LOCUS       NM_014570               2728 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ARF GTPase activating protein 3 (ARFGAP3), transcript
            variant 1, mRNA.
ACCESSION   NM_014570
VERSION     NM_014570.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2728)
  AUTHORS   Chevalier,B., Baatallah,N., Najm,M., Castanier,S., Jung,V.,
            Pranke,I., Golec,A., Stoven,V., Marullo,S., Antigny,F.,
            Guerrera,I.C., Sermet-Gaudelus,I., Edelman,A. and Hinzpeter,A.
  TITLE     Differential CFTR-Interactome Proximity Labeling Procedures
            Identify Enrichment in Multiple SLC Transporters
  JOURNAL   Int J Mol Sci 23 (16), 8937 (2022)
   PUBMED   36012204
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2728)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   3  (bases 1 to 2728)
  AUTHORS   Sun,Y., Li,B., Lu,D., Liu,C., Hong,S. and Hong,L.
  TITLE     Expression of ArfGAP3 in Vaginal Anterior Wall of Patients With
            Pelvic Floor Organ Prolapse in Pelvic Organ Prolapse and Non-Pelvic
            Organ Prolapse Patients
  JOURNAL   Female Pelvic Med Reconstr Surg 27 (1), e64-e69 (2021)
   PUBMED   31868832
  REMARK    GeneRIF: Expression of ArfGAP3 in Vaginal Anterior Wall of Patients
            With Pelvic Floor Organ Prolapse in Pelvic Organ Prolapse and
            Non-Pelvic Organ Prolapse Patients.
REFERENCE   4  (bases 1 to 2728)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 2728)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2728)
  AUTHORS   Collins,J.E., Goward,M.E., Cole,C.G., Smink,L.J., Huckle,E.J.,
            Knowles,S., Bye,J.M., Beare,D.M. and Dunham,I.
  TITLE     Reevaluating human gene annotation: a second-generation analysis of
            chromosome 22
  JOURNAL   Genome Res 13 (1), 27-36 (2003)
   PUBMED   12529303
REFERENCE   7  (bases 1 to 2728)
  AUTHORS   Liu,X., Zhang,C., Xing,G., Chen,Q. and He,F.
  TITLE     Functional characterization of novel human ARFGAP3
  JOURNAL   FEBS Lett 490 (1-2), 79-83 (2001)
   PUBMED   11172815
REFERENCE   8  (bases 1 to 2728)
  AUTHORS   Zhang,C., Yu,Y., Zhang,S., Liu,M., Xing,G., Wei,H., Bi,J., Liu,X.,
            Zhou,G., Dong,C., Hu,Z., Zhang,Y., Luo,L., Wu,C., Zhao,S. and He,F.
  TITLE     Characterization, chromosomal assignment, and tissue expression of
            a novel human gene belonging to the ARF GAP family
  JOURNAL   Genomics 63 (3), 400-408 (2000)
   PUBMED   10704287
REFERENCE   9  (bases 1 to 2728)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   10 (bases 1 to 2728)
  AUTHORS   Matoba,R., Okubo,K., Hori,N., Fukushima,A. and Matsubara,K.
  TITLE     The addition of 5'-coding information to a 3'-directed cDNA library
            improves analysis of gene expression
  JOURNAL   Gene 146 (2), 199-207 (1994)
   PUBMED   8076819
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB458974.1, BC005122.2,
            AF111847.1, BQ019944.1 and AL049757.14.
            
            On Nov 23, 2018 this sequence version replaced NM_014570.4.
            
            Summary: The protein encoded by this gene is a GTPase-activating
            protein (GAP) that associates with the Golgi apparatus and
            regulates the early secretory pathway of proteins. The encoded
            protein promotes hydrolysis of ADP-ribosylation factor 1
            (ARF1)-bound GTP, which is required for the dissociation of coat
            proteins from Golgi-derived membranes and vesicles. Dissociation of
            the coat proteins is a prerequisite for the fusion of these
            vesicles with target compartments. The activity of this protein is
            sensitive to phospholipids. Multiple transcript variants encoding
            different isoforms have been found for this gene. This gene was
            originally known as ARFGAP1, but that is now the name of a related
            but different gene. [provided by RefSeq, Nov 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.186692.1,
                                           SRR5189664.175560.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263245.10/ ENSP00000263245.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                DB458974.1         130-191
            63-1155             BC005122.2         1-1093
            1156-2701           AF111847.1         1122-2667
            2702-2704           BQ019944.1         19-21               c
            2705-2728           AL049757.14        98404-98427         c
FEATURES             Location/Qualifiers
     source          1..2728
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.2"
     gene            1..2728
                     /gene="ARFGAP3"
                     /gene_synonym="ARFGAP1"
                     /note="ARF GTPase activating protein 3"
                     /db_xref="GeneID:26286"
                     /db_xref="HGNC:HGNC:661"
                     /db_xref="MIM:612439"
     exon            1..160
                     /gene="ARFGAP3"
                     /gene_synonym="ARFGAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1642
                     /gene="ARFGAP3"
                     /gene_synonym="ARFGAP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ADP-ribosylation factor GTPase activating protein 1; ARF
                     GAP 3; ADP ribosylation factor GTPase activating protein
                     3"
                     /codon_start=1
                     /product="ADP-ribosylation factor GTPase-activating
                     protein 3 isoform 1"
                     /protein_id="NP_055385.3"
                     /db_xref="CCDS:CCDS14042.1"
                     /db_xref="GeneID:26286"
                     /db_xref="HGNC:HGNC:661"
                     /db_xref="MIM:612439"
                     /translation="MGDPSKQDILTIFKRLRSVPTNKVCFDCGAKNPSWASITYGVFL
                     CIDCSGSHRSLGVHLSFIRSTELDSNWSWFQLRCMQVGGNASASSFFHQHGCSTNDTN
                     AKYNSRAAQLYREKIKSLASQATRKHGTDLWLDSCVVPPLSPPPKEEDFFASHVSPEV
                     SDTAWASAIAEPSSLTSRPVETTLENNEGGQEQGPSVEGLNVPTKATLEVSSIIKKKP
                     NQAKKGLGAKKGSLGAQKLANTCFNEIEKQAQAADKMKEQEDLAKVVSKEESIVSSLR
                     LAYKDLEIQMKKDEKMNISGKKNVDSDRLGMGFGNCRSVISHSVTSDMQTIEQESPIM
                     AKPRKKYNDDSDDSYFTSSSSYFDEPVELRSSSFSSWDDSSDSYWKKETSKDTETVLK
                     TTGYSDRPTARRKPDYEPVENTDEAQKKFGNVKAISSDMYFGRQSQADYETRARLERL
                     SASSSISSADLFEEPRKQPAGNYSLSSVLPNAPDMAQFKQGVRSVAGKLSVFANGVVT
                     SIQDRYGS"
     exon            161..279
                     /gene="ARFGAP3"
                     /gene_synonym="ARFGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            280..352
                     /gene="ARFGAP3"
                     /gene_synonym="ARFGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            353..484
                     /gene="ARFGAP3"
                     /gene_synonym="ARFGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            485..568
                     /gene="ARFGAP3"
                     /gene_synonym="ARFGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            569..656
                     /gene="ARFGAP3"
                     /gene_synonym="ARFGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            657..716
                     /gene="ARFGAP3"
                     /gene_synonym="ARFGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            717..763
                     /gene="ARFGAP3"
                     /gene_synonym="ARFGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            764..903
                     /gene="ARFGAP3"
                     /gene_synonym="ARFGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1032
                     /gene="ARFGAP3"
                     /gene_synonym="ARFGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1155
                     /gene="ARFGAP3"
                     /gene_synonym="ARFGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1287
                     /gene="ARFGAP3"
                     /gene_synonym="ARFGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1411
                     /gene="ARFGAP3"
                     /gene_synonym="ARFGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1502
                     /gene="ARFGAP3"
                     /gene_synonym="ARFGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1624
                     /gene="ARFGAP3"
                     /gene_synonym="ARFGAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..2728
                     /gene="ARFGAP3"
                     /gene_synonym="ARFGAP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2683..2688
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ARFGAP3"
                     /gene_synonym="ARFGAP1"
                     /note="hexamer: AATAAA"
     polyA_site      2701
                     /gene="ARFGAP3"
                     /gene_synonym="ARFGAP1"
                     /note="major polyA site"
ORIGIN      
        1 gcggcctcgt cgctcctgct gaggcggtag ccgcttttcg tcgactctta ccggttggct
       61 gggccagctg cgccgcggct cacagctgac gatgggggac cccagcaagc aggacatctt
      121 gaccatcttc aagcgcctcc gctcggtgcc cactaacaag gtgtgttttg attgtggtgc
      181 caaaaatccc agctgggcaa gcataaccta tggagtgttc ctttgcattg attgctcagg
      241 gtcccaccgg tcacttggtg ttcacttgag ttttattcga tctacagagt tggattccaa
      301 ctggtcatgg tttcagttgc gatgcatgca agtcggagga aacgctagtg catcttcctt
      361 ttttcatcaa catgggtgtt ccaccaatga caccaatgcc aagtacaaca gtcgtgctgc
      421 tcagctctat agggagaaaa tcaaatcgct cgcctctcaa gcaacacgga agcatggcac
      481 tgatctgtgg cttgatagtt gtgtggttcc acctttgtcc cctccaccaa aggaggaaga
      541 tttttttgcc tctcacgttt ctcctgaggt gagtgacaca gcgtgggcat cagcaatagc
      601 agaaccatct tctttaacat caaggcctgt ggaaaccact ttggaaaata atgaaggtgg
      661 acaagagcaa ggaccaagtg tggaaggtct taatgtacca acaaaggcta ctttagaggt
      721 atcctctatc ataaaaaaga aaccaaatca agctaaaaaa ggccttgggg ccaaaaaagg
      781 aagtttggga gctcagaaac tggcaaacac atgctttaat gaaattgaaa aacaagctca
      841 agctgcggat aaaatgaagg agcaggaaga cctggccaag gtggtatcta aagaagaatc
      901 aattgtttca tcattacgat tagcctataa ggatcttgaa attcaaatga agaaagacga
      961 aaagatgaac attagtggca aaaaaaatgt tgactcagac agactcggca tgggatttgg
     1021 aaattgcaga agtgttattt cacattcagt gacttcagat atgcagacca tagagcagga
     1081 atcacccatt atggcaaaac caagaaaaaa gtataatgat gacagtgacg attcatattt
     1141 tacttccagc tcaagttact ttgacgagcc agtggagtta aggagcagtt ctttctctag
     1201 ctgggatgac agttcagatt cctattggaa aaaagagacc agcaaagata ctgaaacagt
     1261 tctgaaaacc acaggctatt cagacagacc tactgctcgc cgcaagccag attatgagcc
     1321 agttgaaaat acagatgagg cccagaagaa gtttggcaat gtcaaggcca tttcatcaga
     1381 tatgtatttt ggaagacaat cccaggctga ttatgagacc agggcccgcc tagagaggct
     1441 gtcggcaagt tcctccataa gctcggctga tctgttcgag gagccgagga agcagccagc
     1501 agggaactac agcctgtcca gtgtgctgcc caacgccccc gacatggcgc agttcaagca
     1561 gggagtgaga tcggttgctg gaaaactctc cgtctttgct aatggagtcg tgacttcaat
     1621 tcaggatcgc tacggttctt aatactgaag tcatgatgtg tatttcctgg agaaattcct
     1681 ctttaaatga acaagtaacc acatctcagg cggcagtgaa gtccagatag ttttgcagat
     1741 tgttttgcta ctttttcata tggtatatgt ttctgatttt taatatttct tttgagaaat
     1801 tctgagttct gatgtaggag ctttcctgtg atttctgttt cacgttcctt cctgtcacac
     1861 cctcctttgg cgtctctgtg tatatccttg ctttattttc ttggaacctt tgatttcaac
     1921 actgagggcc tggagacctc ggctcctcct gctcctgaac caggaggctt catgtggggg
     1981 aggaggagag gtctccatgt gacacatggg ctcagggctg ccagaatcag cggatgctgg
     2041 atgggcctgc agaaacaaca ctcaccacac acacttcctt caaaagacca aaagtgactg
     2101 gtgtctcgtg tgacagattg cttcatttat gtttctacat agtaaggtga ctgccaaata
     2161 atatttgaag tcatctgtct ctttgtaaat tattttatat gacctataaa tttaaaaatg
     2221 tttttcagtg agtgctttta acaaacttaa gcttctgccc tgccaaggga attaatgtta
     2281 tcttgtgaaa ggtgttgctg tttgaattga tgagaaatgg aagatgagaa ctccctaaga
     2341 gttctcataa taaatcatct catcacaaat caatacggta tacagagtta aagtggaatg
     2401 aggtaagaag atacagctac agaaaatagt tgcgtgtatg ggagaacagt cattgtaatt
     2461 gggtagtttt gttaataaat atttttaaat cttgcttttc agaaattacc gaatgtgtat
     2521 aaacaaataa agaaaaataa tttagctgtg ttttagacag cattagaata tattgttcag
     2581 cacagtaaaa tatatttgaa atttgataag ccaaaaatgt ggttttgaat gaatattttg
     2641 tgaatctttc ttaaaagctc aaatttgtag acttctaaat agaataaaca cttgcagcag
     2701 atggcattgc ctacattttt ccctgaaa
//
