LOCUS       NM_001267547            2518 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ARF related protein 1 (ARFRP1), transcript variant 6,
            mRNA.
ACCESSION   NM_001267547
VERSION     NM_001267547.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2518)
  AUTHORS   Wilhelmi,I., Grunwald,S., Gimber,N., Popp,O., Dittmar,G.,
            Arumughan,A., Wanker,E.E., Laeger,T., Schmoranzer,J., Daumke,O. and
            Schurmann,A.
  TITLE     The ARFRP1-dependent Golgi scaffolding protein GOPC is required for
            insulin secretion from pancreatic beta-cells
  JOURNAL   Mol Metab 45, 101151 (2021)
   PUBMED   33359402
  REMARK    GeneRIF: The ARFRP1-dependent Golgi scaffolding protein GOPC is
            required for insulin secretion from pancreatic beta-cells.
REFERENCE   2  (bases 1 to 2518)
  AUTHORS   Yang,F., Li,T., Peng,Z., Liu,Y. and Guo,Y.
  TITLE     The amphipathic helices of Arfrp1 and Arl14 are sufficient to
            determine subcellular localizations
  JOURNAL   J Biol Chem 295 (49), 16643-16654 (2020)
   PUBMED   32972971
  REMARK    GeneRIF: The amphipathic helices of Arfrp1 and Arl14 are sufficient
            to determine subcellular localizations.
REFERENCE   3  (bases 1 to 2518)
  AUTHORS   Zhang,G., Zhang,Q., Zhu,J., Tang,J. and Nie,M.
  TITLE     LncRNA ARFRP1 knockdown inhibits LPS-induced the injury of
            chondrocytes by regulation of NF-kappaB pathway through modulating
            miR-15a-5p/TLR4 axis
  JOURNAL   Life Sci 261, 118429 (2020)
   PUBMED   32931797
  REMARK    GeneRIF: LncRNA ARFRP1 knockdown inhibits LPS-induced the injury of
            chondrocytes by regulation of NF-kappaB pathway through modulating
            miR-15a-5p/TLR4 axis.
REFERENCE   4  (bases 1 to 2518)
  AUTHORS   Ishida,M. and Bonifacino,J.S.
  TITLE     ARFRP1 functions upstream of ARL1 and ARL5 to coordinate
            recruitment of distinct tethering factors to the trans-Golgi
            network
  JOURNAL   J Cell Biol 218 (11), 3681-3696 (2019)
   PUBMED   31575603
  REMARK    GeneRIF: The ARFRP1 is a master regulator of retrograde-carrier
            tethering to the trans-Golgi network (TGN).
            Erratum:[J Cell Biol. 2019 Nov 4;218(11):3880-3881. doi:
            10.1083/jcb.20190509710072019c. PMID: 31604800]
REFERENCE   5  (bases 1 to 2518)
  AUTHORS   Werno,M.W., Wilhelmi,I., Kuropka,B., Ebert,F., Freund,C. and
            Schurmann,A.
  TITLE     The GTPase ARFRP1 affects lipid droplet protein composition and
            triglyceride release from intracellular storage of intestinal
            Caco-2 cells
  JOURNAL   Biochem Biophys Res Commun 506 (1), 259-265 (2018)
   PUBMED   30348522
  REMARK    GeneRIF: lack of Arfrp1 increases the abundance of
            lipolysis-modulating enzymes TERA/VCP, FAF2 and Plin2 at LDs, which
            might decrease lipolysis and reduce availability of fatty acids for
            triglyceride synthesis and their release via chylomicrons.
REFERENCE   6  (bases 1 to 2518)
  AUTHORS   Behnia,R., Panic,B., Whyte,J.R. and Munro,S.
  TITLE     Targeting of the Arf-like GTPase Arl3p to the Golgi requires
            N-terminal acetylation and the membrane protein Sys1p
  JOURNAL   Nat Cell Biol 6 (5), 405-413 (2004)
   PUBMED   15077113
REFERENCE   7  (bases 1 to 2518)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   8  (bases 1 to 2518)
  AUTHORS   Bai,C., Connolly,B., Metzker,M.L., Hilliard,C.A., Liu,X.,
            Sandig,V., Soderman,A., Galloway,S.M., Liu,Q., Austin,C.P. and
            Caskey,C.T.
  TITLE     Overexpression of M68/DcR3 in human gastrointestinal tract tumors
            independent of gene amplification and its location in a four-gene
            cluster
  JOURNAL   Proc Natl Acad Sci U S A 97 (3), 1230-1235 (2000)
   PUBMED   10655513
REFERENCE   9  (bases 1 to 2518)
  AUTHORS   Schurmann,A., Schmidt,M., Asmus,M., Bayer,S., Fliegert,F.,
            Koling,S., Massmann,S., Schilf,C., Subauste,M.C., Voss,M.,
            Jakobs,K.H. and Joost,H.G.
  TITLE     The ADP-ribosylation factor (ARF)-related GTPase ARF-related
            protein binds to the ARF-specific guanine nucleotide exchange
            factor cytohesin and inhibits the ARF-dependent activation of
            phospholipase D
  JOURNAL   J Biol Chem 274 (14), 9744-9751 (1999)
   PUBMED   10092663
REFERENCE   10 (bases 1 to 2518)
  AUTHORS   Schurmann,A., Massmann,S. and Joost,H.G.
  TITLE     ARP is a plasma membrane-associated Ras-related GTPase with remote
            similarity to the family of ADP-ribosylation factors
  JOURNAL   J Biol Chem 270 (51), 30657-30663 (1995)
   PUBMED   8530503
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM546222.1, BC143467.1,
            BC143448.1, AL121845.20, KF511326.1 and AW139294.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001267547.2.
            
            Summary: The protein encoded by this gene is a membrane-associated
            GTP-ase which localizes to the plasma membrane and is related to
            the ADP-ribosylation factor (ARF) and ARF-like (ARL) proteins. This
            gene plays a role in membrane trafficking between the trans-Golgi
            network and endosomes. Alternatively spliced transcript variants
            encoding different isoforms have been identified. [provided by
            RefSeq, May 2012].
            
            Transcript Variant: This variant (6) differs in the 5' UTR,
            compared to variant 1, and encodes isoform A. Variants 1, 6, and 7
            encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.154957.1,
                                           SRR3476690.427859.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000622789.5/ ENSP00000483486.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                BM546222.1         57-116
            61-335              BC143467.1         1-275
            336-336             BC143448.1         276-276
            337-799             BC143467.1         277-739
            800-987             AL121845.20        3774-3961           c
            988-1374            KF511326.1         1-387               c
            1375-2515           AL121845.20        2247-3387           c
            2516-2518           AW139294.1         22-24               c
FEATURES             Location/Qualifiers
     source          1..2518
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..2518
                     /gene="ARFRP1"
                     /gene_synonym="ARL18; ARP; Arp1"
                     /note="ARF related protein 1"
                     /db_xref="GeneID:10139"
                     /db_xref="HGNC:HGNC:662"
                     /db_xref="MIM:604699"
     exon            1..110
                     /gene="ARFRP1"
                     /gene_synonym="ARL18; ARP; Arp1"
                     /inference="alignment:Splign:2.1.0"
     exon            111..209
                     /gene="ARFRP1"
                     /gene_synonym="ARL18; ARP; Arp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..722
                     /gene="ARFRP1"
                     /gene_synonym="ARL18; ARP; Arp1"
                     /note="isoform a is encoded by transcript variant 6; SCG10
                     like-protein; helicase-like protein NHL; ADP ribosylation
                     factor related protein 1; epididymis secretory sperm
                     binding protein"
                     /codon_start=1
                     /product="ADP-ribosylation factor-related protein 1
                     isoform a"
                     /protein_id="NP_001254476.1"
                     /db_xref="CCDS:CCDS13533.1"
                     /db_xref="GeneID:10139"
                     /db_xref="HGNC:HGNC:662"
                     /db_xref="MIM:604699"
                     /translation="MYTLLSGLYKYMFQKDEYCILILGLDNAGKTTFLEQSKTRFNKN
                     YKGMSLSKITTTVGLNIGTVDVGKARLMFWDLGGQEELQSLWDKYYAECHGVIYVIDS
                     TDEERLAESKQAFEKVVTSEALCGVPVLVLANKQDVETCLSIPDIKTAFSDCTSKIGR
                     RDCLTQACSALTGKGVREGIEWMVKCVVRNVHRPPRQRDIT"
     exon            210..297
                     /gene="ARFRP1"
                     /gene_synonym="ARL18; ARP; Arp1"
                     /inference="alignment:Splign:2.1.0"
     exon            298..380
                     /gene="ARFRP1"
                     /gene_synonym="ARL18; ARP; Arp1"
                     /inference="alignment:Splign:2.1.0"
     exon            381..462
                     /gene="ARFRP1"
                     /gene_synonym="ARL18; ARP; Arp1"
                     /inference="alignment:Splign:2.1.0"
     exon            463..533
                     /gene="ARFRP1"
                     /gene_synonym="ARL18; ARP; Arp1"
                     /inference="alignment:Splign:2.1.0"
     exon            534..634
                     /gene="ARFRP1"
                     /gene_synonym="ARL18; ARP; Arp1"
                     /inference="alignment:Splign:2.1.0"
     exon            635..2518
                     /gene="ARFRP1"
                     /gene_synonym="ARL18; ARP; Arp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1636..1641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARFRP1"
                     /gene_synonym="ARL18; ARP; Arp1"
                     /note="hexamer: AATAAA"
     polyA_site      1654
                     /gene="ARFRP1"
                     /gene_synonym="ARL18; ARP; Arp1"
                     /note="major polyA site"
     polyA_site      1709
                     /gene="ARFRP1"
                     /gene_synonym="ARL18; ARP; Arp1"
                     /note="major polyA site"
     regulatory      2497..2502
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARFRP1"
                     /gene_synonym="ARL18; ARP; Arp1"
                     /note="hexamer: TATAAA"
     polyA_site      2507
                     /gene="ARFRP1"
                     /gene_synonym="ARL18; ARP; Arp1"
     polyA_site      2518
                     /gene="ARFRP1"
                     /gene_synonym="ARL18; ARP; Arp1"
ORIGIN      
        1 attccctgag gccggcccgc gtcccgtcag gcgccgcgcg gggttagcgc ggggtcagcg
       61 gaggtcagcg ggggtcagca gcagcggctc cgagggcgcg gcggacgcag ggcaggatgt
      121 acacgctgct gtcgggcttg tacaagtaca tgtttcagaa ggacgagtac tgcatcctga
      181 tcctgggcct ggacaatgct gggaagacga ccttcctgga gcagtcgaaa acccgattta
      241 acaagaacta caaggggatg agtctatcca aaatcaccac caccgtgggc ctaaacatcg
      301 gcactgtgga tgtgggaaag gctcggctca tgttctggga cttaggaggg caggaagagc
      361 tgcagtcttt gtgggacaag tattatgcgg agtgtcacgg cgtcatctac gtcattgact
      421 ccaccgacga ggagaggctg gctgagtcca agcaggcgtt tgagaaggtg gtgaccagcg
      481 aggcgctgtg cggtgtcccc gtcttggtgc tggccaacaa gcaggatgtg gagacgtgcc
      541 tctcaatccc tgacatcaag acggccttca gcgactgcac cagcaagatc ggcaggcgag
      601 attgcctgac ccaggcctgc tcggccctca caggcaaagg ggtgcgcgag ggcatcgagt
      661 ggatggtgaa gtgtgtcgtg cggaatgtgc accggccgcc gcggcagagg gacatcacgt
      721 aggcgcagcc gcgctgccgt cgggacggct ggtcccctgg tgctggagga gtggcctcct
      781 gttggctccc atgctgctga tctggggggt gggtttgctt tgctttgggg ttcttctatt
      841 tactttgttt tctcgaagac aaactttcct ctatgtctgg aaaagcgtag gcatccggag
      901 gctttggagg ggagtctggc agcccggctg gcccaggccc tgcagcggca gcctttccac
      961 agggcgcagc ggcggccttt cgaggccctt tctggggggt ctgagggaga cctggttggg
     1021 aattggggct ccagtgctca ggctggcttg ggctgcatga ggacagccct gtgggaccct
     1081 cgggagaccc cgtggctgtc tccgccccat cgaggaggag gcccgtcagc catggctgcc
     1141 atctggcttc tgccctgtga ccccgtgacc ccgtgacccc ggaagtggtc tggggctgat
     1201 cttgccttga ggaagaccca ggccatgttc ccaaaggcca gcgggggccc tggattgtga
     1261 tgcagcctcg ggacagggct gaggcctgcg ggggaagacc tataccccac gcctgggcct
     1321 ggcttcacct caccctaatc ccccgggagg gagctgactg atgcaaaaag ctgagggggc
     1381 ctgctgggag tggctgtttt tatgccccag ccccgcaagt tggggagtgt ttgtgggggt
     1441 ccagagccct cccccagcca ggagagaacc tcccggaggg gttctctgtg gggccctgtg
     1501 tcccctgctc gggagtaagg ctggtcctgg ggtcctccct gcacggaccc cactgggcct
     1561 gccgagtgct gtgttcttcc tcagtctggc tgtgggcagg agcggcctgc ccagtgtcac
     1621 ccagggtgag tgcaaaataa agacggcgag tgtggctctg tccatccctt ccctcctgga
     1681 gggtggaggc tcctggctgt tggacacggt gatggtgtta ctgggctgct caggggctgg
     1741 tgggcaggtg aggggctccc caggtgggcc tggagagtcc aggcactccc ttcctgcgga
     1801 tgtgggaagg acatggggtc ctgggaggag ctgctgggaa ggggcatgag tcagggtggg
     1861 ggtggcgcag cagctgcggg gctgtgactc acaggagtcg ggccctggaa gtccccgcgt
     1921 cctctccagg ggaccctgtg tgtgttctgc aggttggttc ccaggacctg ggggggacct
     1981 ccagccccgg gaacctggcc gtgctgggga ggcgagtggc tggtgcagcc ccccggttgc
     2041 tctgggtgca tcgggaggct tcagagcctg ccccagagag ggagaagctt cacttcccgg
     2101 aaagcatggg aggcctggag gaggtctttg gcaggtcccc tctcgggaaa tcccctgtga
     2161 gttgggagtg ggaggaattc ataagtgggg ggttagtgtg ggccccggcg actagggctg
     2221 gcctgagccc catcctgttc ttccagcaat gataccctcc caggccctga ccctcgctga
     2281 gcttcagggg cccctgccac gtgccacagc cactgggggc agaggtggca ctccccactg
     2341 atcctcccag ggagggtctg tctgaggtag gggaagcccc gggcagcagt tctgatggca
     2401 ggcagcctga gggatctggg cacagcgggc ggctcaggtg tccccggctg ccctcccagt
     2461 agctgtgcaa ctacaaccag ttttatgaaa aagctttata aaaataagct ttaagaaa
//
