LOCUS       NM_001039841            1565 bp    mRNA    linear   PRI 13-OCT-2024
DEFINITION  Homo sapiens Rho GTPase activating protein 11B (ARHGAP11B),
            transcript variant 1, mRNA.
ACCESSION   NM_001039841 XM_926156 XM_931017 XM_931023 XM_931028 XM_931039
            XM_931045 XM_931050
VERSION     NM_001039841.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1565)
  AUTHORS   Naeimzadeh,Y., Ilbeigi,S., Dastsooz,H., Rafiee Monjezi,M.,
            Mansoori,Y. and Tabei,S.M.B.
  TITLE     Protooncogenic Role of ARHGAP11A and ARHGAP11B in Invasive Ductal
            Carcinoma: Two Promising Breast Cancer Biomarkers
  JOURNAL   Biomed Res Int 2023, 8236853 (2023)
   PUBMED   38046902
  REMARK    GeneRIF: Protooncogenic Role of ARHGAP11A and ARHGAP11B in Invasive
            Ductal Carcinoma: Two Promising Breast Cancer Biomarkers.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1565)
  AUTHORS   Fischer,J., Fernandez Ortuno,E., Marsoner,F., Artioli,A.,
            Peters,J., Namba,T., Eugster Oegema,C., Huttner,W.B., Ladewig,J.
            and Heide,M.
  TITLE     Human-specific ARHGAP11B ensures human-like basal progenitor levels
            in hominid cerebral organoids
  JOURNAL   EMBO Rep 23 (11), e54728 (2022)
   PUBMED   36098218
  REMARK    GeneRIF: Human-specific ARHGAP11B ensures human-like basal
            progenitor levels in hominid cerebral organoids.
REFERENCE   3  (bases 1 to 1565)
  AUTHORS   Xing,L., Kubik-Zahorodna,A., Namba,T., Pinson,A., Florio,M.,
            Prochazka,J., Sarov,M., Sedlacek,R. and Huttner,W.B.
  TITLE     Expression of human-specific ARHGAP11B in mice leads to neocortex
            expansion and increased memory flexibility
  JOURNAL   EMBO J 40 (13), e107093 (2021)
   PUBMED   33938018
  REMARK    GeneRIF: Expression of human-specific ARHGAP11B in mice leads to
            neocortex expansion and increased memory flexibility.
REFERENCE   4  (bases 1 to 1565)
  AUTHORS   Heide,M., Haffner,C., Murayama,A., Kurotaki,Y., Shinohara,H.,
            Okano,H., Sasaki,E. and Huttner,W.B.
  TITLE     Human-specific ARHGAP11B increases size and folding of primate
            neocortex in the fetal marmoset
  JOURNAL   Science 369 (6503), 546-550 (2020)
   PUBMED   32554627
  REMARK    GeneRIF: Human-specific ARHGAP11B increases size and folding of
            primate neocortex in the fetal marmoset.
REFERENCE   5  (bases 1 to 1565)
  AUTHORS   Namba,T., Doczi,J., Pinson,A., Xing,L., Kalebic,N.,
            Wilsch-Brauninger,M., Long,K.R., Vaid,S., Lauer,J., Bogdanova,A.,
            Borgonovo,B., Shevchenko,A., Keller,P., Drechsel,D., Kurzchalia,T.,
            Wimberger,P., Chinopoulos,C. and Huttner,W.B.
  TITLE     Human-Specific ARHGAP11B Acts in Mitochondria to Expand Neocortical
            Progenitors by Glutaminolysis
  JOURNAL   Neuron 105 (5), 867-881 (2020)
   PUBMED   31883789
  REMARK    GeneRIF: an ARHGAP11B-induced, mitochondria-based effect on basal
            progenitor metabolism that is a hallmark of highly mitotically
            active cells appears to underlie its role in neocortex expansion.
REFERENCE   6  (bases 1 to 1565)
  AUTHORS   Florio,M., Namba,T., Paabo,S., Hiller,M. and Huttner,W.B.
  TITLE     A single splice site mutation in human-specific ARHGAP11B causes
            basal progenitor amplification
  JOURNAL   Sci Adv 2 (12), e1601941 (2016)
   PUBMED   27957544
  REMARK    GeneRIF: The data also demonstrate that a single C-->G base
            substitution underlies the ARHGAP11B-mediated basal progenitor
            amplification implicated in neocortex expansion.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1565)
  AUTHORS   Florio,M., Albert,M., Taverna,E., Namba,T., Brandl,H., Lewitus,E.,
            Haffner,C., Sykes,A., Wong,F.K., Peters,J., Guhr,E., Klemroth,S.,
            Prufer,K., Kelso,J., Naumann,R., Nusslein,I., Dahl,A., Lachmann,R.,
            Paabo,S. and Huttner,W.B.
  TITLE     Human-specific gene ARHGAP11B promotes basal progenitor
            amplification and neocortex expansion
  JOURNAL   Science 347 (6229), 1465-1470 (2015)
   PUBMED   25721503
  REMARK    GeneRIF: ARHGAP11B may have contributed to evolutionary expansion
            of human neocortex.
REFERENCE   8  (bases 1 to 1565)
  AUTHORS   Speed,D., Hoggart,C., Petrovski,S., Tachmazidou,I., Coffey,A.,
            Jorgensen,A., Eleftherohorinou,H., De Iorio,M., Todaro,M., De,T.,
            Smith,D., Smith,P.E., Jackson,M., Cooper,P., Kellett,M., Howell,S.,
            Newton,M., Yerra,R., Tan,M., French,C., Reuber,M., Sills,G.E.,
            Chadwick,D., Pirmohamed,M., Bentley,D., Scheffer,I., Berkovic,S.,
            Balding,D., Palotie,A., Marson,A., O'Brien,T.J. and Johnson,M.R.
  TITLE     A genome-wide association study and biological pathway analysis of
            epilepsy prognosis in a prospective cohort of newly treated
            epilepsy
  JOURNAL   Hum Mol Genet 23 (1), 247-258 (2014)
   PUBMED   23962720
REFERENCE   9  (bases 1 to 1565)
  AUTHORS   Riley,B., Williamson,M., Collier,D., Wilkie,H. and Makoff,A.
  TITLE     A 3-Mb map of a large Segmental duplication overlapping the
            alpha7-nicotinic acetylcholine receptor gene (CHRNA7) at human
            15q13-q14
  JOURNAL   Genomics 79 (2), 197-209 (2002)
   PUBMED   11829490
REFERENCE   10 (bases 1 to 1565)
  AUTHORS   van Bon,B.W.M., Mefford,H.C., de Vries,B.B.A. and Schaaf,C.P.
  TITLE     15q13.3 Recurrent Deletion
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   21290787
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091057.6, AL556699.3 and BC105788.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001039841.2.
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC105788.1, MH721907.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000697964.2/ ENSP00000513489.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AC091057.6         133356-133375       c
            21-442              AL556699.3         1-422
            443-443             AC091057.6         132933-132933       c
            444-548             AL556699.3         424-528
            549-1565            BC105788.1         1-1017
FEATURES             Location/Qualifiers
     source          1..1565
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q13.2"
     gene            1..1565
                     /gene="ARHGAP11B"
                     /gene_synonym="B'-T; FAM7B1; GAP (1-8)"
                     /note="Rho GTPase activating protein 11B"
                     /db_xref="GeneID:89839"
                     /db_xref="HGNC:HGNC:15782"
                     /db_xref="MIM:616310"
     exon            1..822
                     /gene="ARHGAP11B"
                     /gene_synonym="B'-T; FAM7B1; GAP (1-8)"
                     /inference="alignment:Splign:2.1.0"
     CDS             694..1497
                     /gene="ARHGAP11B"
                     /gene_synonym="B'-T; FAM7B1; GAP (1-8)"
                     /note="family with sequence similarity 7, member B1; rho
                     GTPase-activating protein 11B; rho-type GTPase-activating
                     protein 11B"
                     /codon_start=1
                     /product="inactive Rho GTPase-activating protein 11B"
                     /protein_id="NP_001034930.1"
                     /db_xref="CCDS:CCDS32185.1"
                     /db_xref="GeneID:89839"
                     /db_xref="HGNC:HGNC:15782"
                     /db_xref="MIM:616310"
                     /translation="MWDQRLVKLALLQHLRAFYGIKVKGVRGQCDRRRHETAATEIGG
                     KIFGVPFNALPHSAVPEYGHIPSFLVDACTSLEEHIHTEGLFRKSGSVIRLKALKNKV
                     DHGEGCLSSAPPCDIAGLLKQFFRELPEPILPADLHEALLKAQQLGTEEKNKAILLLS
                     CLLADHTVHVLRYFFNFLRNVSLRSSENKMDSSNLAVIFAPNLLQTSEGHEKMSSNAE
                     KKGVYQTLSWKRYQPCWVLMVSVLLHHWKALKKVNMKLLVNIREREDNV"
     exon            823..893
                     /gene="ARHGAP11B"
                     /gene_synonym="B'-T; FAM7B1; GAP (1-8)"
                     /inference="alignment:Splign:2.1.0"
     exon            894..990
                     /gene="ARHGAP11B"
                     /gene_synonym="B'-T; FAM7B1; GAP (1-8)"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1244
                     /gene="ARHGAP11B"
                     /gene_synonym="B'-T; FAM7B1; GAP (1-8)"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1353
                     /gene="ARHGAP11B"
                     /gene_synonym="B'-T; FAM7B1; GAP (1-8)"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1500
                     /gene="ARHGAP11B"
                     /gene_synonym="B'-T; FAM7B1; GAP (1-8)"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1565
                     /gene="ARHGAP11B"
                     /gene_synonym="B'-T; FAM7B1; GAP (1-8)"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtggctccg ggtgtctgca gtggagctgg gggcggaagc atgaggctaa cggcttggct
       61 tcagtgaacg caccgggatg tgcaggccgg gaggtagagg caggctgatg ggggagggaa
      121 cgagcagcct gtgagacggg gtgacggcgg ctaccagccc gggcgggcac cgggactgga
      181 agagttgcct gagcagccgg ctggtccggc ggccaggcta gggcgggggc gagcgcccag
      241 ttgagcctgc tggggctgga ggagcgagaa gggttctctt cacatttcag agcgaaccag
      301 acggacagta aggtttggag gaagggggat cgttggaagt agcaggaagt ggagagaatc
      361 tggcaatagg cgagaaaccg aaagaatcag aaagaagtct atgtgagtag ctgaaagcat
      421 tgggtgacca gaaagaaggt cgctgtaagt gaaggaagag tgaggtgtgg ctggatcaaa
      481 gggctaagag aagcgggtct gtgtaagtgg atgtgagtga ggatcaagga aaagccgtgg
      541 aagtggccgg gggtcggggc cgcagaagtg ccagacgggg ccggaaagca gccgagcgga
      601 gttcaaattt gagagcgttt ggaaattgga agacttggtg gcgaacgagg gtcaggacct
      661 gcatcctgcc tcagagttat cgacgtatcc ggaatgtggg atcagaggct ggtgaagttg
      721 gccctgttgc agcatctgcg ggccttctat ggtattaagg tgaagggtgt ccgtgggcag
      781 tgcgatcgca ggagacatga aacagcagcc acggaaatag ggggtaaaat atttggagta
      841 ccttttaatg cactgcccca ttctgctgta ccagaatatg gacacattcc aagctttctt
      901 gtcgatgctt gcacatcttt agaagaacat attcataccg aagggctttt tcggaaatca
      961 ggatctgtga ttcgcctaaa agcactaaag aataaagtgg atcatggtga aggttgccta
     1021 tcttctgcac ctccttgtga tattgcggga cttcttaagc agttttttag ggaactgcca
     1081 gagcccattc tcccagctga tttgcatgaa gcacttttga aagctcaaca gttaggcaca
     1141 gaggaaaaga ataaagctat actgttgctc tcctgtcttc tggctgacca cacagttcat
     1201 gtattaagat acttctttaa ctttctcagg aatgtttctc ttagatccag tgagaataag
     1261 atggatagca gcaatcttgc agtaatattt gcaccaaatc ttcttcagac aagtgaagga
     1321 catgaaaaga tgtcttctaa cgcagaaaag aagggcgtgt accagacttt atcctggaaa
     1381 agataccagc catgttgggt attgatggtc tctgtgctac tccatcactg gaaggctttg
     1441 aagaaggtga atatgaaact cctggtgaat ataagagaaa gagaagacaa cgtgtaggag
     1501 attttgttag tggagcacta aataaattta aacctaacag aacaccttct attacacctc
     1561 aacaa
//
