LOCUS       NM_001025595            3542 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ARF interacting protein 1 (ARFIP1), transcript variant
            1, mRNA.
ACCESSION   NM_001025595
VERSION     NM_001025595.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3542)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 3542)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3542)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3542)
  AUTHORS   Huang,L.H., Lee,W.C., You,S.T., Cheng,C.C. and Yu,C.J.
  TITLE     Arfaptin-1 negatively regulates Arl1-mediated retrograde transport
  JOURNAL   PLoS One 10 (3), e0118743 (2015)
   PUBMED   25789876
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3542)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3542)
  AUTHORS   Ho,W.T., Exton,J.H. and Williger,B.T.
  TITLE     Arfaptin 1 inhibits ADP-ribosylation factor-dependent matrix
            metalloproteinase-9 secretion induced by phorbol ester in HT 1080
            fibrosarcoma cells
  JOURNAL   FEBS Lett 537 (1-3), 91-95 (2003)
   PUBMED   12606037
  REMARK    GeneRIF: inhibits ADP-ribosylation factor-dependent matrix
            metalloproteinase-9 secretion induced by phorbol ester in
            fibrosarcoma cells
REFERENCE   7  (bases 1 to 3542)
  AUTHORS   Suzuki,Y., Tsunoda,T., Sese,J., Taira,H., Mizushima-Sugano,J.,
            Hata,H., Ota,T., Isogai,T., Tanaka,T., Nakamura,Y., Suyama,A.,
            Sakaki,Y., Morishita,S., Okubo,K. and Sugano,S.
  TITLE     Identification and characterization of the potential promoter
            regions of 1031 kinds of human genes
  JOURNAL   Genome Res 11 (5), 677-684 (2001)
   PUBMED   11337467
REFERENCE   8  (bases 1 to 3542)
  AUTHORS   Williger,B.T., Provost,J.J., Ho,W.T., Milstine,J. and Exton,J.H.
  TITLE     Arfaptin 1 forms a complex with ADP-ribosylation factor and
            inhibits phospholipase D
  JOURNAL   FEBS Lett 454 (1-2), 85-89 (1999)
   PUBMED   10413101
REFERENCE   9  (bases 1 to 3542)
  AUTHORS   Tsai,S.C., Adamik,R., Hong,J.X., Moss,J., Vaughan,M., Kanoh,H. and
            Exton,J.H.
  TITLE     Effects of arfaptin 1 on guanine nucleotide-dependent activation of
            phospholipase D and cholera toxin by ADP-ribosylation factor
  JOURNAL   J Biol Chem 273 (33), 20697-20701 (1998)
   PUBMED   9694811
REFERENCE   10 (bases 1 to 3542)
  AUTHORS   Kanoh,H., Williger,B.T. and Exton,J.H.
  TITLE     Arfaptin 1, a putative cytosolic target protein of ADP-ribosylation
            factor, is recruited to Golgi membranes
  JOURNAL   J Biol Chem 272 (9), 5421-5429 (1997)
   PUBMED   9038142
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK304141.1, DC346238.1, BC105114.1, BC103759.1, AK299600.1,
            AK096509.1, AI634366.1 and AC099339.6.
            
            On Nov 22, 2018 this sequence version replaced NM_001025595.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Variants 1, 4, and 5 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.176730.1,
                                           SRR1660805.57770.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000353617.7/ ENSP00000296557.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AK304141.1         18-42
            26-589              DC346238.1         14-577
            590-1435            BC105114.1         463-1308
            1436-1852           BC103759.1         1282-1698
            1853-2259           AK299600.1         1193-1599
            2260-2965           AK096509.1         1993-2698
            2966-3097           AI634366.1         14-145              c
            3098-3542           AC099339.6         97875-98319
FEATURES             Location/Qualifiers
     source          1..3542
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.3"
     gene            1..3542
                     /gene="ARFIP1"
                     /gene_synonym="HSU52521"
                     /note="ARF interacting protein 1"
                     /db_xref="GeneID:27236"
                     /db_xref="HGNC:HGNC:21496"
                     /db_xref="MIM:605928"
     exon            1..273
                     /gene="ARFIP1"
                     /gene_synonym="HSU52521"
                     /inference="alignment:Splign:2.1.0"
     exon            274..375
                     /gene="ARFIP1"
                     /gene_synonym="HSU52521"
                     /inference="alignment:Splign:2.1.0"
     CDS             283..1404
                     /gene="ARFIP1"
                     /gene_synonym="HSU52521"
                     /note="isoform 1 is encoded by transcript variant 1;
                     arfaptin-1; ADP ribosylation factor interacting protein 1"
                     /codon_start=1
                     /product="arfaptin-1 isoform 1"
                     /protein_id="NP_001020766.1"
                     /db_xref="CCDS:CCDS34080.1"
                     /db_xref="GeneID:27236"
                     /db_xref="HGNC:HGNC:21496"
                     /db_xref="MIM:605928"
                     /translation="MAQESPKNSAAEIPVTSNGEVDDSREHSFNRDLKHSLPSGLGLS
                     ETQITSHGFDNTKEGVIEAGAFQGSPAPPLPSVMSPSRVAASRLAQQGSDLIVPAGGQ
                     RTQTKSGPVILADEIKNPAMEKLELVRKWSLNTYKCTRQIISEKLGRGSRTVDLELEA
                     QIDILRDNKKKYENILKLAQTLSTQLFQMVHTQRQLGDAFADLSLKSLELHEEFGYNA
                     DTQKLLAKNGETLLGAINFFIASVNTLVNKTIEDTLMTVKQYESARIEYDAYRTDLEE
                     LNLGPRDANTLPKIEQSQHLFQAHKEKYDKMRNDVSVKLKFLEENKVKVLHNQLVLFH
                     NAIAAYFAGNQKQLEQTLKQFHIKLKTPGVDAPSWLEEQ"
     exon            376..484
                     /gene="ARFIP1"
                     /gene_synonym="HSU52521"
                     /inference="alignment:Splign:2.1.0"
     exon            485..580
                     /gene="ARFIP1"
                     /gene_synonym="HSU52521"
                     /inference="alignment:Splign:2.1.0"
     exon            581..693
                     /gene="ARFIP1"
                     /gene_synonym="HSU52521"
                     /inference="alignment:Splign:2.1.0"
     exon            694..915
                     /gene="ARFIP1"
                     /gene_synonym="HSU52521"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1073
                     /gene="ARFIP1"
                     /gene_synonym="HSU52521"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1248
                     /gene="ARFIP1"
                     /gene_synonym="HSU52521"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..3542
                     /gene="ARFIP1"
                     /gene_synonym="HSU52521"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3074..3079
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARFIP1"
                     /gene_synonym="HSU52521"
                     /note="hexamer: ATTAAA"
     regulatory      3092..3097
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARFIP1"
                     /gene_synonym="HSU52521"
                     /note="hexamer: AGTAAA"
     polyA_site      3097
                     /gene="ARFIP1"
                     /gene_synonym="HSU52521"
                     /note="major polyA site"
     polyA_site      3110
                     /gene="ARFIP1"
                     /gene_synonym="HSU52521"
     regulatory      3517..3522
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARFIP1"
                     /gene_synonym="HSU52521"
                     /note="hexamer: AATAAA"
     polyA_site      3542
                     /gene="ARFIP1"
                     /gene_synonym="HSU52521"
ORIGIN      
        1 ctcctcactt ccggcttcgc tgctcttggt tctggttctg gaggctgggt tgagaggtcg
       61 ccggtccgac tgtcctcggc ggttggtcag tgtgaatttg tgacagctgc agttgctccc
      121 cgcccccgag cagccgaggt gcgtggggga aggggaagaa ggaaaaggtc cgggtcgcgt
      181 ttccgctcag tttttgccag ggttgaggcg attccagaga gcggcggaaa ggataagcct
      241 cgacttagaa gctaccgagt taccctaaga aaggagtcta ccatggctca agaatctccc
      301 aaaaattcag cagcagaaat tccagtgact agtaatggag aagttgatga ctctcgtgaa
      361 catagcttta atagggattt gaagcattca ttaccatctg gacttggtct ctcagaaacc
      421 caaattacat ctcatggctt tgacaatacc aaagagggtg ttattgaagc aggagcattt
      481 caaggttccc cagcaccgcc actgccatct gttatgtctc ctagcagggt tgcagctagt
      541 cgactggctc agcaaggaag tgatttaatt gttcctgcag gtggccagag aacacagaca
      601 aaaagtggac cagttattct agcagatgaa attaaaaatc ctgcaatgga aaagttagaa
      661 cttgttagaa aatggagtct aaacacctat aagtgtactc gacagattat ctctgagaag
      721 ctaggccgtg gctcaagaac tgtggacctt gaacttgaag ctcagattga tatattaagg
      781 gataacaaga aaaaatatga aaatatttta aaactggctc aaacattgtc gacccagctt
      841 ttccagatgg tacataccca aaggcaactt ggagatgcat ttgctgacct gagtttgaag
      901 tcactagaac ttcatgaaga atttggctat aatgccgata cccagaaact gctggctaaa
      961 aatggagaga ctcttcttgg ggccattaat tttttcattg ctagtgtgaa cactttggtg
     1021 aataaaacca ttgaagatac attaatgact gtgaaacagt atgaaagtgc caggattgaa
     1081 tatgatgcat atcgcactga tttggaagaa ctgaatcttg gaccacgtga cgcaaacact
     1141 ctgccaaaga ttgagcagtc acagcatctc ttccaagcac ataaggaaaa atatgataaa
     1201 atgcgcaatg atgtttctgt caaattgaaa tttctagaag aaaataaggt taaagtattg
     1261 cacaatcagc tggtcctttt ccacaatgcc attgccgctt actttgctgg gaatcagaag
     1321 cagcttgaac agacacttaa acagttccat atcaaattga aaacccctgg agtggatgcc
     1381 ccatcttggc ttgaagaaca gtaaaatcac agcggaaaat aaaaagaaag tcgcgttgtt
     1441 atatttctaa accaacctaa caagaattaa gcagagttgg gggaagtggg aggggtgaca
     1501 agcattatag tgattcttgc acaaacagct ttaatttttc cctttttcat actttaacaa
     1561 ttgaactgtt aagggtggtt ttaatgtaaa catagtttct ataatctgaa cacaataatt
     1621 ttcctttttg agaaatcctt ttgtattgtg agggttgatg gctatttctg tagtttgaaa
     1681 acatctaata gagatttgca ctgacaagat aaaaattcaa ggtttttggt cctggaaatg
     1741 agggccgatt gtaacttttc caaagggagg tttacatgat ttgtatcaac atcagatatt
     1801 ttatatgtga atatattaaa catctttaag agattcattt tcatgtatta aagaaaaaag
     1861 aaactatttt gcagagtaaa gttatatggt gttcctgcag cgtccacaca gaggcagcag
     1921 ctctaatgaa tgattagctt gtggagttgt ggcaaatacc tttttaaaaa tgaatctgta
     1981 ccactgtaat tttatttaga ctttttttta aagacacaga aatcacactg tcatttctgt
     2041 gaggctttta agcttatgaa tttgcttcac ccgaagtcat tggacagtta catttgcaat
     2101 ttcttttggt tcataacaaa acctgcttaa gagaattttt ttttttgaca ggtggacgtg
     2161 ggaatggaaa ttcttaatgg tttctggagt agaaatctgt acttagaaaa ctagtttttg
     2221 ggtcagttcc attttgatag aagtgaatac atagacagct tttattgact tccatatgta
     2281 acaataccgt ttaagcctta aatcacagat atgtgccttc tcagatacag taattcttgt
     2341 tcaaccaatg tacaaaatcc ataaagaaac ccctgttgga taatgtttga tgtgtctatt
     2401 ccttccatgg aatggagcac tatgtatgaa tgttgggttt ctttgtactt gttaagccac
     2461 atttgaggtt tatggtaaaa atcatctttt gagtttgctc tttggttttt cttcattcct
     2521 tttgaggatt gggaaaacag aaagattctt tgatttgggt aatgaagagg taatttggga
     2581 cagtgtggtg gtaccaggaa gaaagaggat tggaaaggcc agtactgttt tagttgctcg
     2641 gcactgttgg ttttgtttta atgtggttgc cctgtccact acatggttct atcagtagtg
     2701 taatccattt tcaatgtaaa gctcttttag tttttgtcat agacataaat taatattttg
     2761 agaggcatcc ctcacctgtt catttcttct gtgttgaaat gaagtactta aaattaccgt
     2821 tatacatgaa ctttgtggac tgtaagattt gttatatatg ttcaaatgcc ttttagctgg
     2881 ctttttaatt aatatgcctg ttttgagtgc ttaatacaat gtaatgtgat tgtaaatcat
     2941 acctatttta aatcattcct tcctgtatat ttgtactcag agagccttat tttattcttc
     3001 cagcagaatt actacttgtg atagttcatt tacattcccc agaatgtgcc tctagtgtga
     3061 attttgtatt cttattaaac gtgtttgctg cagtaaatcg tttctctgga ccttcatagt
     3121 ttaagaagta actatttgga aattctgaag acacataatt tgcgttttct gaaccttaaa
     3181 aaaaaaggta cttctgtcac ttataattgt tttagctcag taagctattt tttttcaatg
     3241 tgaatctctt ttgagagctg aacatgtcca ttcttaacca catttcaata acagttactg
     3301 tagctaagga gctaaatagt ttcatggatt aatttttttc agaataaatt taaaatatcc
     3361 atgattctga tagtgggcac atgaccaaaa gaaaaaagta aatcaatata tttagccaat
     3421 ggtacattta ctttgttagg aatgtaattt atgttcatta tagaaaagaa ttagaagaaa
     3481 atttcaagta atagaagata agtaccttcc caagtgaata aatactgcat ggaaccactc
     3541 aa
//
