LOCUS       NM_001012659            5047 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens arginine-fifty homeobox (ARGFX), mRNA.
ACCESSION   NM_001012659
VERSION     NM_001012659.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5047)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   2  (bases 1 to 5047)
  AUTHORS   Li,G. and Holland,P.W.
  TITLE     The origin and evolution of ARGFX homeobox loci in mammalian
            radiation
  JOURNAL   BMC Evol Biol 10, 182 (2010)
   PUBMED   20565723
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5047)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   4  (bases 1 to 5047)
  AUTHORS   Booth,H.A. and Holland,P.W.
  TITLE     Annotation, nomenclature and evolution of four novel homeobox genes
            expressed in the human germ line
  JOURNAL   Gene 387 (1-2), 7-14 (2007)
   PUBMED   17005330
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. This record has been curated by NCBI staff in
            collaboration with Anne Booth and Peter Holland. The reference
            sequence was derived from AC069239.16.
            
            On May 17, 2019 this sequence version replaced NM_001012659.1.
            
            Summary: Homeobox genes encode DNA-binding proteins, many of which
            are thought to be involved in early embryonic development. Homeobox
            genes encode a DNA-binding domain of 60 to 63 amino acids referred
            to as the homeodomain. This gene is a member of the ARGFX homeobox
            gene family. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: LN901400.1, LN901399.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2148874
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334384.5/ ENSP00000335578.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                AC069239.16        30152-30216         c
            66-180              AC069239.16        27349-27463         c
            181-297             AC069239.16        21265-21381         c
            298-446             AC069239.16        13100-13248         c
            447-5047            AC069239.16        7543-12143          c
FEATURES             Location/Qualifiers
     source          1..5047
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.33"
     gene            1..5047
                     /gene="ARGFX"
                     /note="arginine-fifty homeobox"
                     /db_xref="GeneID:503582"
                     /db_xref="HGNC:HGNC:30146"
                     /db_xref="MIM:611164"
     exon            1..65
                     /gene="ARGFX"
                     /inference="alignment:Splign:2.1.0"
     exon            66..180
                     /gene="ARGFX"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1025
                     /gene="ARGFX"
                     /codon_start=1
                     /product="arginine-fifty homeobox"
                     /protein_id="NP_001012677.1"
                     /db_xref="CCDS:CCDS33834.1"
                     /db_xref="GeneID:503582"
                     /db_xref="HGNC:HGNC:30146"
                     /db_xref="MIM:611164"
                     /translation="MRNRMAPENPQPDPFINRNYSNMKVIPPQDPASPSFTLLSKLEC
                     SGTVSAYCSLNLPGSTDPPTSASRVAATTAIRRRHKERTSFTHQQYEELEALFSQTMF
                     PDRNLQEKLALRLDLPESTVKVWFRNRRFKLKKQQQQQSAKQRNQILPSKKNVPTSPR
                     TSPSPYAFSPVISDFYSSLPSQPLDPSNWAWNSTFTESSTSDFQMQDTQWERLVASVP
                     ALYSDAYDIFQIIELYNLPDENEISSSSFHCLYQYLSPTKYQVGGQGSSLSIFAGPAV
                     GLSPAQTWPNMTSQAFEAYSLTDSLEFQKTSNMVDLGFL"
     exon            181..297
                     /gene="ARGFX"
                     /inference="alignment:Splign:2.1.0"
     exon            298..446
                     /gene="ARGFX"
                     /inference="alignment:Splign:2.1.0"
     exon            447..5047
                     /gene="ARGFX"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcatttccag agagagacac accacgtagg actgaaaatg gttactctaa ggggattcgt
       61 gacagatttc agaaaccatg aggaacagaa tggccccaga gaatccccag ccagaccctt
      121 tcatcaatag gaattattcc aacatgaagg tgataccacc acaggatcca gctagtccca
      181 gtttcactct gttatccaag ctggagtgca gtggcacggt ctcggcttac tgcagcctca
      241 acctcccagg ttcaactgat cctcccacct cagcctcccg agtagctgcg actacagcaa
      301 tacggagaag gcataaagaa cgtacttctt tcacccacca acagtatgag gagctagaag
      361 ctctgtttag ccagaccatg ttcccagata gaaatcttca ggagaaacta gctttgagac
      421 tcgacctacc ggagtcaaca gtaaaggttt ggttcaggaa ccggcgattc aaattgaaga
      481 agcagcagca gcagcaatca gcaaagcaac gaaaccagat ccttccatcc aagaagaatg
      541 tgcccacctc ccccagaaca tcccccagtc cttatgcttt ttctcctgtg atttcagatt
      601 tctacagctc ccttccatct cagcccttag acccttccaa ttgggcatgg aactctacct
      661 tcactgagag ttctaccagt gacttccaaa tgcaagatac tcagtgggag aggctggtgg
      721 cctcggttcc tgctttgtac tctgatgcct atgacatatt ccaaatcata gaactgtaca
      781 atcttcctga tgagaatgag atatccagct cttctttcca ctgtctgtat cagtatctct
      841 cacccacaaa gtaccaggta ggaggacagg gttcctctct cagcatcttt gctggtccag
      901 ctgtaggcct atctcctgca caaacctggc ccaatatgac aagccaagcc tttgaagcct
      961 acagtctaac agatagcctg gaattccaga aaacctccaa tatggtagac ttgggatttc
     1021 tctgaccaga gtactaataa atatagatca tttagaaaag tggtcttctt gcctcttgta
     1081 catgactgtt tttttccttt gtctcatttt aacccaacat ctgggtctgt gtctctgatt
     1141 tccatgtaaa tgttgcaaaa agagttttcc aagtagagct gggcactacg taatcagccc
     1201 cacaagtctc cctgagaagc ctgcctagtc cctttcatgg ccaatgagac tccaaaattc
     1261 ccttcccaaa actatcttgg attttctaaa agtaggacag tggttttggg ggttatccac
     1321 ttttattttt ttgaaactag ctctcattct gtcacccagg ctggaataca gtggtacagt
     1381 cacggctcac aaaagccttg acctcctggg ctcaggtgat cctcccacct cagcctcctg
     1441 agtagctagg actacagatg ctcgccacca cacctggcta attttttttt tttgagactg
     1501 agtctcgcac tgtcacccag ggtggagtgc agtggcggga tctcagctca gtgcaacctc
     1561 cacctcctgg ggttcaagtg attctcctgt gtcagcctcc tgagtagctg ggattacagg
     1621 cgtgtgccac catgcctggc taacttttgt atttttagta gagacggggt ttcaccacgt
     1681 tgcccaggct ggtcttgaac tcctgacctc cagtgatccg cctgccttga cctcccaaag
     1741 tgctgggatt acagacatga gccaccgagc ctggccaatt tttgtgtttt ttgtagagac
     1801 gaggttttgc catgttgccc aggctggtct ccaactcctg gacttaacgc catccacctg
     1861 ccacagcctc ccaaagtgct aggaatacag gagtgcacca tcgcacccgg ctgggttatc
     1921 tagtttaaaa acactttttt tcaaggaaac cgaagaaacc atcatccact tttctctctg
     1981 tatcattctg attttagtat atgtgttgtg gaagtgagta cactatcatc cacttttaat
     2041 gacagaaagt tataaactta cattttgttt ccaatttttc attttttgtt tgttatttgt
     2101 tttttgtaga cagcactctg tcacccaggc tggagtgcag tggcaccatc ttggctcact
     2161 gcagcctctg cctcctgggc tcaaacagtc ctcccacctc agccttctga gtagctgaga
     2221 ctacagacat gcgccaccat gtctggctaa tttttgtatt tttagtggag atggggtttc
     2281 gccttgttgc ccaggctgaa tttgggtttt tttaaaatga gactttcagt cctaatttga
     2341 ggggaaatta ctgtcaccac tagttttaat atagtacaat gaaaaaataa tatatatata
     2401 tatagtacaa tggtccagac ataataagag gtgtaaaaac tatcacagga agaaataaaa
     2461 acagattttt gaaggtgaga tgataaactt gcaaaactca caaaataaag agtcaaactt
     2521 ttagaatgac aagttagcat attttccagc cacatgatca acctacaaaa ttaataccat
     2581 ttctgaacac cagtaataaa gaaacataag ggctgggggt ggtggctcat gcctgtaatc
     2641 ccagcacttt gggaggccga ggcgggcgga tcacgaggtc aggagattga gaccagcctg
     2701 actaacatgg tgaaatcccg tctctactaa aaatacaaaa aaaaaaaaaa aaaaaagcca
     2761 ggcatggtgg cacacacctg taatcccagc tactcgggag gctgaggaag gagaattgct
     2821 tgaacctggg aggtggaggt tgcagtgagc tgaggtcgca ccactgcact ccagcctgga
     2881 caacagagca agactctgtc tcaaaaaaaa aataaaaaat aaaaaataaa aaataaaaga
     2941 aacataagat aagtacctct caatgaaaaa tgtaaaagta cctagaaatt cacaaaaaaa
     3001 ttaatacctc tgtggagaaa acttcaaaac ttaaaaaagg acatagaaaa tgttttgaat
     3061 aggccaggcg cagtggctca cacctgtaat cccagcacgt tgggaggcca aggcgggcag
     3121 atcacgaggt caagagatca agaccatcct ggccaacatg gtgaaatcct gcctctacta
     3181 aaaatacaaa aaaaaaaaaa aattagctgg gcatggtggc acacacctgt agtcccagct
     3241 acttgggagg ctgaggcagg agaatcacaa ggattgaaac tatgcagtgt gttctccaaa
     3301 catgatggaa cgaaattaga aatcaataaa atttgggaaa ttcacaaata tgtggatatt
     3361 aaacaacaca ttcctaaata accagtggtt aaagaggtaa tcacagtctg agcaacatgg
     3421 caaaaccctg tgtctacaaa aaataaaaaa ttagctgggc atgacggcca gagcccatgg
     3481 tcccagctac tcgagaggct gaggtaagag catcccttga gccacagagg tcgaggctgc
     3541 agtgagctgt gactgtgcca ctgcactcca gcttgagcaa cacagtgata ctgtctcaat
     3601 aaataaataa atagaagaaa tcatgagtaa aattggaaaa cacttttaac tgaaaaaaac
     3661 aaaagcacaa caaaccaaaa catgggatga agctaaatca atgcttagaa ggaaatttat
     3721 agcttcaaat acttatatac atatttttta aaagtagctt tacataggaa ggaagtggca
     3781 tagttttatc aatatctgtc aaattaaact tcaaggcaaa acttttttat tgagatggag
     3841 tcttgctctg tcacccaggc cgtgcaatct cggctcactg caacctccgc ctcctgggtc
     3901 aaatgattct cctgctttag cctcccaagt agctgggact acaggtgtac gccaccacac
     3961 ccagctaatt tttgtatttt tagtagggac aggttttgcc atgttgccca ggctggcctc
     4021 aaactcctga gctcaagtga tcctcccgtc tcagcctccc aaagggctga gattacaggt
     4081 gtgagctacc tcacctggcc aaaacagttt ttttagaaat gaagtatatt agacaacaac
     4141 aaaaggaaca actaacctga aatatataat aactttgaac ttaaatatac ttaacaacat
     4201 ataccaaaaa tatatgaggc aaattttagc aaaaattaaa attcttaaga aaacttcact
     4261 aatatatagt cataatgtgg tatattcata gaacattctc aataattgat aataacagtc
     4321 caaagaaagc agaaagaagg aaagcctaga acagaaataa atgaaataga gaatagaaaa
     4381 gcaatacaga aaaaaaatta tgaaatcaaa agctggttct ttgaaaagat ctacaaaatg
     4441 gcaaacattt agctagattg accaccccct caaaagactc aaattactag aatcagaaac
     4501 aaaagtcaag attttattac caaacttata gaaataaaaa ttattagaaa gaaatactat
     4561 gaacaattga atgccaacaa attagataaa tgaaatggac aaattcctag gaagacacag
     4621 aataccaaat ctgactccac aagaaataga tgttgtgaat agagcttgct atggtatgaa
     4681 tgtgtccccc acagctcatg cgttggaaac ttaatcccca aagcaacagc tttgagaggt
     4741 gagaccttta agggttacta ggcagagccc ccatgaatgg attaatgcca ttattgtggg
     4801 agtgggttag ttatctcaga agtgggttcc tgataaaagg atgagttcgg ccttcttctt
     4861 ccccaaaatc tttatcccca cccccacctc tatctttctc tctctctctt acctcctcct
     4921 ctcccttcct tctgccatgg gaggatgaaa catgaaggcc ctggccaggt gtggcccctc
     4981 catcttccgt ctgagactgg aagacttccc agccttcaga actgtaagaa ataaatctct
     5041 cttcata
//
