M.L., Skilling,V., Garcia,L., Sullivan,M.L., Lee,H.E.,
            Labek,A., Ferdowsian,H., Auerbach,S.B., Lifton,R.P.,
            Newton-Cheh,C., Breslow,J.L., Stoffel,M., Daly,M.J., Altshuler,D.M.
            and Friedman,J.M.
  TITLE     Genome-wide association studies in an isolated founder population
            from the Pacific Island of Kosrae
  JOURNAL   PLoS Genet 5 (2), e1000365 (2009)
   PUBMED   19197348
REFERENCE   7  (bases 1 to 1670)
  AUTHORS   Satoh,J., Obayashi,S., Misawa,T., Sumiyoshi,K., Oosumi,K. and
            Tabunoki,H.
  TITLE     Protein microarray analysis identifies human cellular prion protein
            interactors
  JOURNAL   Neuropathol Appl Neurobiol 35 (1), 16-35 (2009)
   PUBMED   18482256
REFERENCE   8  (bases 1 to 1670)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   9  (bases 1 to 1670)
  AUTHORS   Bohlson,S.S., Zhang,M., Ortiz,C.E. and Tenner,A.J.
  TITLE     CD93 interacts with the PDZ domain-containing adaptor protein GIPC:
            implications in the modulation of phagocytosis
  JOURNAL   J Leukoc Biol 77 (1), 80-89 (2005)
   PUBMED   15459234
REFERENCE   10 (bases 1 to 1670)
  AUTHORS   Seoh,M.L., Ng,C.H., Yong,J., Lim,L. and Leung,T.
  TITLE     ArhGAP15, a novel human RacGAP protein with GTPase binding property
  JOURNAL   FEBS Lett 539 (1-3), 131-137 (2003)
   PUBMED   12650940
  REMARK    GeneRIF: a potential regulator of Rac1
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP299206.1 and BC038976.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018460.3.
            
            Summary: RHO GTPases (see ARHA; MIM 165390) regulate diverse
            biologic processes, and their activity is regulated by RHO
            GTPase-activating proteins (GAPs), such as ARHGAP15 (Seoh et al.,
            2003 [PubMed 12650940]).[supplied by OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF217507.1, AY219338.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295095.11/ ENSP00000295095.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BP299206.1         90-108
            20-1670             BC038976.1         14-1664
FEATURES             Location/Qualifiers
     source          1..1670
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q22.2-q22.3"
     gene            1..1670
                     /gene="ARHGAP15"
                     /gene_synonym="BM046"
                     /note="Rho GTPase activating protein 15"
                     /db_xref="GeneID:55843"
                     /db_xref="HGNC:HGNC:21030"
                     /db_xref="MIM:610578"
     exon            1..48
                     /gene="ARHGAP15"
                     /gene_synonym="BM046"
                     /inference="alignment:Splign:2.1.0"
     exon            49..227
                     /gene="ARHGAP15"
                     /gene_synonym="BM046"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1490
                     /gene="ARHGAP15"
                     /gene_synonym="BM046"
                     /note="rho-type GTPase-activating protein 15"
                     /codon_start=1
                     /product="rho GTPase-activating protein 15"
                     /protein_id="NP_060930.3"
                     /db_xref="CCDS:CCDS2184.1"
                     /db_xref="GeneID:55843"
                     /db_xref="HGNC:HGNC:21030"
                     /db_xref="MIM:610578"
                     /translation="MQKSTNSDTSVETLNSTRQGTGAVQMRIKNANSHHDRLSQSKSM
                     ILTDVGKVTEPISRHRRNHSQHILKDVIPPLEQLMVEKEGYLQKAKIADGGKKLRKNW
                     STSWIVLSSRRIEFYKESKQQALSNMKTGHKPESVDLCGAHIEWAKEKSSRKNVFQIT
                     TVSGNEFLLQSDIDFIILDWFHAIKNAIDRLPKDSSCPSRNLELFKIQRSSSTELLSH
                     YDSDIKEQKPEHRKSLMFRLHHSASDTSDKNRVKSRLKKFITRRPSLKTLQEKGLIKD
                     QIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQ
                     EEKLNLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVK
                     SLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTLLRAENETGNMAI
                     HMVYQNQIAELMLSEYSKIFGSEED"
     exon            228..296
                     /gene="ARHGAP15"
                     /gene_synonym="BM046"
                     /inference="alignment:Splign:2.1.0"
     exon            297..358
                     /gene="ARHGAP15"
                     /gene_synonym="BM046"
                     /inference="alignment:Splign:2.1.0"
     exon            359..446
                     /gene="ARHGAP15"
                     /gene_synonym="BM046"
                     /inference="alignment:Splign:2.1.0"
     exon            447..536
                     /gene="ARHGAP15"
                     /gene_synonym="BM046"
                     /inference="alignment:Splign:2.1.0"
     exon            537..635
                     /gene="ARHGAP15"
                     /gene_synonym="BM046"
                     /inference="alignment:Splign:2.1.0"
     exon            636..765
                     /gene="ARHGAP15"
                     /gene_synonym="BM046"
                     /inference="alignment:Splign:2.1.0"
     exon            766..888
                     /gene="ARHGAP15"
                     /gene_synonym="BM046"
                     /inference="alignment:Splign:2.1.0"
     exon            889..987
                     /gene="ARHGAP15"
                     /gene_synonym="BM046"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1065
                     /gene="ARHGAP15"
                     /gene_synonym="BM046"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1200
                     /gene="ARHGAP15"
                     /gene_synonym="BM046"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1306
                     /gene="ARHGAP15"
                     /gene_synonym="BM046"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1670
                     /gene="ARHGAP15"
                     /gene_synonym="BM046"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1652..1657
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP15"
                     /gene_synonym="BM046"
                     /note="hexamer: AATAAA"
     polyA_site      1670
                     /gene="ARHGAP15"
                     /gene_synonym="BM046"
                     /note="major polyA site"
ORIGIN      
        1 agttaggagt tgatggcagt ttcaataaca ggtcattgcc gagaaaagga tagcactata
       61 atatgcagaa atctacaaat tctgatactt ccgtggaaac actgaattct acccgccaag
      121 gcacaggagc tgtgcaaatg agaatcaaaa atgccaacag ccaccatgac aggctcagcc
      181 aaagtaaatc catgatcctc accgatgtcg ggaaggtcac tgaacctata tccagacaca
      241 gaaggaatca ttcacagcat atcttgaaag atgtcattcc tccattggaa caactgatgg
      301 ttgaaaaaga aggttatctg caaaaagcta aaattgcaga tggaggaaag aaactaagga
      361 aaaactggtc tacttcctgg attgttcttt ctagtcgaag aattgaattt tacaaagaat
      421 ccaagcaaca ggctctgtcc aatatgaaaa ctgggcacaa accagaaagt gtggatttgt
      481 gtggagcaca cattgaatgg gccaaggaaa aatcgagcag aaagaatgtc tttcagatca
      541 caacagtatc aggaaatgag ttccttctac agtcagatat tgacttcatc atattggatt
      601 ggttccacgc tatcaaaaat gcaattgaca gattgccaaa ggattcaagt tgtccatcaa
      661 gaaacctgga attattcaaa atccaaagat cctctagcac tgaattgcta agtcactacg
      721 acagtgatat aaaagaacag aaaccagagc acagaaaatc tttaatgttc agactgcatc
      781 acagtgcttc cgatacaagc gacaaaaatc gagttaaaag cagattaaag aagtttatta
      841 cccgaagacc ttccctgaaa actctgcaag aaaaaggact tattaaagat caaatttttg
      901 gctctcatct gcacaaagtg tgtgaacgtg aaaattccac agttccgtgg tttgtaaagc
      961 aatgcattga agctgttgag aaaagaggtc tagatgttga tggaatatat cgagttagtg
     1021 gcaatctggc aacaatacag aagttaagat ttattgtcaa ccaagaagag aagctgaatt
     1081 tggacgacag ccagtgggag gacatccacg ttgtcaccgg agcactgaag atgtttttcc
     1141 gggagctgcc tgagccgctc ttcccttaca gtttctttga gcagtttgtg gaagcgatca
     1201 aaaagcaaga caacaacaca agaattgaag ctgtaaaatc tcttgtacaa aaactccctc
     1261 cgccaaatcg tgacaccatg aaagtcctct ttggacatct aactaagata gtggccaaag
     1321 cctccaagaa cctcatgtcc acgcaaagct tggggattgt atttggacct acccttctgc
     1381 gagctgaaaa tgaaacagga aacatggcga tccacatggt ctaccagaac cagatagctg
     1441 agctcatgct gagtgagtac agtaagatct tcggctcaga ggaagactga cagacaagac
     1501 aagctactga atacgttcac atctgtcttg atgcctaata tttttacatt tctgtaaaca
     1561 tatttctgaa atattttttg cctttcaagc gacagatgcc tcattttgtg aaaacttaat
     1621 gatgattttg tgtttaagtt ccaaacattt gaataaaata attgacaata
//
