LOCUS       NM_018287               5060 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens Rho GTPase activating protein 12 (ARHGAP12),
            transcript variant 1, mRNA.
ACCESSION   NM_018287
VERSION     NM_018287.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5060)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5060)
  AUTHORS   Schlam,D., Bagshaw,R.D., Freeman,S.A., Collins,R.F., Pawson,T.,
            Fairn,G.D. and Grinstein,S.
  TITLE     Phosphoinositide 3-kinase enables phagocytosis of large particles
            by terminating actin assembly through Rac/Cdc42 GTPase-activating
            proteins
  JOURNAL   Nat Commun 6, 8623 (2015)
   PUBMED   26465210
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5060)
  AUTHORS   Vinayagamoorthy,N., Hu,H.J., Yim,S.H., Jung,S.H., Jo,J., Jee,S.H.
            and Chung,Y.J.
  TITLE     New variants including ARG1 polymorphisms associated with
            C-reactive protein levels identified by genome-wide association and
            pathway analysis
  JOURNAL   PLoS One 9 (4), e95866 (2014)
   PUBMED   24763700
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5060)
  AUTHORS   Monastyrskaya,K., Sanchez-Freire,V., Hashemi Gheinani,A.,
            Klumpp,D.J., Babiychuk,E.B., Draeger,A. and Burkhard,F.C.
  TITLE     miR-199a-5p regulates urothelial permeability and may play a role
            in bladder pain syndrome
  JOURNAL   Am J Pathol 182 (2), 431-448 (2013)
   PUBMED   23201090
REFERENCE   5  (bases 1 to 5060)
  AUTHORS   Gentile,A., D'Alessandro,L., Lazzari,L., Martinoglio,B.,
            Bertotti,A., Mira,A., Lanzetti,L., Comoglio,P.M. and Medico,E.
  TITLE     Met-driven invasive growth involves transcriptional regulation of
            Arhgap12
  JOURNAL   Oncogene 27 (42), 5590-5598 (2008)
   PUBMED   18504429
  REMARK    GeneRIF: Met-driven invasive growth involves transcriptional
            regulation of Arhgap12.
            GeneRIF: ARHGAP12 inactivates RAC1, thereby impairing cell
            motility, invasion and adhesion to the extracellular matrix. The
            gene is transcriptionally suppressed by Hepatocyte Growth Factor in
            vitro.
REFERENCE   6  (bases 1 to 5060)
  AUTHORS   Peck,J., Douglas,G. 4th, Wu,C.H. and Burbelo,P.D.
  TITLE     Human RhoGAP domain-containing proteins: structure, function and
            evolutionary relationships
  JOURNAL   FEBS Lett 528 (1-3), 27-34 (2002)
   PUBMED   12297274
  REMARK    Review article
REFERENCE   7  (bases 1 to 5060)
  AUTHORS   Zhang,Z., Wu,C., Wang,S., Huang,W., Zhou,Z., Ying,K., Xie,Y. and
            Mao,Y.
  TITLE     Cloning and characterization of ARHGAP12, a novel human rhoGAP gene
  JOURNAL   Int J Biochem Cell Biol 34 (4), 325-331 (2002)
   PUBMED   11854031
  REMARK    GeneRIF: molecular cloning and characterization of ARHGAP12
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY033595.1, AL137485.1,
            AL390715.23 and BM693575.1.
            
            On May 17, 2019 this sequence version replaced NM_018287.6.
            
            Summary: This gene encodes a member of a large family of proteins
            that activate Rho-type guanosine triphosphate (GTP) metabolizing
            enzymes. The encoded protein may be involved in suppressing tumor
            formation by regulating cell invasion and adhesion. Alternatively
            spliced transcript variants encoding multiple isoforms have been
            observed for this gene. [provided by RefSeq, Jul 2012].
            
            Transcript Variant: This variant (1, also known as ARHGAP12b)
            represents the longest transcript and encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.14211.1,
                                           SRR1803613.135031.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344936.7/ ENSP00000345808.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3048              AY033595.1         13-3060
            3049-4744           AL137485.1         1532-3227
            4745-4809           AL390715.23        17922-17986         c
            4810-5060           BM693575.1         452-702
FEATURES             Location/Qualifiers
     source          1..5060
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p11.22"
     gene            1..5060
                     /gene="ARHGAP12"
                     /note="Rho GTPase activating protein 12"
                     /db_xref="GeneID:94134"
                     /db_xref="HGNC:HGNC:16348"
                     /db_xref="MIM:610577"
     exon            1..149
                     /gene="ARHGAP12"
                     /inference="alignment:Splign:2.1.0"
     exon            150..188
                     /gene="ARHGAP12"
                     /inference="alignment:Splign:2.1.0"
     exon            189..943
                     /gene="ARHGAP12"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..2800
                     /gene="ARHGAP12"
                     /note="isoform 1 is encoded by transcript variant 1; rho
                     GTPase-activating protein 12; rho-type GTPase-activating
                     protein 12"
                     /codon_start=1
                     /product="rho GTPase-activating protein 12 isoform 1"
                     /protein_id="NP_060757.4"
                     /db_xref="CCDS:CCDS7170.1"
                     /db_xref="GeneID:94134"
                     /db_xref="HGNC:HGNC:16348"
                     /db_xref="MIM:610577"
                     /translation="MKMADRSGKIIPGQVYIEVEYDYEYEAKDRKIVIKQGERYILVK
                     KTNDDWWQVKPDENSKAFYVPAQYVKEVTRKALMPPVKQVAGLPNNSTKIMQSLHLQR
                     STENVNKLPELSSFGKPSSSVQGTGLIRDANQNFGPSYNQGQTVNLSLDLTHNNGKFN
                     NDSHSPKVSSQNRTRSFGHFPGPEFLDVEKTSFSQEQSCDSAGEGSERIHQDSESGDE
                     LSSSSTEQIRATTPPNQGRPDSPVYANLQELKISQSALPPLPGSPAIQINGEWETHKD
                     SSGRCYYYNRGTQERTWKPPRWTRDASISKGDFQNPGDQELLSSEENYYSTSYSQSDS
                     QCGSPPRGWSEELDERGHTLYTSDYTNEKWLKHVDDQGRQYYYSADGSRSEWELPKYN
                     ASSQQQREIIKSRSLDRRLQEPIVLTKWRHSTIVLDTNDKESPTASKPCFPENESSPS
                     SPKHQDTASSPKDQEKYGLLNVTKIAENGKKVRKNWLSSWAVLQGSSLLFTKTQGSST
                     SWFGSNQSKPEFTVDLKGATIEMASKDKSSKKNVFELKTRQGTELLIQSDNDTVINDW
                     FKVLSSTINNQAVETDEGIEEEIPDSPGIEKHDKEKEQKDPKKLRSFKVSSIDSSEQK
                     KTKKNLKKFLTRRPTLQAVREKGYIKDQVFGSNLANLCQRENGTVPKFVKLCIEHVEE
                     HGLDIDGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHVITGALKMFFRELPEP
                     LFTFNHFNDFVNAIKQEPRQRVAAVKDLIRQLPKPNQDTMQILFRHLRRVIENGEKNR
                     MTYQSIAIVFGPTLLKPEKETGNIAVHTVYQNQIVELILLELSSIFGR"
     exon            944..1207
                     /gene="ARHGAP12"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1348
                     /gene="ARHGAP12"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1429
                     /gene="ARHGAP12"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1555
                     /gene="ARHGAP12"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1630
                     /gene="ARHGAP12"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..1645
                     /gene="ARHGAP12"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1707
                     /gene="ARHGAP12"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1789
                     /gene="ARHGAP12"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1891
                     /gene="ARHGAP12"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..1990
                     /gene="ARHGAP12"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2093
                     /gene="ARHGAP12"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2210
                     /gene="ARHGAP12"
                     /inference="alignment:Splign:2.1.0"
     exon            2211..2309
                     /gene="ARHGAP12"
                     /inference="alignment:Splign:2.1.0"
     exon            2310..2387
                     /gene="ARHGAP12"
                     /inference="alignment:Splign:2.1.0"
     exon            2388..2522
                     /gene="ARHGAP12"
                     /inference="alignment:Splign:2.1.0"
     exon            2523..2625
                     /gene="ARHGAP12"
                     /inference="alignment:Splign:2.1.0"
     exon            2626..5060
                     /gene="ARHGAP12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4128..4133
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP12"
                     /note="hexamer: AATAAA"
     polyA_site      4167
                     /gene="ARHGAP12"
                     /note="major polyA site"
     regulatory      4999..5004
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP12"
                     /note="hexamer: AATAAA"
     polyA_site      5021
                     /gene="ARHGAP12"
                     /note="major polyA site"
ORIGIN      
        1 gtaacttacc ctccctcaga ggccagcctg cggggacggg ccggccgcgg ccgtagccgt
       61 gtgaacgctc ttcgggctcg cgtcgtcgac ccgcagccgc ggggcggact aagaagggag
      121 ccgcctgctg cgaggccgcc gggctcccgg tttaaatgtg atactggtgt agatctcctt
      181 gttctaagct atattcatcc aacaagccat aaagccataa tgtggtataa catccttttt
      241 gagaggtgaa tattattgaa tgaaaatggc tgacagaagt gggaagatta ttccaggaca
      301 agtgtatatt gaggtggaat atgattatga atatgaagca aaggacagaa agattgtgat
      361 aaaacaaggg gagaggtaca tcttggtgaa aaagaccaat gatgactggt ggcaagtcaa
      421 gccagatgaa aactccaaag cgttttatgt gccagcccag tatgtgaagg aggtcacgcg
      481 caaagctctc atgccacctg ttaagcaggt agctggtctg ccaaataact ccacgaaaat
      541 aatgcagagt ttgcatcttc agagatcaac agaaaatgtg aacaaattgc ctgagctttc
      601 aagtttcgga aagccatcgt catctgttca aggaacaggt cttattcgtg atgccaatca
      661 gaattttgga cccagttata atcaaggtca gactgtcaac ctaagcctgg acctgaccca
      721 taataacgga aagtttaaca atgactcaca ttctcctaaa gtttccagcc agaataggac
      781 acgctcattt ggtcattttc ccggtccaga gttcttggat gtagagaaaa ctagcttctc
      841 ccaggaacaa tcttgtgatt ccgcaggaga aggctctgaa agaatacatc aagattctga
      901 atctggtgat gaacttagca gcagctccac tgaacagata agggcaacca cacctccaaa
      961 tcaaggaagg ccagattctc ctgtctatgc taaccttcaa gaactgaaaa tatcccagtc
     1021 tgctcttccc ccacttcctg ggagcccggc aattcagatt aatggagaat gggaaactca
     1081 taaagacagc tcagggcgtt gctattacta taacagaggg acacaggaaa gaacttggaa
     1141 acctcctcgt tggactcggg atgcaagcat cagcaaagga gatttccaaa atccagggga
     1201 tcaagagctt ctttcatcgg aagaaaacta ctacagcact tcttacagcc agtcagatag
     1261 tcagtgtggt tctcctccaa ggggttggtc agaagagttg gatgaacgtg ggcatacctt
     1321 atataccagt gactatacta atgaaaagtg gctcaagcat gttgatgatc aaggtagaca
     1381 atattactac agtgcagacg gatctcggtc agaatgggaa ttgccaaagt ataatgcttc
     1441 atcccagcag caaagagaaa taattaaaag taggagcctg gacaggcggc tgcaagaacc
     1501 aatagtatta acaaagtgga gacatagcac cattgtattg gacactaatg ataaggaatc
     1561 tccaactgcc tcaaaaccct gctttcctga aaatgagtct tctccctcct caccaaagca
     1621 ccaagataca gccagcagtc caaaggatca agagaaatat ggattattaa atgtaacaaa
     1681 aattgctgaa aatgggaaaa aggttcgaaa gaactggttg tcttcttggg cggtgttgca
     1741 gggttcatct ttacttttta ccaaaactca aggaagtagc acaagttggt ttggcagtaa
     1801 tcagtccaaa ccagagttca cagtggacct caagggggca acaattgaga tggcttcaaa
     1861 ggataaatcc agcaaaaaga atgtatttga gctgaaaact cgtcaaggaa cagaactgct
     1921 aattcagtct gacaatgaca ctgttattaa tgattggttt aaagttctta gtagtacaat
     1981 caataatcag gcagtagaaa ctgatgaagg aattgaagag gagataccgg attcaccagg
     2041 aatagaaaag catgataaag aaaaggaaca aaaggatccc aaaaagcttc gttcctttaa
     2101 agtatctagc atagattctt cagaacagaa aaaaaccaag aaaaacttaa agaagtttct
     2161 tacacgacgc cccactttgc aagctgttcg tgaaaaaggt tatattaaag atcaggtatt
     2221 tggatccaat ctcgctaatc tgtgtcagag agagaatggc acagtaccaa agtttgtgaa
     2281 gttatgtatt gaacatgttg aagaacatgg tttggatatt gatgggatat acagagtaag
     2341 tggcaacctc gcagtgatcc agaaactaag gtttgcagtc aatcatgatg agaaattgga
     2401 cttgaatgac agtaaatggg aagatattca tgtcattact ggagccctca aaatgttttt
     2461 tcgagaatta ccagaacctc tttttacatt taatcatttt aatgattttg ttaatgcaat
     2521 taagcaagaa ccaagacagc gagtcgctgc tgttaaggac ctaatcagac agttgccaaa
     2581 gccaaaccaa gacacaatgc agattctttt ccgacatctc agaagagtta tagaaaatgg
     2641 agagaaaaat cgaatgacct atcagagtat agcaattgtt tttggtccca ctctattaaa
     2701 accagaaaaa gagactggta atatagcagt tcatactgtg taccagaatc agattgtaga
     2761 attaattctt ctggaactga gttccatctt cggacgttga ttcttactga agacaacctg
     2821 tggaatagaa gctggattcc atcagatttc aaatgtttat acacaatgta ttttattttt
     2881 tggaccaagc agtgactctt tgattttgca cttttttttt gagggatcag aagggaaggg
     2941 gagagtcgag atgtgtgtta ggccctcata tttgctgctt tgttgcaagt tgatataact
     3001 gcgtgtaatt atgaattcat tttatcctga atgtttgcat ttcatactct gaatttcagt
     3061 aaaaatcaaa acttaaaatt ctaaccagtc atatacactg gataatttgg taagaaaact
     3121 gtattttttt tccctgaaat tggataatgt actttcttct caagattcat gacttgatag
     3181 aacaatactt tcagttatgt tgcaaaggct cttgggcatt ttaaacaaaa tgaagtatat
     3241 ccattttgaa acctgtgtat ttctttttcg gggtttctgc atgcagtggc agtcttaagt
     3301 gccaaaattc attataaccc caaaataacc ccttgatgaa ggcttgctgt cttttactgt
     3361 gttacacagc atccttactg gatatcttag ttgcttgttt gggcagcaca ctaatattac
     3421 ttaaaacact gtgatatact ggagttttag ttagcggaag tcagttcagg gcattttagg
     3481 gctgtcttgc tatactgaat tgtagctaac aatcctaatt atatctagta ccatactgag
     3541 ttattggtat gaccctgtgg aaacacacat tattttatgt aaatataggc taaagactta
     3601 atgtccttta gcttgtgtat ataattgtgt tgtatagtct cagagtacat tctaacccta
     3661 catttctaat cattgttatt ggtaatcttt tctgtgaata ttaggtttcc tccagaaata
     3721 gtccgttatt tgggaaagtt aactgtgtgc acttttagat attaactaca tttacaggca
     3781 aatcactgta atgagaatgg tactggaaaa atactgaata gacttgctaa atggcacatg
     3841 cactacaaga ggaacctttt gggttattta atatgtacag aaaacattag aaaaaattta
     3901 ttacagaatt ctaattccag tatgaatagt ggaaacccat ctgtaaatta gatggatgtt
     3961 ggatggaaaa tgacattgct aaatttgaga atttcttttt acctactaat gtagattgct
     4021 ttgtataata aaacacaggg tttggaaggt tttgttacag ggagcatggt ctgttgaaga
     4081 tttttaaaat gtatttttct agattaactt ctgtacatga aatgtctaat aaaactataa
     4141 gaggtttaga gatttttcca ttggaaatgt gcattttggt ttctaatttt tttgtttttt
     4201 catttactgg catactgtta tacctcattt ttaaaaatca actgaatcca atatttcctg
     4261 tggcaaataa cactttcctc atttcatacc ttttctcctc tcttccatgc caacatttct
     4321 ccacccacaa cgtacacttt ttatttctcc atcaatattt gaaagcgagt gatttgtgac
     4381 caggattttt ttttcttagg gttgcattta taatttacag attgccttcc ttgggaacaa
     4441 gtattttttt gtatgatctg tctaaaaacc tctcacctga attttgtggt agaaagtctg
     4501 tatttgttgt tgtgagcgtg ttaaattgat aacaaaccaa actacttgat agctaaagca
     4561 gattgtttcg ggtggggaga aaaagcccta aatcagaatg tttatatttg cctaaagatg
     4621 tccttaataa tacaatatgc tttagatctt gcttatttag tgattgtata ccaggaaaac
     4681 aattagactc aaatcagtga tgttcttgtt cttggtgttc atgaacatat atcaaagatt
     4741 aaaattgtcc tgtgtttctt gtttcaaggt acgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     4801 gtgtgtgtga agtcttaaat gttttattag tctacagcta atcagtttat tgtaatattg
     4861 tatgtacagt gagattaatg tcttgcgttt tcatcctttg tgaattaaaa attctcactt
     4921 gttttgtaat aacaaagcta gtaatatttt cctgtcttga cagcttggtt ttatagtaga
     4981 aaatatatta aaagctgaaa taaattatca gtggaatttt atttgttagt aagtcttcct
     5041 tcataatgtc attgaaaaag
//
