LOCUS       NM_024605               3270 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens Rho GTPase activating protein 10 (ARHGAP10), mRNA.
ACCESSION   NM_024605 XM_496719
VERSION     NM_024605.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3270)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   2  (bases 1 to 3270)
  AUTHORS   Sekiguchi,M., Sobue,A., Kushima,I., Wang,C., Arioka,Y., Kato,H.,
            Kodama,A., Kubo,H., Ito,N., Sawahata,M., Hada,K., Ikeda,R.,
            Shinno,M., Mizukoshi,C., Tsujimura,K., Yoshimi,A., Ishizuka,K.,
            Takasaki,Y., Kimura,H., Xing,J., Yu,Y., Yamamoto,M., Okada,T.,
            Shishido,E., Inada,T., Nakatochi,M., Takano,T., Kuroda,K.,
            Amano,M., Aleksic,B., Yamomoto,T., Sakuma,T., Aida,T., Tanaka,K.,
            Hashimoto,R., Arai,M., Ikeda,M., Iwata,N., Shimamura,T., Nagai,T.,
            Nabeshima,T., Kaibuchi,K., Yamada,K., Mori,D. and Ozaki,N.
  TITLE     ARHGAP10, which encodes Rho GTPase-activating protein 10, is a
            novel gene for schizophrenia risk
  JOURNAL   Transl Psychiatry 10 (1), 247 (2020)
   PUBMED   32699248
  REMARK    GeneRIF: ARHGAP10, which encodes Rho GTPase-activating protein 10,
            is a novel gene for schizophrenia risk.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3270)
  AUTHORS   Lucken-Ardjomande Hasler,S., Vallis,Y., Pasche,M. and McMahon,H.T.
  TITLE     GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of
            E-cadherin, MMP14, and CFTR DeltaF508
  JOURNAL   J Cell Biol 219 (5) (2020)
   PUBMED   32344433
  REMARK    GeneRIF: GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent
            export of E-cadherin, MMP14, and CFTR DeltaF508.
REFERENCE   4  (bases 1 to 3270)
  AUTHORS   Wang,Z., Yao,L., Li,Y., Hao,B., Wang,M., Wang,J., Gu,W., Zhan,H.,
            Liu,G. and Wu,Q.
  TITLE     miR-337-3p inhibits gastric tumor metastasis by targeting ARHGAP10
  JOURNAL   Mol Med Rep 21 (2), 705-719 (2020)
   PUBMED   31789419
  REMARK    GeneRIF: miR3373p inhibits gastric tumor metastasis by targeting
            ARHGAP10.
REFERENCE   5  (bases 1 to 3270)
  AUTHORS   Luo,N., Chen,D.D., Liu,L., Li,L. and Cheng,Z.P.
  TITLE     CXCL12 promotes human ovarian cancer cell invasion through
            suppressing ARHGAP10 expression
  JOURNAL   Biochem Biophys Res Commun 518 (3), 416-422 (2019)
   PUBMED   31445707
  REMARK    GeneRIF: These findings suggest that CXCL12/CXCR4 promotes ovarian
            cancer cell invasion by suppressing ARHGAP10 expression, which is
            mediated by VEGF/VEGFR2 signaling.
REFERENCE   6  (bases 1 to 3270)
  AUTHORS   Takefuji,M., Asano,H., Mori,K., Amano,M., Kato,K., Watanabe,T.,
            Morita,Y., Katsumi,A., Itoh,T., Takenawa,T., Hirashiki,A.,
            Izawa,H., Nagata,K., Hirayama,H., Takatsu,F., Naoe,T., Yokota,M.
            and Kaibuchi,K.
  TITLE     Mutation of ARHGAP9 in patients with coronary spastic angina
  JOURNAL   J Hum Genet 55 (1), 42-49 (2010)
   PUBMED   19911011
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3270)
  AUTHORS   Marroni,F., Pfeufer,A., Aulchenko,Y.S., Franklin,C.S., Isaacs,A.,
            Pichler,I., Wild,S.H., Oostra,B.A., Wright,A.F., Campbell,H.,
            Witteman,J.C., Kaab,S., Hicks,A.A., Gyllensten,U., Rudan,I.,
            Meitinger,T., Pattaro,C., van Duijn,C.M., Wilson,J.F. and
            Pramstaller,P.P.
  CONSRTM   EUROSPAN Consortium
  TITLE     A genome-wide association scan of RR and QT interval duration in 3
            European genetically isolated populations: the EUROSPAN project
  JOURNAL   Circ Cardiovasc Genet 2 (4), 322-328 (2009)
   PUBMED   20031603
REFERENCE   8  (bases 1 to 3270)
  AUTHORS   Koeppel,M.A., McCarthy,C.C., Moertl,E. and Jakobi,R.
  TITLE     Identification and characterization of PS-GAP as a novel regulator
            of caspase-activated PAK-2
  JOURNAL   J Biol Chem 279 (51), 53653-53664 (2004)
   PUBMED   15471851
  REMARK    GeneRIF: PS-GAP is a novel regulator of caspase-activated PAK-2
REFERENCE   9  (bases 1 to 3270)
  AUTHORS   Shibata,H., Oishi,K., Yamagiwa,A., Matsumoto,M., Mukai,H. and
            Ono,Y.
  TITLE     PKNbeta interacts with the SH3 domains of Graf and a novel Graf
            related protein, Graf2, which are GTPase activating proteins for
            Rho family
  JOURNAL   J Biochem 130 (1), 23-31 (2001)
   PUBMED   11432776
REFERENCE   10 (bases 1 to 3270)
  AUTHORS   Lancaster,C.A., Taylor-Harris,P.M., Self,A.J., Brill,S., van
            Erp,H.E. and Hall,A.
  TITLE     Characterization of rhoGAP. A GTPase-activating protein for
            rho-related small GTPases
  JOURNAL   J Biol Chem 269 (2), 1137-1142 (1994)
   PUBMED   8288572
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093835.3, AK123785.1 and BC011920.2.
            
            On May 17, 2019 this sequence version replaced NM_024605.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.60265.1,
                                           SRR1803611.217951.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336498.8/ ENSP00000336923.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-214               AC093835.3         118057-118270
            215-700             AK123785.1         240-725
            701-2594            BC011920.2         17-1910
            2595-3270           BC011920.2         1912-2587
FEATURES             Location/Qualifiers
     source          1..3270
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.23"
     gene            1..3270
                     /gene="ARHGAP10"
                     /gene_synonym="GRAF2; PS-GAP; PSGAP"
                     /note="Rho GTPase activating protein 10"
                     /db_xref="GeneID:79658"
                     /db_xref="HGNC:HGNC:26099"
                     /db_xref="MIM:609746"
     exon            1..368
                     /gene="ARHGAP10"
                     /gene_synonym="GRAF2; PS-GAP; PSGAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..2575
                     /gene="ARHGAP10"
                     /gene_synonym="GRAF2; PS-GAP; PSGAP"
                     /note="graf-related protein 2; rho-type GTPase-activating
                     protein 10; GTPase regulator associated with focal
                     adhesion kinase 2"
                     /codon_start=1
                     /product="rho GTPase-activating protein 10"
                     /protein_id="NP_078881.3"
                     /db_xref="CCDS:CCDS34075.1"
                     /db_xref="GeneID:79658"
                     /db_xref="HGNC:HGNC:26099"
                     /db_xref="MIM:609746"
                     /translation="MGLQPLEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGK
                     NLIAATKSLSVAQRKFAHSLRDFKFEFIGDAVTDDERCIDASLREFSNFLKNLEEQRE
                     IMALSVTETLIKPLEKFRKEQLGAVKEEKKKFDKETEKNYSLIDKHLNLSAKKKDSHL
                     QEADIQVEQNRQHFYELSLEYVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELA
                     KDFNHYKMELQINIQNTRNRFEGTRSEVEELMNKIRQNPKDHKRASQFTAEGYLYVQE
                     KRPAPFGSSWVKHYCMYRKAAKKFNMIPFEHRSGGKLGDGEVFFLKECTKRHTDSIDR
                     RFCFDIEAADRPGVSLTMQAFSEEERKQWLEALGGKEALSHSFNTAIIPRPEGNAQLD
                     KMGFTIIRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADW
                     EVKTITSALKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKE
                     MLDILVKHLTNVSNHSKQNLMTVANLGVVFGPTLMRPQEETVAALMDLKFQNIVVEIL
                     IENHEKIFRTPPDTTFPEPTCLSASPPNAPPRQSKRQGQRTKRPVAVYNLCLELEDGD
                     NPYPSKEDTPTSSLDSLSSPSPVTTAVPGPPGPDKNHLLADGGSFGDWASTIPGQTRS
                     SMVQWLNPQSPTTTSSNSAVTPLSPGSSPFPFSPPATVADKPPESIRSRKARAVYPCE
                     AEHSSELSFEIGAIFEDVQTSREPGWLEGTLNGKRGLIPQNYVKLL"
     exon            369..464
                     /gene="ARHGAP10"
                     /gene_synonym="GRAF2; PS-GAP; PSGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            465..526
                     /gene="ARHGAP10"
                     /gene_synonym="GRAF2; PS-GAP; PSGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            527..598
                     /gene="ARHGAP10"
                     /gene_synonym="GRAF2; PS-GAP; PSGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            599..700
                     /gene="ARHGAP10"
                     /gene_synonym="GRAF2; PS-GAP; PSGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            701..811
                     /gene="ARHGAP10"
                     /gene_synonym="GRAF2; PS-GAP; PSGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            812..916
                     /gene="ARHGAP10"
                     /gene_synonym="GRAF2; PS-GAP; PSGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1046
                     /gene="ARHGAP10"
                     /gene_synonym="GRAF2; PS-GAP; PSGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1153
                     /gene="ARHGAP10"
                     /gene_synonym="GRAF2; PS-GAP; PSGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1248
                     /gene="ARHGAP10"
                     /gene_synonym="GRAF2; PS-GAP; PSGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1330
                     /gene="ARHGAP10"
                     /gene_synonym="GRAF2; PS-GAP; PSGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1331..1376
                     /gene="ARHGAP10"
                     /gene_synonym="GRAF2; PS-GAP; PSGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1442
                     /gene="ARHGAP10"
                     /gene_synonym="GRAF2; PS-GAP; PSGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1517
                     /gene="ARHGAP10"
                     /gene_synonym="GRAF2; PS-GAP; PSGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1605
                     /gene="ARHGAP10"
                     /gene_synonym="GRAF2; PS-GAP; PSGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1664
                     /gene="ARHGAP10"
                     /gene_synonym="GRAF2; PS-GAP; PSGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..1770
                     /gene="ARHGAP10"
                     /gene_synonym="GRAF2; PS-GAP; PSGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1930
                     /gene="ARHGAP10"
                     /gene_synonym="GRAF2; PS-GAP; PSGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2081
                     /gene="ARHGAP10"
                     /gene_synonym="GRAF2; PS-GAP; PSGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2241
                     /gene="ARHGAP10"
                     /gene_synonym="GRAF2; PS-GAP; PSGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2242..2394
                     /gene="ARHGAP10"
                     /gene_synonym="GRAF2; PS-GAP; PSGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2486
                     /gene="ARHGAP10"
                     /gene_synonym="GRAF2; PS-GAP; PSGAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..3270
                     /gene="ARHGAP10"
                     /gene_synonym="GRAF2; PS-GAP; PSGAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3252..3257
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP10"
                     /gene_synonym="GRAF2; PS-GAP; PSGAP"
                     /note="hexamer: AATAAA"
     polyA_site      3270
                     /gene="ARHGAP10"
                     /gene_synonym="GRAF2; PS-GAP; PSGAP"
                     /note="major polyA site"
ORIGIN      
        1 ggggcgccgc agctagcgct ggtctcggtg gcagctcctc cgcgccgcag gactcggctc
       61 tacgggacat gtccgtgccg cgctcgccgc gcgcccgggc ctgctagctc ctctgtgctc
      121 cctgaacgcg cggcgccgca cctggcagcg gcctcggagc tcggctcggg caggagcgcg
      181 cggccgtgcg caccgcgcag cgaccgctgc cgtcatgggg ctgcagcccc tggagttcag
      241 cgactgctac ctcgacagcc cgtggttccg ggagaggatc cgcgctcacg aagcggaact
      301 cgagaggacc aacaagttca tcaaagagct cattaaggac gggaagaacc tcatcgctgc
      361 gacgaaaagt ctgtcagtgg cccagcggaa gtttgctcat tcactcagag actttaagtt
      421 tgagtttatc ggtgatgctg tgacagatga tgaacgatgc atagatgctt ccttacgtga
      481 attttcaaat tttttgaaga atctggagga acagagagaa attatggcat taagtgtaac
      541 tgaaaccctg attaaaccct tggaaaaatt cagaaaagag caacttggag ctgtaaagga
      601 agaaaaaaag aagtttgaca aagagacaga aaagaattat agtctaattg ataaacattt
      661 gaatttatca gcaaaaaaga aagactcaca tttacaagag gcagatatcc aagtagagca
      721 gaaccggcaa cacttctatg aactgtctct cgagtatgtg tgtaagctgc aggaaatcca
      781 agaaagaaag aagtttgagt ttgtggaacc tatgctgtca ttttttcagg ggatgtttac
      841 cttctatcat cagggccatg aacttgccaa agacttcaat cactacaaaa tggaactaca
      901 gatcaacatt cagaatacac ggaatcgatt tgaaggaaca aggtcagaag tggaagagct
      961 catgaacaaa atcagacaga atcccaagga ccacaaacga gcaagtcagt ttacagccga
     1021 aggctacctg tatgtccagg aaaaaaggcc tgctccgttt ggttccagtt gggtcaaaca
     1081 ctattgcatg tatcgaaaag cagcaaagaa gttcaacatg atcccatttg agcacagatc
     1141 tggagggaaa cttggggacg gagaggtgtt ctttttgaaa gaatgtacca agaggcatac
     1201 tgactccatt gacagaaggt tttgttttga catagaagct gctgatcggc ctggcgtttc
     1261 cttgaccatg caggcatttt ccgaagagga aaggaagcag tggttggaag ctctgggtgg
     1321 aaaggaagct ctgtcccata gttttaatac agccatcatc ccaagaccag aaggaaatgc
     1381 acagttggat aagatggggt tcacaattat cagaaaatgc atcagtgccg ttgaaacacg
     1441 aggtataaat gaccaaggat tgtacagagt tgtgggggtg agttcaaagg tccagagact
     1501 tctgagtatg ttgatggatg taaaaacatg caatgaggtg gacctggaga attctgcaga
     1561 ttgggaagtg aagacaataa caagtgcctt gaaacagtat ttgaggagtc ttccagagcc
     1621 tctcatgacc tatgagttac atggagattt cattgttcca gccaaaagcg gcagcccaga
     1681 atctcgtgtt aatgcgatcc atttcttggt acacaaactg ccagagaaga ataaagagat
     1741 gttggatatt ttggtgaaac acttaacaaa tgtttcaaat cactccaagc agaacctgat
     1801 gactgtggca aacttaggag tggtgtttgg accaactctg atgaggccac aggaagaaac
     1861 tgtcgctgcc ctcatggact tgaagtttca gaatattgtt gtggaaatct taattgaaaa
     1921 ccatgaaaag atttttcgga cgccgcccga tactacattc cctgagccca cctgcctgtc
     1981 agcatcaccc ccaaatgcgc caccaaggca gtcgaagaga caaggccaga gaaccaagag
     2041 gcccgtggcc gtctacaatc tttgtctgga gctggaagat ggtgacaatc cttacccttc
     2101 caaggaggac acccctacca gcagtctgga ctcactttcc tccccgtctc ccgtgactac
     2161 agctgtccct gggcctcctg gaccagacaa aaaccacctt ctggcagatg gagggagctt
     2221 tggagactgg gcatccacta tcccaggcca gacccgatcg tctatggtcc agtggcttaa
     2281 cccacagtct ccaaccacaa caagctccaa ctcagctgtg acacctcttt cacccgggtc
     2341 gtcccctttc cccttttctc ctcctgctac tgtagcggac aagccacctg aaagcatccg
     2401 cagtcggaag gctcgagccg tgtatccgtg tgaagcagaa cacagctcgg aattatcttt
     2461 tgaaatagga gcaatttttg aggatgtaca aacctccagg gaacctggct ggctagaagg
     2521 gactctgaac ggcaagaggg ggctgattcc acagaactac gtcaagctgc tgtagctcct
     2581 ggcctcagag cccctgctga ccctggcacc cagggacctg cctgggggca gagagctgtc
     2641 ttcctcctcc gaggctctgg gctgcaccca caggtacctc cacacttggg agttaccatc
     2701 atcacagtca gccctggggg tggggggtgg tgggcaggga tgggacgcac cacacagaac
     2761 tgtgattgtg gatcaggagg ggaatgtcag gattcgcaaa atggactttt catttgtcaa
     2821 gtattgggac ttgtgatttt taattatcca gcatatagaa tgagagggag ggcagccttc
     2881 tgccacctgt gtcgcctcca ctggcagtca cgccaccaga gccaccctgg ctccctctcc
     2941 tccctgagca cctgctgctg cgattttaaa gggaactgta ctactcgcag tgataggttt
     3001 gcagagtgtg tgcttggctg tggcagccta gcttggagaa gctgctgttg gtgcaaggga
     3061 gatggtctca agtcagaggg aagcagagac gcgcgtctca agcctgccct tcctagacgg
     3121 ccacctgcag gaccccacac tcactgcact ggcagcgtgc actggcgtat ttgtaacagg
     3181 cttctcggtg ctcctcaccc gtgtgctgtt ttccaaacac cacctttttg cctcaaggtc
     3241 tctgtaaatg aaataaactg taatttacta
//
