LOCUS       NM_004308               3395 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens Rho GTPase activating protein 1 (ARHGAP1), mRNA.
ACCESSION   NM_004308
VERSION     NM_004308.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3395)
  AUTHORS   Noda,H., Sakata,S., Baba,S., Togashi,Y., Nakano,K., Hirasawa,T.,
            Nakayama,I., Hata,C., Takamatsu,M., Sugawara,E., Yamamoto,N.,
            Fujisaki,J., Nunobe,S., Iwakiri,K., Takeuchi,K. and Kawachi,H.
  TITLE     Early gastric cancer with RhoGAP fusion is linked to frequent nodal
            metastasis and a part of microtubular-mucocellular histology
  JOURNAL   Gastric Cancer 27 (4), 772-784 (2024)
   PUBMED   38755445
  REMARK    GeneRIF: Early gastric cancer with RhoGAP fusion is linked to
            frequent nodal metastasis and a part of microtubular-mucocellular
            histology.
REFERENCE   2  (bases 1 to 3395)
  AUTHORS   Shankar,S., Chew,T.W., Chichili,V.P.R., Low,B.C. and Sivaraman,J.
  TITLE     Structural basis for the distinct roles of non-conserved Pro116 and
            conserved Tyr124 of BCH domain of yeast p50RhoGAP
  JOURNAL   Cell Mol Life Sci 81 (1), 216 (2024)
   PUBMED   38740643
  REMARK    GeneRIF: Structural basis for the distinct roles of non-conserved
            Pro116 and conserved Tyr124 of BCH domain of yeast p50RhoGAP.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3395)
  AUTHORS   Geci,I., Bober,P., Filova,E., Amler,E. and Sabo,J.
  TITLE     The Role of ARHGAP1 in Rho GTPase Inactivation during Metastasizing
            of Breast Cancer Cell Line MCF-7 after Treatment with Doxorubicin
  JOURNAL   Int J Mol Sci 24 (14), 11352 (2023)
   PUBMED   37511111
  REMARK    GeneRIF: The Role of ARHGAP1 in Rho GTPase Inactivation during
            Metastasizing of Breast Cancer Cell Line MCF-7 after Treatment with
            Doxorubicin.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3395)
  AUTHORS   Tcherkezian,J. and Lamarche-Vane,N.
  TITLE     Current knowledge of the large RhoGAP family of proteins
  JOURNAL   Biol Cell 99 (2), 67-86 (2007)
   PUBMED   17222083
  REMARK    Review article
REFERENCE   5  (bases 1 to 3395)
  AUTHORS   Rittinger,K., Walker,P.A., Eccleston,J.F., Nurmahomed,K., Owen,D.,
            Laue,E., Gamblin,S.J. and Smerdon,S.J.
  TITLE     Crystal structure of a small G protein in complex with the
            GTPase-activating protein rhoGAP
  JOURNAL   Nature 388 (6643), 693-697 (1997)
   PUBMED   9262406
REFERENCE   6  (bases 1 to 3395)
  AUTHORS   Barrett,T., Xiao,B., Dodson,E.J., Dodson,G., Ludbrook,S.B.,
            Nurmahomed,K., Gamblin,S.J., Musacchio,A., Smerdon,S.J. and
            Eccleston,J.F.
  TITLE     The structure of the GTPase-activating domain from p50rhoGAP
  JOURNAL   Nature 385 (6615), 458-461 (1997)
   PUBMED   9009196
REFERENCE   7  (bases 1 to 3395)
  AUTHORS   Lancaster,C.A., Taylor-Harris,P.M., Self,A.J., Brill,S., van
            Erp,H.E. and Hall,A.
  TITLE     Characterization of rhoGAP. A GTPase-activating protein for
            rho-related small GTPases
  JOURNAL   J Biol Chem 269 (2), 1137-1142 (1994)
   PUBMED   8288572
REFERENCE   8  (bases 1 to 3395)
  AUTHORS   Barfod,E.T., Zheng,Y., Kuang,W.J., Hart,M.J., Evans,T.,
            Cerione,R.A. and Ashkenazi,A.
  TITLE     Cloning and expression of a human CDC42 GTPase-activating protein
            reveals a functional SH3-binding domain
  JOURNAL   J Biol Chem 268 (35), 26059-26062 (1993)
   PUBMED   8253717
REFERENCE   9  (bases 1 to 3395)
  AUTHORS   Garrett,M.D., Major,G.N., Totty,N. and Hall,A.
  TITLE     Purification and N-terminal sequence of the p21rho
            GTPase-activating protein, rho GAP
  JOURNAL   Biochem J 276 (Pt 3) (Pt 3), 833-836 (1991)
   PUBMED   1905930
REFERENCE   10 (bases 1 to 3395)
  AUTHORS   Diekmann,D., Brill,S., Garrett,M.D., Totty,N., Hsuan,J.,
            Monfries,C., Hall,C., Lim,L. and Hall,A.
  TITLE     Bcr encodes a GTPase-activating protein for p21rac
  JOURNAL   Nature 351 (6325), 400-402 (1991)
   PUBMED   1903516
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC115088.6.
            
            On Nov 22, 2018 this sequence version replaced NM_004308.4.
            
            Summary: This gene encodes a member of a large family of proteins
            that activate Rho-type guanosine triphosphate (GTP) metabolizing
            enzymes. The encoded protein contains a SRC homology 3 domain and
            interacts with Bcl-2-associated protein family members. [provided
            by RefSeq, Aug 2012].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.985744.1,
                                           SRR1803611.4104.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311956.9/ ENSP00000310491.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AC115088.6         61073-61141         c
            70-251              AC115088.6         56497-56678         c
            252-347             AC115088.6         56182-56277         c
            348-435             AC115088.6         48695-48782         c
            436-567             AC115088.6         42573-42704         c
            568-654             AC115088.6         41815-41901         c
            655-753             AC115088.6         41533-41631         c
            754-861             AC115088.6         41162-41269         c
            862-938             AC115088.6         41009-41085         c
            939-1016            AC115088.6         40727-40804         c
            1017-1145           AC115088.6         40170-40298         c
            1146-1249           AC115088.6         39887-39990         c
            1250-3395           AC115088.6         37602-39747         c
FEATURES             Location/Qualifiers
     source          1..3395
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     gene            1..3395
                     /gene="ARHGAP1"
                     /gene_synonym="CDC42GAP; p50rhoGAP; RHOGAP; RHOGAP1"
                     /note="Rho GTPase activating protein 1"
                     /db_xref="GeneID:392"
                     /db_xref="HGNC:HGNC:673"
                     /db_xref="MIM:602732"
     exon            1..69
                     /gene="ARHGAP1"
                     /gene_synonym="CDC42GAP; p50rhoGAP; RHOGAP; RHOGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            70..251
                     /gene="ARHGAP1"
                     /gene_synonym="CDC42GAP; p50rhoGAP; RHOGAP; RHOGAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..1438
                     /gene="ARHGAP1"
                     /gene_synonym="CDC42GAP; p50rhoGAP; RHOGAP; RHOGAP1"
                     /note="CDC42 GTPase-activating protein; rho-type
                     GTPase-activating protein 1; rho-related small GTPase
                     protein activator; GTPase-activating protein rhoGAP;
                     GTPase-activating protein, Rho, 1; GTPase-activating
                     protein rhoOGAP"
                     /codon_start=1
                     /product="rho GTPase-activating protein 1"
                     /protein_id="NP_004299.1"
                     /db_xref="CCDS:CCDS7922.1"
                     /db_xref="GeneID:392"
                     /db_xref="HGNC:HGNC:673"
                     /db_xref="MIM:602732"
                     /translation="MDPLSELQDDLTLDDTSEALNQLKLASIDEKNWPSDEMPDFPKS
                     DDSKSSSPELVTHLKWDDPYYDIARHQIVEVAGDDKYGRKIIVFSACRMPPSHQLDHS
                     KLLGYLKHTLDQYVESDYTLLYLHHGLTSDNKPSLSWLRDAYREFDRKYKKNIKALYI
                     VHPTMFIKTLLILFKPLISFKFGQKIFYVNYLSELSEHVKLEQLGIPRQVLKYDDFLK
                     STQKSPATAPKPMPPRPPLPNQQFGVSLQHLQEKNPEQEPIPIVLRETVAYLQAHALT
                     TEGIFRRSANTQVVREVQQKYNMGLPVDFDQYNELHLPAVILKTFLRELPEPLLTFDL
                     YPHVVGFLNIDESQRVPATLQVLQTLPEENYQVLRFLTAFLVQISAHSDQNKMTNTNL
                     AVVFGPNLLWAKDAAITLKAINPINTFTKFLLDHQGELFPSPDPSGL"
     exon            252..347
                     /gene="ARHGAP1"
                     /gene_synonym="CDC42GAP; p50rhoGAP; RHOGAP; RHOGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            348..435
                     /gene="ARHGAP1"
                     /gene_synonym="CDC42GAP; p50rhoGAP; RHOGAP; RHOGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            436..567
                     /gene="ARHGAP1"
                     /gene_synonym="CDC42GAP; p50rhoGAP; RHOGAP; RHOGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            568..654
                     /gene="ARHGAP1"
                     /gene_synonym="CDC42GAP; p50rhoGAP; RHOGAP; RHOGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            655..753
                     /gene="ARHGAP1"
                     /gene_synonym="CDC42GAP; p50rhoGAP; RHOGAP; RHOGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            754..861
                     /gene="ARHGAP1"
                     /gene_synonym="CDC42GAP; p50rhoGAP; RHOGAP; RHOGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            862..938
                     /gene="ARHGAP1"
                     /gene_synonym="CDC42GAP; p50rhoGAP; RHOGAP; RHOGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1016
                     /gene="ARHGAP1"
                     /gene_synonym="CDC42GAP; p50rhoGAP; RHOGAP; RHOGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1145
                     /gene="ARHGAP1"
                     /gene_synonym="CDC42GAP; p50rhoGAP; RHOGAP; RHOGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1249
                     /gene="ARHGAP1"
                     /gene_synonym="CDC42GAP; p50rhoGAP; RHOGAP; RHOGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..3395
                     /gene="ARHGAP1"
                     /gene_synonym="CDC42GAP; p50rhoGAP; RHOGAP; RHOGAP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3375..3380
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARHGAP1"
                     /gene_synonym="CDC42GAP; p50rhoGAP; RHOGAP; RHOGAP1"
                     /note="hexamer: AATAAA"
     polyA_site      3395
                     /gene="ARHGAP1"
                     /gene_synonym="CDC42GAP; p50rhoGAP; RHOGAP; RHOGAP1"
                     /note="major polyA site"
ORIGIN      
        1 gttccaccgc ggagccggat gtttgccgag ccttgacagg cgtggcagag ggagcagtgc
       61 ccgagcgcgg tttctcttaa ggttctgcag ggcaaggctg tctgggacag gcttggccat
      121 ggatccgctc tcagagctgc aggatgatct gaccttggat gacaccagcg aggctctgaa
      181 ccagctgaag ctggcctcca tcgatgagaa gaactggccc tcggatgaaa tgcctgactt
      241 ccccaagtca gatgactcca aaagcagctc cccggaactt gtcacacacc tgaagtggga
      301 tgacccatac tatgacatcg cccggcacca gatcgtggag gtggcaggag atgacaagta
      361 tgggcggaag atcattgtgt ttagtgcctg tcgaatgccc cccagccacc agctcgacca
      421 cagcaagctc ctggggtacc tgaagcacac cctggaccag tacgtggaga gtgactacac
      481 acttctgtat ctgcaccacg gcctgaccag cgacaacaag ccctccctca gctggctccg
      541 tgatgcctac cgggagtttg accgcaagta caagaaaaac atcaaggcct tgtacatcgt
      601 gcatccaacc atgttcatca aaactctgct catcctcttc aagcccctca tcagcttcaa
      661 gttcgggcag aagatcttct atgtgaatta cctgagcgag ctgagcgagc acgtgaagct
      721 ggagcagctg gggatccctc gccaagtgct caaatatgac gacttcctga aatccacaca
      781 gaagagcccc gcgacagccc ccaagcccat gcccccacgg ccccccctgc ccaaccagca
      841 gtttggagtc tcgctgcagc acctccagga gaagaatcca gagcaggagc ccattcccat
      901 tgtactcagg gagactgttg cctacttaca ggcccacgct ctcaccaccg agggcatctt
      961 ccggaggtcg gccaacaccc aagtggtccg ggaagtgcag cagaagtaca acatggggct
     1021 gcctgtggat ttcgaccagt acaatgagct gcacctgcca gcagtcatcc tcaagacctt
     1081 cctccgggag cttcctgagc ccctgctcac ctttgacctc tacccccatg tggtgggctt
     1141 cctcaacatt gatgaaagcc agagggtgcc agcgacactg caggtcctcc agacgctgcc
     1201 cgaggagaac taccaggtgc ttcgtttcct gactgctttc ctggtgcaga tttctgcaca
     1261 cagtgaccag aacaagatga ccaacactaa cctggctgtt gttttcggcc ctaacctgct
     1321 gtgggccaag gatgcggcca tcaccctcaa ggccattaat cccatcaaca ccttcaccaa
     1381 gttccttctg gatcaccaag gggagctgtt cccaagcccg gaccccagcg ggctctgaac
     1441 ctggcccctg ccccaccagc cccttctctg gtagcccggg tttggactct tcctcctggc
     1501 atcaggggcc atgaagcccc ctggagagag atgttggagc cacccatcag gcatgctctc
     1561 ccccacctct gtccagcccg cctcacggcc ctggcggcct cgctgttacc agaagacgtt
     1621 tttctctgcc ttacacttct cactgcctct ctggacaccg ggcttttgct gggctctcca
     1681 gagctgggct tggctcttcc agctggagaa ggactgagcc ccagtaaccc ctttcctgct
     1741 ttttcctgcc tctgtttccc tagcaagtgt ggatgaatca aatgactgcc ggctgggctg
     1801 gtagcagggg ccagtcctcc cctcttgatt gctgggaatg agcagctgag ctctttggtg
     1861 tggacaccgc cccaagctga ggtgcctccc tatctggtag gctgccctgc tttgcagaag
     1921 ccccactgca tgaaggcctg agtgcaagca cccttgctcc tgtactgccc ccagcagcgc
     1981 agtctggggt atttcccctg ctgaggagtg acagggctgg agactgtgtc tgctttctgc
     2041 ctcctcttcc acacatcctg ggtcagcctt tcccaagtga tactgcccct ggggtgtcct
     2101 aaccccttgg ttgtgcaggg actggtagct tggatgacat ggctcagagt cccagcatcc
     2161 acttgaaacc tccctctcca cctccccgcc cccgagagct acagcgtgtg atggaatcag
     2221 tgaccggcca ggttagcctc tcccctcttg gcctcctttc ccacacgggc agatcatcag
     2281 ccttcatgtt cttgtggacc tgtctgttac ggagtcacac tggcccctgc cccagccaga
     2341 ggtgactcag tgcctcagga tcttatggct ccttcctcca gctgggggac tcttaaaggg
     2401 gctggggtag agactaagag tgcccgtagg aggggcagag attgtgctga taggtcagtc
     2461 cagataggtg ggttctagca atttccccag gggattaagg ggctctaggg ccaccttttt
     2521 tttttttttt ctgagatgga gtctcgctct gtcaccaggc tggagtgcag tggcgcgatc
     2581 tcggcacacc tccgccttct gggttcaagc aattctcctg cctcagcctc ctgagtagct
     2641 gggactatag gtgcatgcca ccatgcccag ctaatttttg tatttttagt agagacgggg
     2701 tttcaccatg ttggccagga tggtctcgat ctcctgacct catgatccac ccacctcggc
     2761 ctcccaaagt gctgggattc caggcgtgag ccactgcacc cggccagccc tgttgtcttt
     2821 caaagaacct cggccccagt gatggctgat ctcactccca ctgtctcgta gaattacact
     2881 ccttcctggg gatccctctt cctgcagcct tgtccttggg gagtacaggg aagtacctgc
     2941 agtgaccctg cccccatgac cttggccagg caggatgatt ccagagcccg tactgtgggg
     3001 atcctcactg accagcccag ccccatccgc aagccaggct gggcctgggc ataacttcgc
     3061 tgggctctcc caagaccatc agcagtgcat ccagccccct ggggcctggg ctgctgctgg
     3121 ttcttcatca gtcccttggt ctctagcctc ggccagggct gctctgctct ccgccctcct
     3181 ttgtgtatca agtgtcgctc acagccccat tcactgggga gcctttcgga tctatttggt
     3241 ctttctcatg tcccccactg gtctgtaccc cagggagcgg gtgcttgtac tgtgtgaatc
     3301 cagtgttcac attcacactt aatgacttcc ttggcaccaa tcatgtattt caccgtttgc
     3361 actttttgta tttcaataaa aatgttgatg caaaa
//
