LOCUS       NM_001368319            3103 bp    mRNA    linear   PRI 28-AUG-2022
DEFINITION  Homo sapiens ARHGAP11A-SCG5 readthrough (ARHGAP11A-SCG5), mRNA.
ACCESSION   NM_001368319
VERSION     NM_001368319.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3103)
  AUTHORS   Dougherty ML, Underwood JG, Nelson BJ, Tseng E, Munson KM, Penn O,
            Nowakowski TJ, Pollen AA and Eichler EE.
  TITLE     Transcriptional fates of human-specific segmental duplications in
            brain
  JOURNAL   Genome Res 28 (10), 1566-1576 (2018)
   PUBMED   30228200
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            MH721904.1 and BM508069.1.
            
            Summary: This locus represents naturally occurring readthrough
            transcription between the neighboring ARHGAP11A (Rho GTPase
            activating protein 11A) and SCG5 (secretogranin V) genes on
            chromosome 15q13.3. The readthrough transcript encodes a fusion
            protein that shares sequence identity with both the ARHGAP11A and
            SCG5 gene products. [provided by RefSeq, Feb 2019].
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA1965299, SAMEA1966682
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 6447, 9824
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3100              MH721904.1         29-3128
            3101-3103           BM508069.1         23-25               c
FEATURES             Location/Qualifiers
     source          1..3103
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q13.3"
     gene            1..3103
                     /gene="ARHGAP11A-SCG5"
                     /note="ARHGAP11A-SCG5 readthrough"
                     /db_xref="GeneID:114118903"
                     /db_xref="HGNC:HGNC:56310"
     exon            1..865
                     /gene="ARHGAP11A-SCG5"
                     /inference="alignment:Splign:2.1.0"
     CDS             737..2614
                     /gene="ARHGAP11A-SCG5"
                     /codon_start=1
                     /product="ARHGAP11A-SCG5 protein"
                     /protein_id="NP_001355248.1"
                     /db_xref="GeneID:114118903"
                     /db_xref="HGNC:HGNC:56310"
                     /translation="MWDQRLVRLALLQHLRAFYGIKVKGVRGQCDRRRHETAATEIGG
                     KIFGVPFNALPHSAVPEYGHIPSFLVDACTSLEDHIHTEGLFRKSGSVIRLKALKNKV
                     DHGEGCLSSAPPCDIAGLLKQFFRELPEPILPADLHEALLKAQQLGTEEKNKATLLLS
                     CLLADHTVHVLRYFFNFLRNVSLRSSENKMDSSNLAVIFAPNLLQTSEGHEKMSSNTE
                     KKLRLQAAVVQTLIDYASDIGRVPDFILEKIPAMLGIDGLCATPSLEGFEEGEYETPG
                     EYKRKRRQSVGDFVSGALNKFKPNRTPSITPQEERIAQLSESPVILTPNAKRTLPVDS
                     SHGFSSKKRKSIKHNFNFELLPSNLFNSSSTPVSVHIDTSSEGSSQSSLSPVLIGGNH
                     LITAGVPRRSKRIAGKKVCRLTMVSRMVSTMLSGLLFWLASGWTPAFAYSPRTPDRVS
                     EADIQRLLHGVMEQLGIARPRVEYPAHQAMNLVGPQSIEGGAHEGLQHLGPFGNIPNI
                     VAELTGDNIPKDFSEDQGYPDPPNPCPVGKTDDGCLENTPDTAEFSREFQLHQHLFDP
                     EHDYPGLGKWNKKLLYEKMKGGERRKRRSVNPYLQGQRLDNVVAKKSVPHFSDEDKDP
                     E"
     exon            866..936
                     /gene="ARHGAP11A-SCG5"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1033
                     /gene="ARHGAP11A-SCG5"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1287
                     /gene="ARHGAP11A-SCG5"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1451
                     /gene="ARHGAP11A-SCG5"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1598
                     /gene="ARHGAP11A-SCG5"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1673
                     /gene="ARHGAP11A-SCG5"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1841
                     /gene="ARHGAP11A-SCG5"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1971
                     /gene="ARHGAP11A-SCG5"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2204
                     /gene="ARHGAP11A-SCG5"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2354
                     /gene="ARHGAP11A-SCG5"
                     /inference="alignment:Splign:2.1.0"
     exon            2355..2464
                     /gene="ARHGAP11A-SCG5"
                     /inference="alignment:Splign:2.1.0"
     exon            2465..2518
                     /gene="ARHGAP11A-SCG5"
                     /inference="alignment:Splign:2.1.0"
     exon            2519..3103
                     /gene="ARHGAP11A-SCG5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2876..2881
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP11A-SCG5"
                     /note="hexamer: AATAAA"
     polyA_site      2897
                     /gene="ARHGAP11A-SCG5"
     regulatory      3078..3083
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP11A-SCG5"
                     /note="hexamer: AATAAA"
     polyA_site      3097
                     /gene="ARHGAP11A-SCG5"
                     /note="major polyA site"
ORIGIN      
        1 tttgagcctg ggctgaaact gcgggtgtga cccccccgtg gtggctctgg gtgtctgcgg
       61 aggagctggg ggcggaagca tgaggctaac ggcttggctt cagtgaacgc accgggatgt
      121 gcaggccggg aggtagaggc aggctgatgg gggagggaac gagcagcctg tgagacgggg
      181 tgacggcggc taccagcccg ggcgggcacc gggactggaa gagttgcctg agcagccggc
      241 tggtccggcg gccaggctag ggcgggggcg agcgcccagt tgagcctgct ggggctggag
      301 gagcgagaag ggttttcttc acatttcaga gcgaaccaga cggggacagt aaggtttgga
      361 ggaaggggga tcgttggaag tagcaagaag tggagagaat ctggcaatag acgagaaacc
      421 gaaagaatca gaaagaagtc tatgtgagta gctgaaagca ttgggtgacc agaaagaagg
      481 tcggtgtaag tgaaggaaga gtgaggtgtg gctggatcaa agggctaaga gaagcgggtc
      541 tgtgtaagtg gatgtgagtg aggatcaagg aaaagccgtg gaagtggccg ggggtcgggg
      601 ccgcagaagt gccagacggg gccggaaagc agccgagcgg agttcaaatt tgagagcgtt
      661 tggaaattgg aagacttggt ggcgaacgag ggtcaggacc tgcatcctgc ctcagagagt
      721 tatcgacgta tccggaatgt gggatcagag gctggtgagg ttggccctgt tgcagcatct
      781 gcgggccttc tatggtatta aggtgaaggg tgtccgtggg cagtgcgatc gcaggagaca
      841 tgaaacagca gccacggaaa tagggggtaa aatatttgga gtacctttta atgcactgcc
      901 ccattctgct gtaccagaat atggacacat tccaagcttt cttgtcgatg cttgcacatc
      961 tttagaagac catattcata ccgaagggct ttttcggaaa tcaggatctg tgattcgcct
     1021 aaaagcacta aagaataaag tggatcatgg tgaaggttgc ctatcttctg cacctccttg
     1081 tgatattgcg ggacttctta agcagttttt tagggaactg ccagagccca ttctcccagc
     1141 tgatttgcat gaagcacttt tgaaagctca acagttaggc acagaggaaa agaataaagc
     1201 tacactgttg ctctcctgtc ttctggctga ccacacagtt catgtattaa gatacttctt
     1261 taactttctc aggaatgttt ctcttagatc cagtgagaat aagatggaca gcagcaatct
     1321 tgcagtaata tttgcaccga atcttcttca gacaagtgaa ggacatgaaa agatgtcttc
     1381 taacacagaa aagaagctac gattacaggc tgcagtagta cagactctta tcgattatgc
     1441 atcagatatt gggcgtgtac cagattttat cctggaaaag ataccagcca tgttgggtat
     1501 tgatggtctc tgtgctactc catcactgga aggctttgaa gaaggtgaat atgaaactcc
     1561 tggtgaatat aagagaaaga gaagacaaag tgtaggagat tttgttagtg gagcactaaa
     1621 taaatttaaa cctaacagaa caccttctat tacacctcaa gaagaaagaa ttgcccagct
     1681 atctgaatca ccagtgattc ttacaccaaa tgctaagcgt acattgccag tagattcttc
     1741 tcatggtttc tcaagtaaga aaaggaagtc catcaagcac aattttaact ttgagctgtt
     1801 gccaagtaat ctcttcaata gcagttctac accggtatca gttcacatcg atacaagctc
     1861 agaagggtca tctcagagtt cactctctcc tgtactcatt ggtggaaacc atttgatcac
     1921 tgcaggtgtg ccaaggcgaa gtaaaagaat tgcaggcaaa aaagtttgca ggttgacaat
     1981 ggtctccagg atggtctcta ccatgctatc tggcctactg ttttggctgg catctggatg
     2041 gactccagca tttgcttaca gcccccggac ccctgaccgg gtctcagaag cagatatcca
     2101 gaggctgctt catggtgtta tggagcaatt gggcattgcc aggccccgag tggaatatcc
     2161 agctcaccag gccatgaatc ttgtgggccc ccagagcatt gaaggtggag ctcatgaagg
     2221 acttcagcat ttgggtcctt ttggcaacat ccccaacatc gtggcagagt tgactggaga
     2281 caacattcct aaggacttta gtgaggatca ggggtaccca gaccctccaa atccctgtcc
     2341 tgttggaaaa acagatgatg gatgtctaga aaacacccct gacactgcag agttcagtcg
     2401 agagttccag ttgcaccagc atctctttga tccggaacat gactatccag gcttgggcaa
     2461 gtggaacaag aaactccttt acgagaagat gaagggagga gagagacgaa agcggaggag
     2521 tgtcaatcca tatctacaag gacagagact ggataatgtt gttgcaaaga agtctgtccc
     2581 ccatttttca gatgaggata aggatccaga gtaaagagaa gatgctagac gaaaacccac
     2641 attacctgtt aggcctcagc atggcttatg tgcacgtgta aatggagtcc ctgtgaatga
     2701 cagcatgttt cttacataga taattatgga tacaaagcag ctgtatgtag atagtgtatt
     2761 gtcttcacac cgatgattct gctttttgct aaattagaat aagagctttt ttgtttcttg
     2821 ggtttttaaa atgtgaatct gcaatgatca taaaaattaa aatgtgaatg tcaacaataa
     2881 aaagcaagac tatgaaaggc tcagatttct tgcagtttaa aatggtgtct gaggttgtac
     2941 tattttggcc aagtctgtag aaagctgtca tttgattttg attatgtagt tcatccagcc
     3001 cttgggcatt gttatacacc agtaaagaag gctgtactca agaggaggag ctgacacatt
     3061 tcacttggct gcgtcttaat aaacatgaat gcaagcattg gca
//
