LOCUS       NM_001376558            1763 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ARF interacting protein 2 (ARFIP2), transcript variant
            13, mRNA.
ACCESSION   NM_001376558 XM_005252840
VERSION     NM_001376558.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1763)
  AUTHORS   Jiang,F., Xu,Y., Jiang,Z., Hu,B., Lv,Q. and Wang,Z.
  TITLE     Deciphering the immunological and prognostic features of
            hepatocellular carcinoma through ADP-ribosylation-related genes
            analysis and identify potential therapeutic target ARFIP2
  JOURNAL   Cell Signal 117, 111073 (2024)
   PUBMED   38302034
  REMARK    GeneRIF: Deciphering the immunological and prognostic features of
            hepatocellular carcinoma through ADP-ribosylation-related genes
            analysis and identify potential therapeutic target ARFIP2.
REFERENCE   2  (bases 1 to 1763)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 1763)
  AUTHORS   Qin,K., Tian,G., Zhou,D. and Chen,G.
  TITLE     Circular RNA circ-ARFIP2 regulates proliferation, migration and
            invasion in human vascular smooth muscle cells via
            miR-338-3p-dependent modulation of KDR
  JOURNAL   Metab Brain Dis 36 (6), 1277-1288 (2021)
   PUBMED   33837886
  REMARK    GeneRIF: Circular RNA circ-ARFIP2 regulates proliferation,
            migration and invasion in human vascular smooth muscle cells via
            miR-338-3p-dependent modulation of KDR.
REFERENCE   4  (bases 1 to 1763)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1763)
  AUTHORS   Nguyen,T.N., Padman,B.S., Zellner,S., Khuu,G., Uoselis,L.,
            Lam,W.K., Skulsuppaisarn,M., Lindblom,R.S.J., Watts,E.M.,
            Behrends,C. and Lazarou,M.
  TITLE     ATG4 family proteins drive phagophore growth independently of the
            LC3/GABARAP lipidation system
  JOURNAL   Mol Cell 81 (9), 2013-2030 (2021)
   PUBMED   33773106
REFERENCE   6  (bases 1 to 1763)
  AUTHORS   Shin,O.H. and Exton,J.H.
  TITLE     Differential binding of arfaptin 2/POR1 to ADP-ribosylation factors
            and Rac1
  JOURNAL   Biochem Biophys Res Commun 285 (5), 1267-1273 (2001)
   PUBMED   11478794
REFERENCE   7  (bases 1 to 1763)
  AUTHORS   Tarricone,C., Xiao,B., Justin,N., Walker,P.A., Rittinger,K.,
            Gamblin,S.J. and Smerdon,S.J.
  TITLE     The structural basis of Arfaptin-mediated cross-talk between Rac
            and Arf signalling pathways
  JOURNAL   Nature 411 (6834), 215-219 (2001)
   PUBMED   11346801
REFERENCE   8  (bases 1 to 1763)
  AUTHORS   D'Souza-Schorey,C., Boshans,R.L., McDonough,M., Stahl,P.D. and Van
            Aelst,L.
  TITLE     A role for POR1, a Rac1-interacting protein, in ARF6-mediated
            cytoskeletal rearrangements
  JOURNAL   EMBO J 16 (17), 5445-5454 (1997)
   PUBMED   9312003
REFERENCE   9  (bases 1 to 1763)
  AUTHORS   Kanoh,H., Williger,B.T. and Exton,J.H.
  TITLE     Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation
            factor, is recruited to Golgi membranes
  JOURNAL   J Biol Chem 272 (9), 5421-5429 (1997)
   PUBMED   9038142
REFERENCE   10 (bases 1 to 1763)
  AUTHORS   Van Aelst,L., Joneson,T. and Bar-Sagi,D.
  TITLE     Identification of a novel Rac1-interacting protein involved in
            membrane ruffling
  JOURNAL   EMBO J 15 (15), 3778-3786 (1996)
   PUBMED   8670882
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC084337.7.
            
            On May 20, 2020 this sequence version replaced NM_001376558.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.3440786.1,
                                           SRR11853563.4797.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2159931
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396777.8/ ENSP00000379998.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               AC084337.7         70045-70145         c
            102-242             AC084337.7         69137-69277         c
            243-339             AC084337.7         68786-68882         c
            340-458             AC084337.7         67954-68072         c
            459-680             AC084337.7         67552-67773         c
            681-838             AC084337.7         66855-67012         c
            839-1013            AC084337.7         66532-66706         c
            1014-1763           AC084337.7         65333-66082         c
FEATURES             Location/Qualifiers
     source          1..1763
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..1763
                     /gene="ARFIP2"
                     /gene_synonym="POR1"
                     /note="ARF interacting protein 2"
                     /db_xref="GeneID:23647"
                     /db_xref="HGNC:HGNC:17160"
                     /db_xref="MIM:601638"
     exon            1..101
                     /gene="ARFIP2"
                     /gene_synonym="POR1"
                     /inference="alignment:Splign:2.1.0"
     exon            102..242
                     /gene="ARFIP2"
                     /gene_synonym="POR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..1169
                     /gene="ARFIP2"
                     /gene_synonym="POR1"
                     /note="isoform 2 is encoded by transcript variant 13;
                     partner of RAC1 (arfaptin 2); ADP ribosylation factor
                     interacting protein 2"
                     /codon_start=1
                     /product="arfaptin-2 isoform 2"
                     /protein_id="NP_001363487.1"
                     /db_xref="CCDS:CCDS7765.1"
                     /db_xref="GeneID:23647"
                     /db_xref="HGNC:HGNC:17160"
                     /db_xref="MIM:601638"
                     /translation="MTDGILGKAATMEIPIHGNGEARQLPEDDGLEQDLQQVMVSGPN
                     LNETSIVSGGYGGSGDGLIPTGSGRHPSHSTTPSGPGDEVARGIAGEKFDIVKKWGIN
                     TYKCTKQLLSERFGRGSRTVDLELELQIELLRETKRKYESVLQLGRALTAHLYSLLQT
                     QHALGDAFADLSQKSPELQEEFGYNAETQKLLCKNGETLLGAVNFFVSSINTLVTKTM
                     EDTLMTVKQYEAARLEYDAYRTDLEELSLGPRDAGTRGRLESAQATFQAHRDKYEKLR
                     GDVAIKLKFLEENKIKVMHKQLLLFHNAVSAYFAGNQKQLEQTLQQFNIKLRPPGAEK
                     PSWLEEQ"
     exon            243..339
                     /gene="ARFIP2"
                     /gene_synonym="POR1"
                     /inference="alignment:Splign:2.1.0"
     exon            340..458
                     /gene="ARFIP2"
                     /gene_synonym="POR1"
                     /inference="alignment:Splign:2.1.0"
     exon            459..680
                     /gene="ARFIP2"
                     /gene_synonym="POR1"
                     /inference="alignment:Splign:2.1.0"
     exon            681..838
                     /gene="ARFIP2"
                     /gene_synonym="POR1"
                     /inference="alignment:Splign:2.1.0"
     exon            839..1013
                     /gene="ARFIP2"
                     /gene_synonym="POR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1763
                     /gene="ARFIP2"
                     /gene_synonym="POR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1743..1748
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARFIP2"
                     /gene_synonym="POR1"
                     /note="hexamer: AATAAA"
     polyA_site      1763
                     /gene="ARFIP2"
                     /gene_synonym="POR1"
                     /note="major polyA site"
ORIGIN      
        1 gagtccctga cctgctgcta ggatcgcgac gggaactgga gcccgaggtc cccgcgcggc
       61 ccgggcctgg cgccctgagg ggaagagcgg cccggcccga gggtgctggg gtggagagtt
      121 ttactccaat acctttccta gccatgacgg acgggatcct agggaaggca gccacaatgg
      181 agatccctat ccacgggaac ggcgaagcca ggcagcttcc tgaagatgat gggctggagc
      241 aggacctcca gcaggtgatg gtgtcaggac ccaacctcaa tgaaaccagc attgtgtctg
      301 gtggctatgg gggctctggt gatggactca tccccacagg gtctggccgc catccatctc
      361 acagcaccac tccttctggc cctggagatg aggtggctcg gggcattgct ggagaaaagt
      421 ttgacatcgt caagaaatgg ggcatcaaca cctataagtg cacaaagcaa ctgttatcag
      481 aacgatttgg tcgaggctca cggactgtgg acctggagct agagctgcag attgagttgc
      541 tgcgtgagac gaagcgcaag tatgagagtg tcctgcagct gggccgggca ctgacagccc
      601 acctctacag cctgctgcag acccagcatg cactgggtga tgcctttgct gacctcagcc
      661 agaagtcccc agagcttcag gaggaatttg gctacaatgc agagacacag aaactactat
      721 gcaagaatgg ggaaacgctg ctaggagccg tgaacttctt tgtctctagc atcaacacat
      781 tggtcaccaa gaccatggaa gacacgctca tgactgtgaa acagtatgag gctgccaggc
      841 tggaatatga tgcctaccga acagacttag aggagctgag tctaggcccc cgggatgcag
      901 ggacacgtgg tcgacttgag agtgcccagg ccactttcca ggcccatcgg gacaagtatg
      961 agaagctgcg gggagatgtg gccatcaagc tcaagttcct ggaagaaaac aagatcaagg
     1021 tgatgcacaa gcagctgctg ctcttccaca atgctgtgtc cgcctacttt gctgggaacc
     1081 agaaacagct ggagcagacc ctgcagcagt tcaacatcaa gctgcggcct ccaggagctg
     1141 agaaaccctc ctggctagag gagcagtgag ctgctcccag cccaacttgg ctatcaagaa
     1201 agacattggg aagggcagcc ccagggtgtg ggagattgga catggtacat cctttgtcac
     1261 ttgccctctg gcttgggctc ctttttctgg ctggggcctg acaccagttt tgcccacatt
     1321 gctatggtgg gaagagggcc tggaggccca gaagttgctg ccctgtctat cttcctggcc
     1381 acagggcttc attcccagat cttttccttc cacttcacag ccaacggcta tgacaaaacc
     1441 actccctggc caatggcatc actcttcagg ctggggtgtg ctccctgacc aatgacagag
     1501 cctgaaaatg ccctgtcagc caatggcagc tcttctcgga ctcccctggg ccaatgatgt
     1561 tgcgtctaat accctttgtc tctcctctat gcgtgcccat tgcagagaag gggactggga
     1621 ccaaaggggt ggggataatg gggagcccca ttgctggcct tgcatctgaa taggcctacc
     1681 ctcacccacc cacccagttt aattgtgctt agagcccaag aagattggga tctagcacta
     1741 ggaataaacc tttcataaaa gca
//
