LOCUS       NM_018011               3363 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens arginine and glutamate rich 1 (ARGLU1), mRNA.
ACCESSION   NM_018011
VERSION     NM_018011.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3363)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3363)
  AUTHORS   Bachus,S., Akkerman,N., Fulham,L., Graves,D., Helwer,R., Rempel,J.
            and Pelka,P.
  TITLE     ARGLU1 enhances promoter-proximal pausing of RNA polymerase II and
            stimulates DNA damage repair
  JOURNAL   Nucleic Acids Res 52 (10), 5658-5675 (2024)
   PUBMED   38520408
  REMARK    GeneRIF: ARGLU1 enhances promoter-proximal pausing of RNA
            polymerase II and stimulates DNA damage repair.
REFERENCE   3  (bases 1 to 3363)
  AUTHORS   Chan,S.N. and Pek,J.W.
  TITLE     Distinct biogenesis pathways may have led to functional divergence
            of the human and Drosophila Arglu1 sisRNA
  JOURNAL   EMBO Rep 24 (2), e54350 (2023)
   PUBMED   36533631
  REMARK    GeneRIF: Distinct biogenesis pathways may have led to functional
            divergence of the human and Drosophila Arglu1 sisRNA.
REFERENCE   4  (bases 1 to 3363)
  AUTHORS   Li,F., Li,J., Yu,J., Pan,T., Yu,B., Sang,Q., Dai,W., Hou,J.,
            Yan,C., Zang,M., Zhu,Z., Su,L., Li,Y.Y. and Liu,B.
  TITLE     Identification of ARGLU1 as a potential therapeutic target for
            gastric cancer based on genome-wide functional screening data
  JOURNAL   EBioMedicine 69, 103436 (2021)
   PUBMED   34157484
  REMARK    GeneRIF: Identification of ARGLU1 as a potential therapeutic target
            for gastric cancer based on genome-wide functional screening data.
REFERENCE   5  (bases 1 to 3363)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 3363)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3363)
  AUTHORS   Varjosalo,M., Keskitalo,S., Van Drogen,A., Nurkkala,H.,
            Vichalkovski,A., Aebersold,R. and Gstaiger,M.
  TITLE     The protein interaction landscape of the human CMGC kinase group
  JOURNAL   Cell Rep 3 (4), 1306-1320 (2013)
   PUBMED   23602568
REFERENCE   8  (bases 1 to 3363)
  AUTHORS   Hegele,A., Kamburov,A., Grossmann,A., Sourlis,C., Wowro,S.,
            Weimann,M., Will,C.L., Pena,V., Luhrmann,R. and Stelzl,U.
  TITLE     Dynamic protein-protein interaction wiring of the human spliceosome
  JOURNAL   Mol Cell 45 (4), 567-580 (2012)
   PUBMED   22365833
REFERENCE   9  (bases 1 to 3363)
  AUTHORS   Zhang,D., Jiang,P., Xu,Q. and Zhang,X.
  TITLE     Arginine and glutamate-rich 1 (ARGLU1) interacts with mediator
            subunit 1 (MED1) and is required for estrogen receptor-mediated
            gene transcription and breast cancer cell growth
  JOURNAL   J Biol Chem 286 (20), 17746-17754 (2011)
   PUBMED   21454576
  REMARK    GeneRIF: establish ARGLU1 as a new MED1-interacting protein
            required for estrogen-dependent gene transcription and breast
            cancer cell growth.
REFERENCE   10 (bases 1 to 3363)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB482545.1, BC050434.1, AA445997.1, AI623424.1 and AL442127.7.
            
            On Nov 22, 2018 this sequence version replaced NM_018011.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.716059.1,
                                           SRR1660807.243613.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000400198.8/ ENSP00000383059.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                DB482545.1         30-53
            25-1205             BC050434.1         1-1181
            1206-1521           AA445997.1         79-394
            1522-1722           AI623424.1         22-222              c
            1723-3363           AL442127.7         6819-8459           c
FEATURES             Location/Qualifiers
     source          1..3363
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q33.3"
     gene            1..3363
                     /gene="ARGLU1"
                     /note="arginine and glutamate rich 1"
                     /db_xref="GeneID:55082"
                     /db_xref="HGNC:HGNC:25482"
                     /db_xref="MIM:614046"
     exon            1..565
                     /gene="ARGLU1"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..1040
                     /gene="ARGLU1"
                     /codon_start=1
                     /product="arginine and glutamate-rich protein 1"
                     /protein_id="NP_060481.3"
                     /db_xref="CCDS:CCDS41906.1"
                     /db_xref="GeneID:55082"
                     /db_xref="HGNC:HGNC:25482"
                     /db_xref="MIM:614046"
                     /translation="MGRSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSR
                     ESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKRE
                     EEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRR
                     VEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAK
                     LAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKIILGKGKSRPKLSFSLKTQD"
     exon            566..791
                     /gene="ARGLU1"
                     /inference="alignment:Splign:2.1.0"
     exon            792..875
                     /gene="ARGLU1"
                     /inference="alignment:Splign:2.1.0"
     exon            876..3363
                     /gene="ARGLU1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1687..1692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARGLU1"
                     /note="hexamer: AATAAA"
     polyA_site      1709
                     /gene="ARGLU1"
                     /note="major polyA site"
     regulatory      3342..3347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARGLU1"
                     /note="hexamer: TATAAA"
     polyA_site      3363
                     /gene="ARGLU1"
ORIGIN      
        1 gcagctgcca tcttaggggc gcctggcgct acgggtttct cgttggaggc ggccttcgtg
       61 gcagctgtag acgccgggaa aaggcataaa gtccgttggc cgacaccttt ctttcctccg
      121 gcctcggtag aaccgccagc ccgcgtccga aggcggaggc gaggggaact ggccgcgtga
      181 ggggcctgag gcgagcggtt agagcgtctc ccggaaggat gggccggtct cggagccgga
      241 gctcgtcccg ctccaagcac accaagagca gcaagcacaa caagaagcgc agccggtccc
      301 ggtcgcgatc ccgggacaag gagcgcgtgc ggaagcgttc caaatctcgg gaaagtaaac
      361 ggaaccggcg gcgggagtcg cggtcccgtt cgcgctccac caacacggcc gtgtcccggc
      421 gcgagcggga ccgggagcgc gcctcgtccc cgcccgaccg catcgacatc ttcgggcgca
      481 cggtgagcaa gcgcagcagc ctggacgaga agcagaagcg agaggaggag gagaagaaag
      541 cggagttcga gcggcagcga aaaattcgac agcaagaaat agaagaaaaa ctcatcgagg
      601 aagaaacagc acgaagagta gaagaattgg tagcaaaaag ggtggaggaa gaactggaga
      661 aaaggaagga tgaaattgaa cgagaagttc tccgaagggt ggaggaagcc aaacgcatca
      721 tggaaaagca gttgctcgaa gaactcgagc gacagagaca agctgagctt gccgcacaaa
      781 aagctagaga ggaggaagaa cgtgcaaaac gtgaggagct agagcgaata ctggaagaga
      841 ataaccgaaa aattgcagaa gcacaagcca aactggccga agaacagttg agaattgttg
      901 aagaacaaag aaagattcat gaggaaagga tgaaactaga acaagaacga caacgtcaac
      961 aaaaagaaga acaaaaaatt atcctgggca aggggaagtc caggccaaaa ctgtccttct
     1021 cattaaaaac ccaggattaa attgcaaact ctgaactttt tacaaagaaa aatggaaaaa
     1081 ctttgtatgg tagcttcatg ttgaagtggt tttttgtttt tgtttttgtt tttttaattt
     1141 gtaaaatctg gaaagttagc ttgttctaat aggggctatg ctctgcaatt cccttttttt
     1201 tttttttttt ccttccacta agtcaaatcc ttatcagatc attgttgtat tctaaggagt
     1261 gacgtatttt tcacctgttt ggattctata ttagtggtct gaggaagagc agatcacatt
     1321 gtaaaactat ggatggtctg ataaggcttt tactgacccc actgacttca gagttatact
     1381 ctgtttgcta catcataatg ctggttttgc tgactttttg tttttttata tatttataaa
     1441 aaaagaaaaa gttggtgatt gcattgggaa attcccaggg tattactgga cctatgtggt
     1501 gtattgttaa accagtgtcc ttgtgatact gttgctcttg atgttcctga tacaggtaag
     1561 gaaacagttg gtcaactctg atacaaagta tatatacagt tcagtattgt ctctgttcat
     1621 tttgttttta tttcattgac aaaatcaaac cagcattccc cattgtgtaa ataaatgatt
     1681 ttgctgaata aagtaaagtc ttaaattcat atgttgaagc aatttttttt aatgttatgt
     1741 taagtcttaa agagggtggt tcactttttg atggtcaacc atttagaagt cttagaacta
     1801 tatttcctct tgtttatact tttaacatag ggtttatatg tacattaaat atacttgtga
     1861 attagtattt aatggctatt tttacaaata tcaactttat gctgatagag caaatggcat
     1921 cagtgttacc tttaagaaag actaacaaca tccagaagat ttaaattctc aaacctgtgc
     1981 ctctgtttta ggatataagt attatcacaa agtatactta ataaaggcta gaaaaatgct
     2041 tttaaattat ggaatctgag atcgttttca gagtgggcca tcagaaagaa cttagcttta
     2101 tactgtcaaa aaaaggctaa gatggtcgag tcattttcat tgtgtagtgt acttgcacgt
     2161 ttatttttag gacaaacaca tttgaacttt atgaattttt tttttttttt tgcatgtgaa
     2221 atcttatgaa tggctttcat tttatacact agaatctgcc tcatttactc ttaacatatg
     2281 tttaagtata ctggtattaa aacattcaag aaaaggatat tgatctaaaa tgctacctga
     2341 gatgcataaa catgtcatca agtagagaaa atatttttat ttttgcccaa tattttttag
     2401 acagtttgat tattcttaaa aattgaaaac ataagctaaa gagatgacta aatggtagat
     2461 tattttgtgt gtgcatgcta ggaaaaatgc tgttgcttta gttttgagct cttcaatgag
     2521 tctaattgtg gtaaggaaca atataaaatc agtttaaaga tctttaaagg tagaatttta
     2581 aataggcatg aaatatagtg agaactttta gtaaacatac tacttactct aaaatcaaac
     2641 attttatttt cctaaagaat ataggttgcc aaaaaatatt ttatctctaa atataggtta
     2701 gctgtaatta tttcatgaat tttttttttt ttcaatgtaa ctttttttgg tgaagattca
     2761 tggttcctaa gttctgtatt caagtttttg gaaatgttta tttaaaaact gttctataca
     2821 agtgttcaaa acattgtatc taaagagagt agcctggact taaaatattt gaaatcagct
     2881 tatgcgtgcc ttttaatttt ttttttaagt ttcttactgc cacatatggt gtgaagtgac
     2941 agtaagttgc ttaatgacat cctgcagtat ctgcttgctt ttggagactc cagtgagatg
     3001 ttgaaattgt tcctgtgctt ggtaactact ttcctctgcc aggctatggg aaagaggatg
     3061 taattgtgaa taatatacac catccagtct ttaatgtgct gcaacaatgt agtaatttgt
     3121 ttttttcatt tgttcccact gcctttgtgt acatagaaaa cttaaaaatt tcccccagtc
     3181 tattagaagt taagatgttc cctaatttat taaatatgcc tttattcaca atttgttttt
     3241 ttaggttatt cttaatgcat tatagaatta agtatgactt tgtttatttt tattacagta
     3301 tgtagttatt gacatattgt ggtttgcaga attatcaatt gtataaacta aacctttaaa
     3361 tta
//
